ライフサイエンスコーパス: pro-TRH

1 All pro-TRH neurons receiving contacts by alpha-MSH-containi

2 with in situ hybridization revealed that all pro-TRH mRNA-positive neurons in these ventral medullary

3 h an anatomical association between CART and pro-TRH-producing neurons in the PVN and demonstrate tha

4 veal the morphological relationships between pro-TRH mRNA-containing neurons and CART- and alpha-MSH-

5 did not augment the ability of PC2 to cleave pro-TRH to either N- or C-terminal forms.

6 itivity of prothyrotropin-releasing hormone (pro-TRH) gene expression in the paraventricular nucleus

7 Rat prothyrotropin-releasing hormone (pro-TRH) is endoproteolyzed within the regulated secreto

8 Prothyrotropin-releasing hormone (pro-TRH) is initially cleaved by the prohormone converta

9 The prothyrotropin-releasing hormone (pro-TRH) precursor (26 kDa) undergoes proteolytic cleava

10 ddition to catecholamine and angiotensin II, pro-TRH/TRH may be another important axis that affects h

11 roid axis can affect metabolism, deficits in pro-TRH processing may contribute to the obese and diabe

12 dependently stimulated a 10-fold increase in pro-TRH biosynthesis, with a maximum response at 10 nm.

13 The finding that TRbeta2 localized in pro-TRH-synthesizing neurons in the ventral medullary nu

14 convertase, and particularly PC1 and PC2, in pro-TRH processing, recombinant vaccinia viruses were us

15 thyroid hormone receptor beta2 (TRbeta2) in pro-TRH-synthesizing neurons in the Rpa, Rob and the PPR

16 n hypophysiotropic TRH neurons by increasing pro-TRH gene expression and the biosynthesis of TRH.

17 in the mechanism by which leptin influences pro-TRH gene expression.

18 situ hybridization with digoxigenin-labeled pro-TRH cRNA probe.

19 llular subdivisions of the PVN and to 34% of pro-TRH neurons in the medial parvocellular subdivision,

20 ties were juxtaposed to approximately 70% of pro-TRH neurons in the anterior and periventricular parv

21 ART was co-contained in approximately 80% of pro-TRH neuronal perikarya, whereas colocalization with

22 Transcript abundance of pro-TRH can be increased in cultured cardiac fibroblasts

23 H has an important role in the activation of pro-TRH gene expression in hypophysiotropic neurons via

24 Concentrations of pro-TRH forms are increased in homozygotes.

25 re, we show that after MI, the expression of pro-TRH is induced in the heart coordinately with the pr

26 When a mutant form of pro-TRH, which has the dibasic sites of initial processi

27 -IR axons densely innervated the majority of pro-TRH mRNA-containing neurons in all parvocellular sub

28 Proteolysis of pro-TRH begins in the trans-Golgi network and forms two

29 s may be necessary for downstream sorting of pro-TRH-derived peptides as it occurs before Golgi exit

30 eam sorting events that result in storage of pro-TRH-derived peptides in mature secretory granules.

31 3 d prevented fasting-induced suppression of pro-TRH in the PVN but had no effect on AGRP mRNA in the

32 ART prevented fasting-induced suppression of pro-TRH in the PVN when administered intracerebroventric

33 Our strategy was to block the transport of pro-TRH or its intermediates from one subcellular compar

34 ted that initial processing action of PC1 on pro-TRH in the trans-Golgi network, and not a cargo-rece

35 inant PC1 and PC2 process partially purified pro-TRH to cryptic peptides in vitro and that pro-TRH an

36 whereas neuropeptide Y treatment suppressed pro-TRH biosynthesis approximately 3-fold.

37 utively secreted form of PC1 does not target pro-TRH peptides to the constitutive secretory pathway b

38 Furthermore, the C-terminal pro-TRH-derived peptides were more efficiently released

39 ro-TRH to cryptic peptides in vitro and that pro-TRH and PC1 mRNAs are coexpressed in primary culture

40 In summary, our data show that pro-TRH-derived peptides are differentially sorted withi

41 We now report that when pro-TRH is transiently expressed in GH4C1 cells, a neuro

42 ronal perikarya, whereas colocalization with pro-TRH was found in <10% of the anterior parvocellular

43 y a portion of CART-IR axons in contact with pro-TRH neurons were immunoreactive for alpha-MSH.

44 hed asymmetric synaptic specializations with pro-TRH neurons.