ライフサイエンスコーパス: pro-oxidant

1 gain entrance into cells and function as a 'pro-oxidant'.

2 etabolically active ferrous form is a strong pro-oxidant.

3 agent that can function as both an anti- and pro-oxidant.

4 as well as treatment with CdCl(2), a potent pro-oxidant.

5 carried out with manganese (30 microM) as a pro-oxidant.

6 C lost its antioxidant properties and became pro-oxidant.

7 iferone (2) and scopoletin (3) were slightly pro-oxidant.

8 NRF2 binding until it becomes inactivated by pro-oxidants.

9 en pro-oxidants and antioxidants in favor of pro-oxidants.

10 es in the levels of mitochondrial Ca(2+) and pro-oxidants.

11 endent modulation in activity in response to pro-oxidants.

12 ssing CYP2E1 against cytotoxicity induced by pro-oxidants.

13 ofiles in response to herbicide safeners and pro-oxidants.

14 crease in periodontal inflammation and serum pro-oxidants.

15 nce of ascorbic acid or 6-hydroxydopamine as pro-oxidants.

16 H in the three assays and in the presence of pro-oxidants.

17 eased fibromodulin production in response to pro-oxidants.

18 to the oxidative stress initiated by chronic pro-oxidant Abeta exposure.

19 by itself is a mild antimicrobial and has a pro-oxidant ability.

20 Thus, due to apparent pro-oxidant action of DEDTC, our data do not support its

21 effect on lipid peroxidation, inducing both pro-oxidant actions at low (5-20) micromolar concentrati

22 dings suggest that, despite 3-HK might exert pro-oxidant actions under certain conditions, these chan

23 sed for quantifying simultaneously anti- and pro-oxidant activities as function of concentration and

24 we directly demonstrated that both anti- and pro-oxidant activities of etoposide are realized in cell

25 nvironmental particulate matter (PM) directs pro-oxidant activities that may alter DC function.

26 In conclusion, honey phenolics with pro-oxidant activities were necessary intermediates that

27 ) systems] as well as for the observation of pro-oxidant activities, with the measurements registerin

28 At low content, honey polyphenols exerted pro-oxidant activity damaging to DNA.

29 eltacta1, Deltagsh1 and Deltaoye2glr1, while pro-oxidant activity in Deltasod1 cells was seen.

30 been observed to exert both antioxidant and pro-oxidant activity in lipid foods, and factors that in

31 4h, EGCG (5-100 muM) was observed to exhibit pro-oxidant activity in low pH (pH 2-4) emulsions, as de

32 tudy suggests that pheomelanin's redox-based pro-oxidant activity may contribute to sustaining a chro

33 However, this pro-oxidant activity of alpha-tocopherol is prevented by

34 (EGCG), and matrix pH (2-7) on the net anti-/pro-oxidant activity of EGCG in flaxseed oil-in-water (o

35 MPO-dependent pro-oxidant activity of etoposide was directly demonstra

36 radical species formed show a potential for pro-oxidant activity of this compound.

37 an antioxidant, PDTC has been shown to exert pro-oxidant activity on proteins both in vitro and in vi

38 aHb) to maintain its structure and limit its pro-oxidant activity.

39 not converted to reactive intermediates with pro-oxidant activity.

40 ct had indeed antioxidant protection, and no pro-oxidant activity.

41 None of the tested metals showed a pro-oxidant activity.

42 cells, controls S1P1 expression through its pro-oxidant activity.

43 ess and have decreased circulating levels of pro-oxidant advanced glycation end-products (AGEs).

44 hat sustained exposure to the high levels of pro-oxidant AGEs in normal diets (Reg(AGE)) contributes

45 Serum iron, a potential pro-oxidant, also decreased by 45% with exercise from 15

46 osure of primary rat cortical neurons to the pro-oxidant amyloid beta peptide promotes nuclear accumu

47 anoceria; CNPs) have been found to have both pro-oxidant and anti-oxidant effects on different cell s

48 A series of pro-oxidant and antioxidant enzymes, such as the NADPH o

49 Angiotensin II (Ang II) is a pro-oxidant and fibrogenic cytokine.

50 However, any form of iron is a pro-oxidant and its addition will cause off-flavours and

51 ministration of Levodopa (l-DOPA) which is a pro-oxidant and may disrupt sulfhydryl homeostasis.

52 PKCbeta phosphorylation sites regulating the pro-oxidant and pro-apoptotic function of p66.

53 unction and be partially responsible for the pro-oxidant and pro-inflammatory effects of uric acid.

54 an antioxidant for cells susceptible to the pro-oxidant and proapoptotic properties of vitamin C.

55 Taken together, our data demonstrate a novel pro-oxidant and proapoptotic role of Trx in anthracyclin

56 alveolar bone loss (ABL) and serum levels of pro-oxidants and antioxidant enzymes in rats with experi

57 ve stress is defined as an imbalance between pro-oxidants and antioxidants in favor of pro-oxidants.

58 le cells exhibit an increased sensitivity to pro-oxidants, and conversely, Stra13 overexpression prov

59 dence for a mechanistic link between Ca(2+), pro-oxidants, and inhibition of complex I utilizing mito

60 ity: use of antioxidant crowns, chelation of pro-oxidants, and varying plant content in hops.

61 Pro-oxidants are considered as major constituents of veh

62 dized glutathione and steady-state levels of pro-oxidants as assayed using an oxidation-sensitive flu

63 Remarkably alpha-tocopherol acted as a pro-oxidant at 25 and 40 degrees C, in particular during

64 e cod protein in the presence and absence of pro-oxidants at pH 8 and 36 degrees C to achieve 20% deg

65 gen peroxide and diamide, although these two pro-oxidants by themselves had opposing effects on JNK1

66 olox and PhC can exert either antioxidant or pro-oxidant capacities depending on their concentration,

67 ly those with quinoa flour, reduced the AAPH pro-oxidant capacity in co-culture cells.

68 HA-mac contained more iron, a pro-oxidant catalyst, but paradoxically had less oxidati

69 on TTB stability could be due to a possible pro-oxidant character.

70 lioblastoma (GBM) cells to ascorbate through pro-oxidant chemistry involving redox-active labile iron

71 een shown to have pro-oxidant potential, the pro-oxidant chemistry of dihydrolipoic acid has not been

72 is emerging as promising cancer therapy via pro-oxidant chemistry.

73 Pro-oxidant components of PM2.5 are capable of directly

74 ondrial toxin 3-nitropropionic acid, and the pro-oxidant compound iron sulfate.

75 without exogenous supplementation of excess pro-oxidant compounds in clinically relevant blood produ

76 Exposure of cells to pro-oxidant conditions in culture led to a greater inhib

77 enase-1 (HO-1) is induced under a variety of pro-oxidant conditions such as those associated with isc

78 s shown that this stimulation is promoted by pro-oxidant conditions that result in increased hepatic

79 tro study suggested that aPL may derive from pro-oxidant conditions, we sought a relationship between

80 ows that CaMKII activity is also enhanced by pro-oxidant conditions.

81 or l-3,4-dihydroxyphenylalanine (DOPA) under pro-oxidant conditions.

82 NRF-1-Tfam binding was augmented under pro-oxidant conditions.

83 ene expression in 3T3 cells are inhibited by pro-oxidant conditions.

84 mixture of vehicle exhaust that comprised of pro-oxidant constituents of exhaust, namely, carbon diox

85 t hydrogen peroxide or the chemotherapy drug/pro-oxidant cyclophosphamide.

86 ethine into profibrotic pantothenic acid and pro-oxidant cystamine, we tested this pathway in the pat

87 rol (RSV) acts either as an antioxidant or a pro-oxidant depending on contexts.

88 Behavior is bimodal antioxidant/pro-oxidant depending on the concentration.

89 APDH at functional residues upon exposure to pro-oxidants diamide and H2O2 Here we hypothesize that r

90 cubation of the cells with azidothymidine, a pro-oxidant drug, significantly improves the limit of de

91 d major intracellular antioxidant, acts as a pro-oxidant during myeloperoxidase-catalyzed metabolism

92 atitis by production of nitric oxide-derived pro-oxidants (e.g., peroxynitrite).

93 cular weight fraction, our results support a pro-oxidant effect due to the catalytic formation of hyd

94 evidence that caspases partially mediate the pro-oxidant effect of Bax.

95 responding bell-shaped curves displaying the pro-oxidant effect of flavonols quercetin and kaempferol

96 (and GSH only partially) inhibited the weak pro-oxidant effect of peroxynitrite, which produced litt

97 uced hemolysis, but at high concentrations a pro-oxidant effect on erythrocyte morphology was observe

98 while demonstrating that it had no perceived pro-oxidant effect.

99 In both assays, pro-oxidant effects at higher lioAW concentrations were

100 tivity toward thiols is a determinant of its pro-oxidant effects in HL-60 cells.

101 s strong antioxidant properties, it also has pro-oxidant effects in the presence of free transition m

102 nt effects, with the largest antioxidant and pro-oxidant effects observed at the higher EGCG concentr

103 re, to circumvent the extracellular in vitro pro-oxidant effects of AA, we loaded HL60, U266, and RPM

104 ASMC with Cu((II))ATSM protected against the pro-oxidant effects of angiotensin II (Ang II) by attenu

105 facts associated with the poor transport and pro-oxidant effects of ascorbic acid (AA).

106 In vitro results have been confounded by pro-oxidant effects of ascorbic acid and an overlapping

107 d, thereby avoiding transition metal-related pro-oxidant effects of ascorbic acid.

108 The proposed anti- and pro-oxidant effects of nitric oxide (NO) derivatives, su

109 Plausible mechanisms for the antioxidant and pro-oxidant effects of trolox and PhC on MP are discusse

110 cant roles in determining net antioxidant or pro-oxidant effects, with the largest antioxidant and pr

111 tract, while also considering their possible pro-oxidant effects.

112 ther organs because of its bioreactivity and pro-oxidant effects.

113 ly deleterious transition metal ion-mediated pro-oxidant effects.

114 reported to kill cancer cells with catalytic pro-oxidant effects.

115 of diazoxide are mediated by generation of a pro-oxidant environment.

116 peroxidase, but also significantly decreased pro-oxidant enzyme levels, such as iNOS and gp91-phox, t

117 C to T substitution at position +242) of the pro-oxidant enzyme NADPH oxidase p22phox subunit gene an

118 K pathways, and suppresses the expression of pro-oxidant enzyme via AMPK pathway.

119 ved.O(2)(-), whereas the inhibitors of other pro-oxidant enzymes were ineffective.

120 ysregulations of the expression of anti- and pro-oxidant enzymes, mitochondrial biogenesis and functi

121 oxidant enzymes, and increased expression of pro-oxidant enzymes.

122 against a high dose of the chemotherapy drug/pro-oxidant etoposide.

123 a feature of ARDS, and we hypothesized that pro-oxidant forces may contribute to the onset and progr

124 nd with extensive DNA damage, transactivates pro-oxidant genes that contribute to apoptosis.

125 Haptoglobin (Hp) binds free pro-oxidant Hb, thereby modulating its harmful effects.

126 o arise from the transient accumulation of a pro-oxidant heme A-Cox1 stalled intermediate.

127 Heme oxygenase (HO)-1 degrades the pro-oxidant heme and generates carbon monoxide and antio

128 in part through increased metabolism of the pro-oxidant heme but that higher levels of HO activity o

129 se (HO) isozymes are thought to detoxify the pro-oxidant heme to the potent antioxidant, bilirubin.

130 mal enzyme that catalyzes the degradation of pro-oxidant heme.

131 te limiting enzyme in the degradation of the pro-oxidant hemin/heme from blood, here we investigated

132 uronal loss due to prolonged exposure to the pro-oxidant hemoglobin, with complete protection at 10 m

133 To understand the efficacy of pro-oxidant hepatic perturbations in Wilson disease, we

134 activation of JNK1 by PEITC was inhibited by pro-oxidants hydrogen peroxide and diamide, although the

135 sly reported that hydroquinone (HQ), a major pro-oxidant in cigarette smoke, foodstuff, and atmospher

136 Because ascorbic acid is a strong pro-oxidant in the presence of transition metals in vitr

137 bic acid, AA) can act as an antioxidant or a pro-oxidant in vitro, depending on the absence or the pr

138 ated monoterpenes (e.g. linalool) may act as pro-oxidants in essential oil.

139 t oxidative stress caused by three different pro-oxidants in normoglycemic conditions.

140 We hypothesized that prolonged exposure to pro-oxidants in vehicle emissions result in behavioral a

141 We observed that prolonged exposure to pro-oxidants in vehicle exhaust increased anxiety-and de

142 er cells were more susceptible to additional pro-oxidant injury through thyroid hormone, which accele

143 We report here that a mild pro-oxidant intracellular milieu induced by either pharm

144 In the absence of pro-oxidant ions in the aqueous phase, lipid oxidation o

145 se (PD) cases, which could contribute to the pro-oxidant iron accumulation that characterizes the pat

146 rriprotoporphyrin IX), a potential source of pro-oxidant iron in bone marrow, on in vitro photodynami

147 manganese as an antioxidant in the midst of pro-oxidant iron.

148 The expression of hsp-16-2 induced by the pro-oxidant juglone and by heat shock was significantly

149 were isolated, and their HCV RNA synthesis, pro-oxidant levels, and resistance to oxidative injury w

150 t marker CAT and decreased expression of the pro-oxidant marker NOX-4.

151 g that iron accelerated thrombosis through a pro-oxidant mechanism.

152 that both of the AP1 motifs are required for pro-oxidant-mediated activation of the ferritin H gene.

153 ynthesize hydroperoxyacids, which are potent pro-oxidant mediators.

154 Cysteinylglycine is a pro-oxidant metabolite of glutathione and a precursor of

155 These data underscore the role of a pro-oxidant milieu in chemoresistance of hematopoietic a

156 nes can interact to produce a Duox-dependent pro-oxidant milieu that could increase the pathologic po

157 ree heme in building up defense against this pro-oxidant milieu.

158 ical molecular switch in the transduction of pro-oxidant mitogenic signals.

159 However, heme is a pro-oxidant molecule capable of propagating reactions le

160 because sympathetic neurons contain several pro-oxidant molecules involved in noradrenaline metaboli

161 h can be suppressed either by treatment with pro-oxidants or by co-deletion of Yap.

162 rrelations, or the lack thereof, between the pro-oxidant parameters and the redox potentials, antioxi

163 e state of erythroid progenitor cells by the pro-oxidant Paraquat reversed the effect of UCP2 deficie

164 We concluded that pro-oxidant perturbations were uniquely effective for ce

165 MK-801 had a pronounced pro-oxidant potential, and when administered in combinat

166 xidants, in general, have been shown to have pro-oxidant potential, the pro-oxidant chemistry of dihy

167 atory shear causes a sustained activation of pro-oxidant processes resulting in redox-sensitive gene

168 hypothesized to be caused either by enhanced pro-oxidant production or decreased levels of antioxidan

169 xidized glutathione and a 3-fold increase in pro-oxidant production.

170 ells from cell killing as well as suppressed pro-oxidant production.

171 s, reduced macrophage parasite burden, while pro-oxidants promoted it.

172 However, ascorbic acid also has pro-oxidant properties and may cause apoptosis of lympho

173 d with oxidative stress, possibly due to the pro-oxidant properties of beta-amyloid present in the se

174 The pro-oxidant properties of ethanol may thus act independe

175 Ascorbic acid, known to potentiate the pro-oxidant properties of iron, was also capable of mark

176 carcinogenesis and implicated pheomelanin's pro-oxidant properties that act through the generation o

177 his gene therapy strategy exploits the toxic pro-oxidant property of methylselenol, which is released

178 mutase 1 and catalase, and activation of the pro-oxidant protein kinase C isoform beta-II (PKCbetaII)

179 involving REDD1, an mTORC1 inhibitor and the pro-oxidant protein TXNIP.

180 iomarkers for assessing stress, toxicity and pro-oxidant quality of chemicals and aquatic environment

181 iomarkers for assessing stress, toxicity and pro-oxidant quality of chemicals and aquatic environment

182 complexes can catalyze both antioxidant and pro-oxidant reactions, whereby the disparate reactivity

183 s species correlate well (r=0.9946) with the pro-oxidant reactivity manifested by flavonoids in the p

184 An assay for the pro-oxidant reactivity of natural products is hence prop

185 is type of surgery and represent a potential pro-oxidant risk for oxidative damage.

186 The GSEs play a dual antioxidant/pro-oxidant role in vivo according with the cellular ant

187 posing these functions, it may also assume a pro-oxidant role under some conditions.

188 , we show that combining GLN starvation with pro-oxidants selectively kills GLN addicted cells.

189 glucocorticoid receptor (GR) and downstream pro-oxidant signaling.

190 es an overproduction of pro-inflammatory and pro-oxidant signals.

191 Imexon, a pro-oxidant small molecule, has antitumor activity in pr

192 The pro-oxidants sodium arsenite, cadmium chloride, and hydr

193 in II type 1 (AT(1)) receptor antagonists on pro-oxidant species observed in the pathogenesis of athe

194 the enzyme myeloperoxidase that produces the pro-oxidant species, hypochlorous acid (HOCl).

195 Thus, depending on the pro-oxidant species, the level and duration of the oxida

196 nate the soft Cu(I) cation and thereby yield pro-oxidant species.

197 Puma, and Noxa) have been shown to induce a pro-oxidant state at mitochondria (1-4).

198 roteolysis is triggered during the renal I/R pro-oxidant state by a still unknown mechanism, which mi

199 vulnerable to oxidative stress owing to the pro-oxidant state generated during melanin synthesis, an

200 ligo is thought to be instigated by a highly pro-oxidant state in the epidermis.

201 Inducing a pro-oxidant state similar to that in NGF-deprived, wild-

202 by an arginine-deficient and highly specific pro-oxidant state, with elevated levels of methylated ar

203 w dose rate exhibited a shift towards a more pro-oxidant state.

204 Next, pro-oxidant stimulation of the cell wall integrity pathw

205 in its nuclear translocation in response to pro-oxidant stimuli and that the importin alpha-beta het

206 ed with cardiovascular disease are linked to pro-oxidants such as advanced glycation end products (AG

207 an be induced in cultured cells treated with pro-oxidants such as tert-butylhydroquinone, 2,3-dimetho

208 As a pro-oxidant, tBHQ regulates the expression of cytoprotec

209 Treatment of KB cells with the lipid pro-oxidant tert-butyl hydroperoxide induced transient i

210 urposes, we also examined the effects of the pro-oxidant tert-butyl-hydroperoxide (TBHP) and of the d

211 Here, we report that the pro-oxidant, tert-butyl dihydroquinone (BHQ), modulates

212 use NOS enzymes produce nitric oxide (NO), a pro-oxidant that can damage neurons.

213 s a potent antioxidant and can also act as a pro-oxidant that induces oxidative stress on the vascula

214 may contribute to the role of ascorbate as a pro-oxidant that is potentially capable of loosening the

215 ere metabolised during storage, and acted as pro-oxidants that promoted lipid oxidation in both high

216 in albumin oxidation, and albumin acts as a pro-oxidant; this promotes oxidative stress and inflamma

217 n renders cells susceptible to hydroperoxide pro-oxidants, though this type of sensitivity is specifi

218 ld be used to trigger release of copper as a pro-oxidant to increase oxidative stress or as a tool to

219 pherol can act either as an antioxidant or a pro-oxidant to inhibit or facilitate, respectively, lipi

220 We next treated patient cells with pro-oxidants to mimic the oxidative stress associated wi

221 so reports of dihydrolipoic acid acting as a pro-oxidant under certain circumstances.

222 herol (alpha-TOH) has been found to act as a pro-oxidant under many in vitro conditions.

223 nsitivity of the mutant to exogenously added pro-oxidants, we infer that the reactive oxygen species

224 itin heavy chain (ferritin H) was induced by pro-oxidants, which is a part of cellular antioxidant re

225 lavonols, morin and rutin were progressively pro-oxidant, while 7-hydroxyflavone and hesperetin were

226 known regarding the response of aconitase to pro-oxidants within intact mitochondria.