ライフサイエンスコーパス: pro-opiomelanocortin

1 -Y and pro-opiomelanocortin signals favoring pro-opiomelanocortin.

2 d epidermal melanocytes, as well as mRNA for pro-opiomelanocortin.

3 ary hormones lutropin (LH), thyrotropin, and pro-opiomelanocortin.

4 , the intracellular routing and secretion of pro-opiomelanocortin/adrenocorticotropin and growth horm

5 terns, leptin sensitivity, and expression of pro-opiomelanocortin/agouti-related peptide/neuropeptide

6 cle, and adipose tissue as well as increased pro-opiomelanocortin and decreased agouti-related peptid

7 Both pro-opiomelanocortin and growth hormone levels were elev

8 he intracellular misrouting and secretion of pro-opiomelanocortin and growth hormone via the constitu

9 macrophages/monocytes were found to express pro-opiomelanocortin and to now constitute the majority

10 nephrine and in hypothalamic neuropeptide Y, pro-opiomelanocortin, and gamma-aminobutyric acid neuron

11 agonist 6beta-naltrexol; (2) pro-enkephalin, pro-opiomelanocortin, and pro-dynorphin KO mice showed r

12 ) was found to induce Fos expression in both pro-opiomelanocortin- and neuropeptide Y-expressing neur

13 products together with endogenous products, pro-opiomelanocortin- and PAM-derived products encoded b

14 Pro-opiomelanocortin anterior pituitary cells express si

15 Pro-opiomelanocortin (ARC(POMC)) neurons are viewed as t

16 n, including corticotropin releasing factor, pro-opiomelanocortin B, and glucose transporter type 2 i

17 N- and O-linked oligosaccharides on pro-opiomelanocortin both bear the unique terminal seque

18 the arcuate nucleus were predominantly from pro-opiomelanocortin cells, with a notable lack of proje

19 throughout the central nervous system and on pro-opiomelanocortin-expressing cells in the hypothalamu

20 for ghrelin-triggered synaptic plasticity of pro-opiomelanocortin-expressing neurons, and for ghrelin

21 ptide cleaved from the precursor pro-hormone pro-opiomelanocortin, from which other peptides such as

22 H by induction of cAMP with up-regulation of pro-opiomelanocortin gene expression and subsequent prod

23 ARC glucose-excited neurons did not show pro-opiomelanocortin immunoreactivity.

24 d amounts of both leptin and arcuate nucleus pro-opiomelanocortin messenger RNA.

25 d in 68.1% of arcuate neurons that expressed pro-opiomelanocortin mRNA but was not significantly coex

26 leus (pPVN) and increased anterior pituitary pro-opiomelanocortin mRNA expression 4 h after IL-1beta

27 ral nucleus of the solitary tract, a site of pro-opiomelanocortin mRNA expression.

28 Pro-opiomelanocortin mRNA was also decreased after dexam

29 hown to bind to an amino-terminal peptide of pro-opiomelanocortin (N-POMC) at pH 5.5 and hypothesized

30 ses revealed that Sirt1 mRNA is expressed in pro-opiomelanocortin neurons that are critical for norma

31 , by stimulating beta-endorphin release from pro-opiomelanocortin neurons that innervate the POA/AH.

32 ocyte-derived hormone leptin, stimulation of pro-opiomelanocortin neurons, and subsequent activation

33 etion through the sympathetic system and via pro-opiomelanocortin neurons, which could serve as the c

34 P-1 receptors with neuropeptide tyrosine and pro-opiomelanocortin neurons.

35 s of neuropeptide Y, agouti-related peptide, pro-opiomelanocortin, or cocaine- and amphetamine-relate

36 stream regulatory elements to assess whether pro-opiomelanocortin peptide (POMC), and its opioid clea

37 anocytes deprived of any exogenous supply of pro-opiomelanocortin peptides.

38 e the effects of STZ-diabetes and fasting on pro-opiomelanocortin (POMC) and agouti-related peptide (

39 Pro-opiomelanocortin (POMC) and agouti-related protein (

40 nin-concentrating hormone] and anorexigenic [pro-opiomelanocortin (POMC) and cocaine-amphetamine-rela

41 mRNA levels of pro-dynorphin (proDYN), pro-opiomelanocortin (POMC) and pro-enkephalin (proENK)

42 rocessing of two neuroendocrine prohormones, pro-opiomelanocortin (POMC) and pro-orphanin FQ (pOFQ)/n

43 ulate appetite, namely neuropeptide Y (NPY), pro-opiomelanocortin (POMC) and the leptin receptor isof

44 e we show that suppression of ROS diminishes pro-opiomelanocortin (POMC) cell activation and promotes

45 rtisolism and elevated plasma proinsulin and pro-opiomelanocortin (POMC) concentrations but a very lo

46 protein (AgRP) mRNA expression increased and pro-opiomelanocortin (POMC) decreased in response to fas

47 functional loss of both alleles of the human pro-opiomelanocortin (POMC) gene leads to a very rare sy

48 Posttranslational modification of the pro-opiomelanocortin (POMC) gene transcript results in t

49 he two pituitary cell types that express the pro-opiomelanocortin (POMC) gene, the anterior lobe cort

50 Since alpha-MSH is coded for by the pro-opiomelanocortin (POMC) gene, we examined if POMC ge

51 ), corticotropin-releasing hormone (CRH) and pro-opiomelanocortin (POMC) in the context of the limbic

52 and mice with 5-HT2CRs re-expression only in pro-opiomelanocortin (POMC) neurons (2C/POMC mice).

53 rotonin 2C receptors (Htr2c) specifically in pro-opiomelanocortin (POMC) neurons had normal body weig

54 Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-t

55 The arcuate pro-opiomelanocortin (POMC) neurons in particular have b

56 gnaling in agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons in regulating hepati

57 In the hypothalamic arcuate nucleus (ARC), pro-opiomelanocortin (POMC) neurons inhibit feeding and

58 tonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcu

59 Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety.

60 ivation of Nscl-2 in GnRH neurons but not in pro-opiomelanocortin (POMC) neurons reduced POMC neurons

61 enetic stimulation of ARC TH cells inhibited pro-opiomelanocortin (POMC) neurons through synaptic mec

62 disrupted glucose sensing in glucose-excited pro-opiomelanocortin (POMC) neurons via transgenic expre

63 In addition, we found that pro-opiomelanocortin (POMC) neurons were crucial for the

64 mulation, likely including satiety-promoting pro-opiomelanocortin (POMC) neurons, demonstrated opposi

65 vation of hypothalamic arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons, which are also disi

66 ed in the opposite direction in anorexigenic pro-opiomelanocortin (POMC) neurons.

67 asing the anorexigenic tone due to activated pro-opiomelanocortin (POMC) neurons.

68 etylcholine receptors leads to activation of pro-opiomelanocortin (POMC) neurons.

69 lized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons.

70 ed in mice with 5-HT(2C)Rs expressed only in pro-opiomelanocortin (POMC) neurons.

71 PY nerve terminals, thus activating adjacent pro-opiomelanocortin (POMC) neurons.

72 on with decreased number of appetite-curbing pro-opiomelanocortin (POMC) neurons; whether the reducti

73 outi-related peptide (AgRP) and anorexigenic pro-opiomelanocortin (POMC) neuropeptides.

74 RNA levels of ProDynorphin (proDYN), but not pro-opiomelanocortin (POMC) nor proEnkephalin (proENK) w

75 Mice lacking ROCK1 in either pro-opiomelanocortin (POMC) or agouti-related protein ne

76 ol include hypothalamic neurons that express pro-opiomelanocortin (POMC) or neuropeptide-Y (NPY) and

77 pression of agouti-related peptide (AGRP) or pro-opiomelanocortin (POMC) positively and negatively in

78 uropeptide Y and increases expression of the pro-opiomelanocortin (POMC) precursor of alphaMSH.

79 Melanocortins are peptides, cleaved from the pro-opiomelanocortin (POMC) precursor, that act in the b

80 AtT20 pituitary cells transfected with a rat pro-opiomelanocortin (POMC) promoter (-706/+64) linked t

81 , multiple agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) subtypes, and an orexigenic

82 sorting receptor that directs the prohormone pro-opiomelanocortin (POMC) to the regulated secretory p

83 ypothalamic circuits, resulting in increased pro-opiomelanocortin (POMC) tone, followed by decreased

84 Thus, mRNAs encoding NPY and pro-opiomelanocortin (POMC) were colocalized in the arcu

85 membranes containing [(35)S]sulfate labeled pro-opiomelanocortin (POMC)(5) in the trans-Golgi, we ca

86 Pro-opiomelanocortin (POMC), ACTH, and cortisol were mea

87 oexpress the melanocortin precursor molecule pro-opiomelanocortin (POMC), and administration of insul

88 rotein 130 (gp 130), leptin receptor (OB-R), pro-opiomelanocortin (POMC), neuropeptide Y (NPY), gluco

89 om peptides derived from the ACTH precursor, pro-opiomelanocortin (POMC), to maintain its tonic state

90 Pro-opiomelanocortin (POMC)- and agouti-related peptide

91 Because the pro-opiomelanocortin (POMC)-derived melanocortin system

92 Pro-opiomelanocortin (POMC)-derived peptides (the melano

93 The pro-opiomelanocortin (POMC)-derived peptides, alpha-mela

94 lamus (ARH) satiety signaling (anorexigenic) pro-opiomelanocortin (POMC)-expressing and hunger signal

95 We show that FoxO1 ablation in pro-opiomelanocortin (Pomc)-expressing neurons in mice (

96 Satiety-signaling, pro-opiomelanocortin (POMC)-expressing neurons in the ar

97 ssing neurons but induces no net response in pro-opiomelanocortin (POMC)-expressing neurons.

98 ng glucokinase regulatory protein (GCKR) and pro-opiomelanocortin (POMC).

99 nthesis and packaging of a sulfated hormone, pro-opiomelanocortin (POMC).

100 bioactive peptides are cleavage products of pro-opiomelanocortin (POMC).

101 and amphetamine-regulated transcript, CART; pro-opiomelanocortin, pomc1a) neurons in the brain.

102 s, including neuropeptides deriving from the pro-opiomelanocortin precursor protein and localized a s

103 In order to follow possible pro-opiomelanocortin processing in the melanosome, human

104 trated the presence of the entire system for pro-opiomelanocortin processing in the melanosome.

105 The pro-opiomelanocortin product alpha-melanocyte stimulatin

106 omain also prevented stimulated secretion of pro-opiomelanocortin products in AtT-20 cells.

107 ws identification of 14 of these peptides as pro-opiomelanocortin prohormone-derived molecules.

108 ent protein (DsRed) under the control of the pro-opiomelanocortin promoter and distal upstream regula

109 transgenic mice in which 770-bp fragment of pro-opiomelanocortin promoter directs expression of the

110 recombinant adeno-associated virus encoding pro-opiomelanocortin (rAAV-POMC) or control vector was d

111 an autocrine intramelanosomal production of pro- opiomelanocortin-related peptides and an autocrine

112 these organelles themselves actually produce pro-opiomelanocortin-related peptides in their acidic en

113 t of an imbalance between neuropeptide-Y and pro-opiomelanocortin signals favoring pro-opiomelanocort

114 Neutrophils expressed pro-opiomelanocortin, the precursor of beta-endorphin (a

115 e PC chimeras efficiently cleaved endogenous pro-opiomelanocortin to the correct bioactive peptides.

116 receptor for targeting prohormones, such as pro-opiomelanocortin, to the regulated secretory pathway

117 In Cpefat mice, pro-opiomelanocortin was accumulated 24-fold above norma

118 Furthermore, pro-opiomelanocortin was secreted constitutively at high

119 mouse lacking CPE, the pituitary prohormone, pro-opiomelanocortin, was missorted to the constitutive

120 Double-label studies indicated that VGF and pro-opiomelanocortin were coexpressed in lateral arcuate