ライフサイエンスコーパス: pro-apoptotic

1 as soluble receptor agonists are but weakly pro-apoptotic.

2 ore anti-proliferative, anti-angiogenic, and pro-apoptotic.

3 on of DUX4, which inhibits myogenesis and is pro-apoptotic.

4 blish if proteins of the apoptotic cascades [pro-apoptotic: active caspase 3, 8, and 9 and DIABLO (di

5 d to activate immune response and to exhibit pro-apoptotic activity against some tumor cells.

6 elated apoptosis-inducing-ligand (TRAIL)-has pro-apoptotic activity in a range of cancers and synergi

7 ophobic aryl substitution were essential for pro-apoptotic activity in cancer cells.

8 ted that ATF3 activated p53 and promoted its pro-apoptotic activity in mouse thymi and small intestin

9 nonresponsive cell types susceptible to the pro-apoptotic activity of IFN-lambda, revealing the comb

10 Phomoxanthone A (1) showed the strongest pro-apoptotic activity when tested against a panel of hu

11 tion of the immune system in parallel to its pro-apoptotic activity.

12 affinity, which correlates with its stronger pro-apoptotic activity.

13 imilar affinity for both domains were potent pro-apoptotic agents in cancer cell lines and efficaciou

14 turated fatty acids as antiproliferative and pro-apoptotic agents in MDA-MB-231 breast cancer cells.

15 Pro-apoptotic analogues of vitamin E (VE) exert selectiv

16 Pro-apoptotic and anti-apoptotic Bcl-2 family proteins r

17 A study of pro-apoptotic and anti-apoptotic Bcl-2 family proteins s

18 OvCa patient-derived xenografts induces both pro-apoptotic and anti-apoptotic signaling responses tha

19 two analogs of the hit with high cytotoxic, pro-apoptotic and anti-mitotic activities.

20 time and dose-dependant manner by activating pro-apoptotic and anti-proliferative signaling cascades

21 ies revealed that SETD8 ablation rescued the pro-apoptotic and cell-cycle arrest functions of p53 by

22 as two opposing actions: antitumoral through pro-apoptotic and cytostatic activities, and pro-tumoral

23 ing down MAT2BV1 potentiated the resveratrol pro-apoptotic and growth-suppressive effects, whereas th

24 -sulfur cluster biosynthesis, the release of pro-apoptotic and non-cell-autonomous signalling molecul

25 ng ERK1/2 kinase and inhibited expression of pro-apoptotic and pro-fibrotic JNK and TGFbeta1 proteins

26 Furthermore, we show that the pro-apoptotic and pro-tumorigenic functions of PKCdelta

27 l death is regulated by interactions between pro-apoptotic and prosurvival members of the Bcl-2 famil

28 hondria directly and exclusively through its pro-apoptotic and vacuolating cytotoxin VacA.

29 wo functionally distinct proteins, Mcl-1(S) (pro-apoptotic) and Mcl-l(L) (anti-apoptotic); the latter

30 ellular responses, in which many anti-viral, pro-apoptotic, and anti-proliferative proteins are highl

31 increase phosphorylation and inactivation of pro-apoptotic BAD at Ser(112) and Ser(136) by MEK1/2 and

32 ike apoptotic response requires formation of pro-apoptotic Bak complexes with hundreds of subunits, s

33 hat interacts with the BH3-binding groove of pro-apoptotic Bak to cause Bak oligomerization, Bak-medi

34 In pro-apoptotic Bak, we demonstrate that the corresponding

35 In contrast, angiogenin expression blocked pro-apoptotic Bax and p21 expression, induced Bcl-2 and

36 Here, we show that genetic deletion of pro-apoptotic Bax disrupts regulation of cerebellar neur

37 three different types are increased when the pro-apoptotic Bax gene is knocked out.

38 Pro-apoptotic Bax induces mitochondrial outer membrane p

39 Pro-apoptotic BAX is a cell fate regulator playing an im

40 How the pro-apoptotic Bax protein permeabilizes the mitochondria

41 teins Bcl-2 and XIAP were up-regulated while pro-apoptotic BAX was down-regulated.

42 ak, Bok has long been considered part of the pro-apoptotic Bax-like subfamily, but no studies have ye

43 ing pathway (i.e., OTUD7B and TNIP2) and the pro-apoptotic Bcl-2 associated death promoter (BAD) prot

44 echanistic insights into the function of the pro-apoptotic BCL-2 family member BOK have remained elus

45 mportantly, the promotion of a high anti- to pro-apoptotic Bcl-2 family member ratio by acidosis rend

46 Three WM cell lines expressed pro-apoptotic Bcl-2 family members Bim or Bax and Bak at

47 The multidomain pro-apoptotic Bcl-2 family proteins BAK and BAX are beli

48 Pro-apoptotic Bcl-2 homology 3 (BH3)-only proteins antag

49 ed by radiotherapy increases the activity of pro-apoptotic BCL-2 pathway proteins, and lymphomas are

50 The pro-apoptotic Bcl-2 protein Bax can permeabilize the out

51 Pro-apoptotic Bcl-2-associated X protein (BAX) is an exe

52 election within exon 2 to produce either the pro-apoptotic Bcl-x(s) or the anti-apoptotic Bcl-x(L).

53 Conversely, the pro-apoptotic Bcl2 family member, Noxa, is a critical in

54 optosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim).

55 effects primarily through interactions with pro-apoptotic BH3 containing proteins that achieve high

56 hosphorylation of a distal serine inhibits a pro-apoptotic BH3 domain and promotes cell survival.

57 ting with Bcl-2 and exposing its potentially pro-apoptotic BH3 domain.

58 the in vitro sensitivity of ALPS DNTC to the pro-apoptotic BH3 mimetic, ABT-737.

59 duction of SOX2, which in turn represses the pro-apoptotic BH3-only genes BIM and BMF.

60 ment caused increased accumulation of NOXA a pro-apoptotic BH3-only member of the BCL2 family.

61 correlated with increased expression of the pro-apoptotic BH3-only protein BIM, cleaved caspase 3 an

62 s apoptosis by preventing degradation of the pro-apoptotic BH3-only protein p53-upregulated modulator

63 iation-induced apoptosis, loss of p53 or the pro-apoptotic BH3-only protein Puma restored survival of

64 this by upregulating a cluster of redundant pro-apoptotic BH3-only proteins and suppressing pro-surv

65 n expression of MCL-1 but importantly induce pro-apoptotic BIM expression.

66 rolled by c-FLIP isoforms, which function as pro-apoptotic (c-FLIPL only) or anti-apoptotic (c-FLIPL/

67 kine and ER stress-induced activation of the pro-apoptotic calcium-dependent enzyme, calpain, and par

68 nt with activation of anti-proliferative and pro-apoptotic canonical target genes.

69 the up-regulation of molecules implicated in pro-apoptotic cascades such as p53, p21(Waf1), and p27(K

70 luciferase biosensors detect granzyme B and pro-apoptotic caspase activation within minutes of targe

71 aB-driven gene transcription pathway and the pro-apoptotic caspase pathway.

72 Caspase-9 has two splice variants, pro-apoptotic caspase-9a and anti-apoptotic caspase-9b,

73 e insensitive to TRAIL, robust activation of pro-apoptotic caspases by NK cell-derived TRAIL was dete

74 d BIR3 domain inhibitors that displace bound pro-apoptotic caspases.

75 come from binding of the BIR domains to the pro-apoptotic caspases.

76 m its BIR domains, which bind to and inhibit pro-apoptotic caspases.

77 amide biosynthesis, which contributes to the pro-apoptotic cellular response.

78 gents, including paclitaxel (Taxol), involve pro-apoptotic ceramide in their anticancer effects.

79 nstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced per

80 ivation was prevented, assembly of the TNFR1 pro-apoptotic complex II was reduced, and TNF-induced ap

81 Under pro-apoptotic conditions, however, cyt c gains cardiolip

82 a BDNF-independent manner in NB cells under pro-apoptotic conditions, such as serum deprivation and

83 hat distinguish them functionally from their pro-apoptotic counterparts.

84 R4 that encodes a decoy receptor for TRAIL-a pro-apoptotic cytokine that is a promising target for th

85 nalized with linTT1 peptide in tandem with a pro-apoptotic [D(KLAKLAK)2] peptide showed p32-dependent

86 tion, BOK is stabilized to initiate a unique pro-apoptotic death program.

87 Diverse pro-apoptotic drugs, including topoisomerase II inhibito

88 he gene expression of both proliferative and pro-apoptotic E2F1 target genes.

89 sed by cancer cells, once activated, exert a pro-apoptotic effect in different tumors.

90 al and proliferative effect of estrogen to a pro-apoptotic effect in human breast cancer (BCa) MCF-7

91 ); and (v) complete abrogation of the normal pro-apoptotic effect of dexamethasone and fluticasone fu

92 estrogen receptor 1 (GPER1) may mediate the pro-apoptotic effect of estrogen.

93 is, and importantly, antagonizing the normal pro-apoptotic effect of GCS.

94 GSPE enhanced the pro-apoptotic effect of high glucose and showed clear an

95 cological and molecular means suppressed the pro-apoptotic effect of KCNB1 oxidation.

96 hondrial biogenesis may account for the poor pro-apoptotic effect of metformin in cancer cells.

97 easome, and that binding to IP3Rs limits the pro-apoptotic effect of overexpressed Bok.

98 BB-Cl-amidine had a pro-apoptotic effect on all Th subsets in vitro with Th1

99 icipate in this process by either activating pro-apoptotic effectors or inhibiting anti-apoptotic com

100 rs the endocytic fate of FPR2/ALX and evokes pro-apoptotic effects in response to agonist activation.

101 strogen receptors may not be involved in the pro-apoptotic effects of E2 on the n-3 PUFA-treated BCa

102 Thus, anti-nucleolar and pro-apoptotic effects of protein C are flavivirus-specie

103 ation of p53 function is associated with the pro-apoptotic effects of Tnv-6 in many tumors.

104 n of MLK3 in the HER2+ cell line blunted the pro-apoptotic effects of trastuzumab and lapatinib.

105 Inhibitors selective for XIAP should exert pro-apoptotic effects through competition with the termi

106 Associated with these cell cycle and pro-apoptotic effects, we observed increased CCNA2 and B

107 it, and ERalpha knockdown failed to block E2 pro-apoptotic effects.

108 enario, this can have either pro-survival or pro-apoptotic effects.

109 ed to the mitochondria, wherein they trigger pro-apoptotic events leading to shrinkage of basal KCs u

110 These pro-apoptotic events were absent in KI mice and were att

111 tein 5 (PDCD5) has been proposed to act as a pro-apoptotic factor and tumor suppressor.

112 subsequently promotes the expression of the pro-apoptotic factor BAX (Bcl-2-associated X protein), a

113 response and the resulting up-regulation of pro-apoptotic factor CCAAT/enhancer-binding protein homo

114 he extracellular medium, acting as a soluble pro-apoptotic factor in neighboring cells.

115 d as a mediator of cell cycle arrest or as a pro-apoptotic factor in stressful conditions, the MAP3K

116 es apoptosis by increasing the expression of pro-apoptotic factor p53-upregulated modulator of apopto

117 that modulate the expression of PDCD4, a key pro-apoptotic factor, and also reveals new insights into

118 stress-induced cleavage of caspase-2 and the pro-apoptotic factor, Bid, leading to subsequent release

119 In addition, the pro-apoptotic factors FoxO1/3 are overly degraded by ace

120 optosis through ATF4-dependent expression of pro-apoptotic factors including Bid and Trb3.

121 Pro-apoptotic family members contain a weakly conserved

122 or development by its anti-proliferative and pro-apoptotic features.

123 We demonstrate that the pro-apoptotic fragment of the bone marrow kinase on chro

124 eaved in the intestinal mucosa to generate a pro-apoptotic fragment that is spatially restricted to t

125 so highlights the potential role of villin's pro-apoptotic function in the pathogenesis of inflammato

126 m2 phosphorylates BAD, which antagonizes the pro-apoptotic function of BAX.

127 Consistent with the pro-apoptotic function of MLK3, stable knockdown of MLK3

128 gs suggest that HER2 activation inhibits the pro-apoptotic function of MLK3, which plays a mechanisti

129 ylation sites regulating the pro-oxidant and pro-apoptotic function of p66.

130 AmotL1 inhibits pro-apoptotic function of YAP, whereas ZO-2 enhances it.

131 otes podocyte survival by inhibiting dendrin pro-apoptotic function.

132 and this phosphorylation is crucial for its pro-apoptotic function.

133 nhibiting p53 aggregation can reactivate p53 pro-apoptotic function.

134 T activation of AKT and by hindering p40-MET pro-apoptotic function.

135 and inhibit YAP's nuclear translocation and pro-apoptotic function.

136 KDM3A suppressed pro-apoptotic functions of p53 by erasing p53-K372me1, a

137 ng the normal transcriptional activation and pro-apoptotic functions of p53.

138 -fold, and adenoviral vectors expressing the pro-apoptotic gene Bax by >150,000-fold.

139 neurogenesis by conditional deletion of the pro-apoptotic gene Bax in stem cells reduced excitatory

140 nducible transgenic mouse model in which the pro-apoptotic gene Bax is deleted from neural stem cells

141 translocated to the nucleus, and induced the pro-apoptotic gene BCL2-like 11 (Bim).

142 a novel association of a polymorphism in the pro-apoptotic gene FASTKD2 (fas-activated serine/threoni

143 show that Nos-Pum-mediated repression of the pro-apoptotic gene head involution defective (hid) is re

144 of zfh-2 many cells ectopically express the pro-apoptotic gene head involution defective, activate c

145 chemotherapy, associated with increased P53 pro-apoptotic gene promoter occupancy and target gene ex

146 stream activities as genetic ablation of the pro-apoptotic gene Puma reverts the reproductive abnorma

147 Delivery of the pro-apoptotic gene PUMA to FLS via human adenovirus type

148 rus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a r

149 ediated by transcriptional repression of the pro-apoptotic gene reaper.

150 genes BCL2 and BCL2L1 was downregulated and pro-apoptotic gene TNFSF10 was upregulated in MSB1 cells

151 ulates the transcription of the neighbouring pro-apoptotic gene, Bcl2l11 (also known as Bim), by prom

152 pecies (ROS) and induction of transcripts of pro-apoptotic genes and TNF-alpha in vitro at a concentr

153 Here we show that deletion of the pro-apoptotic genes Bak and Bax in osterix (Osx, also kn

154 ting mutated p53 to induce the expression of pro-apoptotic genes in breast cancer with mutant p53.

155 , it is dispensable for induction of several pro-apoptotic genes in response to DNA damage.

156 rmore, PEITC treatment induced expression of pro-apoptotic genes in tumor cells, which was partially

157 er, the expression of E2F1 proliferative and pro-apoptotic genes is correlated with the levels of UCH

158 ll cycle regulator p21(WAF1), as well as the pro-apoptotic genes PUMA and NOXA, three transcriptional

159 These include pro-apoptotic genes that are transcriptionally down-regu

160 clin-dependent kinase, osteocyte marker, and pro-apoptotic genes were increased in isolated Men1 knoc

161 ene targets (including tumor suppressors and pro-apoptotic genes) and resistance to cytotoxic chemoth

162 G9a augmented p53-dependent transcription of pro-apoptotic genes, including Bax and Puma, resulting i

163 h by avoiding transcription of p53-dependent pro-apoptotic genes.

164 target membranes to form pores that deliver pro-apoptotic granzymes into the target cell.

165 These large pores facilitate the entry of pro-apoptotic granzymes, thereby rapidly killing the tar

166 ubset of breast cancer patients treated with pro apoptotic hormonal therapy, BST2 expression correlat

167 tivity including selective repression of the pro-apoptotic HRK protein in NF-kappaB-low tumors.

168 Genetic codepletion of Hdac1 with Hdac2 was pro-apoptotic in Emicro-Myc lymphoma in vitro and in viv

169 Resveratrol is growth-suppressive and pro-apoptotic in liver cancer cells.

170 masomes directly utilize caspase-8 as both a pro-apoptotic initiator and major IL-1beta-converting pr

171 Mechanistically, PARP14 inhibits the pro-apoptotic kinase JNK1, which results in the activati

172 es exocytosis and promotes the export of the pro-apoptotic ligand Eiger (Drosophila TNF).

173 tastasis with stem-cell mediated delivery of pro-apoptotic ligands and have important clinical implic

174 ultimately led to induction of the important pro-apoptotic marker gene chop.

175 In fact, multiple pro-apoptotic markers were increased, whereas anti-apopt

176 Deltapsi(m)) substantiated the intracellular pro-apoptotic mechanism activated by the binding of this

177 through VDR-dependent anti-proliferative and pro-apoptotic mechanisms.

178 nts of the unfolded protein response and the pro-apoptotic mediators CamkII and Stat1 was impaired in

179 The first direct activator of BAX, a pro-apoptotic member of the BCL-2 family, has been recen

180 Translocation of the pro-apoptotic member, Bax, from the cytosol to the mitoc

181 sequences are found on both pro-survival and pro-apoptotic members, although their primary function i

182 PARgamma) transcriptional suppression of the pro-apoptotic microRNA-15a (miR-15a) gene, resulting in

183 Also, Bax activation and pro-apoptotic mitochondrial intermembrane space protein

184 ofound reduction in the kinase activity of a pro-apoptotic mixed lineage kinase 3 (MLK3) in HER2-posi

185 ctor FoxO3a, and decreased expression of the pro-apoptotic molecule Bim.

186 The pro-apoptotic molecule, Bim, was significantly elevated

187 IL-33 also increased the expression of pro-apoptotic molecules, including Bcl-2-associated X pr

188 blocked by pharmacological inhibition of the pro-apoptotic molecules, JNK, glycogen synthase kinase 3

189 Interestingly, Bim, a highly pro-apoptotic negative regulator of Bcl-2, was upregulat

190 h low anti-apoptotic BCL-xL expression, high pro-apoptotic NOXA expression, and paradoxical, MYCN-dri

191 tic cytoplasmic CLU was decreased, while the pro-apoptotic nuclear CLU was largely maintained, after

192 mor selectivity and antitumor efficacy of IP pro-apoptotic NWs.

193 s and requires the nuclear and mitochondrial pro-apoptotic p53 program to induce and execute apoptosi

194 kine-induced activation of the IRE1alpha/JNK pro-apoptotic pathway in cytokine-exposed beta cells.

195 A novel pro-apoptotic pathway initiated by the interaction betwe

196 This cofilin-p53 pro-apoptotic pathway is subject to negative regulation

197 nd thereby inhibit the p-eIF2alpha/ATF4/CHOP pro-apoptotic pathway, identifying miR-30b-5p and miR-30

198 initiates retrograde activation of a somatic pro-apoptotic pathway, which, in turn, is required for d

199 stress, suppresses the p-eIF2alpha/ATF4/CHOP pro-apoptotic pathway.

200 helical distortions, we have determined that pro-apoptotic pathways are activated by the formation of

201 and initiate cell death through induction of pro-apoptotic pathways.

202 asculature-homing peptide (CGKRK) fused to a pro-apoptotic peptide [D(KLAKLAK)2] coated on iron oxide

203 A fusion peptide of M2pep with pro-apoptotic peptide KLA (M2pepKLA) was further used to

204 or example, intracellular delivery of KLA, a pro-apoptotic peptide, results in toxicity against a var

205 ins, as well as cell entry and function of a pro-apoptotic peptide.

206 oteasome activity, which was consistent with pro-apoptotic phenotype of these cells.

207 ion of BAX protein expression resulting in a pro-apoptotic phenotype.

208 cipient resulted in a pro-inflammatory and a pro-apoptotic phenotype.

209 signalling and explained the differences in pro-apoptotic potential between soluble and membrane-bou

210 ncer cell populations even in the absence of pro-apoptotic pressure.

211 tion or by novel treatments toward oxidative/pro-apoptotic processes implicated by MAO-A overexpressi

212 rted as SIRT1/2 inhibitors were endowed with pro-apoptotic properties in human U937 leukemia cells an

213 a germinal center B-cell-derived tumor, the pro-apoptotic properties of c-MYC must be counterbalance

214 cause this pathway is normally halted by the pro-apoptotic protease caspase-8 and the IAP ubiquitin l

215 llele occurrence and increased levels of the pro-apoptotic protein appoptosin in PSP patients.

216 uzumab treatment, but rather inactivated the pro-apoptotic protein BAD, the BCl-2-associated death pr

217 ty and selective binder of the BH3 region of pro-apoptotic protein Bad.

218 mitochondria, MCL-1 interacts with the major pro-apoptotic protein BAK and prevents BAK-BAK homo-olig

219 ation of the cell death pathway demonstrated pro-apoptotic protein Bax 'activation' and caspase cleav

220 ential of a pharmacological activator of the pro-apoptotic protein BAX to suppress acute myeloid leuk

221 , and functions to activate the Bcl-2 family pro-apoptotic protein Bax.

222 s significantly reduced the induction of the pro-apoptotic protein Bim both in vitro and in mice.

223 rtinib treatment increased expression of the pro-apoptotic protein Bim by as much as 144% in Z119 cel

224 Increasing Grx1 reduces the pro-apoptotic protein Bim expression through regulating

225 hat was 'rescued' by genetic deletion of the pro-apoptotic protein Bim or transgenic expression of Bc

226 dd45alpha, the tumor suppressor PTEN and the pro-apoptotic protein Bim.

227 In this manner, treatments that increase pro-apoptotic protein expression increase the efficacy o

228 Bortezomib induced an upregulation of the pro-apoptotic protein Noxa, loss of mitochondrial transm

229 in Bfl-1 and a decrease in expression of the pro-apoptotic protein Noxa.

230 Now, Simon et al. identify the pro-apoptotic protein Puma as a key factor in this cell

231 Reduced expression of the pro-apoptotic protein SMAC (second mitochondria-derived

232 ns of key mitophagic/autophagic proteins and pro-apoptotic protein such as ROS, VDAC1, LC-3II and Cas

233 NOXA is a pro-apoptotic protein that functions by binding the BCL2

234 One primary pro-apoptotic protein that responds to both PERK and Ire

235 -ATPase (SERCA), and decreases levels of the pro-apoptotic protein thioredoxin-interacting protein (T

236 ell apoptosis through induction of CHOP, the pro-apoptotic protein, and sensitizes cells to lipopolys

237 f 1, 2 and 10mg/kg could alter the levels of pro-apoptotic protein, Bax, anti-apoptotic protein, Bcl-

238 Death receptor 5 (DR5), a cell surface pro-apoptotic protein, triggers apoptosis upon ligation

239 gy to Bax and Bak, has been proposed to be a pro-apoptotic protein.

240 l-2 and Bcl-xL), while reduced expression of pro-apoptotic proteins (AIF and Bax).

241 hospho-Erk1/2) proteins, and upregulated the pro-apoptotic proteins (Bad, Bim, Bax and Bid) leading t

242 pha) significantly reduced the expression of pro-apoptotic proteins (Bax and PUMA) and autophagic pro

243 onsequent DNA fragmentation, accumulation of pro-apoptotic proteins (p27, p53, p89 PARP fragments), a

244 for death" by elevated BCL-2, which binds to pro-apoptotic proteins and holds them in check.

245 Bok is most closely related to the pro-apoptotic proteins Bak and Bax, but in contrast to B

246 ses in the mitochondrial levels of activated pro-apoptotic proteins Bax and Bid, and to a lesser exte

247 s correlates with increased abundance of the pro-apoptotic proteins BCL2L11 and BBC3, and with decrea

248 lear membrane protein lamin A, expression of pro-apoptotic proteins c-Jun N-terminal kinase 3, caspas

249 and our understanding of the roles played by pro-apoptotic proteins in non-death scenarios.

250 Furthermore, the expression levels of the pro-apoptotic proteins of CHOP/GADD153 and caspase-12 we

251 eted NSCLC cells show elevated expression of pro-apoptotic proteins of the Bcl-2 family, caspase recr

252 s, the pore opens, increasing the release of pro-apoptotic proteins, and ultimately resulting in cell

253 ks the ability of BCL-XL to bind and inhibit pro-apoptotic proteins, in combination with a MEK inhibi

254 he mitochondrial envelope and the release of pro-apoptotic proteins, leading to cell death.

255 One of the pro-apoptotic proteins, tBid, can induce apoptosis by pr

256 -apoptotic proteins to counter expression of pro-apoptotic proteins, WM samples expressed both pro- a

257 activation of BNIP3 and BNIP3L, which encode pro-apoptotic proteins.

258 complementary set of anti-proliferative and pro-apoptotic proteins.

259 guously into the Bax-like Bcl-2 subfamily of pro-apoptotic proteins.

260 K381 prevents p53 from associating with the pro-apoptotic PUMA gene promoter, activating transcripti

261 ose integrated action drives upregulation of pro-apoptotic Puma, which, unexpectedly, is confined to

262 Dysfunction of Bax, a pro-apoptotic regulator of cellular metabolism is implic

263 nd EZH2 in PAX3-FOXO1 RMS cells impaired the pro-apoptotic response, whereas the overexpression of FB

264 letion of Hdac1 with Hdac2 mediates a robust pro-apoptotic response.

265 A pro-apoptotic role for AMPK is suggested by the finding

266 e death and/or fibrosis, suggesting that the pro-apoptotic role of IRF3 is independent of TLR signali

267 PKR's pro-apoptotic role through eukaryotic initiation factor

268 that, given a variable, slowly accumulating pro-apoptotic signal arising from anti-apoptotic protein

269 otic signal, or (2) all the cells generate a pro-apoptotic signal but the majority silences this path

270 inhibition: (1) only a few cells generate a pro-apoptotic signal, or (2) all the cells generate a pr

271 nduced p75(NTR) and attenuates activation of pro-apoptotic signaling and cell death.

272 ng technique to measure early changes in net pro-apoptotic signaling at the mitochondrion ("priming")

273 of protein expression as well as by blocking pro-apoptotic signaling cascades.

274 N-3 PUFA treatment initiated the pro-apoptotic signaling of estrogen by increasing GPER1-

275 e to link n-3 PUFAs biologic effects and the pro-apoptotic signaling of estrogen in breast cancer cel

276 The resulting release of pro-apoptotic signaling proteins leads to cell destructi

277 t, and kidneys, are profoundly refractory to pro-apoptotic signaling, leading to cellular resistance

278 of PKCdelta is necessary and sufficient for pro-apoptotic signaling.

279 iratory chain defect, metabolic disturbance, pro-apoptotic signalling, and oxidative stress.

280 ignant transformation, our study reveals how pro-apoptotic signals can elevate ROS past a previously

281 suggesting that this occurs by antagonizing pro-apoptotic signals induced by TNF.

282 hat represses FOXO-mediated transcription of pro-apoptotic Smac/DIABLO orthologue, Hid in germline st

283 Ceramide is a pro-apoptotic sphingolipid with unique physical characte

284 ty shifts the intracellular balance from the pro-apoptotic sphingolipids ceramide and sphingosine to

285 UCH37 localizes to the promoters of E2F1 pro-apoptotic target genes such as caspase 3, caspase 7,

286 pression of its CASP10, DAP1, HOXA5, and HRK pro-apoptotic target genes.

287 We showed previously that P53 pro-apoptotic target promoters are enriched with H3K9me3

288 e that in response to P53 stabilization, its pro-apoptotic target promoters become enriched with the

289 AP II ser5-CTD phosphorylation on these same pro-apoptotic target promoters, which correlated with re

290 ategy to assist in surmounting resistance to pro apoptotic therapies.

291 /10B apoptosis-inducing ligand (TRAIL) based pro-apoptotic therapies that induce death receptor signa

292 e ROS past a previously hypothesised 'lethal pro-apoptotic threshold' to induce death; an observation

293 ctions, including negative regulation of the pro-apoptotic transcription factor p53.

294 of PTEN, FOXO3a, P300 and most of the direct pro-apoptotic transcriptional targets of FOXO3a are sign

295 olves upregulation of Rb1/E2F cell cycle and pro-apoptotic transcriptional targets, including cyclin

296 the sensing surface that are related to the pro-apoptotic treatment.

297 Following a pro-apoptotic trigger, cytosolic BAX is activated and tr

298 rm cells with the corresponding elevation of pro-apoptotic Trp53 and Trp63 genes' expression.

299 The p53 pro-apoptotic tumour suppressor is mutated or functional

300 In contrast, IFNgamma increased pro-apoptotic TXNIP post-transcriptionally via induction