ライフサイエンスコーパス: prioritization

1 neural substrates that support such dynamic prioritization.

2 teristics provide the foundation for HT risk prioritization.

3 cal discovery chemistry, applied to compound prioritization.

4 he impact of their uncertainties on chemical prioritization.

5 of noncoding regulatory elements complicate prioritization.

6 vel impacts, which could affect conservation prioritization.

7 7 non-recurrent exonic variants remained for prioritization.

8 specific molecular networks for disease gene prioritization.

9 be employed for variant filtration and gene prioritization.

10 ollage is a new data fusion approach to gene prioritization.

11 olutionarily informed models of conservation prioritization.

12 en should help guide ophthalmologic research prioritization.

13 power of existing and future studies through prioritization.

14 zed by MS/MS similarity was used for further prioritization.

15 new web-based application for candidate gene prioritization.

16 hes to identify potentially causal genes for prioritization.

17 r variant calling, filtering, annotation and prioritization.

18 es and demonstrated its utility for chemical prioritization.

19 rful technique for novel gene identification/prioritization.

20 sory modulation may contribute to behavioral prioritization.

21 unctional annotations and network-based gene prioritization.

22 ost, a novel method specific for RNA variant prioritization.

23 contributes to sex differences in behavioral prioritization.

24 modulation of olfactory preferences and food prioritization.

25 ecific regulatory networks and for regulator prioritization.

26 eneral preparatory mechanism for value-based prioritization.

27 ols) to optimize the power of candidate-gene prioritization.

28 d to a cumulative threats index for possible prioritization.

29 ant to therapeutic target identification and prioritization.

30 ulness for variant filtering, annotation and prioritization.

31 ites providing an important clue for variant prioritization.

32 ing another layer of information for variant prioritization.

33 elevant GBD classification based on rules of prioritization across the pathways found.

34 icals that are planetary boundary threats is prioritization against profiles defined in terms of envi

35 on fusion detection tools, candidate fusion prioritization algorithms and dedicated fusion databases

36 ds with 7 popular network-based disease gene prioritization algorithms on diseases from Online Mendel

37 obal biodiversity hotspot [5], using spatial prioritization analyses that maximize species conservati

38 s and supported by quantitative conservation prioritization analyses, and illustrate it using the Cor

39 tions, haplogroup assignment, functional and prioritization analysis of mitochondrial variants) as we

40 ix new susceptibility loci, and further gene prioritization analysis of these loci implicated BATF3,

41 criptive statistics, trend tests and spatial prioritization analysis we show that in most places on e

42 ms biologically meaningful candidate variant prioritization and can be more accurate than another rec

43 A) domains from DNA sequences, which enables prioritization and dereplication, and integration with o

44 argue that Africans should take the lead in prioritization and evaluation of environmental hazards,

45 Our recommendations include advocating for prioritization and funding of VMMC, increasing strategic

46 r a more streamlined approach enabling rapid prioritization and identification of likely pathogenic v

47 proach is capable of accurate candidate gene prioritization and illustrate its strengths and weakness

48 ers could use these progression risk data in prioritization and in determining the timing of treatmen

49 ent committee identified gaps in the SRS for prioritization and intervention and piloted the system i

50 Gene prioritization and pathway analysis have focused on a pr

51 xicity testing is transforming chemical risk prioritization and provides an opportunity for integrati

52 ugmenting limited scope assessments, and for prioritization and screening of very data limited chemic

53 molecular networks for studying disease gene prioritization and show the superiority of our network m

54 Through prioritization and stringent selection criteria, we sele

55 We discuss these emerging criteria for gene prioritization and the potential impact on the field of

56 Steps 1, 2 and 3 were discovery, prioritization and validation for tracking suicidality,

57 are a major technology, but require adequate prioritization and validation of candidate genes from th

58 hus providing a dataset that facilitates the prioritization and validation of mutations identified in

59 top biomarker from our sequential discovery, prioritization and validation steps, BCL2, predicted fut

60 pecies approach to candidate identification, prioritization and validation.

61 nt of computational frameworks to aid in the prioritization and visualization of these diverse data t

62 Current approaches to chemical screening, prioritization, and assessment are being reenvisioned, d

63 ssessment, global and national public health prioritization, and drug pricing will determine the pote

64 in protein function prediction, disease gene prioritization, and patient stratification.

65 traditionally used in candidate disease gene prioritization applications with experimental data from

66 me Atlas Consortium (TCGA), we propose a new prioritization approach based on the analysis of the dis

67 We expect that this combined prioritization approach may increase accuracy and decrea

68 The results from the prioritization approach revealed rs10995 as the most lik

69 oped an interactive, reproducible, web-based prioritization approach that builds on our earlier work.

70 Here, we demonstrate the use of a spatial prioritization approach to efficiently prioritize specie

71 Therefore, when compared with the univariate prioritization approach, a joint modeling of eQTL action

72 Integrated, efficient, and global prioritization approaches are necessary to manage the on

73 additional resources and value-based patient prioritization are needed to manage patients with HCV.

74 We formulate the problem of candidate gene prioritization as an optimization problem based on netwo

75 stronger signals in the whole dataset after prioritization based on a subset of samples.

76 sis tools such as variant filtering and gene prioritization based on phenotype.

77 ovides two complementary methods for network prioritization based on: (i) network direct neighborhood

78 enes is important for follow-up analyses and prioritization because genes are the main entities in bi

79 prioritization in the wider context of gene prioritization, burden testing and genotype-phenotype as

80 ience and reward expectations influence this prioritization but their relative contributions and unde

81 ther spatially is important for conservation prioritization, but the relationship remains poorly unde

82 r, we also show that a reliance on ROI-based prioritization can sometimes exacerbate disagreements ov

83 Experience-driven visual prioritization can thus be economically irrational, driv

84 r sizeable number and poorer annotation make prioritization challenging.

85 ach using Latent Semantic Indexing (LSI) for prioritization, clustering and functional annotation of

86 include functional annotation, disease gene prioritization, comparative analysis of biological syste

87 antly improve the accuracy of candidate gene prioritization compared with the state-of-the-art method

88 Seq data sets and show that our significance prioritization correlates with the ability to reproducib

89 s of inquiry should examine how geographical prioritization could affect HIV transmission.

90 Vaccine prioritization criteria include risk of death, total dea

91 uality and transparent data to inform future prioritization decisions.

92 for meningitis epidemics to refine the final prioritization decisions.

93 uality and transparent data to inform future prioritization decisions.

94 eive equal model for end-stage liver disease prioritization, despite variable risks of tumor progress

95 At least some carbohydrate prioritization effects occur at the level of monosacchar

96 kshop voting often differed, suggesting that prioritization efforts relying solely on requests for to

97 Further, we conducted a spatial prioritization exercise to optimize seabird conservation

98 n exposures will inform toxicity testing and prioritization for chemical risk assessment.

99 n status of the jaguar and propose a spatial prioritization for conservation actions.

100 ithin intact organisms are needed to support prioritization for developmental neurotoxicity testing i

101 ysis of single nucleotide variants and their prioritization for experimental characterization.

102 differentiate the lead compounds and enable prioritization for in vivo studies, we applied a semi-me

103 Finally, we show that prioritization for modification of a specific lysine sid

104 There is currently no systematic or national prioritization for monitoring waters for chemicals with

105 f compound mechanism of toxicity and used in prioritization for more in-depth toxicological testing.

106 associated with SVOCs and conduct risk-based prioritization for SVOC chemicals of concern.

107 protein function prediction and disease gene prioritization gaining wide recognition.

108 ymorphism (SNP) level, top ranked SNPs after prioritization have both higher replication rates and co

109 To date, empirical approaches to marine prioritization have not considered larval connectivity a

110 EAR prioritization identified multiple sites, biological pat

111 e uncover a neural substrate of such dynamic prioritization in contralateral visual brain areas and s

112 pex detection algorithms in order to perform prioritization in data sets produced via LC-HR-MS.

113 fects of noradrenergic processes on stimulus prioritization in humans and stress the importance of po

114 ntegrative, pathway-based reference for drug prioritization in individual patients.

115 ehavioral and neuronal correlates of sensory prioritization in rats.

116 perties could support scaffold selection and prioritization in small molecule development projects.

117 Pediatric prioritization in the allocation and development of impr

118 the more recalcitrant isomers, thus allowing prioritization in the evaluation of environmental fate a

119 We place variant prioritization in the wider context of gene prioritizati

120 Finally, to facilitate variant prioritization in WES studies, we have pre-computed our

121 We conclude that attentional prioritization in working memory can be dynamically stee

122 Thus, we show that systematic prioritization in zebrafish can accelerate the pace of d

123 Computational approaches for variant prioritization include machine learning methods utilizin

124 Computational gene prioritization is based on various pieces of correlative

125 Their prioritization is premised on performing cellular-level

126 Exome variant filtering and prioritization led to the identification of compound het

127 proved to be more selective than model-based prioritization, making it the method of choice for focus

128 ication provide intracortical mechanisms for prioritization, Mather and colleagues' arguments suggest

129 nformation close to optimal using a geometry-prioritization method based on the Voronoi diagram of sp

130 We describe GenoWAP, a GWAS signal prioritization method that integrates genomic functional

131 Using a forced-ranking prioritization method, stakeholders prioritized 10 of 23

132 om their perspectives using a forced-ranking prioritization method.

133 flexible and can utilize many data types and prioritization methods based upon available data and des

134 Prioritization methods can identify high-confidence cand

135 Previous ASD gene prioritization methods have focused on a priori knowledg

136 Results of our meta-analysis lead to the prioritization of 8 single-nucleotide polymorphisms (SNP

137 aking, provided that the uncertainty affects prioritization of actions.

138 change on diarrheal diseases and aid in the prioritization of adaptation measures.

139 rotective human immunity and facilitates the prioritization of Ags for further evaluation as vaccine

140 tation-level interpretation, including joint prioritization of all nonsilent mutation consequence typ

141 uctural annotation of metabolites and guides prioritization of analysis by using Mass2Motif prevalenc

142 ssessment of hydrophobic character to enable prioritization of antibodies during the discovery proces

143 expression data, for the classification and prioritization of ASD risk genes.

144 deficient when IDA is diagnosed owing to the prioritization of available iron to red blood cells over

145 rm is designed to support identification and prioritization of biological targets for follow-up.

146 g clones between conditions, and enables the prioritization of biomarkers for follow-up experiments b

147 Prioritization of cancer fusion drivers for validation c

148 s useful results in cases where an efficient prioritization of cancer-associated genes is needed.

149 Thus, proteomics data enabled prioritization of candidate driver genes.

150 overlooked and provide a new method for the prioritization of candidate genetic mutations.

151 el network based approach for the systematic prioritization of candidate inhibitors for arbitrary tar

152 This methodology can be used to aid in the prioritization of candidate mutations for functional val

153 disparity and uncertainty regarding optimal prioritization of candidates.

154 The identification and prioritization of chemically tractable therapeutic targe

155 Prioritization of chemicals in commerce against some of

156 To facilitate the ranking and prioritization of chemicals that lack toxicity values, i

157 tegy for high-throughput (HT) exposure-based prioritization of chemicals under the ExpoCast program.

158 PK behaviors can significantly influence the prioritization of chemicals, though the impact of such i

159 though few objective data exist to guide the prioritization of comparative effectiveness research (CE

160 method for analyzing the sensitivity of the prioritization of compounds to a multiparameter profile

161 the potential to guide the organization and prioritization of contact investigations in similar sett

162 coding regulatory elements and to facilitate prioritization of critical loci for important cellular f

163 sequences, which is crucial for conservation prioritization of data-deficient species.

164 ing mortality explained discrepancies in the prioritization of death among stakeholders-inevitability

165 consent process for each involved party, the prioritization of deceased donor kidneys, the allocation

166 in/Pathways Resource (SyPPRes), enabling the prioritization of disease risk factors and their placeme

167 This is partly remedied by prioritization of disease-associated variants that overl

168 Prioritization of donor hearts to children waitlisted on

169 , enhancing confidence, self-regulation, and prioritization of efforts toward advancing focal goals.

170 o define a point of departure for risk-based prioritization of environmental chemicals.

171 Prioritization of evidence-based medical education is ne

172 sociated tools, which includes functional re-prioritization of existing genome-wide association study

173 role in naturally occurring variation in the prioritization of feeding and exploration.

174 In C. elegans, the prioritization of feeding versus mate searching depends

175 We further used this capability to improve prioritization of functional variants including expressi

176 Prioritization of funding sources and retention of feder

177 Prioritization of future areas for protection is hampere

178 siae The results suggest that prediction and prioritization of future experimental interventions, suc

179 ine activity in drinking water and to inform prioritization of future monitoring, chemical testing an

180 el organisms provide a powerful approach for prioritization of genes and pathogenic variants identifi

181 Our results suggest that knowledge-guided prioritization of genes using ProGENI gives new insight

182 ssion networks and feature-and-network-based prioritization of genetic factors and molecular mechanis

183 g pipelines, allowing the categorization and prioritization of genetic variants for follow up analysi

184 and tools, including improved filtering and prioritization of genome variation, Manhattan plot visua

185 ul toolset for the analysis, annotation, and prioritization of genomic variants in coding and non-cod

186 Attention, the prioritization of goal-relevant stimuli, and expectation

187 le relative ranking of a set of compounds, a prioritization of groups of compounds (e.g., low, medium

188 ch leverages tissue-specific networks for re-prioritization of GWAS results.

189 ying tumor biology which can be utilized for prioritization of HCC LT candidates.

190 PR are identified, allowing for differential prioritization of HCC recipients based on their variable

191 The discovery and prioritization of heritable phenotypes is a computationa

192 served trade-off between travel distance and prioritization of high-reward sites (with a slight modif

193 gical activity, but challenges remain in the prioritization of hit series.

194 Prediction and prioritization of human non-coding regulatory variants i

195 ential threats and opportunities, leading to prioritization of IAS threats is seen as an essential co

196 To guide the prioritization of implementation, we evaluate ten land m

197 We show that this leads to effective prioritization of information for both ions and position

198 s to the processes that permit selection and prioritization of information processing in different co

199 ylation or by binding of pUb is required for prioritization of K572 for modification, suggesting that

200 Our methods may be useful for candidate gene prioritization of large-scale RNAi-based screens.

201 the study of molecular mechanisms of action, prioritization of lead candidates, toxicity testing and

202 ologically based PK models can assist in the prioritization of leading preclinical drug candidates fo

203 Model for End-Stage Liver Disease (MELD) prioritization of liver recipients with renal dysfunctio

204 ation to support risk management, by helping prioritization of management among chemicals and environ

205 tical regions, and reflect enhanced cortical prioritization of memory representations that serve as a

206 existing methods, making heritability-based prioritization of millions of phenotypes based on data f

207 function during organ morphogenesis, allows prioritization of multiple microRNAs in parallel for sub

208 on of variants (GWAVA), a tool that supports prioritization of noncoding variants by integrating vari

209 ectly repress defence, consistent with plant prioritization of nutritional stress over defence.

210 composition of habitat-building species and prioritization of particular configurations for protecti

211 Organ Sharing (UNOS) and Eurotransplant for prioritization of patients with HCC.

212 efficacy of this method in the triaging and prioritization of potent antibiotics that target the bac

213 ted by the careful injection of noise in the prioritization of potential targets.

214 Most importantly, SubmiRine allows for the prioritization of predicted miR-TSVs according to their

215 Prioritization of PrEP to 80% of individuals at highest

216 can identify novel asthma genes by enabling prioritization of putative functional variants for assoc

217 we present ContastRank, a new method for the prioritization of putative impaired genes in cancer.

218 and genomic data using HitWalker allowed for prioritization of rare oncogenic mutations that may have

219 This review contributes to a strategic prioritization of research efforts across multiple disci

220 estimates are a basis for decision making in prioritization of research into risk-reducing measures,

221 rsistent, site-specific function, suggesting prioritization of research on slow-changing controls.

222 al cortex (LPFC) plays a central role in the prioritization of sensory input based on task relevance.

223 f a plant's life cycle depends on successful prioritization of signaling favoring either growth or de

224 As a case study, prioritization of six lumber treatment alternatives [mic

225 graphic variations in care seeking may guide prioritization of some regions for intensified engagemen

226 , better illustrate their uncertainty, allow prioritization of source categories, and improve samplin

227 proved substrate scoping studies; direct the prioritization of specific exemplar structures for synth

228 Our work enables prioritization of subjects for sequencing to facilitate

229 ata from distinct experimental platforms for prioritization of targets and treatments.

230 at vary along multiple dimensions, requiring prioritization of the important dimensions to support op

231 a cancer dependency map that facilitates the prioritization of therapeutic targets.

232 To assist in prioritization of topics for evidence synthesis, we crea

233 ay improve the selection process for and the prioritization of transplant candidates.

234 Our data could inform the prioritization of tumor types (and subtypes) for possibl

235 approaches for the systematic and efficient prioritization of tumor-context specific protein activit

236 l evidence for function predictions, and the prioritization of uncharacterized proteins for experimen

237 gh-throughput genomic data make analysis and prioritization of variants difficult for researchers wit

238 In other cases, HIA analysis will allow the prioritization of variants for additional investigation.

239 Initial prioritization of variants for causality was by mutation

240 r the lower-frequency category, suggesting a prioritization of weakly learned information early in a

241 the unsupervised clustering, and subsequent prioritization of, correlated features through Gestalt c

242 n empirical determination of uncertainty for prioritization on absolute exposure potential.

243 This information enables ranking and prioritization on chemicals or health effects of interes

244 s to assess the role of treatment timing and prioritization on predicted cost-effectiveness.

245 vaccine targets solely through bioinformatic prioritization on the basis of their expression levels a

246 combinatorial studies without computational prioritization, our approach offers a significant advanc

247 th on financial hardship and medical therapy prioritization, particularly in certain high-risk sociod

248 We present a peak-calling prioritization pipeline (PePr) for identifying consisten

249 cancer resources with a streamlined variant-prioritization pipeline.

250 as effected by expertise, displaying better prioritization, planning and awareness.

251 Computational gene prioritization presents itself as a solution to this pro

252 The analyst is therefore required to perform prioritization prior to nontarget structural elucidation

253 lternative splicing patterns, resulting in a prioritization problem for many machine learning algorit

254 We compared three published prioritization procedures, which use different statistic

255 the amygdala can initiate endogenous memory prioritization processes in the absence of emotional inp

256 Gene prioritization refers to a family of computational techn

257 Adaptive behavioral prioritization requires flexible outputs from fixed neur

258 clinical guidelines for review and return of prioritization results.

259 An intensity-based prioritization revealed that only 4 targets were among t

260 c models for baseline activity and utilizing prioritization rules to ensure a manageable number of 'a

261 e help of African countries, WHO developed a prioritization scheme and used or adapted existing immun

262 309 compounds to 1858) through the ToxPi(TM) prioritization scheme for endocrine disruption.

263 idence CD regions, 598 of 1328 genes had low prioritization scores, highlighting genes unlikely to co

264 Research prioritization should be guided by impact of disease.

265 ile and active role in adaptive sensorimotor prioritization.SIGNIFICANCE STATEMENT In many situations

266 We argue that prioritization, simultaneity, and mutual exclusion are m

267 xt, we validated the top biomarkers from the prioritization step for relevance to suicidal behavior,

268 decreased biomarkers from the discovery and prioritization steps, in a completely independent test c

269 Prioritization strategies of nurses leave patients vulne

270 s (in eight probands) survived our filtering/prioritization strategy.

271 eir co-expressed partners, in candidate gene prioritization studies and in improving our understandin

272 Existing gene prioritization techniques already significantly improve

273 r enrichment analysis and network-based gene prioritization to assist the user in extracting meaningf

274 ntry-wide risk assessment tool, the District Prioritization Tool (DPT), was developed to help nationa

275 ncing data (GeMSTONE), a cloud-based variant prioritization tool with high-level customization and a

276 he learning methodology of Endeavour (a gene prioritization tool) to train a genomic model and rank a

277 Here we describe a new variant prioritization tool, OVA (ontology variant analysis), in

278 The agency also developed a toxicological prioritization tool, ToxPi, to facilitate using ToxCast

279 another recently published candidate variant prioritization tool.

280 lculate exposure-activity ratios (EARs) as a prioritization tool.

281 Many prioritization tools and online interpretation resources

282 ially damaging alleles identified by variant-prioritization tools in light of gene function, disease,

283 dical ontologies with the outputs of variant-prioritization tools.

284 s due to resource restrictions, which demand prioritization towards either growth or defense, dependi

285 Further, prioritization used two multidimensional frameworks-the

286 62-Mb exome enrichment, followed by variant prioritization using bioinformatic prediction tools, var

287 solution mass spectrometry and a model-based prioritization using consumption data, readily predictab

288 We now generalize the discovery, prioritization, validation, and testing of such markers

289 IPM experts and extensionists." Differential prioritization was also evident among developing-country

290 Sensory prioritization was also reflected in neuronal activity i

291 Furthermore, this dynamic prioritization was associated with the temporally specif

292 ), dominating unprioritized PrEP, while risk prioritization was cost-saving.

293 Final prioritization was generated hierarchically on the basis

294 l in the classification of samples, and thus prioritization, when compared to the other evaluated app

295 icidal ideation (CADM1, CLIP4, DTNA, KIF2C), prioritization with CFG for prior evidence (SAT1, SKA2,

296 Bioinformatic prioritization with Variant Annotation Analysis and Sear

297 ntial for treatment assessment and pollutant prioritization within regulatory applications, as highli

298 nto the neural implementation of attentional prioritization within working memory.

299 e or integration to supplement existing gene prioritization workflows.

300 er of key areas in which additional research prioritization would facilitate both research fields sim