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1 Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues (LTs), due to

2 While PrPC is principally a glycosylphosphatidylinositol-anchored memb

3 es and nonsymmetrically substituted ketones, principally a single product was found among the four ex

4 Although principally a strike-slip plate boundary, the faulted ma

5 development in RB-deficient livers that was principally absent in RB-sufficient tissue.

6 Conservation outcomes are principally achieved through the protection of intact ha

7 of hundreds of alternative splicing events, principally acting as a splicing repressor with only a s

8 ptake by liver and other peripheral tissues, principally adipose and muscle and with concurrently hig

9 neurons (MNs) are the neuronal class that is principally affected in amyotrophic lateral sclerosis (A

10 y resulted in impaired NKT cell development, principally affecting the formation and survival of long

11 e data are consistent with models where eRF3 principally affects binding interactions between eRF1 an

12 sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyc

13 e kinase domain and does not dimerize, it is principally an antagonist of lymphangiogenesis by seques

14 nding of activation products derived from C3 principally, and also from C4, impaired immunoglobulin G

15 tion of CICR by induction decay in the model principally arose from the steep Ca(2+) dependence of Ry

16 data suggest that endogenous alphaSyn exists principally as a 60-kDa tetramer in living cells but is

17 ine is a nitrogenous chemical substance used principally as a starting material for the manufacture o

18 current models indicate that Upf2 functions principally as an activator of Upf1 and a bridge between

19 Seasonal cold is causal, but, we contend, principally as an ecologically relevant evolutionary pre

20 on' is the tendency to experience one's body principally as an object, to be evaluated for its appear

21 Industrially the avocado pulp is exploited principally as oil and paste, generating a huge quantity

22 Lesions occur principally as side-effects from phenytoin, nifedipine,

23 t as dissolved iron (<0.025 mum) at pH 4 but principally as small (<0.45 mum) iron oxyhydroxide parti

24 e toxicity caused by silver nanoparticles is principally associated with bioavailable silver ions in

25 mbination fitting determined that Sr(2+) was principally associated with CaCO3.

26 tion on discharge, with this rehealing being principally associated with the solid-solution reaction

27 soforms were immunolocalized in ameloblasts, principally at maturation stage.

28 This remarkable change is principally attributable to the development of so-called

29 ompared to wheat flour bread, which could be principally attributed to retardation of amylopectin ret

30 to manage adult NMZL patients are presented, principally based on immunochemotherapy (when treatment

31 e in vivo role of CD1a has remained unclear, principally because CD1a is lacking in mice.

32 ndex was very heterogeneous between studies, principally because of differing age ranges, the increme

33 ractable tumor despite therapeutic advances, principally because of its invasive properties.

34 als, were more sensitive to synaptic fatigue principally because of reduced vesicle recycling rates.

35 ne of the most intractable of human cancers, principally because of the highly infiltrative nature of

36 ered for DMD, or other muscular dystrophies, principally because skeletal-muscle-related symptoms are

37 Principally, because of the far greater dependence of th

38 MBD enrichment, however, appears principally biased towards the recovery of CpG-rich and

39 ine structure (EXAFS) determined that Hg was principally bound to biothiols and/or proteins in M. sat

40 epted that cAMP regulates gene transcription principally by activating the protein kinase A (PKA)-tar

41 Thus, channel dynamics are determined principally by activation kinetics.

42 black-hole growth at 0.5 </= z </= 1 occurs principally by coherent rather than chaotic accretion ep

43 Driven principally by consanguineous homozygosity of GLRB mutat

44 the ocean-atmosphere system affect evolution principally by driving the synchronous extinction of lin

45 second, that adaptive radiations are driven principally by ecological opportunity rather than by the

46 iously described lncRNAs, NEAT1 is regulated principally by HIF-2 rather than by HIF-1.

47 within cancer susceptible epithelial tissues principally by influencing early events in malignant tra

48 Targeting and insertion are managed in cells principally by interactions between ribosomes and membra

49 1 reduced (alpha3beta4)2beta4-nAChR function principally by lowering cell-surface expression, whereas

50 yritization and kerogenization are regulated principally by placement and duration of the decaying or

51 IL-10 was generated principally by radio-resistant tissue, and was not requi

52 he expression of over 100 genes and operons, principally by repressing during growth genes whose prod

53 erse cardiovascular events (MACE) after PCI, principally by resulting in a larger postprocedure lumen

54 che signal can promote stem cell maintenance principally by stimulating stem cell proliferation.

55 ibody that neutralizes TNF-alpha and is used principally by systemic administration to treat many inf

56 Benign genital warts are caused principally by the alpha10 viruses HPV6 and HPV11.

57 found that FDG uptake by tumors was dictated principally by the driver oncogene and was not independe

58 In the heart, CXCL12 is expressed principally by the epicardium, and its receptor CXCR4 is

59 hosphate (ppp) are detected in the cytoplasm principally by the innate immune receptor Retinoic Acid

60 mergence of strains being determined instead principally by the prevailing profile of population-leve

61 al rapid tension fall in the model is caused principally by the reversal of the first tensing step, b

62 cts generates colour and flavour, controlled principally by the time course of product temperature an

63 e-coupled CA1 pyramidal cells was controlled principally by their inhibitory inputs, which dominated

64 and their fate is thought to be constrained principally by their position.

65 Epithelial barrier function is defined principally by tight junctions, which, in turn, depend o

66 nd that the degree of helping was determined principally by two factors that constrain successful ind

67 idylinositol 4-phosphate (PI4P), synthesized principally by two intracellular enzymes, PI4-kinases II

68 protein contacts the Rae1*Nup98 heterodimer principally by two protrusions projecting from the globu

69 arcinoma, are common cancers that are caused principally by ultraviolet (UV) radiation.

70 durable protection from the virus, is driven principally by unconventional processing of antigen synt

71 is required for tumour growth and is induced principally by vascular endothelial growth factor A (VEG

72 ensive, abundant, and sustainable materials, principally, C and Fe, demonstrates remarkable current a

73 acts to achieve a pH of 9, and filtration of principally calcium phosphate.

74 acts to achieve a pH of 9, and filtration of principally calcium phosphate.

75 ANC depletion at Moat and Emerald lakes was principally caused by acid deposition, and recovery in A

76 ogy, and secondary (functional) MR, which is principally caused by global or regional left ventricula

77 re diagnosed with cervical cancer, a disease principally caused by human papillomavirus (HPV).

78 r of pulses, the central spin decoherence is principally caused by second- or fourth-order nuclear sp

79 Interventions in the teenage group were principally caused by trauma-related injuries (burns, 22

80 oup; interventions in the teenage group were principally caused by trauma-related injuries.

81 h TAp63 to modulate key biological pathways, principally cell-cycle regulation, extracellular matrix

82 The avian genome is principally characterized by its constrained size, which

83 syndrome is an autosomal recessive disorder principally characterized by postnatal growth failure an

84 semblies, homogeneous protein recruitment is principally characterized by uniform rates of cooperativ

85 gae (Chlorophyta) and single-celled diatoms (principally Cocconeis spp.), which were high light accli

86 ers that vary in both size and shape but are principally composed of dimeric building blocks.

87 , the fragment screening sets often used are principally comprised of sp(2) -rich aromatic compounds,

88 ive millennial tree-ring chronologies, which principally comprises Eurasian sites, suggests that the

89 pathways and their interacting network were principally confirmed by an independent transcriptome se

90 heat, the diploid-like chromosome pairing is principally controlled by the Ph1 gene via preventing ho

91 The subtypes could be principally correlated with instantaneous (initial) and

92 atic alcohols transforms the C-O bond from a principally covalent bond to a complete charge-shift bon

93 its cellular receptor CD4 and a coreceptor, principally CXCR4 or CCR5.

94 saturate, aromatic, and polar fractions, are principally derived from petroleum sources.

95 information conveyed by human speech, is not principally determined by basilar membrane mechanics.

96 Being principally different from the packing of molecules in t

97 infection, virus-neutralizing antibodies are principally directed against gD, gB, and, to a lesser ex

98 nriched expression pattern of these genes is principally directed by islet transcription factors bind

99 ess of lymphoma in specific PIDD populations principally drove this increased incidence, while no inc

100 ology of type C waveforms (negative AIx) was principally due to a forward travelling (re-reflected) d

101 This is principally due to a lower occurrence of death and MI in

102 owever, we conclude that for males, this was principally due to deterioration in barrier defences, wh

103 of high-fat diet-induced insulin resistance principally due to improved insulin sensitivity in the l

104 iting increasing interest in honeydew honey, principally due to its functional properties.

105 Breast cancer mortality is principally due to recurrent tumors that arise from a re

106 nity of PD-L2 versus PD-L1 for human PD-1 is principally due to the 3-fold smaller dissociation rate

107 f peptide drugs to the brain is challenging, principally due to the blood brain barrier and the low m

108 Scores on the CMTPedS tended to worsen principally during childhood (ages, 3-10 years) for part

109 es, 43 (5.2%) such events occurred in women, principally during jogging, cycling, and swimming.

110 Rapidly cycling SCs function principally during normal tissue maintenance and are hig

111 are a unique group of Old World monkeys that principally eat leaves and seeds rather than fruits and

112 e gQDs exhibit unusual single-QD properties, principally emitting from dim gray states but having hig

113 Brain death is principally established using clinical criteria includin

114 which forms methane and short-chain alkanes, principally ethane, propane and butane.

115 esponses to 20th century climate change have principally examined effects related to ubiquitous incre

116 Tumor cells principally exhibit increased mitochondrial transmembran

117 heir relative proportions differ: beta-cells principally express Nav1.7 and alpha-cells Nav1.3.

118 In the brain, ATP1A3 is principally expressed in neurons.

119 tified as a target of miR-199a-5p, which was principally expressed in quiescent mouse hepatic stellat

120 Clay minerals are principally Fe-Mg illite, mixed layers of illite/smectit

121 ow a limited repertoire of inductive signals-principally FGFs, Wnts and BMPs-set up domains of transc

122 ontroversy regarding cancer hazard findings, principally findings on lymphoma/leukemia diagnoses.

123 These discovery efforts have principally focused on culturing bacteria from natural e

124 While research studies have principally focused on determining the magnitude of prot

125 The field of immunology is principally focused on the molecular mechanisms by which

126 levels in bone for osseointegrated implants, principally for external hex connections.

127 tum and nucleus accumbens core in which they principally form asymmetric synapses.

128 The transmissible prion agent is principally formed of PrP(Sc) itself and is associated w

129 ee text] band, while it has an extra band of principally [Formula: see text] orbital character, which

130 peculiarities of the larvae include features principally found in spider-associated insect groups, im

131 aded, whereas older reticulocytes (CD71(-)), principally found in the peripheral blood, were rarely i

132 vs. deciduous angiosperms, high LMA resulted principally from larger cell sizes, greater major vein a

133 mber and laminar position, which is produced principally from layers II-IV neurons.

134 While available evidence (stemming principally from mechanistic studies) has indicated that

135 's 21st-century SLR contribution are derived principally from regions where present-day mass loss is

136 Developments over the last 5 to 10 years, principally from studies on comprehensively phenotyped p

137 reduced capacity to interact with solvents, principally from the 10% substitution level, with dimini

138 In inorganic semiconductors, these result principally from the Coulomb interaction between Wannier

139 nnervation of the vertebrate head is derived principally from the neurons of trigeminal and superior

140 ition and evolution of Mars has been derived principally from the SNC (shergottite-nakhlite-chassigni

141 tonian westerly wind field appears to differ principally from the trade wind pattern of the preceding

142 uter medulla, the osmolality gradient arises principally from vigorous active transport of NaCl, with

143 al transplant for a moderate-risk condition, principally Fuchs dystrophy or pseudophakic or aphakic c

144 undergoing PK for a moderate risk condition, principally Fuchs' dystrophy or pseudophakic or aphakic

145 ified 'settler' TFs whose genomic binding is principally governed by proximity to open chromatin.

146 oceramics and living cells is complex, it is principally governed by the implant's surface chemistry.

147 s associated with significant complications, principally graft-versus-host disease (GVHD) and opportu

148 n of ground-state prebiotic building blocks, principally HCN.

149 ratory studies on commercially bred species (principally honeybees and bumblebees) have identified su

150 Principally, however, we describe the growth of the CSD

151 ial peptides essential for the host barrier, principally human alpha-defensin 5 (HD5) and HD6.

152 The expression of proteins differed principally in a region- and layer-specific pattern, wit

153 watershed (r = 0.52 +/- 0.09, mean +/- SD), principally in cold areas, and with CMIgy across 9% of t

154 ncer usually result from coding alterations, principally in genes involved in DNA repair, whereas alm

155 ying potassium 3.2 (Kir3.2) channel is found principally in neurons that regulate diverse brain funct

156 gray but not white matter volumes, observed principally in regions where structure generally did not

157 ine exhibited 30-65-fold lower amounts of SM principally in the amount of 16:0.

158 Findings were principally in the frontal lobe, superior parietal lobes

159 f functional specialization, being expressed principally in the lower CNS; while GlyT1 has activity i

160 Glucosinolates, found principally in the plant order Brassicales, are modulate

161 nset T1D from the U.K. and that these differ principally in the proportion of infiltrating CD20(+) B

162 by evolutionary and economic theory, to act principally in their own interests.

163 In the parenchyma, DPP4 was found principally in type I and II cells and alveolar macropha

164 rial phenotype than loss of Hh signaling and principally induced a different BMP ligand.

165 The product of this research is principally information published in scientific journals

166 omponents of the viral capsid reported to be principally involved in cell entry with the correspondin

167 Gap junctions are principally involved in forming the electrical connectio

168 Club cells are principally involved in protection and maintenance of br

169 minal region of one of the two b subunits is principally involved in the binding of subunit delta, wh

170 Enamel formation is a staged process principally involving secretory and maturation stages, e

171 milabile chelate facilitates conversion of a principally ligand-based singly occupied molecular orbit

172 Though still principally limited by the plurality of conformational s

173 Pain was principally localized to the hands and the feet, neuropa

174 These subunits are principally located in pyramidal cell dendrites, althoug

175 ls distinguish extensive immune infiltrates, principally located in tertiary lymphoid structure germi

176 Glacial pollen and rare speleothem archives principally located in the Mediterranean domain.

177 erly array of whitish discrete accumulations principally located in the perifovea, termed dot pseudod

178 Spectral domain OCT showed them to be principally located on or in the RPE/Bruch's membrane co

179 an only be made using common macaque models, principally Macaca rhesus and Macaca fascicularis, exper

180 d immune response in African trypanosomes is principally mediated by antigenic variation, the sequent

181 potential-evoked neurotransmitter release is principally mediated by CaV2.1 calcium channels (CaV2.1)

182 Mitochondrial turnover is principally mediated by mitophagy, the trafficking of da

183 alterations in local L-arginine metabolism, principally mediated by the enzymes arginase (Arg) and i

184 that the effect of education on lifespan is principally mediated through smoking while the effect of

185 notic, and sedative agents, actions that are principally mediated via their ability to potentiate pha

186 c normative values for RV measurements among principally middle-aged and older adults.

187 etrazine-generated arylaziridinium ions that principally modify guanine-N7 sites on DNA.

188 Rabbit IgG showed a principally monomeric species, which is well resolved fr

189 trifugation showed that both IgG4 forms were principally monomeric with sedimentation coefficients s2

190 on precursors of limited ionization ability, principally N,O-acetals, without the use of an exogenous

191 much narrower specificity for small lesions, principally N3-methyladenine (3mA).

192 Similarly, resting mouse T cells expressed principally Neu5Gc, and Neu5Ac was induced upon activati

193 nt bond to a complete charge-shift bond with principally "no-bond" character.

194 a fungal cell wall-derived product composed principally of particulate beta-glucans, whereas inflamm

195 h, in other photosynthetic organisms, relies principally on a range of plastid-localized ATP generati

196 is generally assumed that nanocarriers rely principally on abnormal leaky vasculature for tumor acce

197 Cerebellar research has focused principally on adult motor function.

198 nagement of CKD in primary care should focus principally on identifying the minority of people at hig

199 at increased GABA synaptic activity impinges principally on indirect pathway MSNs.

200 topoietic differentiation previously focused principally on its myeloid activities and also indicated

201 evelopment of this promising field, focusing principally on lessons gleaned from immunological princi

202 s about the nature of teaching have depended principally on naturalistic observation and some experim

203 standard for clinical prognostication relies principally on pathological staging.

204 The N-type assignment in frog is based principally on pharmacological sensitivity to omega-cono

205 ical developments, and centre our discussion principally on the increasing trend to exploit the large

206 Most studies focused principally on the overstory trees with little attention

207 transition activated under pressure depends principally on the pressure-transmitting fluid used.

208 propria of the entire gastrointestinal tract principally originating from cholinergic enteric neurons

209 he photosynthetic growing season, manifested principally over Eurasia rather than North America, is a

210 s of each that showed burst characteristics (principally period and spike frequency) similar to the a

211 Emerging contaminants are principally personal care products not readily removed b

212 aphorin family that is GPI-linked, expressed principally postnatally, and enriched in sensory cortex.

213 latives) are a moderately diverse lineage of principally predatory animals, at least in their immatur

214 is a type II extracellular membrane protein principally present on the surface of chondrocytes that

215 lutionarily into several families, and it is principally proteins from three families, the DEAD-box,

216 etalliferous release occurring when sulfide (principally pyrite)-containing rock from mining activiti

217 While the demonstration is principally qualitative at this point, it is believed th

218 Five flavonol glycosides, principally quercetin-3-O-glucoside and quercetin-3-O-ru

219 vine and chicken enzymes, product release is principally rate-limiting in catalysis.

220 m neutralizing antibody responses, but these principally recognize only the infecting serotype.

221 Wzb principally recognizes the phosphate of its phosphotyros

222 f cross-presentation of phagocytosed OVA may principally reflect a requirement for recycling MHC-I mo

223 Furthermore, these findings principally reflected alterations in the schizophrenia s

224 This principally reflected profoundly defective IFN-gamma pro

225 Neuroimaging biomarkers-principally regional atrophy on structural MR imaging, p

226 Translation is principally regulated at the initiation stage.

227 Fibrogenic pathways in the liver are principally regulated by activation of hepatic stellate

228 a Inducible transcription Factors (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II)

229 plasma membrane, cholesterol homeostasis is principally regulated through sterol-sensing proteins th

230 hylphthalamic acid indicated that PFT1/MED25 principally regulates auxin transport and response.

231 ection by increasing circulating neutrophils principally regulation of G-CSF production.

232 NaF PET has high overall impact, principally related to its effect on replacing intended

233 ntly, we elucidate meteorological mechanisms principally related to wind speed and temperature that d

234 nd should complement predictive methods that principally rely on the computing of descriptors such as

235 s, the 5'-methylguanosine (cap) structure is principally removed by the Nudix family decapping enzyme

236 t is strongly associated with complications, principally respiratory sepsis, and systemic inflammatio

237 of high-molecular-weight hyaluronan (HA) is principally responsible for generating pressures that ca

238 ests that the C-terminal domain of hISG15 is principally responsible for interactions.

239 The two NTD-bound resveratrol molecules are principally responsible for promoting tighter binding be

240 s suggested that mutation at position 89 was principally responsible for the changes in inhibitory po

241 luorescence-lifetime imaging microscopy, are principally responsible for the decrease in catalytic pe

242 e remain controversial as available data are principally retrospective, and there is therefore little

243 d by increased pacing, phosphorylated ser302 principally, ser282 to a lesser degree, and ser273 not a

244 lture and showed a predominance of bacteria, principally Streptococcus pneumoniae, >75% being of sero

245 ble the visual cortex, an area that has been principally studied for its sensory processing function,

246 t in experimental cancer metastases has been principally studied in the 4T1 mammary tumor model, wher

247 pes, and provides evidence that connectivity principally supports host metapopulations afflicted by f

248 Phenolic compounds can principally suppress the off-flavor development in ultra

249 e first minute of the session when intake is principally taste-driven.

250 Crosslinking traps principally tetrameric alphaS in intact normal neurons,

251 Principally, TgAMA4 lacks both a deep surface groove and

252 This in vivo finding is discordant with the principally TH1-oriented response to Ft frequently obser

253 nefits of an asexual reproductive existence: principally, that it is rapid and convenient.

254 to this disproportionally high productivity, principally the extensive shallow-water banks covered in

255 requires more conventional model organisms; principally the mouse, because of similarities in crania

256 -induced gingival overgrowth lesions exhibit principally the presence of inflammation and little fibr

257 RTN neurons are glutamatergic and innervate principally the respiratory pattern generator; they regu

258 We suggest that sampling errors are principally the result of inaccuracies in measuring the

259 ndosome trafficking during the assembly, but principally the secretion, of infectious virus.

260 Biological oceanic processes, principally the surface production, sinking and interior

261 nderlying the thrombolytic effects of NAC is principally the VWF that cross-link platelets in arteria

262 Principally, the finding that NRG3 classes II and III ar

263 ction with the HIV-1 PR, which appears to be principally, though not exclusively, driven by electrost

264 ow that Scc2 binds dynamically to chromatin, principally through an association with cohesin.

265 d approximately 160 m widening over 6 years) principally through fluvial plucking and block topple.

266 r tuning the surface properties of polymers, principally through free-radical chemistry.

267 increased progressively starting at 4 weeks, principally through nonproliferative growth.

268 nteracts with the N-terminal half of TRN-SR2 principally through the HEAT repeats 4, 10, and 11.

269 IgE functions principally through two receptors, FcepsilonRI and CD23

270 e the lateral plasma membrane between cells, principally tight junctions in vertebrates and septate j

271 Tonic BCR signaling acts principally to activate AKT, and forced activation of AK

272 ula were in many cases compound-specific due principally to conditions affecting signal intensity suc

273 sulfate column, Fe(III) solids were reduced principally to FeS(am), whereas As(V) was reduced to a p

274 Moreover, SAP bound principally to hepatosplenic amyloid, whereas p5+14 was

275 , such as Saccharomyces cerevisiae, responds principally to nutrients, e.g., nitrogen and phosphate s

276 sis, and that the stasis is likely to be due principally to selective pressure acting on pollen morph

277 w that alpha5(GFP) neurons in the IP project principally to the MnR/PMnR and DTg/interfascicular dors

278 aluated using a MALLS (batch-mode) detector, principally to understand the role played by different s

279 In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol est

280 This bimodality is principally underscored by the antagonistic actions of t

281 Pathway analysis showed principally up-regulation of pattern recognition and inn

282 n widely reported, with mRNA detection based principally upon RT-PCR assays.

283 Povidone-iodine (PVI) is principally used as an antimicrobial agent.

284 So far, such nanofluidic capabilities have principally used components such as channels, nozzles or

285 rom muscle injury in models of older animals principally used insults that primarily affect only the

286 Principally, using a precancerous cell line, we propose

287 : for instance, typhus group rickettsiae are principally vectored by insects (i.e., lice and fleas),

288 to influence bone quality and osteoporosis, principally via calcium-dependent alteration of bone str

289 CRs) ubiquitously inhibit neurotransmission, principally via Gbetagamma, which acts via a number of p

290 that controls organelle membrane composition principally via regulation of phosphatidylinositol 4-pho

291 spontaneously under physiological conditions principally when a glycyl residue is at the carboxyl sid

292 the broader implications of these findings, principally whether deviations from Haldane's rule might

293 uantitatively using electrochemical methods, principally with disk carbon fiber microelectrode ampero

294 chievement that had been previously observed principally with DNA structures.

295 indentified sites, emissions were associated principally with one or the other orientation of the tra

296 el substrate preprolactin (pPL) was isolated principally with Sec61alphabetagamma upon membrane targe

297 Our reasons extend beyond those concerned principally with the environment, to also include impact

298 witch fibre recruitment boundary in the rat) principally within glycolytic fast-twitch muscle.

299 ular effects of nNOS-derived NO are manifest principally within glycolytic muscle.

300 s upstream of c-Jun N-terminal kinase (JNK), principally ZAK.