ライフサイエンスコーパス: probasin

1 nsactivation from mouse mammary tumor virus, probasin, and prostate-specific antigen promoters.

2 There was no difference between probasin bcl-2 transgenic mice, bax-/- mice, and control

3 tic indices in the ventral prostate from the probasin-bcl-2 and bax-/- mice following castration sugg

4 histologic appearance of the prostates from probasin-bcl-2 transgenic mice or bax-/- mice did not di

5 Probasin-bcl-2 transgenic mice were crossed with TRAMP (

6 The double transgenic, probasin-bcl-2 X TRAMP F1 (BxT) mice exhibited an increa

7 ss the SV40 early genes (T/t antigens) under probasin control.

8 AR stimulation on the probasin core promoter could be partially induced with B

9 Addition of the enhancer to the probasin core promoter failed to impact the SWI/SNF requ

10 We show that Nkx3.1(Cre) and Probasin(Cre) alleles drive expression of Cre recombinas

11 e created a mouse prostate tumor model using probasin-Cre-mediated deletion of Apc.

12 1 enhanced AR-dependent transactivation of a probasin-derived reporter gene.

13 Previously, we established that probasin-driven ErbB-2 transgenic mice presented with hi

14 her individual genetic model and, unlike the probasin-driven-ErbB-2 mice, progression to adenocarcino

15 e show that mono-allelic loss of pten in the probasin-driven-ErbB-2 model resulted in increased nucle

16 ation of prostate-specific antigen (PSA) and probasin enhancer/promoter regions requires the N/C inte

17 The dependence of the PSA and probasin enhancer/promoters on the N/C interaction for t

18 sponsive elements from the prostate-specific probasin gene promoter and levels of the AR-regulated ce

19 mposite promoter, ARR(2)PB, based on the rat probasin gene; and (b) the use of a powerful artificial

20 erved that the SV40 Tag and endogenous mouse probasin genes are expressed at low levels in the thymus

21 proliferation cell nuclear antigen, ODC, and probasin in the dorsolateral prostate.

22 A second AR target promoter, probasin, maintained a low level of activation in the ab

23 ved either from the highly prostate-specific probasin (PB) promoter or from a more potent synthetic v

24 ote tumor development in mouse prostate with probasin promoter (ARR2PB)-driven, prostate-specific exp

25 , a murine AR transgene regulated by the rat probasin promoter (Pb) was used to generate transgenic m

26 hed with a prostate epithelial-specific long probasin promoter and the SV40 large T antigen (LPB-Tag

27 In the large probasin promoter directed SV40-large T-antigen (LPB-Tag

28 struct comprised of the minimal -426/+28 rat probasin promoter driving prostate-specific epithelial e

29 r (AR)-binding sites, placed upstream of the probasin promoter elements necessary for basal transcrip

30 ic mice with the rat prostate-specific large probasin promoter linked to the SV40-large T antigen (Ta

31 We used the probasin promoter to target a human bcl-2 transgene spec

32 enes (T/t antigens) under an androgen-driven probasin promoter were cross-bred with male C57BL/6 tran

33 the SV40 T-antigen under the control of the probasin promoter, and spontaneously develop prostate ca

34 ing the human NIS cDNA linked to a composite probasin promoter, ARR(2)PB, aiming toward specific expr

35 e prostatic epithelium using an improved rat probasin promoter, ARR(2)PB.

36 CV787 contains the prostate-specific rat probasin promoter, driving the adenovirus type 5 (Ad5) E

37 ombining prostate-specific loss of Pten with probasin promoter-driven PSGR overexpression.

38 Hence, in the 12T-10 large probasin promoter-Tag mouse, high-grade prostatic intrae

39 Probasin promoter-targeted expression of an activated Er

40 round and expresses SV40 T-antigen under the probasin promoter.

41 control of the prostate epithelial-specific Probasin promoter.

42 nd also from an integrated androgen-specific probasin promoter.

43 ouse prostate under the control of an (ARR)2-Probasin promoter.

44 ugh 24 weeks of age, differentiation markers probasin, PSP-94, and Nkx3.1 were sig nificantly decreas

45 , and ARR2PB, derived from hK2, PSA, and rat probasin regulatory elements, to generate the EZC1, EZC2

46 arge T Ag (Tag) under the control of the rat probasin regulatory elements.

47 Transactivation of PSA and probasin response regions also depends on activation fun