ライフサイエンスコーパス: proangiogenic

1 ress nerve growth factor (NGF), which can be proangiogenic.

2 Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

3 thus providing mechanistic insight into its proangiogenic actions in vitro and in vivo.

4 racellular matrix, promoting EC adhesion and proangiogenic activation by engaging alpha(v)beta(3).

5 ly weakly integrin-dependent EC adhesion and proangiogenic activation by fibronectin.

6 ) and mediates Tat-dependent EC adhesion and proangiogenic activation.

7 ts role in Tat interaction, EC adhesion, and proangiogenic activation.

8 The circRNA cZNF292 exhibits proangiogenic activities in vitro.

9 uted tomography and histology, corroborating proangiogenic activities of M2-polarized liver macrophag

10 sis via proproliferative, antiapoptotic, and proangiogenic activities.

11 Proangiogenic activity during adipose tissue expansion i

12 g antibodies removed the CA-STAT5A-dependent proangiogenic activity from the conditioned medium of EC

13 g antibodies removed the CA-STAT5A-dependent proangiogenic activity from the conditioned medium of EC

14 aling exerts this effect by antagonizing the proangiogenic activity of vascular endothelial growth fa

15 s antiangiogenic activity in contrast to the proangiogenic activity of VEGF-A.

16 tion of this regulatory axis next showed the proangiogenic activity of ZO-1 in both ex vivo and in vi

17 In vitro, FGD6 could regulate proangiogenic activity, and oxidized phospholipids incre

18 is a lipid-signaling mediator known to have proangiogenic activity, but the mechanisms are largely u

19 ing the C-terminal region) endowed of potent proangiogenic activity.

20 unctions of VEGF that are independent of its proangiogenic activity.

21 nses, phagocytosis, chemokine secretion, and proangiogenic activity.

22 26 is shown to free at least one target, the proangiogenic adrenomedullin, from repression, enhancing

23 clinical studies have assessed the impact of proangiogenic and antiangiogenic factors on endothelial

24 ined for changes in CNV lesion volume and in proangiogenic and antiangiogenic gene expression after p

25 enesis has been demonstrated to involve both proangiogenic and antiangiogenic stimuli, with the level

26 Cargo with opposing actions (eg, proangiogenic and antiangiogenic) had similar release pr

27 IL-8, tumor necrosis factor (TNF)-alpha, the proangiogenic and antiapoptotic enzyme cyclooxygenase-2,

28 PCR profiling showed that piPSC-ECs released proangiogenic and antiapoptotic factors in the ischemic

29 iPSC-CMs could release significant levels of proangiogenic and antiapoptotic factors in the ischemic

30 Vs were enriched in miRNAs and proteins with proangiogenic and cytoprotective properties.

31 reased expression of genes associated with a proangiogenic and immunoinhibitory phenotype.

32 CSF-2 and CSF-3 confer proangiogenic and immunomodulatory properties to mesench

33 h and must respond to multiple destabilizing proangiogenic and inflammatory cytokines.

34 so, the laser burn-induced overexpression of proangiogenic and inflammatory factors was observed in t

35 MSCs drive monocyte differentiation toward a proangiogenic and lipopolysaccharide-unresponsive phenot

36 Exosomes can be proangiogenic and may have cardioprotective properties.

37 Nintedanib targets proangiogenic and pro-fibrotic pathways mediated by the

38 he miR-155/CCN1 regulatory axis balances the proangiogenic and proinflammatory activities of microgli

39 ) induces a transcriptional induction of the proangiogenic and proinflammatory cytokine angiopoietin-

40 tes tumor angiogenesis through repression of proangiogenic and proinflammatory cytokines.

41 ethyl)pyrrole (CEP), which was shown to have proangiogenic and proinflammatory functions.

42 Angiopoietin-2 (Ang2) is a proangiogenic and proinflammatory vascular destabilizer

43 This proangiogenic and prolymphangiogenic microenvironment is

44 LNA-92a exerts cell-protective, proangiogenic, and anti-inflammatory effects.

45 eparanase (HPSE) is a potent protumorigenic, proangiogenic, and prometastatic enzyme that is overexpr

46 ammatory M1 as opposed to anti-inflammatory, proangiogenic, and tissue repair M2 phenotype, which may

47 thus contributing to the immunosuppressive, proangiogenic, and tumor-promoting effects of this pleio

48 of fragments lacking the C-terminal region (proangiogenic) are present in circulation in healthy sub

49 hosphorylation of VEGF receptors and promote proangiogenic behavior in endothelial cells, indicated b

50 nitoring to show that the host response to a proangiogenic biomaterial can be drastically affected by

51 ctional changes, endowing them with enhanced proangiogenic capabilities and, importantly, with a mark

52 itioning CSCs in high glucose attenuated the proangiogenic capacity of CSCs.

53 ased expression of glyoxalase-1 restored the proangiogenic capacity of diabetic CSCs, suggesting a me

54 mall (albeit not significant) shift toward a proangiogenic CD206(+)MHCII(-)(M2-like) macrophage respo

55 IIa) elicits TF cytoplasmic domain-dependent proangiogenic cell signaling independent of the alternat

56 Clinical studies using bone marrow-derived proangiogenic cells (PACs) have demonstrated modest impr

57 Emerging evidence demonstrates that proangiogenic cells (PACs) originate from the BM and are

58 approach to improve therapeutic efficacy of proangiogenic cells for the treatment of ischemic diseas

59 Expression of the proinflammatory and proangiogenic chemokine IL-8, which is regulated at the

60 deletion had no effect on the expression of proangiogenic chemokine or vascular endothelial growth f

61 results in elevated systemic levels of this proangiogenic chemokine that raises concerns for tumorig

62 is study demonstrates that VEGF-A recruits a proangiogenic circulating subset of CD11b(+)/Gr-1(+) neu

63 This inflammatory signature included several proangiogenic CXCR2 receptor ligands.

64 ow that KIT D816V promotes expression of the proangiogenic cytokine CCL2 in neoplastic mast cells.

65 thelial growth factor A (VEGF-A) is a potent proangiogenic cytokine elevated in patients with periphe

66 inhibiting TF-FVIIa signaling that leads to proangiogenic cytokine expression and tumor cell migrati

67 For example, VEGF, a major proangiogenic cytokine induced by hypoxia, plays a criti

68 Semaphorin 4D (Sema4D) is a proangiogenic cytokine produced by several malignancies,

69 portant for VEGF, bFGF, EGF, IL-6, and other proangiogenic cytokine secretion in stromal and tumor ce

70 ect tumoral effects and through reduction of proangiogenic cytokine secretion via the microenvironmen

71 vascular endothelial growth factor (VEGF), a proangiogenic cytokine.

72 ophages into the laser lesions and increases proangiogenic cytokines promoting CNV.

73 hosphorylation required for the induction of proangiogenic cytokines.

74 dition, we recently postulated that they are proangiogenic due to their ability to induce the secreti

75 nockdown in vitro and may play a role in the proangiogenic effect of MEF2C knockdown on retinal EC tu

76 we demonstrated a paracrine promigratory and proangiogenic effect of miR-143-3p-enriched exosomes fro

77 iogenic response to injury and inhibited the proangiogenic effect of TNFalpha in cultures of aortic r

78 receptor 2 in ECs and largely mediated their proangiogenic effect.

79 function independently of its CNV-promoting proangiogenic effect.

80 ngosine-1-phosphate also seemed to exert its proangiogenic effects by stimulating directional filopod

81 s and their supernatants exerted more potent proangiogenic effects compared with CD34(-) PBMC subsets

82 clude that NT exerts its proinflammatory and proangiogenic effects during acute colitis via a NTR1-pr

83 ifferentiation of BMCs in vitro, and reveals proangiogenic effects in ovo.

84 To test whether the proangiogenic effects of B act via activation of VEGF pa

85 alization of BMP receptors and abrogates the proangiogenic effects of BMP signaling in endothelial ce

86 vel molecular mechanism underlying increased proangiogenic effects of CD34(+) PBMCs, that is, angiomi

87 resulted in significant loss or increase of proangiogenic effects of CD34(+) PBMCs.

88 f ADAM10/17 or knockdown of DLL4 reduced the proangiogenic effects of fibulin-3 in culture.

89 ecular targets, which may mediate prohealing/proangiogenic effects of SDF-1alpha-primed BMDSC was eva

90 These proangiogenic effects were absent when platelets were tr

91 an important mediator with inflammatory and proangiogenic effects, in human gingival fibroblasts (HG

92 tion of their release impaired CD34(+) PBMCs proangiogenic effects.

93 es provides a novel pathway causing impaired proangiogenic effects.

94 latelet cyclooxygenase-1 product with strong proangiogenic effects.

95 nce that soluble CEA is sufficient to induce proangiogenic endothelial cell behaviors, including adhe

96 ation of MMPs, has the ability to generate a proangiogenic environment by altering the balance betwee

97 udy, we show that targeting the formation of proangiogenic epoxyeicosatrienoic acids (EET) by the cyt

98 evalent in many human cancers and can elicit proangiogenic expression in several cell types, but thei

99 ls of the fibrovascular scaffold express the proangiogenic factor IL-1beta strongly, whereas retinal

100 The results from this study suggest that the proangiogenic factor MMP9 may play a role as a biomarker

101 Proangiogenic factor production in CCL19- and CCL21-acti

102 ferentiation while increasing proliferation, proangiogenic factor secretion, and myofibroblastic diff

103 for the induction of Ephrin-B2, an essential proangiogenic factor that drives endothelial cell tubule

104 r cells by the upregulated expression of the proangiogenic factor VEGF-A and by increased tumor angio

105 share some transcriptional targets, like the proangiogenic factor VEGFA.

106 Furthermore, we find that VEGF, a potent proangiogenic factor, is induced by activation of STAT5A

107 othelial growth factor A (VEGF) is a crucial proangiogenic factor, which regulates blood vessel suppl

108 tically increase the levels of VEGF, a major proangiogenic factor.

109 genes belonging to the following categories: proangiogenic factors (MMP9, VEGFA), chemokines (CXCL1,

110 LK1 in angiogenesis in the context of common proangiogenic factors [PAF; VEGF-A and basic fibroblast

111 ble change in the level of IL-1beta or other proangiogenic factors analyzed.

112 NK cell depletion decreased the delivery of proangiogenic factors and delayed uterine spiral artery

113 ntrol the balance between antiangiogenic and proangiogenic factors and initiate the angiogenic switch

114 nce of this recruitment is the generation of proangiogenic factors and matrix metalloproteinase prote

115 endothelial cells to produce VEGF and other proangiogenic factors and provide the inflammatory micro

116 upregulating the expression and secretion of proangiogenic factors by breast cancer cells.

117 bent assay was used to examine production of proangiogenic factors by IL-7-activated macrophages, RA

118 athogenesis by inducing production of potent proangiogenic factors from macrophages and endothelial c

119 Whereas the roles of proangiogenic factors in carcinogenesis are well establi

120 s to target IL-6 and TNF-alpha as additional proangiogenic factors in the cornea during the developme

121 , and decreased expression of HIF-1alpha and proangiogenic factors NF-kappaB and VEGFR2 in the 7-d fi

122 nding, correlating with diminished levels of proangiogenic factors PGE(2) and VEGF in cutaneous wound

123 ist because of the local production of other proangiogenic factors that may cause resistance to anti-

124 the following 2 mechanisms: (1) secretion of proangiogenic factors that stimulate endogenous neovascu

125 ting polypeptides form a balance of anti and proangiogenic factors tightly regulated by proteolysis.

126 sfully applied using various combinations of proangiogenic factors together with a biodegradable deli

127 did not increase the secretion of the common proangiogenic factors VEGF and basic fibroblast growth f

128 in significantly increased secretion of the proangiogenic factors VEGF and platelet-derived growth f

129 al NK (dNK) cells lack cytotoxicity, secrete proangiogenic factors, and regulate trophoblast invasion

130 precise regulation of hypoxia-inducible and proangiogenic factors, and that amacrine and horizontal

131 ed by hypoxia-driven residual VEGF and other proangiogenic factors, combinations of agents from these

132 t miR-184 directly targets and represses the proangiogenic factors, friend of Gata 2 (FOG2), platelet

133 xia, drive expression of stem cell genes and proangiogenic factors, further linking cellular hierarch

134 dition, we found that Gli3 regulates several proangiogenic factors, including thymidine phosphorylase

135 In response to tumor-secreted proangiogenic factors, PRAK is activated by p38 via a va

136 ced the autocrine expression of two relevant proangiogenic factors, vascular endothelial growth facto

137 is a known mitogen, and both FGF2/MMP-9 are proangiogenic factors.

138 oing so, maintains the pool of nerve-derived proangiogenic factors.

139 regulated by a complex interplay of anti and proangiogenic factors.

140 STAT5A regulates the secretion of autocrine proangiogenic factors.

141 the responsiveness of ischemic myocardium to proangiogenic factors.

142 STAT5A regulates the secretion of autocrine proangiogenic factors.

143 cells also exhibited prolonged elevation of proangiogenic factors.

144 ogenesis by augmenting expression of several proangiogenic factors/genes.

145 administered CgA was cleaved in favor of the proangiogenic form and was associated with increased mic

146 e) HYAL-1 degrades hyaluronic acid (HA) into proangiogenic fragments that support tumor progression.

147 FABP4 exhibits a proangiogenic function in vitro, but whether it plays a

148 ver, factors that confer a context-dependent proangiogenic function of BMP2 signaling within endothel

149 in for Clathrin, is essential to mediate the proangiogenic function of BMP2 signaling.

150 de a molecular basis for a context-dependent proangiogenic function of BMP2 signaling.

151 A proangiogenic function of tissue-infiltrating monocytes/

152 etion of myeloid-derived KDR compromised its proangiogenic function, which inhibited the angiogenic s

153 tivation of VEGF expression and promotes its proangiogenic function.

154 xpanding its role in cancer beyond its known proangiogenic function.

155 Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy

156 Pharmacological targeting of MSCs proangiogenic functions may prevent their contribution t

157 Unlike well-characterized proangiogenic functions of endothelial cell Nrp1, the co

158 hat alpha9beta1 cross-suppresses alpha3beta1 proangiogenic functions.

159 Hydrogen sulfide is a vasorelaxant and proangiogenic gas with therapeutic potential in several

160 ed anti-inflammatory, immunosuppressive, and proangiogenic gene products compared with macrophages fr

161 ted with aPL-positive IgG expressed multiple proangiogenic genes, including vascular endothelial grow

162 FCSCs produced an abundance of the proangiogenic growth factor vascular endothelial growth

163 ompanied by suppressed circulating levels of proangiogenic growth factors (EGF [epidermal growth fact

164 Proangiogenic growth factors (GFs) stimulate cell prolif

165 angiogenic switch via paracrine secretion of proangiogenic growth factors and by direct luminal incor

166 Q in hydrogels formed spheroids and secreted proangiogenic growth factors that significantly increase

167 ice despite robust up-regulation of multiple proangiogenic HIF targets, including PlGF, adrenomedulli

168 motes cell proliferation and survival and is proangiogenic, implicating it as a contributor to virus-

169 ion of angiopoietin-like protein 4, which is proangiogenic in an adipose tissue context.

170 In vitro, NaHS was proangiogenic in an endothelial tube assay and attenuate

171 se tumoricidal activity but become extremely proangiogenic, inducing significant neovascularization,

172 asL) preferentially induces the migration of proangiogenic M2 macrophages into the laser lesions and

173 cytokine production in aged macrophages and proangiogenic M2 macrophages.

174 s and hypermethylation of anti-inflammatory, proangiogenic M2-Mvarphi genes in hyperlipidemia and T2D

175 varphis, compared with anti-inflammatory and proangiogenic M2-Mvarphis in hyperlipidemia and T2DM isc

176 emical screen to identify drugs that inhibit proangiogenic M2-type macrophage polarization and block

177 Proangiogenic M2-type macrophages promote various pathol

178 s in various conditions that are promoted by proangiogenic M2-type macrophages, including neovascular

179 t the polarization of macrophages toward the proangiogenic M2-type.

180 sed with endothelial cells and expressed the proangiogenic marker TIE2.

181 n increased upregulation of inflammatory and proangiogenic markers.

182 Our data thus indicate that the proangiogenic mechanism of LPA may in part be via switch

183 ivation promoted upregulation of a number of proangiogenic mediators (VEGF, FGF-2, IL-6, etc.) and do

184 man tumors results in elevated expression of proangiogenic mediators and a concomitant decrease in an

185 at promotes secretion of proinflammatory and proangiogenic mediators as part of a unique senescence p

186 Primary antibodies against inflammatory and proangiogenic mediators such as RAGE, GFAP, 5-LO, VEGF a

187 associated with enhanced phosphorylation of proangiogenic mediators VEGF receptor 2 and endothelial

188 protein levels with concomitant increases in proangiogenic mediators.

189 secretion from human CD34(+) cells contains proangiogenic, membrane-bound nanovesicles called exosom

190 ygenase (COX) and cytochrome P450 to produce proangiogenic metabolites.

191 e-HSC cross-talk also generated a permissive proangiogenic microenvironment, particularly by inducing

192 We further show that the proangiogenic microfibrillar-associated protein 5 (MFAP5

193 ce in mice and humans, resulting in a novel, proangiogenic microRNA with a unique targetome.

194 argeted nanoparticle transfection to deliver proangiogenic microRNA-132 (miR-132) to cultured ECs bef

195 tumors demonstrated increased expression of proangiogenic MIP-2 (CXCL2) ex vivo.

196 sized that miR-126, an endothelial-specific, proangiogenic miR, is down-regulated in the peripheral m

197 Specifically, proangiogenic miR-126 was regulated by GATA2 transcripti

198 Nanoparticle-mediated delivery of proangiogenic miR-126 was tested in the reendothelializa

199 ssion of miR-221 was mediated through direct proangiogenic miR-221 target genes ICAM1 and ETS1.

200 Exosome-shuttled proangiogenic miRNAs may signify amplification of stem c

201 CD34Exo were found to be enriched with proangiogenic miRNAs such as miR-126-3p.

202 d for IL-17 receptor A, and for protumor and proangiogenic molecular mediators, which were up-regulat

203 vascular endothelial growth factor (a potent proangiogenic molecule), display reduced cytotoxicity, a

204 tal skin did not reveal the expected bent to proangiogenic molecules, indicating a complex regulation

205 e ERK pathway and inhibits the expression of proangiogenic molecules.

206 ischemia, MAPCs stimulate the recruitment of proangiogenic monocytes through endothelial activation a

207 ery of blood flow through the recruitment of proangiogenic monocytes.

208 These proangiogenic MPs were selectively recruited to sites of

209 led to downregulation of KDR, suppression of proangiogenic myeloid cells, and prevention of low-grade

210 angiogenic switch through the positioning of proangiogenic neutrophils in proximity to Cyp46a1(+) isl

211 e the mechanism of CD34(+) stem cell-induced proangiogenic paracrine effects and to examine if exosom

212 ession profiles of cytokines contributing to proangiogenic paracrine effects.

213 tively regulates angiogenesis counter to its proangiogenic parental molecule.

214 20(+) lymphocytes, which in turn initiates a proangiogenic pathway leading to enhanced angiogenesis a

215 Mdm2 phosphorylation on Ser(166) is a novel proangiogenic pathway within the skeletal muscle.

216 has been identified as a new CXCL2-dependent proangiogenic pathway.

217 e capacity to rapidly upregulate alternative proangiogenic pathways, increased invasive capacity, and

218 487b targetome that is enriched for multiple proangiogenic pathways.

219 SP-induced migration provides enrichment for proangiogenic PC.

220 ity to promote further polarization toward a proangiogenic phenotype.

221 on and blunted in vivo signaling through the proangiogenic phosphoinositide-3-kinase/Akt/eNOS cascade

222 luble fms-like tyrosine kinase 1 (sFlt1) and proangiogenic placental growth factor (PlGF) at presenta

223 encing the mobilization and recruitment of a proangiogenic population of bone marrow-derived myeloid

224 simultaneously increased the osteogenic and proangiogenic potential of entrapped cocultured cells.

225 The proangiogenic potential of genetically engineered mesenc

226 essing tumors exhibited relatively increased proangiogenic potential, suggesting that prostate tumor-

227 ith endothelial phenotype and enhanced their proangiogenic potential.

228 d for induction of VEGF and exhibit elevated proangiogenic potential.

229 simultaneously promote their osteogenic and proangiogenic potential.

230 echanisms that blunted endothelial IL-25 and proangiogenic progenitor cell thymic stromal lymphopoiet

231 c asthma model, whereas adoptive transfer of proangiogenic progenitor cells from wild-type mice in an

232 We hypothesized that bone marrow-derived proangiogenic progenitor cells that contain eotaxins con

233 cterized by high circulating CD34(+)CD133(+) proangiogenic progenitors, and endothelial cells that ha

234 endothelial TGF-beta signals favors Smad1/5 proangiogenic programs and dictates increased angiogenic

235 Here, we show that the proangiogenic, proinflammatory cytokine CXCL7 is an inde

236 demonstrating impaired in vitro and in vivo proangiogenic properties (proliferation, migration, tube

237 ess immunoregulatory, anti-inflammatory, and proangiogenic properties and, therefore, have the potent

238 like growth factor signaling may mediate the proangiogenic properties of embryonic-derived macrophage

239 me pair, predetermines immunosuppressive and proangiogenic properties of myeloid cells.

240 The IGFBP-vWC form has potent proangiogenic properties promoting retinal endothelial c

241 s of CD34(+) PBMCs, associated with impaired proangiogenic properties that could be rescued by miR-mi

242 20-HETE is known to have prohypertensive and proangiogenic properties, the effects of CYP4F-derived m

243 MC subsets and their relevance for different proangiogenic properties.

244 rowth of certain neoplasias because of their proangiogenic properties.

245 y analysis revealed attenuated expression of proangiogenic proteins in ischemic AMPKalpha2(DeltaMC) h

246 paB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1

247 Expression of proangiogenic proteins phospho-endothelial nitric oxide

248 showed significant decrease in the levels of proangiogenic proteins versus nonspecific control-transf

249 sis by regulating the expression of secreted proangiogenic proteins.

250 ate from these platelets contained decreased proangiogenic proteins.

251 sion.Significance: This study highlights the proangiogenic receptor neuropilin 1 in macrophages and m

252 re sCD146 binds to angiomotin to stimulate a proangiogenic response.

253 Akt, and NF-kappaB for a proinflammatory and proangiogenic response.

254 ets potentially mediating the prohealing and proangiogenic responses.

255 aken together, these results reveal a novel, proangiogenic role of fibulin-3 in gliomas, highlighting

256 crovascular endothelial cells, implicating a proangiogenic role of the hemiketals in inflammatory sit

257 Consistent with a proangiogenic role, gammadelta T cells promoted the form

258 Consistent with proangiogenic roles for alpha3beta1, alpha3-null keratin

259 activated Src, which in turn phosphorylated proangiogenic RTKs, including platelet-derived growth fa

260 Angiogenin (ANG) is a 14-kDa multifunctional proangiogenic secreted protein whose expression level co

261 f mTOR, substantially amplifying the initial proangiogenic signal.

262 igration of endothelial cells (ECs) toward a proangiogenic signal.

263 ds that induce a sustained inhibition of the proangiogenic signaling generated by tumor hypoxia still

264 ts demonstrate that GRM1 activation triggers proangiogenic signaling in melanoma, offering a mechanis

265 in that has also been found to function as a proangiogenic signaling molecule.

266 cape antiangiogenic therapy by activation of proangiogenic signaling pathways.

267 sh whether blue light filtering could modify proangiogenic signaling produced by retinal pigmented ep

268 Melanoma exosomes can incite a proangiogenic signaling program capable of remodeling ti

269 w antiangiogenic compound (22) that inhibits proangiogenic signaling under hypoxic conditions in brea

270 ing the strong adhesion that is required for proangiogenic signaling via these integrins.

271 ed H-Ras in mediating nitric oxide-dependent proangiogenic signaling.

272 during angiogenesis by positively titrating proangiogenic signaling.

273 However, the molecular links between proangiogenic signals and downstream gene expression rem

274 ken together, these results demonstrate that proangiogenic signals converge to enhance expression and

275 te a prominent role for SOX11 as a driver of proangiogenic signals in MCL, and highlight the SOX11-PD

276 dothelial cell (EC) activation and changed a proangiogenic signature.

277 tein, can activate latent antiangiogenic and proangiogenic sites, respectively.

278 ithin the tumor microenvironment and produce proangiogenic soluble factors.

279 Turning this switch toward a proangiogenic state involves an altered interplay betwee

280 tissues, ECs divide and migrate rapidly upon proangiogenic stimulation.

281 failure to recruit cells able, to respond to proangiogenic stimuli.

282 There is an unmet need for proangiogenic therapeutic molecules for the treatment of

283 nts with ephrin-B2/Fc (EFNB2) improves their proangiogenic therapeutic potential in diabetic ischemic

284 TR3/Nur77 is a potential candidate for proangiogenic therapy.

285 of the chemokine CXCL12 and infiltration by proangiogenic TIE2-expressing macrophages (TEMs).

286 way by modulating the turnover of the master proangiogenic transcription factor hypoxia-inducible fac

287 of the TSP-1 promoter repressed by NR4A2 and proangiogenic transcription factors, including NF-kappaB

288 whether it plays a role in the expression of proangiogenic vascular endothelial growth factor (VEGF)

289 Inappropriate expression of proangiogenic vascular endothelial growth factor (VEGF)

290 progenitor cells (EPCs) and plasma levels of proangiogenic vascular endothelial growth factor and of

291 ntal growth factor (PlGF) is a member of the proangiogenic vascular endothelial growth factor family,

292 nly by cystathionine gamma-lyase (CSE), is a proangiogenic vasodilator.

293 gulation through selective downregulation of proangiogenic VEGF isoforms (via SRPK1 inhibition) or co

294 n 8-encoded residues, which are found in all proangiogenic VEGF-A isoforms, in Nrp binding.

295 The proangiogenic VEGF-A165a isoform is neuroprotective in h

296 d a corresponding reduction in levels of the proangiogenic VEGF-A165a splice isoform.

297 p-regulation of prooxidant NADPH oxidase and proangiogenic VEGF.

298 SRPIN340 reduced the expression of proangiogenic VEGF165 without affecting VEGF165b express

299 wth factor (VEGF)-A results in production of proangiogenic VEGFxxxa isoforms (VEGF165a, 165 for the 1

300 gel assay, we showed that ct-8,9-E-11-HET is proangiogenic, whereas ct-8,9-E-15-HET is not active.