ライフサイエンスコーパス: privilege

1 am superior to others" and "I am entitled to privileges").

2 in the brain and can readily overcome immune privilege.

3 immunotherapy approaches to overcome immune privilege.

4 lls into PDAC and establish a site of immune privilege.

5 lation of molecular components of CNS immune privilege.

6 an intrinsic degree of MC-maintained immune privilege.

7 trict it so as to maintain elites' power and privilege.

8 the role of IL-4 in the abrogation of immune privilege.

9 ensal bacteria and pathogens maintain immune privilege.

10 , despite its perception as a site of immune privilege.

11 ms that together contribute to ocular immune privilege.

12 e plays a dual role: in vision and in immune privilege.

13 ent a newly recognized form of ocular immune privilege.

14 ls the metabolic landscape to support immune privilege.

15 d, we have reevaluated the concept of immune privilege.

16 ort RS cell survival and foster their immune privilege.

17 derived from autologous iPSCs will be immune-privileged.

18 suggest that MSCs may not actually be immune privileged.

19 ive effects, and are considered to be immune privileged.

20 in patient referrals or physician admitting privileges.

21 ve and to make recommendations about driving privileges.

22 disclose a novel ligand design based on the privileged (1,1'-biphenyl)-2-ylphosphine framework that

23 ng: 1) IL-17A is necessary for ocular immune privilege; 2) IL-17A is not required for the induction o

24 The first syntheses of privileged [5,6]-bicyclic heterocycles, with ring-juncti

25 laser burn (RLB) to one eye abrogated immune privilege (ACAID) bilaterally for an extended period of

26 rted gaze, thus providing a neural basis for privileged access of direct gaze to awareness.

27 studied the neural mechanisms underlying the privileged access of direct gaze to visual awareness.

28 d cortisol enables emotional stimuli to gain privileged access to amygdala-hippocampus circuits, even

29 s may be able to satisfy this demand through privileged access to an additional source of chromophore

30 axonal pathway, the LoC of chick embryos has privileged access to the CSF through a specialized glial

31 these data demonstrate that screams occupy a privileged acoustic niche that, being separated from oth

32 standing of mechanisms underlying CNS immune privilege and CNS drainage.

33 ortant role in maintaining testicular immune privilege and display reduced proinflammatory capacity c

34 ent IPCC allografts exhibited certain immune privilege and enjoyed long-term survival in diabetic NOD

35 ential for the maintenance of corneal immune privilege and establish a new paradigm whereby interplay

36 teral eye to induce changes to ocular immune privilege and has a central role in the bilateral loss o

37 ic diseases rob corneal allografts of immune privilege and increase immune rejection.

38 s shed new light on the phenomenon of immune privilege and on its role, as well as its limitations, i

39 ssed their role in developing RS cell immune privilege and survival.

40 We took the advantages of immune privilege and transparent nature of developing zebrafish

41 l cell somata and proximal dendrites, have a privileged and influential position for regulating the f

42 mately 400 clinical phenotypes, finding many privileged and liable structures.

43 The eye is an immunologically privileged and profoundly immunosuppressive environment.

44 or fishermen to build a portfolio of harvest privileges and potentially reduce their income risk.

45 aining tumor cell growth, cultivating immune privilege, and promoting transformation.

46 rate that Flt3L overcomes the brain's immune privilege, and supports the clinical development of Flt3

47 medical homes, be allowed hospital admitting privileges, and be paid equally for the same clinical se

48 standards, regulations, titling, prescribing privileges, and scope and standards of practice.

49 ypothesize that the three-way junction is a "privileged architecture" for the elaboration of aptamers

50 oducts entail biologically pre-validated and privileged architectures for TRP recognition.

51 us system (CNS) and disruption of its immune privilege are major contributors to the pathogenesis of

52 aptations of the immune system coined immune privilege are required to confer protection from autoatt

53 avors those residing in or able to travel to privileged areas, to the detriment of the patients dying

54 wn of stem cell lineage confinement-granting privileges associated with both fates-is not only hallma

55 s a pathogen strategy to create local immune privilege at epithelial surfaces, attenuating innate res

56 starkly with whites and minorities from more privileged backgrounds, for whom college completion is a

57 The cornea is an immune privileged barrier tissue that relies primarily on innat

58 y provides efficient and rapid access to the privileged benzimidazol-2-one scaffold.

59 ction of fragments that bind proteins with a privileged binding mode, in the absence of any structura

60 applied to 2-pyrones, which are delicate and privileged biological motifs.

61 By functionalizing the privileged biphenyl-2-ylphosphine with a basic amino gro

62 atalysts are positively charged analogues of privileged bis(3,5-trifluoromethyl)phenyl substituted th

63 enies reveal that C. intestinalis occupies a privileged branch in the tree of life: it is our nearest

64 ,5-diketopiperazines, DKPs) can be viewed as privileged building blocks for the synthesis of heterocy

65 Saturated aza-heterocycles are highly privileged building blocks that are commonly encountered

66 ed directly to the liver do not enjoy immune privilege but rather require immunosuppression to preven

67 s suggest that TM maintain testicular immune privilege by inhibiting NF-kappaB signaling through impa

68 (AqH) are thought to preserve ocular immune privilege by inhibiting proinflammatory NO production by

69 ell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune resp

70 Arenes and heteroarenes are privileged candidates for (18)F-incorporation as they ar

71 or S vs (L + M)], providing evidence for two privileged cardinal chromatic mechanisms implemented ear

72 Privileged cells display an ultrafast cell cycle of appr

73 atal porcine Sertoli cells (NPSC) are immune privileged cells showing innate phagocytic and antibacte

74 drites rather than the soma, constituting a "privileged" channel for synaptic inputs located in these

75 se natural biopolymers comprise functionally privileged chemical scaffolds for folding or the evoluti

76 Correction for 'Privileged chiral N-heterocyclic carbene ligands for asy

77 ain of the AP-2 beta2 subunit appendage is a privileged CLASP-binding surface that recognizes a cogna

78 , these cells must enter the immunologically privileged CNS through a breach in the relatively imperm

79 tricted from entry into the "immunologically privileged" CNS.

80 s disease (toxocariasis) mainly in the under-privileged communities in developed and developing count

81 ficant role in excluding the drug from these privileged compartments.

82 In this work, the energetically privileged conformation of a disaccharide (lactose as te

83 Immune privilege describes how the immune system responds to pa

84 roach for the synthesis of pharmacologically privileged disubstituted naphthalene-1,4-diols and napht

85 atent pathogens and persistence in an immune-privileged enteric niche.

86 Invasion of immunologically privileged erythrocytes provides a relatively protective

87 cularly stable and influential, representing privileged experiences that shape enduring behaviors.

88 We suggest that people privilege explanations relying on inherent rather than c

89 e antigens are sequestered within the immune-privileged eye.

90 We demonstrate that although no structurally privileged folding level exists, TADs emerge as a functi

91 ilar properties, or rather TADs constitute a privileged folding scale with maximal impact on the orga

92 However, GCs are considered to be immune privileged for antiviral CD8 T cells.

93 the translation machinery and appears to be privileged for the synthesis of polypeptides encoded by

94 ers should be cautious about approving laser privileges for optometrists practicing in other states u

95 itively establishing the V exon location as "privileged" for SHM.

96 udy suggesting the favorable binding of the "privileged" fragment 8-hydroxyquinoline with HIV-1 integ

97 rt sequence, of a constrained mimetic of the privileged H-bonded conformation of (-)-lobeline.

98 and limits inflammation, designated "immune privilege." However, there is not an absolute lack of an

99 signals regulate the disruption of avascular privilege in photoreceptors are unknown.

100 on stimulates immunity but can create immune privilege in some settings.

101 proposing a revised interpretation of immune privilege in the brain, which takes beneficial neuro-imm

102 The liver appears to be privileged in terms of immune tolerance, with a low inci

103 ons predict that the Diels-Alder reaction is privileged in the case of ethyl nitrosoacrylate and poin

104 consistently across disciplines for granting privileges in EBTs that reflect the necessary knowledge

105 hat mechanisms associated with ocular immune privilege, in combination with paucity of age-related an

106 tumors may exhibit the phenomenon of immune privilege, in which immunogenic tissue is protected from

107 ntry into nonphagocytic cells, creation of a privileged intracellular niche, and subversion of potent

108 The immune privilege (IP) of hair follicles (HFs) has been well est

109 We believe this immune privilege is caused by the absence of antigen presenting

110 ommitted T cells can be disarmed, but immune privilege is unable to protect from uveitogenic T cells

111 Immune privilege is used by the eye, brain, reproductive organs

112 Thus, only the privileged item was susceptible to disruptive TMS over M

113 rectly through reduced interference from the privileged item.

114 Privileged items were recalled with less precision, wher

115 field, some phosphinoamides became the real privileged ligands and an indispensable part of a standa

116 previously difficult-to-access precursors of privileged ligands like BINOL, BINAM, QUINAP and many ot

117 broadly, these results challenge the assumed privileged link between bistable stimuli and visual awar

118 This privileged linker can enhance CMP-based biomaterials and

119 innervate the surfaces of mammalian bone, a privileged location for the regulation of biomechanical

120 se of infection because the bacteria hide in privileged locations.

121 s ago, as societal wealth increased to allow privileging long-term goals over immediate needs.

122 Through the development of a privileged m-terphenylsulfonamide for (arene)RuCl(monosu

123 it is very difficult to abrogate the immune privileged mechanism called anterior chamber-associated

124 lloimmunity, including immune and angiogenic privilege, mechanisms of allosensitization, cellular and

125 th an embedded cinnamic acid derivative, two privileged medicinal chemistry scaffolds.

126 aken to test the idea that modulating immune privilege might be an effective therapeutic approach to

127 Selective AII connections ensure that a privileged minority of RGC types receives direct input f

128 ydrogen bonds (IMHB) and may be considered a privileged molecular descriptor for use in drug discover

129 ntroduce DTTs and related architectures as a privileged motif to engineer chalcogen bonds into functi

130 -proline cyclobutyl amide moiety as a highly privileged motif.

131 Bicyclic chiral scaffolds are privileged motifs in medicinal chemistry.

132 d by the ease of preparation and immunologic privilege, MSCs are emerging as an extremely promising t

133 rstanding of the catalyst structure in these privileged multifunctional frameworks and identify new d

134 ting drug development efforts based on these privileged natural product scaffolds.

135 udies established, among other features, the privileged nature of a properly positioned nitro moiety

136 The immunologically privileged nature of the cornea results in high success

137 played a key role in formation of the immune-privileged niche, and predicted poor prognosis in human

138 ault by being located in an immunologically "privileged" niche.

139 immune modulation in the classically immune-privileged ocular haven.

140 g graduate students, we had the pleasure and privilege of being in Joan Steitz's laboratory at a pivo

141 keen appreciation of, and gratitude for, the privilege of caring for sick persons.

142 stration of anti-IL-17A abolished the immune privilege of corneal allografts but had no effect on the

143 expression of ACAID and abolished the immune privilege of corneal allografts.

144 ion and may instead contribute to the immune privilege of corneal allografts.

145 ylation of lipid A contributes to the immune privilege of most commensal Neisseria strains by reducin

146 Strategies to reverse the immune privilege of PDAC, which is regulated by extratumoral ma

147 on or critique of examinations given for the privilege of professional practice and for safeguarding

148 l of Clinical Investigation and have had the privilege of publishing scientific knowledge that will b

149 I have had the privilege of seeing major advances in nutrition during m

150 he public by which the profession enjoys the privilege of self-regulation and the public is assured t

151 The concept of immune privilege of the central nervous system (CNS) has domina

152 We examine the notion of immune privilege of the CNS in light of both earlier findings a

153 tions of a revised perspective on the immune privilege of the CNS on the etiology and pathology of di

154 mphasizes the fact that understanding immune privilege of the CNS requires intimate knowledge of its

155 rovoked dismissal of the existence of immune privilege of the CNS.

156 s is crucially important in mediating immune privilege of the fetus during pregnancy.

157 ring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune

158 he CNS remains speculative, given the immune privilege of this organ.

159 st vulnerable and, therefore, also the most "privileged" of tissues; paradoxically, it remains subjec

160 he brain, previously thought of as an immune-privileged organ, is now known to communicate extensivel

161 gh the inner ear has been known as an immune-privileged organ, there is emerging evidence indicating

162 Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T ce

163 We now know that the brain is not an immune privileged organ.

164 The liver is an immunologic privileged organ; liver allografts are accepted across m

165 macrophages or if ranavirus exploits immune privileged organs, such as the brain, in order to establ

166 iculate and geniculocortical projections are privileged over modulatory projections by their layer of

167 lanatory perspectives no one of which can be privileged over others using scientific data alone.

168 One item might be privileged over others, making it more accessible and th

169 from this review that there is no single or privileged perspective to study interruptions.

170 numerous available reference genomes, offer privileged perspectives to further examine these fundame

171 al conditions, suggesting that it might be a privileged pharmacological target.

172 omic rearrangement events underlie an immune privilege phenotype in a subset of B-cell lymphomas.

173 e shown that ligand efficient-molecules with privileged physical properties and low dose are less lik

174 an employment relationship with any of their privileged physicians.

175 an employment relationship with any of their privileged physicians.

176 Inversion polymorphisms have occupied a privileged place in Drosophila genetic research since th

177 s as to its value, and none should receive a privileged place in economic analysis of climate policy.

178 placental viral infections within the immune-privileged placenta.

179 geted for imaging analysis, glycans occupy a privileged position by virtue of their primary location

180 mong all functional groups, alkynes occupy a privileged position in synthetic and medicinal chemistry

181 We have identified the privileged position in the core scaffold of the imidazo[

182 iew, we explore how calcium ended up in this privileged position.

183 eal neovascularization, which revokes immune privilege, prevents corneal allograft rejection.

184 select behaviorally relevant information for privileged processing.

185 hly decorated derivatives of the medicinally privileged pyridine heterocycle.

186 be controlled subtly by manipulation of the privileged quinolone core at the 2 or 3 position.

187 ey's angular size and speed co-vary within a privileged range.

188 RC1, the gatekeeper of anabolism, occupies a privileged regulatory position.

189 tations based on reward values, suggesting a privileged replay of information yielding positive outco

190 receptors and synaptic regions of the immune-privileged retina implies a role in visual transmission.

191 -small molecule interactions to identify the privileged RNA structures and chemical spaces that inter

192 r and systemic iron homeostasis and reveal a privileged role for the intestine in their regulation by

193 ctive or passive turns in the dark implies a privileged role for vestibular cues during human angular

194 Thus, threonine sites play a privileged role in promoting timely arrestin binding and

195 Locally translated CaMKII has a privileged role in regulation of spontaneous release, wh

196 The CF(3) group enjoys a privileged role in the realm of medicinal chemistry beca

197 rain areas, but that the striatum may have a privileged role in timing because it has a more accurate

198 mily of indolic natural products represent a privileged scaffold for the design of molecules to contr

199 s microwave heating to access a biologically privileged scaffold in an efficient route amenable to li

200 Indazoles represent a privileged scaffold in medicinal chemistry.

201 ted that the 6-aminoquinolone chemotype is a privileged scaffold to obtain antibacterial and antivira

202 ional core, glitazone, which is considered a privileged scaffold upon which to build a drug selective

203 We used a privileged scaffold with proven cellular potency as well

204 ology for a rapid and modular access to this privileged scaffold.

205 As this field expands, the use of these privileged scaffolds has permitted the development of to

206 s to aryl-alpha-ketoamide amides, a class of privileged scaffolds in medicinal chemistry and importan

207 In this review, we will detail those privileged scaffolds that have guided medicinal chemistr

208 level exists, TADs emerge as a functionally privileged scale defined by maximal boundary enrichment

209 tion via two separate dendrites, providing a privileged scenario for in vivo examination of dendritic

210 al licensure requirements, credentialing and privileging, scope of care, quality, and responsibility

211 s of disease and can sometimes be viewed as "privileged," since they intrinsically hinder partitionin

212 Privileged sinefungin scaffolds are expected to have bro

213 The CNS is considered an immune privileged site because its repertoire of highly immunog

214 ers in the mammalian body, creates an immune-privileged site for postmeiotic spermatid development to

215 ction in the seminiferous tubules, an immune-privileged site in the testis protected by the blood-tes

216 The lens has been considered to be an immune privileged site not susceptible to the immune processes

217 al view that the brain is an immunologically privileged site shielded behind the blood-brain barrier,

218 hough intraocular tumors reside in an immune-privileged site where immune responses are suppressed, s

219 Although once believed to be an immune privileged site, it is now known that antimicrobial resp

220 hough intraocular tumors reside in an immune privileged site, some tumors are rejected nonetheless.

221 As an immune-privileged site, the eye, and particularly the outer cor

222 the BTB to exert their effects at the immune-privileged site.

223 D-1:PD-L1 interaction in creating an "immune-privileged" site for initial viral infection and subsequ

224 We propose that the airspace is a "privileged" site, thereby uniquely sensitive to dyslipid

225 fuse large B-cell lymphoma arising in immune-privileged sites (eg, the central nervous system) shows

226 hypothesis that B cell follicles are immune privileged sites and suggest that strategies to augment

227 tic stem-cell niches more broadly are immune-privileged sites by examining the haematopoietic stem/pr

228 ells using prime-boost vaccines by targeting privileged sites for Ag presentation.

229 33, 276, and 525 were previously reported as privileged sites for the nonenzymatic binding of d-gluco

230 Thus, dysregulated innate immunity at immune-privileged sites may be an essential mechanism triggerin

231 tion in inflammatory responses within immune privileged sites such as the brain and eye is less under

232 BOV disseminates into and persists in immune-privileged sites was impossible due to the absence of a

233 ctions in humans, mainly localized in immune privileged sites, such as the brain and the eye.

234 mune-suppressive environments, called immune-privileged sites, where multiple mechanisms cooperate to

235 promoted the establishment of cancer immune-privileged sites.

236 ion, revealing the need to target these drug-privileged sites.

237 an persist in survivors for months in immune-privileged sites; however, viral relapse causing life-th

238 ic methyltransferase inhibitors by screening privileged small-molecule scaffolds against diverse meth

239 nature of reprogramming can be overcome in a privileged somatic cell state and suggest that cell-cycl

240 We identified a privileged somatic cell state, from which acquisition of

241 Analyses of selected sequences using the RNA Privileged Space Predictor (RNA-PSP) program show that e

242 sequentially so that the last item was in a privileged state by virtue of recency.

243 animal development gained an epigenetically privileged state in germ cells, manifested in amniotes b

244 ssibility for routine surgery and its immune privileged state make the eye an ideal target for releas

245 nearly all ES cells cycle in and out of this privileged state, which is partially controlled by histo

246 cue" to bring one of the two targets into a privileged state.

247 we show that Del-1 contributes to the immune privilege status of the CNS.

248 Our findings demonstrate both the privileged status of germline genome integrity and speci

249 f during healing and suggest that the immune-privileged status of the CNS may contribute to failure o

250 beta-Lactones are a privileged structural motif found in both therapeutic ag

251 1,4-Disubstituted aromatic piperazines are privileged structural motifs recognized by aminergic G p

252 s is likely to permit the identification of "privileged" structural scaffolds, providing frameworks s

253 Chromone is recognized as a privileged structure and a useful template for the desig

254 from the 1,4-benzodiazepin-2-one nucleus, a privileged structure in medicinal chemistry, we have syn

255 steric antagonists based on the 2-arylindole privileged structure scaffold (e.g., 1-3).

256 Substitution on the phenylpiperazine privileged structures (2-methoxy vs 2,3-dichloro) influe

257 ely related HIV-1 protease were evaluated as privileged structures against HTLV-1 protease (HTLV-1 PR

258 New discoveries of marine natural product privileged structures and compound classes that are bein

259 ation of a benzoxazinone M1 scaffold with D2 privileged structures derived from putative and clinical

260 k validates chromone-based acylhydrazones as privileged structures for antagonizing STAT SH2 domains,

261 ts of efficacy, affinity, and bias for three privileged structures for the D2R, exploring changes to

262 The synthetic utility of the privileged structures formed from this one-pot process w

263 The use of privileged structures in drug discovery has proven to be

264 The isoxazolidine ring represents one of the privileged structures in medicinal chemistry, and there

265 g our studies on flavonoid-like scaffolds as privileged structures in medicinal chemistry, in this pa

266 2-dihydro-3H-indazol-3-ones, which are known privileged structures possessing remarkable diverse phar

267 rt a convenient and efficient route to these privileged structures starting from easily accessible 2-

268 Privileged structures such as 2-arylindoles are recurren

269 hydroisoquinoline head group with other D2R "privileged structures" generated orthosteric antagonists

270 ture-guided hybridization approach using two privileged substructures gave instant access to a new se

271 retina visual cycle is thought to provide a privileged supply of 11-cis-retinal to cones by using 11

272 though the retina is often considered immune-privileged, suppression of host immune-mediated cell rej

273 that the arylthioamide scaffold represents a privileged template for designing MAGL inhibitors.

274 ragment-molecules, most of which contain the privileged tetrahydropyran (THP) scaffold.

275 We are both pleased and privileged that each of us has practiced our profession

276 ly significant"; 2) nullism, the tendency to privilege the hypothesis of no difference or no effect w

277 Rather than privileging the self comprising primarily individual qua

278 en reported to be hypoimmunogenic or 'immune privileged'; this property is thought to enable MSC tran

279 sults suggest that Tregs preserve CNS immune privilege through selective control of CNS-specific Th c

280 an indiscriminate maintenance of CNS immune privilege through Treg-mediated negative regulation coul

281 he as yet unknown mechanisms regulating this privileged tissue growth.

282 c cells (DC) reside in the cornea, an immune-privileged tissue, is unknown.

283 tissue reservoir rather than immunologically privileged tissues (i.e., testes).

284 s; 2) heart and vessels are the inflammation-privileged tissues and less easy to be inflamed because

285 It is a great privilege to contribute to the Reflections essays.

286 in seminiferous tubules and providing immune privilege to meiotic and postmeiotic cells.

287 also covering many wonderful people I had a privilege to work with, are summarized below.

288 I was thus privileged to join the Laboratory at an early stage in i

289 few states where optometrists have surgical privileges to perform laser trabeculoplasty (LTP).

290 rists in other states are lobbying to obtain privileges to perform LTP and other laser procedures.

291 clinician must achieve before being granted privileges to perform these procedures.

292 beta3 integrin subtype, thereby representing privileged tools for integrin-based personalized medicin

293 integrated stress response (ISR) that show "privileged" translation despite inhibited eukaryotic ini

294 an 100 currently marketed drugs contain this privileged unit, which remains highly sought after synth

295 sist nearer the active zone and exhibit more privileged use in the next RRP.

296 Targeting immune privilege using cytotoxic molecules or by increasing exp

297 CR1(hi) patrolling monocytes serve as immune-privileged vehicles to transport MCMV via the bloodstrea

298 The results are in line with privileged visual processing of hands as highly salient

299 ogenous genes in heterochromatic contexts as privileged while foreign DNA can be suppressed with no r

300 sets of murine hematopoietic progenitors are privileged whose progeny cells predominantly adopt the p