ライフサイエンスコーパス: primordial germ cell

1 in four cell-stage embryos is specified as a primordial germ cell.

2 c and Tol2 transposons efficiently transpose primordial germ cells.

3 an trap and mutate endogenous transcripts in primordial germ cells.

4 ble elements for the genetic manipulation of primordial germ cells.

5 acquired properties normally associated with primordial germ cells.

6 llectively called wunens, act redundantly in primordial germ cells.

7 ult body and perhaps to hold the fate of the primordial germ cells.

8 eterogeneous neoplasms thought to arise from primordial germ cells.

9 into the major somatic cell types as well as primordial germ cells.

10 enetic changes required for specification of primordial germ cells.

11 ressed Hro-nos appears to be associated with primordial germ cells.

12 s and consist of somatic cells and migratory primordial germ cells.

13 is also required for the normal migration of primordial germ cells.

14 opment on the maternal allele, and erased in primordial germ cells.

15 d correspond to cells previously proposed as primordial germ cells.

16 , become incorporated into vegetally derived primordial germ cells.

17 omponents necessary for determination of the primordial germ cells.

18 major axes and to determine the fate of the primordial germ cells.

19 l for the specification and proliferation of primordial germ cells.

20 ntified wunen 2 as a repellant for migrating primordial germ cells.

21 ion that is distinct from its requirement in primordial germ cells.

22 , axis determination, and development of the primordial germ cells.

23 y impairs SDF-1/CXCR4-dependent migration of primordial germ cells.

24 omotes active demethylation of the genome in primordial germ cells.

25 Because in mammals primordial germ cells also track through endoderm on the

26 conserved molecular program underlying both primordial germ cell and multipotent cell specification

27 Teratocarcinomas are tumors that arise from primordial germ cells and are readily curable with DNA-d

28 ch has key parallels with those operating in primordial germ cells and early embryos.

29 or their mesodermal predecessors; defects in primordial germ cells and germ line appear to be seconda

30 t to occur only twice during development, in primordial germ cells and in the pre-implantation embryo

31 fertility arises from a defect in migrating primordial germ cells and occurs equally in male and fem

32 em cells and induced pluripotent stem cells, primordial germ cells and oocytes.

33 e allantois, blood islands of the yolk sack, primordial germ cells and the amnion.

34 mechanisms for induction and maintenance of primordial germ cells and the basic signaling pathways t

35 ient vectors for the genetic manipulation of primordial germ cells and the chicken genome.

36 pecific signal-receptor combinations between primordial germ cells and their immediate environment es

37 guishable cells of totipotent human embryos, primordial germ cells, and stable cell lines.

38 Hypomethylated primordial germ cells appear to limit this risk by expre

39 migration and development to mature gametes, primordial germ cells are characterized by their lack of

40 In C. elegans, primordial germ cells are generated through four rounds

41 vasa and nanos orthologues, we find that the primordial germ cells are specified from at least the bl

42 Therefore, one of the reasons why primordial germ cells are unique is because this is the

43 In mouse embryos, the primordial germ cells arise during gastrulation prior to

44 New primordial germ cells arise from piwi-expressing germlin

45 Primordial germ cells arise from the proximal epiblast,

46 h early embryogenesis and differentiation of primordial germ cells but is reduced substantially durin

47 enome-wide demethylation that takes place in primordial germ cells, but leads to defective DNA demeth

48 quired for the colonization of the gonads by primordial germ cells, but not for earlier stages in ger

49 endodermal cells interact with and regulate primordial germ cells by actively excising and digesting

50 We demonstrate that chicken primordial germ cells can be modified in vitro using tra

51 DNA demethylation in postmigratory primordial germ cells coincides with erasure of genomic

52 onserved regulators that are enriched at the primordial germ cell cytoplasmic bridge to ensure its st

53 pletion caused by defective proliferation of primordial germ cells, decreased body weight, and partia

54 interrogate the epigenetic reprogramming of primordial germ cells, defining the timings of methylati

55 midstage embryos and its persistence in the primordial germ cells depend on wild-type MES-2 and MES-

56 a germ-cell reporter to quantify and isolate primordial germ cells derived from both male and female

57 major body axes and for the localization of primordial germ cell determinants during Drosophila mela

58 ention that sea urchins do not have obligate primordial germ cells determined in early development, t

59 g of the germ line are those associated with primordial germ cell development and subsequent fetal ge

60 (Dnd1), an RNA-binding protein required for primordial germ cell development during later stages of

61 Primordial germ cell development uses programmed cell de

62 og revealed that it is essential for Gryllus primordial germ cell development, and is regulated by up

63 e essential for silencing transposons during primordial germ cell development, and MIWI-bound piRNAs

64 ated for in hematopoiesis, melanogenesis and primordial germ cell development, but is critical in spe

65 found TE-specific endosiRNAs present during primordial germ cell development.

66 he kit receptor (Kit) is haplosufficient for primordial germ cell development.

67 eprogramming occurs: early mouse embryos and primordial germ cell development.

68 possibly other maternal RNAs, which promotes primordial germ cell development.

69 tified is not essential for hematopoiesis or primordial germ cell development.

70 thylation occur during the initial stages of primordial germ cell development; however, all consequen

71 TGCT susceptibility, consistent with failed primordial germ cell differentiation as an initiating st

72 This is the first evidence for primordial germ cells displaying these behaviours in any

73 Through careful analyses of primordial germ cell distribution in developing Drosophi

74 as the zebrafish lateral line primordium and primordial germ cells, Drosophila border cell clusters,

75 required for the survival and maintenance of primordial germ cells during embryogenesis.

76 (meiotic) germline and in the development of primordial germ cells during embryogenesis.

77 required for the survival and maintenance of primordial germ cells during embryogenesis.

78 While primordial germ cells during embryonic development are n

79 Such global reprogramming occurs in primordial germ cells, early embryos, and embryonic stem

80 blastocysts (embryonic stem cells, ESC) and primordial germ cells (embryonic germ cells, EGC).

81 The derivation of germ-line competent avian primordial germ cells establishes a cell-based model sys

82 Furthermore, primordial germ cells express, and appear to be function

83 s of epiblast development for competency for primordial germ cell fate.

84 Primordial germ cells first appear in extraembyronic tis

85 Using the in vivo model of zebrafish primordial germ cells for studying chemokine-directed si

86 Finally, we observed that modified primordial germ cells form functional gametes as demonst

87 Mouse primordial germ cells form germline cysts, but the role

88 nt, we reasoned that they might also support primordial germ cell formation.

89 ubule-dependent process; mRNAs necessary for primordial germ-cell formation are enriched in the germ

90 L (deleted in azoospermia-like) functions in primordial germ-cell formation, whereas closely related

91 y reflect the normal developmental switch in primordial germ cells from an undermethylated genome to

92 raeus japonensis entails the regeneration of primordial germ cells from body parts that lack gonads.

93 Here we isolate primordial germ cells from embryoid bodies, and derive c

94 Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for developmen

95 Human primordial germ cells (hPGCs), the precursors of sperm a

96 itates the trans-epithelial migration of the primordial germ cells in early embryos.

97 We also propose a novel role for primordial germ cells in mediating coalescence of the Ca

98 In laboratory mice, TGCTs arise from primordial germ cells in only the 129 inbred strains, an

99 We find a drastic reduction of primordial germ cells in Smad1-deficient embryos, sugges

100 s has two somatic gonadal precursors and two primordial germ cells in stereotyped positions within it

101 velopment of both the abdominal segments and primordial germ cells in the Drosophila embryo.

102 ked the progeny of individual, newly arrived primordial germ cells in the E10.5 gonad.

103 metes is established by the proliferation of primordial germ cells in the early embryo.

104 e germ-line stem cells that are derived from primordial germ cells in the embryo and give rise to spe

105 erated with endogenous embryonic Sertoli and primordial germ cells in the generation of testicular co

106 The developmental fate of primordial germ cells in the mammalian gonad depends on

107 in is cytoplasmic and expressed in migratory primordial germ cells in the region of the gonadal ridge

108 mutagenesis with transplantation of mutated primordial germ cells into a wild-type host.

109 at embryoid bodies support maturation of the primordial germ cells into haploid male gametes, which w

110 Over the first 4 days of their life, primordial germ cells invade the endoderm, migrate into

111 genomic demethylation of proliferative phase primordial germ cells is a mechanism by which germ cell

112 melanogaster, formation of the axes and the primordial germ cells is regulated by interactions betwe

113 Formation of primordial germ cells is robust, but terminal gametogene

114 n of replicating mtDNA between proliferating primordial germ cells, is responsible for the different

115 gh they are also recruited to the germ line, primordial germ cells lacking Nanog fail to mature on re

116 Pluripotent stem cell-derived human primordial germ cell-like cells (hPGCLCs) provide import

117 th previously reported ChIP-seq datasets for primordial germ cell-like cells and E18.5 small intestin

118 elopmental stage prior to segregation of the primordial germ cell lineage at gastrulation.

119 Messenger RNA encoding the primordial germ-cell marker, vasa, was present for more

120 aneously initiate expression of mesoderm and primordial germ cell markers asymmetrically on the embry

121 ripotent stem cell differentiation into late primordial germ cells, meiotic germ cells and ovarian fo

122 other mammals and whether, in some species, primordial germ cells might be a more tractable source t

123 Primordial germ cell migration appeared normal within Ft

124 e-spanning protein that negatively regulates primordial germ cell migration.

125 ish deadend (dnd-MO-Vivo) effectively caused primordial germ cell mis-migration and differentiation i

126 opmental cell migration, such as that of the primordial germ cells, occurred normally in the absence

127 olII-dependent transcription is repressed in primordial germ cells of many animals during early devel

128 Interestingly, overexpression of p53 in primordial germ cells of out mutant embryos partially su

129 We show that primordial germ cells of the cricket Gryllus bimaculatus

130 ls of blastocysts (embryonic stem cells) and primordial germ cells of the developing gonadal ridge (e

131 hich only Ftm, Fto, and Fts are expressed in primordial germ cells of the early gonad.

132 triggers widespread chromosome damage in the primordial germ cells of the nematode C. elegans.

133 la is a novel gene specifically expressed in primordial germ cells, oocytes, preimplantation embryos,

134 cells derived from preimplantation embryos, primordial germ cells or teratocarcinomas are currently

135 ing Caenorhabditis elegans embryogenesis the primordial germ cell, P(4), is generated via a series of

136 ncb mutant mice were infertile and exhibited primordial germ cell (PGC) defects during embryogenesis.

137 P granules, do not appear to be required for primordial germ cell (PGC) determination [3], but their

138 hat sox7 plays a novel and important role in primordial germ cell (PGC) development and that ephrinB1

139 The 'last cell standing' model describes primordial germ cell (PGC) development in axolotls, in w

140 Primordial germ cell (PGC) development is characterized

141 ing a morpholino oligonucleotide that blocks primordial germ cell (PGC) development, we generate embr

142 le (F0 generation) progeny in regards to the primordial germ cell (PGC) epigenetic reprogramming of t

143 piblast cells to develop toward a restricted primordial germ cell (PGC) fate during murine gastrulati

144 last cells that are already predisposed to a primordial germ cell (PGC) fate, which then progress to

145 ell-Less (GCL) protein is a key regulator of primordial germ cell (PGC) formation in Drosophila embry

146 mitochondria at the posterior at the site of primordial germ cell (PGC) formation through an actin-de

147 f embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation.

148 it receptor tyrosine kinase is essential for primordial germ cell (PGC) growth both in vivo and in vi

149 KitL, via its receptor cKit, supports primordial germ cell (PGC) growth, survival, migration a

150 by miRNAs that confers genetic robustness on primordial germ cell (PGC) migration.

151 g, how the methylation mark is erased during primordial germ cell (PGC) reprogramming remains unclear

152 nding of the molecular programs that control primordial germ cell (PGC) specification and differentia

153 ption factor BLIMP1 is a master regulator of primordial germ cell (PGC) specification and is suppress

154 te model organisms on the molecular basis of primordial germ cell (PGC) specification have revealed t

155 amaki et al. identify T as a key mediator of primordial germ cell (PGC) specification in the embryo.

156 Primordial germ cell (PGC) specification is a universal

157 Primordial germ cell (PGC) specification occurs either b

158 monstrate that Blimp1, which is required for primordial germ cell (PGC) specification, is dispensable

159 embryo, illustrate many typical features of primordial germ cell (PGC) specification.

160 allantois morphogenesis, cardiac looping and primordial germ cell (PGC) specification.

161 hich they are competent for both somatic and primordial germ cell (PGC) specification.

162 aster germline determinant BLIMP1 to promote primordial germ cell (PGC) specification.

163 erm plasm inheritance correlates with higher primordial germ cell (PGC) survival probability.

164 edness to pluripotent stem cell (ESC, iPSC), primordial germ cell (PGC), and differentiated somatic r

165 lomes from mouse gametes, early embryos, and primordial germ cell (PGC), as well as single-base-resol

166 efective allantois formation and the lack of primordial germ cells (PGC), but also show phenotypes th

167 ads to failure in pole-plasm maintenance and primordial-germ-cell (PGC) formation, whereas doubling a

168 the formation of TFs and cap cells, anterior primordial germ cells (PGCs) adjacent to TFs/cap cells c

169 de erasure of DNA methylation takes place in primordial germ cells (PGCs) and early embryos and is li

170 ing demethylation of DNA occurs in mammalian primordial germ cells (PGCs) and in early embryos, and i

171 end (dnd) mRNA is specifically expressed in primordial germ cells (PGCs) and is required for PGC mig

172 rentiating aggregates of cells that putative primordial germ cells (PGCs) and more mature gametes can

173 NA methylation reprogramming occurs in mouse primordial germ cells (PGCs) and preimplantation embryos

174 DNA methylation patterns need to be reset in primordial germ cells (PGCs) and preimplantation embryos

175 Primordial germ cells (PGCs) and preimplantation embryos

176 Drosophila melanogaster the proliferation of primordial germ cells (PGCs) and survival of the somatic

177 dazl first shows cell-specific expression in primordial germ cells (PGCs) approaching the gonad at st

178 In Drosophila, primordial germ cells (PGCs) are set aside from somatic

179 or example, in Xenopus and zebrafish embryos primordial germ cells (PGCs) are specified by germ plasm

180 Primordial germ cells (PGCs) are the embryonic precursor

181 Primordial germ cells (PGCs) are the founder cells of th

182 Primordial germ cells (PGCs) are the precursor of the ge

183 Primordial germ cells (PGCs) are the precursors of sperm

184 Primordial germ cells (PGCs) are the precursors of sperm

185 Primordial germ cells (PGCs) are the progenitors of repr

186 orhabditis elegans larvae are starved, their primordial germ cells (PGCs) arrest in the post-S phase.

187 During gastrulation, primordial germ cells (PGCs) associate tightly with the

188 e stem cells (GSCs) descend from a subset of primordial germ cells (PGCs) at the onset of oogenesis.

189 anos protein expression is restricted to the primordial germ cells (PGCs) during early embryogenesis.

190 ential survival and proliferation factor for primordial germ cells (PGCs) during their migration in t

191 Mouse primordial germ cells (PGCs) erase global DNA methylatio

192 In the mouse embryo, significant numbers of primordial germ cells (PGCs) fail to migrate correctly t

193 ximately 5% of human iPSCs differentiated to primordial germ cells (PGCs) following induction with bo

194 s study, we performed nuclear transfer using primordial germ cells (PGCs) from earlier stages at 8.5-

195 The migration of primordial germ cells (PGCs) from their place of origin

196 Primordial germ cells (PGCs) give rise to male and femal

197 Primordial germ cells (PGCs) give rise to the germ line

198 In animals, primordial germ cells (PGCs) give rise to the germ lines

199 es are deployed within this region, only the primordial germ cells (PGCs) have been closely studied.

200 inning at embryonic day 11.5 after migrating primordial germ cells (PGCs) have entered the gonad.

201 During embryogenesis, primordial germ cells (PGCs) have the potential to enter

202 uires the specification and proliferation of primordial germ cells (PGCs) in an extragonadal location

203 tory (E10.5) or postmigratory (E12.5) murine primordial germ cells (PGCs) in culture; however, it is

204 , has a crucial role in the specification of primordial germ cells (PGCs) in mice at embryonic day 7.

205 blastocysts, is also expressed in unipotent primordial germ cells (PGCs) in mice, where its precise

206 we tracked the distribution and migration of primordial germ cells (PGCs) in the Cx43alpha1KO mouse e

207 epends on the expansion of a small number of primordial germ cells (PGCs) in the early embryo.

208 e requires the specification and survival of primordial germ cells (PGCs) in the embryo as well as th

209 Evidence suggests that the specification of primordial germ cells (PGCs) in the mammalian embryo doe

210 e rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwart

211 patterns of Pt-vasa and Pt-piwi to show that primordial germ cells (PGCs) in the spider arise during

212 nt/beta-catenin signaling pathway in chicken primordial germ cells (PGCs) in vitro.

213 Primordial germ cells (PGCs) in Xenopus are specified th

214 egulation of migration initiation is that of primordial germ cells (PGCs) in zebrafish embryos.

215 ome activation (ZGA) and RNA localization in primordial germ cells (PGCs) in zebrafish.

216 dermal precursors, mesodermal precursors and primordial germ cells (PGCs) into the interior of the em

217 The migration of primordial germ cells (PGCs) is a useful model for study

218 The sex of primordial germ cells (PGCs) is determined in developing

219 ticular, the relationship between EpiSCs and primordial germ cells (PGCs) is unknown, and is worthy o

220 We have profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs

221 Specification of primordial germ cells (PGCs) marks the beginning of the

222 During development, primordial germ cells (PGCs) migrate from the sites of t

223 These primordial germ cells (PGCs) migrate to the developing s

224 During development, primordial germ cells (PGCs) navigate a complex journey

225 ritical chromatin modifications occur in the primordial germ cells (PGCs) of emergent starved L1 larv

226 pressed in multipotent cells, stem cells and primordial germ cells (PGCs) of organisms as diverse as

227 The primordial germ cells (PGCs) of the mouse are derived fr

228 eport that the translational activity in the primordial germ cells (PGCs) of the sea urchin embryo (S

229 nd the erasure of parental imprints in mouse primordial germ cells (PGCs) on embryonic day 11.5 (E11.

230 Ter)) results in a significant early loss of primordial germ cells (PGCs) prior to colonization of th

231 In the developing embryo, primordial germ cells (PGCs) represent the exclusive pro

232 ed from migrating 10.5-days-postcoitum (dpc) primordial germ cells (PGCs) showed normal morphological

233 ells (GSCs) in Drosophila are descendants of primordial germ cells (PGCs) specified during embryogene

234 During mouse development, primordial germ cells (PGCs) that give rise to the entir

235 melanogaster requires directed migration of primordial germ cells (PGCs) towards somatic gonadal pre

236 To acquire this property, primordial germ cells (PGCs) transit through an unpreced

237 hEG) cells derive from the transformation of primordial germ cells (PGCs) under appropriate culture c

238 Primordial germ cells (PGCs) undergo dramatic rearrangem

239 Primordial germ cells (PGCs) undergo proliferation, inva

240 Mouse primordial germ cells (PGCs) undergo sequential epigenet

241 been suggested to mediate migration of early primordial germ cells (PGCs), a process that is little u

242 protein DND1 is required for the survival of primordial germ cells (PGCs), as well as the suppression

243 os from either GSCs or their precursors, the primordial germ cells (PGCs), causes both cell types to

244 istic insight on how the key determinants of primordial germ cells (PGCs), including Prdm14, induce r

245 obal, as seen in preimplantation embryos and primordial germ cells (PGCs), or locus specific, which c

246 Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role

247 m somatic lineages is the differentiation of primordial germ cells (PGCs), precursors of sex-specific

248 two somatic gonad precursors (SGPs) and two primordial germ cells (PGCs), provides an accessible mod

249 ) results in mismigration and elimination of primordial germ cells (PGCs), resulting in fewer PGCs co

250 of Drosophila GSCs and their precursors, the primordial germ cells (PGCs), specifically requires CycB

251 the gene expression profile between ESCs and primordial germ cells (PGCs), the founders of the germ c

252 Primordial germ cells (PGCs), the precursors of sperm an

253 In animals, specification of the primordial germ cells (PGCs), the stem cells of the germ

254 n animal development is the specification of primordial germ cells (PGCs), which become the stem cell

255 Here we investigate Drosophila primordial germ cells (PGCs), which migrate through the

256 Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms the epige

257 transcriptional program for pluripotency in primordial germ cells (PGCs).

258 onstruct to the DDX4 (vasa) locus in chicken primordial germ cells (PGCs).

259 ave been generated from both human and mouse primordial germ cells (PGCs).

260 ficially reconstructed by transplantation of primordial germ cells (PGCs).

261 ved from 11.5 or 12.5 days post coitum (dpc) primordial germ cells (PGCs).

262 ertional mutation leading to a deficiency of primordial germ cells (PGCs).

263 Cs) provide important opportunities to study primordial germ cells (PGCs).

264 own to regulate the directional migration of primordial germ cells (PGCs).

265 with unmethylated cytosines is a hallmark of primordial germ cells (PGCs).

266 ly embryos, embryonic stem cells (ESCs), and primordial germ cells (PGCs).

267 nt embryonic cells and, strikingly, to early primordial germ cells (PGCs).

268 addition to functioning in proliferation of primordial germ cells, POG also functioned in spermatoge

269 sociated with cell cycle deficits within the primordial germ cell population that initiates just befo

270 Early primordial germ cells possess imprinting marks similar t

271 We concluded that Rev7 is required for primordial germ cell proliferation and embryonic viabili

272 s detected, we report a critical decrease in primordial germ cell proliferation by E12.5.

273 Specification of primordial germ cells requires global repression of tran

274 criptional and epigenetic landscape of human primordial germ cells, revealing a unique transcriptiona

275 tissue-specific gene expression of a set of primordial germ cell-specific genes.

276 esis that this molecular mechanism regulated primordial germ cell specification in a last common bila

277 M, a linker histone-like protein involved in primordial germ cell specification, zinc finger protein,

278 ssential role for Smad1-dependent signals in primordial germ cell specification.

279 n Drosophila melanogaster and other animals, primordial germ-cell specification in the developing emb

280 Mutations in p53 result in excess primordial germ cells that are ectopic to the gonads.

281 use are derived from a founder population of primordial germ cells that are set aside early in embryo

282 osed that nongonadal GCTs arise from ectopic primordial germ cells that have aberrantly migrated duri

283 nongonadal germ cell tumors are derived from primordial germ cells that have consistently lost the im

284 tal ridges as indifferent gonads, harbouring primordial germ cells that have migrated there.

285 ince both subtypes are thought to arise from primordial germ cells, the epigenetic differences seen b

286 methylation has been observed in zygotes and primordial germ cells, the responsible enzyme(s) have be

287 P expression was observed in the blastocyst, primordial germ cells, thymus, arterioles, osteoblasts,

288 vy chain gene by homologous recombination in primordial germ cells to establish fully transgenic chic

289 d to maintain stem cell pluripotency and for primordial germ cells to retain proliferative capability

290 ecting transcriptional repression and causes primordial germ cells to stray away from the somatic gon

291 Before the initiation of meiosis, mouse primordial germ cells undergo a series of epigenetic rep

292 Current methods to modify primordial germ cells using DNA or retroviral vectors ar

293 ell lines can also be derived from unipotent primordial germ cells via a poorly understood process of

294 on cells, such as the founder population of primordial germ cells where rapid and dynamic changes oc

295 developing into reproductive larvae possess primordial germ cells whereas embryos developing into so

296 pha severely reduces the number of embryonic primordial germ cells, which require Oct-4 expression fo

297 More generally, gene targeting in avian primordial germ cells will foster advances in diverse fi

298 el, results in severely decreased numbers of primordial germ cells within the early gonad.

299 n of both the somatic gonadal precursors and primordial germ cells within the primordium, but does no

300 PIE-1 disappears upon the birth of the primordial germ cells Z2 and Z3, yet these cells appear