ライフサイエンスコーパス: proapoptotic

1 t signaling node that is either mitogenic or proapoptotic.

2 Treatments with the autoantibodies induced proapoptotic activities and suppressed the surface expre

3 ression reverses shPUM antiproliferative and proapoptotic activities.

4 ession (RT-PCR) studies confirmed the strong proapoptotic activity (increase in p53, decrease in v-my

5 rotein kinase B (AKT) pathway and shows high proapoptotic activity against chronic lymphocytic leukem

6 minal region of Bax, directly activating its proapoptotic activity by inducing a conformational chang

7 -15 signals in macrophages to suppress their proapoptotic activity by inhibiting TNF and nitric oxide

8 death in neoplastic cells by re-engaging the proapoptotic activity induced by unliganded dependence r

9 This proapoptotic activity is mediated by a microRNA cargo, m

10 is, VDAC2 controls both the localization and proapoptotic activity of BAK.

11 , these Bcl-2 family proteins also block the proapoptotic activity of Bcl-2-associated X (Bax) and Bc

12 Here we show that GSK-3beta inactivates the proapoptotic activity of HLXB9 by phosphorylating HLXB9

13 During this process, the latent proapoptotic activity of JNK becomes apparent following

14 It is unclear whether the antiproliferative/proapoptotic activity of oncogenes can be pharmacologica

15 cells carrying the ELANE mutations evade the proapoptotic activity of the NE mutants in SCN patients.

16 seudokinase 3) is a stress-induced gene with proapoptotic activity that was previously described as h

17 eubiquitinases with micromolar IC50, and its proapoptotic activity was studied on several cancer cell

18 We combined these assays of CL-induced proapoptotic activity with structural and dynamic studie

19 e, an iminosugar endowed with an interesting proapoptotic activity, has been accomplished using an en

20 BAD hyperphosphorylation, which inhibits its proapoptotic activity, was increased in both AdKO mouse

21 a critical functional switch controlling its proapoptotic activity.

22 whereas the short isoform (Mcl-1S) displays proapoptotic activity.

23 inally, we evaluate the IL-11Ralpha-targeted proapoptotic agent bone metastasis-targeting peptidomime

24 lling but also potently sensitize PEL to the proapoptotic agents tumor necrosis factor alpha and etop

25 poorly responsive to current therapies with proapoptotic agents.

26 illing and the sensitization of PEL cells to proapoptotic agents.

27 regulators of apoptosis and consist of both proapoptotic and antiapoptotic factors.

28 s dictated by a shift in the balance between proapoptotic and antiapoptotic gene expression programs.

29 significant antioxidant, antiproliferative, proapoptotic and antibacterial activities of raspberry p

30 rogramming, which resulted in suppression of proapoptotic and cell-cycle-regulatory target genes.

31 dings, significantly increased expression of proapoptotic and proinflammatory factors was also found

32 non-neuronal cells have shown that Bif-1 is proapoptotic and promotes mitochondrial fragmentation.

33 This process is regulated by proapoptotic and prosurvival members of the B-cell lymph

34 c-Abl plays both proapoptotic and prosurvival roles, and our findings sug

35 ey regulator of the cellular balance between proapoptotic and prosurvival sphingolipids.

36 were due to an exaggerated activation of the proapoptotic arms of the endoplasmic reticulum stress re

37 study was to further clarify the role of the proapoptotic B-cell lymphoma 2 homology domain 3 (BH3)-o

38 corticoids converges on the induction of the proapoptotic B-cell lymphoma-family protein Bim to produ

39 enuates PIM1-mediated phosphorylation of the proapoptotic BAD and activates BAD-dependent apoptosis.

40 ns and NF-kappaB-independent inactivation of proapoptotic BAD protein.

41 orylation, and mitochondrial localization of proapoptotic Bad.

42 Proapoptotic Bak exhibits marked heterogeneity, which is

43 on in the C-terminal transmembrane domain of proapoptotic BAX (G179E) was found, which abrogated BAX

44 rs in response to a cellular upregulation of proapoptotic Bax, as small interfering RNA (siRNA)-media

45 otein FPV039 promiscuously binds to cellular proapoptotic Bcl-2 and engages all major proapoptotic Bc

46 is tremendous interest to understand how the proapoptotic BCL-2 effector members (e.g. BCL-2-associat

47 a mitochondrial size that is permissive for proapoptotic BCL-2 family function.

48 nduces target cell apoptosis by cleaving the proapoptotic Bcl-2 family member Bid, which, together wi

49 e responses, decitabine also upregulated the proapoptotic BCL-2 family member BNIP3, which is known t

50 s coincided with increased expression of the proapoptotic Bcl-2 family members Noxa, Puma, and Bax.

51 h after exposure, before the upregulation of proapoptotic Bcl-2 family molecules.

52 st is the frequent biallelic deletion of the proapoptotic BCL-2 family protein BIM.

53 m the mitochondria, which is promoted by the proapoptotic Bcl-2 family protein, Bax.

54 ies and do not depend on the presence of the proapoptotic Bcl-2 family proteins Bax or Bak, indicatin

55 e for binding BH3 peptides and does not bind proapoptotic Bcl-2 family proteins Bax or Bak.

56 sociated apoptosis is mediated mainly by the proapoptotic BCL-2 family proteins BIM and BMF, and thei

57 While it is established that all proapoptotic Bcl-2 homology 3 (BH3)-only proteins bind a

58 ) blocked the mitochondrial translocation of proapoptotic Bcl-2 members and ER stress.

59 The proapoptotic Bcl-2 protein Bax by itself is sufficient t

60 in response pathway to systematically define proapoptotic BCL-2 protein composition after stress and

61 Proapoptotic BCL-2 proteins converge upon the outer mito

62 were found to regulate the expression of the proapoptotic Bcl-2 proteins DP5 and PUMA and consequent

63 ross talk between a key family of miRNAs and proapoptotic Bcl-2 proteins in human pancreatic beta-cel

64 manifested by capturing and neutralizing the proapoptotic Bcl-2 proteins via their BH3 death domains.

65 lar proapoptotic Bcl-2 and engages all major proapoptotic Bcl-2 proteins.

66 otein-protein interactions between anti- and proapoptotic Bcl-2 proteins.

67 tics, additional specificity is conferred by proapoptotic BCL-2 proteins.

68 oteins to date, FPV039 engaged with cellular proapoptotic Bcl-2 with affinities comparable with those

69 he serine (S)184 phosphorylation site of the proapoptotic Bcl2 family member Bax as an anticancer str

70 of c-MYC and subsequent upregulation of the proapoptotic BCL2 family member PUMA, whereas inhibition

71 pathway, which results in suppression of the proapoptotic BCL2-family member protein BIM (BCL2L11).

72 is locus, two common variants located at the proapoptotic BCL2L11 gene associated with UACR: rs116907

73 ion factor that binds and transactivates the proapoptotic BCL2L11 locus encoding BIM.

74 We previously reported the proapoptotic beta cell differentiation factor HLXB9 as a

75 unotoxins also reduce the levels of selected proapoptotic BH-3-only proteins.

76 d TrkA and transcriptional regulation of the proapoptotic BH3 family members BimEL, Harakiri,and Puma

77 egrated stress response, which activated the proapoptotic BH3 protein Noxa and its downstream targets

78 was also a significant up-regulation of the proapoptotic BH3-containing protein, PUMA.

79 Here we show that loss of the proapoptotic BH3-only protein Bim or, to a lesser extent

80 al studies have revealed that binding of the proapoptotic BH3-only protein PUMA induces significant u

81 s by specific regulation of the mRNA for the proapoptotic BH3-only protein, Bim.

82 y repressing the gene egl-1, which encodes a proapoptotic BH3-only protein.

83 ed to generate cells deficient for all eight proapoptotic BH3-only proteins (OctaKO) and those that l

84 The proapoptotic BIM protein is an important mediator of glu

85 IL-4 blocked upregulation of proapoptotic Bim protein levels induced by BCR crosslink

86 h increased levels of nuclear FOXO3A and the proapoptotic BIM protein.

87 lular domain and beta-catenin, deficiency of proapoptotic Bim, increased proliferation, and survival

88 he death pathway by pharmacologic mimicry of proapoptotic BIM.

89 cl-XL, but related to the degradation of the proapoptotic Bim.

90 and less consistently with downregulation of proapoptotic Bmf, Hrk, and BimEL A major role for Mcl-1

91 rately up-regulated c-Myc and down-regulated proapoptotic Bmf, unlike most mature B cells in the adul

92 iciency augments virus-induced activation of proapoptotic c-Jun N-terminal kinase (JNK) signaling.

93 cells and is required for activation of the proapoptotic Ca(2+)-Erk pathway that is selectively acti

94 surface receptor TRAIL-R2, and activation of proapoptotic caspase-8.

95 PIDDosome-PIDD-RAIDD-caspase-2 complex-is a proapoptotic caspase-activation platform of elusive sign

96 chanism by which mitochondria and downstream proapoptotic caspases regulate the activation of antivir

97 This is mediated partly via suppression of proapoptotic cathepsin D (CatD) via cocomplexing of the

98 cell death, in part through up-regulation of proapoptotic CCAAT/enhancer binding protein homologous p

99 PERK-ATF4-CHOP pathway, upregulation of the proapoptotic cell surface receptor TRAIL-R2, and activat

100 Mechanistically, Bcl2L13 binds to proapoptotic ceramide synthases 2 (CerS2) and 6 (CerS6)

101 o death caused by proteotoxic agents and the proapoptotic chemotherapeutic LCL-161.

102 arming (REW) during interbout arousal (IBA), proapoptotic conditions that are lethal to nonhibernatin

103 ene signature and new vulnerabilities to the proapoptotic drug, ABT-263.

104 ak-dependent apoptosis in response to common proapoptotic drugs like doxorubicin and staurosporine, b

105 and CXCR1 signaling pathways to reverse the proapoptotic effect of the IL-32gamma isoform, leading t

106 ations suggested a potent antiproliferative, proapoptotic effect of the nanodrug in the metastatic ce

107 tor 2alpha, nuclear XBP1, and the downstream proapoptotic effector nuclear C/EBP homologous protein.

108 er cells deficient in ISR and the downstream proapoptotic effector, CHOP, promoting tumor growth and

109 significantly greater antiproliferative and proapoptotic effects beyond those achieved by monotherap

110 Our results suggest that, in contrast to its proapoptotic effects in vitro, selective PT Mfn2 deficie

111 sed sensitivity to the growth inhibitory and proapoptotic effects of a novel broad spectrum neuropept

112 rella" that protects cholangiocytes from the proapoptotic effects of bile salts by maintaining them d

113 eas antagomirs to miR-15a/16-1 abolished the proapoptotic effects of BL-8040.

114 otective effects of rat and human v1 and the proapoptotic effects of rat v2 and human v4 by modulatin

115 The proapoptotic effects of S1PR2 are phenocopied by ectopic

116 he lead 1, is not cytotoxic but enhances the proapoptotic effects of staurosporine by reducing MMP ac

117 llenged their sensitizing effects toward the proapoptotic effects of staurosporine in the TT cell lin

118 ncer during chronic inflammation through its proapoptotic effects.

119 s and directly binds and inhibits Casp8p41's proapoptotic effects.

120 factor KEAP1, the phosphatase PGAM5 and the proapoptotic factor AIFM1.

121 ls and prevented nuclear accumulation of the proapoptotic factor apoptosis inducing factor.

122 creases in inhibitory phosphorylation of the proapoptotic factor Bad and activating phosphorylation o

123 factor Bcl-2 and decreased expression of the proapoptotic factor Bax.

124 Proapoptotic factor Bim (Bcl2l11) controls T lymphocyte

125 tly aggravated OGD-induced expression of the proapoptotic factor Bim and proinflammatory cytokines MC

126 g a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B

127 melanocyte differentiation gene MITF and the proapoptotic factor SOX9, thereby preventing differentia

128 as initially identified as a p53-responsive, proapoptotic factor, but no clear function has been desc

129 p38 signaling and reduced expression of the proapoptotic factors Bim, DP5, and c-Myc.

130 re elevation of a unique set of HuR-targeted proapoptotic factors was documented.

131 E2F4 occupies promoter regions of proapoptotic factors, such as B-Myb, under basal conditi

132 cessive Ca(2+), or kill neurons by releasing proapoptotic factors.

133 is specifically facilitates the induction of proapoptotic Fas ligand upon TCR restimulation, accounti

134 optosis, but the mechanisms that control its proapoptotic function are poorly understood.

135 BCL-2 family proteins BIM and BMF, and their proapoptotic function is conserved between mouse and hum

136 s provide strong evidence that targeting the proapoptotic function of Kv2.1 is an effective and highl

137 RNA restored proper phosphorylation and the proapoptotic function of the GCR.

138 Bim and Nur77, two TCR-induced proteins with proapoptotic function, Bim has been shown to be importan

139 oxidase activity that represents its pivotal proapoptotic function, but we do not observe evidence fo

140 in ligase Fbxo45, resulting in loss of Par-4 proapoptotic function.

141 by mechanisms that may not be related to its proapoptotic function.

142 RAIL-induced cell death, consistent with its proapoptotic function.

143 ol of genes clustered around prosurvival and proapoptotic functions among others.

144 Our data suggest that NR4A1 has proapoptotic functions in aggressive lymphoma cells and

145 ing the switch between the proautophagic and proapoptotic functions of beclin 1 and ATG5 during infla

146 hat PINK1-Parkin has both cytoprotective and proapoptotic functions.

147 We found that high expression of the proapoptotic gene Bcl2-interacting mediator of cell deat

148 FNAR KO Tregs had a higher expression of the proapoptotic gene Bim and higher frequency of active cas

149 xpression, whereas reduced expression of the proapoptotic gene coding Bcl2-associated X protein was o

150 bition of p53 and enhancing p53's effects on proapoptotic gene expression and apoptosis in breast can

151 f epithelial HuR as a contextual modifier of proapoptotic gene expression in intestinal cancers, acti

152 ad box o3 (FOXO3a), leading to repression of proapoptotic gene expression, because the immunosuppress

153 ell death by tipping the balance in favor of proapoptotic gene expression.

154 strain of SINV was engineered to express the proapoptotic gene reaper from Drosophila.

155 -dependent transcriptional activation of the proapoptotic gene reaper.

156 apoptosis were upregulated in neurons, while proapoptotic gene transcription was increased in fibrobl

157 und to be caused by direct repression of the proapoptotic gene, Puma (Bbc3), by Slug.

158 .g., XIAP and GADD45B) and downregulation of proapoptotic genes (e.g., CASP8 and APAF1) in infected P

159 ity to block the induction of MDM2, p21, and proapoptotic genes after genotoxic stress.

160 sed expression of Fas, caspases, and related proapoptotic genes and decreased expression of Ets-1 and

161 cute ablation of D-cyclins upregulated these proapoptotic genes and led to Fas- and caspase 8-depende

162 a regulator of the transcription of several proapoptotic genes and through its binding interactions

163 omplex maintains repressive chromatin around proapoptotic genes Bim and BMF and regulates multiple my

164 ucleus, thus inhibiting transcription of the proapoptotic genes CD95/Fas and caspase 7 and de-repress

165 ival and increased the expression of several proapoptotic genes during cellular stress.

166 RER also mediates P53-dependent induction of proapoptotic genes following DNA damage, and the chromat

167 apoptosis, through activation of its target proapoptotic genes NOXA and PUMA.

168 rovide mechanisms by which RET represses the proapoptotic genes through direct interaction with and p

169 indicate that, through direct repression of proapoptotic genes, (aberrant) expression of FOXP1 compl

170 IRER mediates the expression of surrounding proapoptotic genes, and we use an in vivo reporter of th

171 s increase cytoprotective genes and decrease proapoptotic genes, improve immune clearance of Abeta, a

172 tor FOXO1, causing elevated transcription of proapoptotic genes.

173 hed that FOXP1 directly represses a set of 7 proapoptotic genes.

174 ownstream of expression of the p53-regulated proapoptotic genes.

175 ncreased expression levels of p53-regulated, proapoptotic genes.

176 uded a few tumor-suppressor (CDH1, RCAN) and proapoptotic (GLIPR1, FAS) genes.

177 nhanced activity of the antihypertrophic and proapoptotic GSK-3beta molecule.

178 ta indicate that delayed proinflammatory and proapoptotic host responses to arenavirus infection coul

179 to characterize the systems-level impact of proapoptotic human truncated BID on the cellular network

180 reduced immunosuppression requirements with proapoptotic immunosuppression and among rejection-free

181 showed that the XPO1 inhibitor selinexor is proapoptotic in CLL cells and disrupts B-cell receptor s

182 lidated that the synergistic action of these proapoptotic JAK1 targets is obligatory for the remodeli

183 signalosome, and removing ASK1 abrogated the proapoptotic kinase activity of IRE1alpha.

184 We show MST1 as a proapoptotic kinase and key mediator of apoptotic signal

185 (pCatD) form of cathepsin D (mature CatD), a proapoptotic lysosomal aspartate protease, is an interac

186 tter functional axis involves suppression of proapoptotic lysosomal protein cathepsin D by promotion

187 gesting that at high levels, STAT3 activates proapoptotic mechanisms and induces apoptosis in CLL cel

188 Unlike Bax, a proapoptotic member of the Bcl-2 family, Bcl-xL is not c

189 This locus encodes a pair of critical proapoptotic microRNAs, miR-15a/16-1.

190 t melanomas can skew toward an intracellular proapoptotic milieu, increase DR expression, and overcom

191 These results show that UBR5 downregulates proapoptotic MOAP-1 and suggest that UBR5 can confer cis

192 ng for the antiapoptotic molecule Bcl-2, the proapoptotic molecule Bax, and the apoptosis executor en

193 ion, was associated with upregulation of the proapoptotic molecule Bid, and was blocked by Bcl2 overe

194 tumor suppressor PTEN, ERK phosphatases, the proapoptotic molecule Daxx, and the Hedgehog pathway tra

195 s' tumors characterized by low levels of the proapoptotic molecule p53-upregulated modulator of apopt

196 was attributable to a dramatic reduction in proapoptotic molecules Bim, Bax, and Fas in CD28(null) T

197 ever, increasing evidence also suggests that proapoptotic molecules can contribute to the development

198 ted the ability of BH3 mimetics to derepress proapoptotic molecules from anti-apoptotic proteins.

199 ciated with impaired expression of IRF-1 and proapoptotic molecules such as Fas ligand, its receptor

200 BMDMs in turn secreted proapoptotic molecules that stimulated hepatocyte apopto

201 ch leads to activation of a p53-independent, proapoptotic network centered on nuclear relocalization

202 oduction of bax or a bax mutant incapable of proapoptotic oligomerization equally restored neuronal C

203 is a tumor suppressor that can induce either proapoptotic or prosenescent posttranslational modificat

204 deficient mice, indicating that loss of this proapoptotic p53 target gene results in protection from

205 We identified inhibition of proapoptotic p53 upregulated modulator of apoptosis (PUM

206 led a multifaceted role for Bcl-2 in binding proapoptotic partners including Bax, Bak, Bik, and Bim.

207 ), which suggests that p53 promotes both the proapoptotic pathway and postapoptotic events.

208 l-III, resulting in a reduction in a natural proapoptotic pathway for controlling airway eosinophilia

209 In addition, proapoptotic pathways are activated in P1 knock-in preme

210 ld-type MEFs, indicating that EGR1 modulates proapoptotic pathways following VEEV infection.

211 n, reduced histologic damage, suppression of proapoptotic pathways, and reduced inflammation.

212 line triggers ER stress response and induces proapoptotic pathways.

213 Herein, we engineered proapoptotic peptide nanoparticles from mitochondria-dis

214 udies revealed that Atg7 knockdown induced a proapoptotic phenotype in AML cells, which was manifeste

215 NORE1A acts to suppress its proapoptotic phosphorylation of p53 but enhance its pros

216 during the disease progression, however, the proapoptotic pressure on the residual beta-cell mass inc

217 exceeding a threshold level, c-MYC induced a proapoptotic program and loss of CSC potential both in v

218 administration of GILZ efficiently induces a proapoptotic program that promotes resolution of neutrop

219 If unsuccessful, the UPR initiates a proapoptotic program to eliminate the malfunctioning cel

220 ee shotgun proteomics demonstrated that both proapoptotic programmed cell death protein 5 and antiapo

221 increased resistance of these tumor cells to proapoptotic/pronecrotic signals.

222 e RASSF1A showed that, despite retaining its proapoptotic properties, the mutant was completely unabl

223 ase-1, we identify an important role for the proapoptotic protease caspase-8 in promoting beta-glucan

224 ibition was dependent on the coexpression of proapoptotic protein BAD.

225 rectly binds and activates the mitochondrial proapoptotic protein BAK.

226 originally identified as a suppressor of the proapoptotic protein Bax to inhibit cell death in animal

227 sistently associated with an increase in the proapoptotic protein BAX, whereas ABT-737 caused dose-de

228 tants caused frank neurotoxicity akin to the proapoptotic protein Bax.

229 as mediated by up-regulation of the BH3-only proapoptotic protein Bcl-2-like protein 11 (Bim).

230 yclin-dependent kinase inhibitor p15 and the proapoptotic protein Bcl2l11 (Bim).

231 ration through the silencing of the BH3-only proapoptotic protein BIK and promotes the elongation of

232 progenitors and increased expression of the proapoptotic protein Bim (also known as Bcl-2L11).

233 )2 family proteins, BA treatment induces the proapoptotic protein BIM and exerts dose-dependent letha

234 roliferation, as well as a deficiency of the proapoptotic protein Bim and idiopathic PAH PAVSMC survi

235 on were associated with up-regulation of the proapoptotic protein Bim and the T-box transcription fac

236 Here, we report the BH3-only proapoptotic protein Bim as an APC(Cdc20) target, such t

237 14Jalpha18 iNKT TCR transgene or loss of the proapoptotic protein Bim did not rescue iNKT cell matura

238 -2 and Mcl-1 and increased expression of the proapoptotic protein Bim.

239 fine-tuning the levels of expression of the proapoptotic protein BIM.

240 lts in posttranslational modification of the proapoptotic protein Bim.

241 ximal tubular cell apoptosis and upregulated proapoptotic protein expression, which were both rescued

242 RNA (miR) miR-125b, which in turn suppresses proapoptotic protein expression.

243 lpain-mediated cleavage events that generate proapoptotic protein fragments.

244 ypothesized that neuronal pentraxin (NP1), a proapoptotic protein induced by low neuronal activity, c

245 cointeracting cathepsin D, a stress-released proapoptotic protein negatively impacting HHV-8 latently

246 otic BCL2 protein or inactivation of the p53 proapoptotic protein rescues these thymocytes from apopt

247 PB1-F2 is a small proapoptotic protein supposed to contribute to the virul

248 1-associated protein (PSAP), a mitochondrial proapoptotic protein that forms a complex with Bax upon

249 e, we describe a novel pathway involving the proapoptotic protein Trib3 in neuronal death associated

250 sphorylation of mTORC1 targets including BAD proapoptotic protein was observed in response to PKA act

251 stic explanation by which BRCA1 can act as a proapoptotic protein.

252 rotein with high homology to the multidomain proapoptotic proteins BAX and BAK, yet Bok(-/-) and even

253 ell death was rescued with codeletion of the proapoptotic proteins Bax and Bak.

254 hat VZV triggered the phosphorylation of the proapoptotic proteins Bim and BAD but had little or no e

255 plicing changes modulate the function of the proapoptotic proteins BIM and BAX, JNK signaling, and en

256 such as BCL-2 and MCL-1 and directly trigger proapoptotic proteins such as the mitochondrial executio

257 IBMs are utilized by a number of proapoptotic proteins to antagonize IAP function.

258 tein response, a significant upregulation of proapoptotic proteins was detected, including the transc

259 stress coincides with greater expression of proapoptotic proteins.

260 uclear translocation of FoxO3, and increased proapoptotic PUMA expression.

261 It is a proapoptotic Ras effector and plays an important role in

262 mpts to stimulate the extrinsic pathway with proapoptotic receptor agonists (PARAs) have been disappo

263 g immunoglobulin-like lectin (Siglec)-F is a proapoptotic receptor on mouse eosinophils, but little i

264 the cyclin-dependent genes (p15 and p21) and proapoptotic regulators (NOXA and PERP), attenuated prol

265 to show that Hax-1 is a family of anti- and proapoptotic regulators that may modulate cell survival

266 an prosurvival Bcl-2 proteins with all their proapoptotic relatives.

267 The proapoptotic response elicited by valinomycin is associa

268 and IL-5 alone significantly diminished the proapoptotic response to dexamethasone.

269 t life span of monocytes and their antiviral proapoptotic response to infection.

270 observed that HCV-RNA transfection induces a proapoptotic response within HTR8 that could affect the

271 al, whereas long-lasting activation favors a proapoptotic response.

272 thelial HuR indirectly downregulates certain proapoptotic RNAs to attenuate colitis-associated cancer

273 This proapoptotic role also required the BRCA1-A complex memb

274 data unravel new molecular mechanisms for a proapoptotic role of miR-125b in monocytes and identify

275 meayamycin B promotes the generation of the proapoptotic, short splicing variant (MCL1-S) and dimini

276 kade, inhibition of mitogenic signaling, and proapoptotic signal induction in basal and mesenchymal s

277 S-dependent activation of the ATM and CaMKII proapoptotic signaling cascades.

278 ined endogenous SirT1 activity and prevented proapoptotic signaling in metabolically stressed HepG2 c

279 tyrosine kinases, was used to impinge on the proapoptotic signaling pathway activated by oxidized KCN

280 hifting Ras signaling away from prosenescent/proapoptotic signaling pathways.

281 intained deacetylase activity and attenuated proapoptotic signaling, whereas overexpressed wild type

282 asmic reticulum stress and the expression of proapoptotic signals, including TNF-alpha, resulting in

283 MEK and ERK, and heightened the activity of proapoptotic small-molecule navitoclax, a BCL-2 family i

284 anisms of EC protection from cell-extrinsic, proapoptotic stimuli have not been investigated.

285 , in its ability to confer cytoprotection to proapoptotic stimuli, and in maintaining endothelial cel

286 Fs]) apoptosis induced by a wide spectrum of proapoptotic stimuli.

287 , may sensitize chemoresistant tumor cell to proapoptotic stimuli.

288 fibrin matrix with unaltered sensitivity to proapoptotic stress compared with wild-type ECs.

289 K1 and SphK2) catalyze the conversion of the proapoptotic substrate d-erythrosphingosine to the promi

290 rosurvival AKT/mTOR pathways and stimulating proapoptotic survivin and BAX pathways.

291 creased apoptosis and elevated expression of proapoptotic targets Noxa and Puma seen in Hdac8-deleted

292 a group of genes that are hypoxia-inducible proapoptotic targets of p53, including inositol polyphos

293 of mRNA and protein encoded by Cebpa and its proapoptotic targets, Arl6ip5 and Tnfrsf10b, in betaTC1

294 CD19L to the soluble extracellular domain of proapoptotic TNF-related apoptosis-inducing ligand (sTRA

295 not restricted to Yersinia infection and to proapoptotic Toll-IL-1R domain-containing adapter induci

296 ism, resistance to oxidative stress, and the proapoptotic transcription factor CHOP (GADD153/DDIT3).

297 otein (CHOP), the major ER stress-associated proapoptotic transcription factor, protected fibroblasts

298 omes activated and, in turn, counteracts the proapoptotic transcriptional program induced by TNF-alph

299 PRIGHTLY-expressing melanocytes, whereas the proapoptotic tumor suppressor gene DPPIV/CD26 was down-r

300 It is the activation of this proapoptotic UPR in pancreatic beta-cells that has been