ライフサイエンスコーパス: pro-MMP-2

1 on pathway of matrix prometalloproteinase-2 (pro-MMP-2).

2 nt injury disrupts the enzymatic cleavage of pro-MMP-2.

3 e proteases necessary to cleave and activate pro-MMP-2.

4 ndirectly by activating soluble MMPs such as pro-MMP-2.

5 proteolysis and physiological activators of pro-MMP-2.

6 Both pro-MMP-9 (96 kDa) and pro-MMP-2 (72 kDa) were seen in the control specimens, a

7 or P4C10 antibodies stimulated MMP-dependent pro-MMP-2 activation and accumulation of a M(r) 43,000 f

8 with concanavalin A stimulated MMP-dependent pro-MMP-2 activation and accumulation of M(r) 55,000 and

9 uncation mutant MT1 Delta C with more robust pro-MMP-2 activation and cell surface expression than wi

10 3-MMP and analyzed the exchange chimeras for pro-MMP-2 activation and collagen degradation at the cel

11 MT1-MMP itself, but also for MT3-MMP in both pro-MMP-2 activation and collagenolysis, consistent with

12 rosine phosphorylation, blocked ConA-induced pro-MMP-2 activation and ConA-induced MT1-MMP mRNA level

13 Stimulation of pro-MMP-2 activation and growth in collagen I was also o

14 MT3-MMP requires TIMP-2 to accomplish full pro-MMP-2 activation and this process is enhanced in mar

15 ergistically with TIMP-2 in the promotion of pro-MMP-2 activation by MT1-MMP in a process that depend

16 Pro-MMP-2 activation by MT1-MMP involves the formation o

17 n here in Timp2-null cells demonstrates that pro-MMP-2 activation by MT1-MMP requires TIMP-2.

18 r 3, in contrast to GM6001, had no effect on pro-MMP-2 activation by MT1-MMP.

19 ergistically with TIMP-2 in the promotion of pro-MMP-2 activation by MT1-MMP.

20 MT3-MMP and TIMP-2 or TIMP-3 suggesting that pro-MMP-2 activation by MT3-MMP involves ternary complex

21 confirmed by the dose-dependent promotion of pro-MMP-2 activation by sodium orthovanadate in the pres

22 ffect of TIMP-2 on MT1-MMP processing and on pro-MMP-2 activation in a cellular system could not be e

23 talloproteinase (MT1-MMP) (MMP-14) initiates pro-MMP-2 activation in a process that is tightly regula

24 a broad-spectrum MMP inhibitor, in enhancing pro-MMP-2 activation in cells infected to express MT1-MM

25 are less likely to promote MT1-MMP-dependent pro-MMP-2 activation in the presence of TIMP-2, while ma

26 a suggest that beta1 integrin stimulation of pro-MMP-2 activation involves MT1-MMP posttranslational

27 TIMP-4, in contrast, cannot support pro-MMP-2 activation with either enzyme.

28 genolysis is not required for stimulation of pro-MMP-2 activation, and denatured collagen does not el

29 T1080 fibrosarcoma cells results in enhanced pro-MMP-2 activation, proliferation within a three-dimen

30 t catalytic domains determine the pattern of pro-MMP-2 activation, whereas pexin-like domains modulat

31 t MT1-MMP acts via mechanisms independent of pro-MMP-2 activation.

32 dose-dependent increase in MT1-MMP-dependent pro-MMP-2 activation.

33 unaffected by TIMP-1, and is accompanied by pro-MMP-2 activation.

34 decreased secretion of pro-MMP-9, as well as pro-MMP-2 and active MMP-2 from elastase-treated male ra

35 (MT1-MMP or MMP-14) is a major activator of pro-MMP-2 and is essential for skeletal development.

36 Gelatin zymography revealed pro-MMP-2 and its activated form, a-MMP-2, in both uninv

37 le P4C10 antibodies stimulated expression of pro-MMP-2 and its inhibitor, tissue inhibitor of metallo

38 zymes in culture media or affinity-purified (pro-MMP-2 and MMP-9) were examined by SDS-PAGE zymograph

39 orbent assay, we observed that CSF levels of pro-MMP-2 and pro-MMP-7 were increased in association wi

40 livers did not show an increase in inactive pro-MMP-2 and pro-MMP-9 and did not contain active MMP-2

41 TIMPs) and did not activate pro-gelatinases (pro-MMP-2 and pro-MMP-9) even in the presence of exogeno

42 e inactive matrix metalloproteinases (MMPs), pro-MMP-2 and pro-MMP-9, are elevated at 30 minutes and

43 to the cell surface, subsequently activating pro-MMP-2 and promoting TGF-beta1 signaling.

44 the mature proteinase capable of activating pro-MMP-2 and stimulating cell locomotion.

45 agen-induced MT1-MMP-dependent activation of pro-MMP-2 and up-regulation of MT1-MMP at the gene and p

46 MT1-MMP and TIMP-2 was capable of activating pro-MMP-2, and exogenous TIMP-2 had a biphasic effect on

47 proliferation, production of VEGF, IL-8, and pro-MMP-2, and migration and invasion of RA-FLS.

48 tor specifically converted pro-MMP-9 but not pro-MMP-2, another member of the gelatinase family.

49 mponents and is a physiological activator of pro-MMP-2, another MMP involved in malignancy.

50 cell surface that promotes the hydrolysis of pro-MMP-2 by a neighboring TIMP-2-free MT1-MMP.

51 sistently, TIMP-2 enhanced the activation of pro-MMP-2 by MT1-MMP.

52 TIMP-3 also enhances the activation of pro-MMP-2 by MT3-MMP but not by MT1-MMP.

53 ctivation of pro-matrix metalloproteinase-2 (pro-MMP-2) by MDA-MB-231 human breast cancer cells is ap

54 chromatography experiments demonstrated that pro-MMP-2 can assemble trimolecular complexes with a cat

55 Ala+TIMP-2 variant exhibited conformational, pro-MMP-2 complex formation and fibroblast growth modula

56 pro-MMP-2 complex on the cell surface that promotes the

57 The closely related pro-MMP-2 exhibits a weaker affinity for alpha2(IV) comp

58 P), a novel transmembrane MMP that activates pro-MMP-2 (gelatinase A), is expressed in human atherosc

59 helial cells (HUVECs) released pro-MMP-9 and pro-MMP-2 in a constitutive manner and were not influenc

60 6001 enhance MT1-MMP-dependent activation of pro-MMP-2 in the presence of tissue inhibitor of metallo

61 Functional analysis revealed that pro-MMP-2 in the supernatants from human bone marrow str

62 h activation and autocatalytic maturation of pro-MMP-2 in trans suggest that MT1-MMP should exist as

63 ix metalloproteinase (MT1-MMP), can activate pro-MMP-2 in tumor metastasis.

64 1 MMP (MT1-MMP), a cell surface activator of pro-MMP-2, in cell extracts.

65 Also, binding of TIMP-2 to pro-MMP-2 is stronger at both the high and low affinity

66 ctivation of pro-matrix metalloproteinase 2 (pro-MMP-2) is considered to be critical for cell migrati

67 y demonstrates that MT1-MMP, an activator of pro-MMP-2, is expressed by SMCs and Mphi in human athero

68 s multimolecular complex formation involving pro-MMP-2, membrane type 1-MMP (MT1-MMP), and tissue inh

69 the formation of a tri-molecular complex of pro-MMP-2, MMP-14, and tissue inhibitor of metalloprotei

70 CCL1 induced VSMC pro-MMP-2 mRNA and protein secretion.

71 al fibroblasts with concanavalin A activates pro-MMP-2 on the cell surface by converting it to the 65

72 ecreased activation of pro-MMP-13 but not of pro-MMP-2 or pro-MMP-8.

73 trix metalloproteinase-1 that then activates pro-MMP-2-promoting migration and extracellular matrix i

74 or study showed that MMP-2 activity, but not pro-MMP-2 protein, decreases after RPE oxidative injury,

75 inity for pro-MMP-9 than for active MMP-9 or pro-MMP-2, requiring the N-terminal propeptide domain of

76 MP promotes matrix degradation by activating pro-MMP-2, these results suggest a novel mechanism where

77 with the prodomain could modulate binding of pro-MMP-2 to its gelatin substrate.

78 tissue inhibitor of metalloproteinase-2 with pro-MMP-2 to MT1-MMP-expressing monocytes.

79 PAF-induced expression of pro-MMP-2 was causally related to PAF-induced CREB and A

80 MT1-MP, known to activate pro-MMP-2, was increased in involved areas.

81 ha(3)beta(1) strongly promotes activation of pro-MMP-2, whereas alpha(2)beta(1) integrin clustering h