ライフサイエンスコーパス: probe

1 ing a fluorophosphonate (FP2) activity-based probe.

2 tent in vivo is now possible using the MitoB probe.

3 ith a ferrocene molecule, which acts a redox probe.

4 s a dual scanning electrochemical microscopy probe.

5 ificant dominated by the charge of the redox probe.

6 ecular exchange interactions in this type of probe.

7 e porous substrate) during filtration can be probed.

8 of serine and cysteine, using electrophilic probes.

9 nd steric interactions in easy-to-synthesize probes.

10 erent ethnicities, using molecular inversion probes.

11 the scientific literature as useful chemical probes.

12 ses of live-cell imaging with antibody-based probes.

13 a conducting polymer, to immobilize the PNA probes.

14 n tethered by an ER/K linker flanked by FRET probes.

15 set of fluorescently labeled oligonucleotide probes.

16 CIPRO), were chosen as nonresonant molecular probes.

17 xchange processes as functional paramagnetic probes.

18 tigen-specific contexts, such as with B-cell probes.

19 within cells, as determined by intracellular probing.

20 s also tested for five cycles indicating the probe 1 could be used in a reversible manner.

21 The probe 1 selectively detected CN(-) under the UV-vis spec

22 Optimized probe 2 (XO44) covalently modified up to 133 endogenous

23 In particular, Formaldehyde Probe 573 (FAP573), based on a resorufin scaffold, is th

24 While each method probes a unique aspect of complex pore structure of shal

25 In this probe, a carbon dot-doped silica core serves as a refere

26 frared laser pulses through atmospheric air, probing air dispersion in the 3.6-4.2-mum wavelength ran

27 This nanotransistor probe allows digitized reporting of dynamic maturation a

28 ich through the use of fluorochrome labelled probes allows the target molecules to be detected by mea

29 sequencing and multiplex ligation-dependent probe amplification and retrospectively analyzed medical

30 We probe anaerobic respiration of bacteria in the presence

31 s outcome relies on precise knowledge of the probe and analyte concentrations.

32 ADPL should be amenable to diverse probe and protein families to detect active enzymes at s

33 Cells actively probe and respond to the stiffness of their surroundings

34 o receive Golay-coded transmissions from the probe and these data were processed to obtain tracking i

35 hat compression is a function of size of the probe and volume fraction of the crowder.

36 rce microscopy, leveraging molecular tension probes and fluorescence polarization microscopy to measu

37 These selective probes and inhibitors are now available to the plant sci

38 The diffusion of a series of small probes and the compact but disordered 4E binding protein

39 g and processing information, and ultimately probing and controlling behaviour at the quantum level.

40 ve materials, molecular machines, biological probes, and even commercial medicines.

41 Only natural amino acids were used as probes, and thus possible structural perturbations were

42 molecules such as functionalized fluorescent probes, antibodies, or plasmid DNA to living cells requi

43 SECM probe, we implement cyclic voltammetry probe approach surfaces (CV-PASs), consisting of CVs per

44 stems based on the EvaGreen dye and a TaqMan probe are proposed and compared.

45 many lives, but current fluorescence imaging probes are limited in their detection ability, particula

46 ll STED nanoscopy.Ratiometric fluorescent pH probes are useful tools to monitor acidification of vesi

47 rientation reproductions for items that were probed at expected times.

48 hat are deuterated apart from (1)H/(13)C NMR probes at isoleucine delta1 methyl groups, which facilit

49 Silicon probes based on microfabrication can yield large-scale,

50 be affected by sequence mismatches in primer/probe binding regions, RT-dPCR may be the optimal molecu

51 significant nucleotide mismatching in primer/probe binding regions, while evaluation of a WHO interna

52 we describe the discovery of a new chemical probe, bisamide (CCT251236), identified using an unbiase

53 e parameters (plaque index [PI], bleeding on probing [BOP], and probing depth [PD] >/=4 mm) and crest

54 ll-angle X-ray scattering (SAXS) geometry to probe both the structural and dynamical properties durin

55 esearch to move from its original domain, of probing bulk media, to imaging biological tissues and si

56 Chromatin organization can be probed by Chromosomal Capture (5C) data, from which the

57 segmental flexibility in the native state as probed by heteronuclear NMR spectroscopy and multiple co

58 ties of this unique high-valent state may be probed by in situ spectroscopy.

59 The allosteric mechanism was probed by microsecond MD simulations in explicit water,

60 expected, the radicals' decay, specifically probed by the oxyl's subsurface vibration, parallels tha

61 opes, these easy-to-use membrane DNA tension probes can be broadly used to measure intercellular tens

62 of hepatitis B virus integration sites from probe capture data, the verified experiments show that m

63 ge (280-350 eV) is a very powerful method to probe carbon speciation.

64 NA using single-molecule molecular inversion probes (cDNA-smMIPs) that enable highly multiplexed rese

65 nesis increases the effective diffusivity of probe chains.

66 Such inhibitors find use as mechanistic probes, chemical biology tools, and therapeutics.

67 This probe combines highly selective and sensitive ex vivo de

68 vestigated utilizing a (2)H-labeled silolane probe; complete scrambling at the silicon center was obs

69 ephthalic acid is the most appropriate OH(*) probe compound for the characterization of electrochemic

70 ed methods for tissue manufacture, accessing probe compounds, and generating new leads that yield man

71 nd quantify DOM photochemical activity using probe compounds.

72 To this end, we used genetically encoded probes consisting of the PtdIns4P-binding domain of the

73 n an electrode inserted inside a nanopipette probe containing electrolyte solution and a second elect

74 xin B, along with 6,286 control sequences to probe contributions to folding and binding, and identifi

75 pulse-trains inserted at different phases to probe cortical excitability.

76 ew complementary approaches - stable isotope probing coupled with nanoscale secondary ion mass spectr

77 ing as models of the OMM, is investigated to probe cytochrome c-induced permeability.

78 rate the production of dozens of records per probe, decode the spatial arrangements of 7 unique probe

79 onal selection, signaling amplification, and probe dependence.

80 us bleeding index (mSBI), plaque index (PI), probing depth (PD), and clinical attachment level (CAL).

81 e index [PI], bleeding on probing [BOP], and probing depth [PD] >/=4 mm) and crestal bone loss (CBL)

82 tool for periodontal examinations, including probing depth measurements, but is limited by systematic

83 The probe design exploits a lysyl residue in EGFP that is es

84 Under optimized experimental conditions, the probe detects bilirubin selectively in the presence of o

85 The probe detects the bilirubin through FRET mechanism.

86 However, these methods probe different facets of internal friction and have bee

87 for chemically discerning measurements that probe disease.

88 To achieve it, probe DNA (PDNA) was immobilized on the surface of ZnO/P

89 gth and high temperature allows the chimeric probe DNA distinguishing perfect-matched and single-mism

90 Remaining intact probe DNAs are then bound onto upconversion nanoparticle

91 on device in which solvent moves through the probe, drawing in the analytes in preparation for ioniza

92 ered system for quantitatively assessing the probe efficacy; an ideal probe exhibits high reactivity

93 rder to induce superconductivity, as well as probe electron transport.

94 e calibration scans confirmed that imprinted probes enable sub-diffraction limited imaging with a spa

95 combination of static and dynamic structural probes enabled us to derive direct correspondence betwee

96 minutes after injection of collagen-specific probe EP-3533.

97 Likewise, this probe evidenced high selectivity and sensitivity and fas

98 ively assessing the probe efficacy; an ideal probe exhibits high reactivity with its protein targets

99 However, very few NIR-IIb fluorescent probes exist currently.

100 nd potential of transcriptome-wide structure probing experiments.

101 Observations from probes far from the Earth are not affected by these brig

102 erential pulse voltammetry signal of a redox probe ([Fe(CN)6](3-)/[Fe(CN)6](4-)) that is altered upon

103 Although a few paradigms probed fear conditioning/extinction or utilized peripher

104 strated the usage of this dual-functionality probe for both flow cytometry and mass cytometry in a mi

105 Tyr-Au NPs were successfully used as a dual probe for colorimetric and fluorescence turn-on assays o

106 ical characterization as a live-cell imaging probe for different fungal pathogens.

107 1-(13)C]-glycerate ([(13)C]-Glyc) as a novel probe for evaluating glycolysis using hyperpolarized (13

108 e of action suggests that it may be a useful probe for examining energy metabolism, particularly in B

109 comparable or even superior performance as a probe for PSMA-targeted RGS and also hint toward the une

110 acetate) is the most widely used fluorogenic probe for the detection of general oxidative stress.

111 of the analyzed sample and a microelectrode probe for the localized electrochemical analysis of the

112 ingosine and diacylglycerol; uncaging of the probe for these two species triggered calcium signaling

113 92 hemagglutinins (HAs) were constructed and probed for reactivity with ferret antisera against MN/10

114 crease access to wireless optofluidic neural probes for advanced in vivo pharmacology and optogenetic

115 red as one of the most sensitive families of probes for detection and imaging applications.

116 ymers were demonstrated as chemiluminescence probes for detection of different chemical analytes.

117 The availability of probes for functional studies of mammalian Nav is limite

118 erting nanocrystals as promising fluorescent probes for in vivo imaging in this spectral region.

119 quadruplex nucleic acids, providing valuable probes for local structure, dynamics, and ligand binding

120 programmable material building blocks and as probes for measuring and manipulating intracellular proc

121 biosensing when using ultrathin fiber optic probes for research purposes.

122 Fluorescent probes for signal generation were designed to consume pr

123 s have accelerated the discovery of chemical probes for studying biological processes.

124 s largely unexplored protein family as novel probes for super-resolution microscopy.

125 We designed novel PET imaging probes for the murine and human granzyme B isoforms that

126 a distinct yet complementary set of imaging probes for understanding disease mechanisms in three dim

127 oughly investigated the suitability of these probes for use in electrochemical advanced oxidation pro

128 esigned a family of ratiometric endosomal pH probes for use in live-cell STED nanoscopy.Ratiometric f

129 By combining Kelvin probe force microscopy imaging and phase-field simulatio

130 re we collected over 100 distinct structural probes from radiolytic footprinting, disulfide trapping,

131 els for 36,778 transcript expression traits (probes) from 2,765 individuals to comprehensively invest

132 Bioorthogonally activated smart probes greatly facilitate the selective labeling of biom

133 in proteins requires the incorporation of IR probe groups with spectrally isolated absorptions to avo

134 , we developed (1) a GSH-based photoaffinity probe (GSTABP-G) to target the "G site", and (2) an ABP

135 Chemical probes have also achieved greater prominence alongside c

136 ever, robustness analyses show that all nine probes have previously been found to be associated with

137 Three different CPEs were used to probe how structural variations impact biocurrent genera

138 Here we probe how the crystal packing alters microsecond dynamic

139 Here we experimentally probe hyper-complex quantum theories, studying one of th

140 iverse applications, including approaches to probe, image and control protein function, and to precis

141 icated by the most differentially methylated probes implicated gamma-aminobutyric acid (GABA), dopami

142 tic nanoparticles) was compared as detection probe in LFIA, being gold nanoparticles that showed bett

143 properties, for the first time, as the redox probe in the development of HCV core antigen electrochem

144 th inherent properties was used as the redox probe in the development of the TNT aptasensor was used.

145 pes of mixed anomaly could be experimentally probed in condensed matter systems known as Weyl semimet

146 decode the spatial arrangements of 7 unique probes in a homogeneous sample, and repeatedly sample th

147 neous sample, and repeatedly sample the same probes in different states.The spatial organisation of n

148 The probe incorporated into the bacterial ribosomal RNA deco

149 me, would enable high-density nanomechanical probing inside materials.

150 at the resolution of the Rayleigh scattering probe is adequate to detect nanoparticles as small as C6

151 We find that the use of the probe is an effective tool for exploring the thermodynam

152 hat the cis state is the "on" state when the probe is inserted into the DOPC membrane, while it is in

153 The chemical probe is orally bioavailable and displays efficacy in a

154 aracterization of 6AlkGlcNAc shows that this probe is selectively incorporated into O-GlcNAcylated pr

155 The periodontal probe is the gold standard tool for periodontal examinat

156 rom cells reacted with fluorescently labeled probes is a widely-used method for assessing cell biolog

157 of DCFH2-DA, as many other fluorogenic redox probes, is mainly confined to the detection of intracell

158 d themselves spectacle independent yet, when probed, it was determined that the respondent actually w

159 f the three serine proteinase activity-based probe-labelled enzymes isolated was biochemically distin

160 This stereochemical probe led to inversion of configuration in a kinetic res

161 igation products from complex panels of LISH probes ('LISH-seq'), which can be amplified efficiently

162 ic incoherent neutron scattering (EINS) that probes local motions of a system at the atomic level by

163 cts are often determined by experiments that probe long-range heteronuclear contacts for fibrils temp

164 D configurations: the low temperature plasma probe (LTP) and the dielectric barrier discharge for sof

165 ategy for constructing modular hybridization probes (M-Probes) that overcomes these challenges.

166 None of these probes maintained an association with ADHD trajectories

167 We expect that these probes may be readily adapted to study the mechanisms un

168 These novel probes may be used to understand the emerging biology of

169 ques so far, there is a clear need for local-probe measurements.

170 Using a high-throughput RNA structure probing method, we provide nucleotide resolution insight

171 environment and the utilisation of scanning probe microscopies as a primary characterisation tool ar

172 scopy (SICM) is a nanopipette-based scanning probe microscopy technique that utilizes the ionic curre

173 ese processes have been revealed by scanning probe microscopy.

174 ymers and polymer composites, these flexible probes minimized tissue response to achieve chronic mult

175 th of suitably high-resolution techniques to probe molecular architecture in situ and integrate infor

176 is typically accomplished by using reactive probe molecules, but prior studies have not thoroughly i

177 Using two probes, more than 700 well-isolated single neurons were

178 that can yield time-resolved information and probe multiple protein binding partners simultaneously,

179 tion and scattering losses of the nano-sized probe neglected in previous models based on low-frequenc

180 ology, electrophysiology, and microdialysis; probed neuronal activation by c-Fos immunohistochemistry

181 or using fermionic optical lattice clocks to probe new phases of matter.

182 In this study, we report a probe of lanthanide-coordinated semiconducting polymer d

183 wever, there has been no direct experimental probe of these dark excitons.

184 e Observatory opened the door to alternative probes of stellar and galactic evolution, cosmology and

185 As an example, different probes of subunit rotation in the ribosome have provided

186 arge dating based on direct, non-destructive probing of chronometric information.

187 e soft X-ray regime above 200 eV, permit the probing of electronic excitation, chemical state, and at

188 rogen-vacancy (NV) color centers enables the probing of nanoscale ensembles down to approximately 30

189 Orthogonal optical probes offer a low-noise alternative for direct simultan

190 onventional optical, X-ray and photoelectron probes often fail to provide interface-specific informat

191 he target DNA partly hybridizes with capture probe on the gold sensing chip and the unpaired fragment

192 eterogeneous distribution of oligonucleotide probes on the surface, negatively affecting to both hybr

193 and the dispensing cycles of the capture DNA probes on the test-zone), the biosensor could detect a m

194 antages that can reduce sensitivity, such as probing only a small percentage of the nanoprobes presen

195 and surface vibrational modes using a single probe, our work represents advances in the detection and

196 trast, proteins kept in the folded state and probed over week-long experiments show greatly reduced r

197 se and accurate positioning of Hg-based SECM probes over any sample and enable the deployment of CV-P

198 ed SHAPE-mutational profiling (SHAPE-MaP) to probe PAN in its nuclear, cytoplasmic or viral environme

199 n methods, due to the ability of neutrons to probe pore spaces inaccessible to N2 and mercury.

200 The optimized sensing probe possesses a remarkably good sensitivity of 26.2nm/

201 ghly selective (high in beta) in forming the probe-protein adducts.

202 d (2D IR) and IR polarization selective pump-probe (PSPP) spectroscopies were used to investigate CO2

203 % amplitude using a 14mm diameter transducer probe, reaching 1214.2+/-64.3mg/100ml of total FAAs.

204 manner by using 4-nitrophenol reduction as a probe reaction.

205 Computational analysis of these probes revealed a convergence of pathways indicating act

206 s on a imidazolium based IL and use particle-probe rheology to (i) catch this phenomenon and (ii) hig

207 Compared to the other redox probes, riboflavin is superior in its oxidization in neg

208 The corresponding probes selectively targeting mitochondria, lysosomes, an

209 stal structure, we gained insight on how the probe senses ligand-induced conformational change in RNA

210 mmobilization of single stranded DNA (ssDNA) probe sequences on a wide variety of electrode substrate

211 Ideally, an electrical probe should be capable of recording from large numbers

212 arly stages of growth with unobtrusive laser probes should give insight on the particle formation mec

213 ontaining nearly the entire mesh electronics probe showed that the tissue interface was uniform and n

214 The probe shows high selectivity to HNO over other reactive

215 We find nine CpG probes significantly associated with EA.

216 his in mind, a purpose-built optoelectronics probe station capable of simultaneous optical-electrical

217 This is achieved by computing probe structures that capture the chemical and structura

218 Clinical Phenotyping and Resource Biobank (C-PROBE) study and the Seattle Kidney Study (SKS), we test

219 eening per enzyme: 4-8 d; and activity-based probe synthesis: 1-2 weeks).

220 Despite the development of chemical probes targeting the BRD9 bromodomain, there is a limite

221 Validation of probe targets and "G" and "H" site specificity was carri

222 A wide range of molecular probing technologies involving real-time polymerase chai

223 e individual oligomers by slowly ramping the probe temperature and collecting data-dependent tandem m

224 e report a Co2-based magnetic resonance (MR) probe that enables the ratiometric quantitation and imag

225 (Xan), we show here that KIE is a selective probe that identifies the experimentally reactive spin s

226 A fibre-optic probe that integrates a nitrogen-vacancy (NV) diamond qu

227 -1-ylsulfonyl) benzoate (NPSB-B), a chemical probe that specifically labels reactive cysteine sulfhyd

228 Herein, probes that are capable of imaging tiny (<1 mm) micromet

229 agnetic resonance shift and optical emission probes that are sensitive to the local solution environm

230 constructing modular hybridization probes (M-Probes) that overcomes these challenges.

231 ion provides a highly sensitive yardstick to probe the allosteric modulation in contrast to the tradi

232 ysiological, and ultrastructural analyses to probe the architecture of ribbon synapses by perturbing

233 This approach has broad potential to probe the binding of a variety of ligands to metal nanop

234 sults also reflect the value of studies that probe the common genetic basis of salutary social bonds

235 ed spectroscopy has been used in the past to probe the dynamics of internal proton transfer reactions

236 Theory is combined to probe the electronic structure and orbitals responsible

237 phase; we used photoelectron spectroscopy to probe the first two electronic states of the radical cat

238 from D1-N87A and D1-N87D variant strains to probe the function of the D1-Asn(87) residue in the wate

239 o the arylsilane provides not only a tool to probe the impact of the conformational flexibility of Ar

240 how the method can be used to simultaneously probe the impact on neural encoding of natural stimulus

241 We used it to probe the importance of lipid peroxidation in progressio

242 -resolved optical reflection spectroscopy to probe the inter-LL transitions at individual valleys and

243 Here we selectively probe the interface magnetization of SrTiO3/La0.5Ca0.5Mn

244 might use its force-generation machinery to probe the mechanical properties of the opposing antigen-

245 the paucity of experimental methods able to probe the mobility and density of the FG-polypeptides an

246 To better probe the p53 response, SJSA cells (shCDK19 versus shCTR

247 irradiation has been successfully applied to probe the photostability of photocatalysts.

248 Here, we probe the solution structure and dynamics of active and

249 Molecular dynamics simulations were used to probe the structure and dynamics of the system at a rang

250 The oscillations enable us to probe the surface structure.

251 rt a novel technique and device structure to probe the thermoelectric transport across Au/h-BN/graphe

252 Biochemical techniques probed the mechanism of inhibition, revealing the mutant

253 We also probed the nucleotide dependence of this interaction, co

254 We probed the peptide acceptor specificities of the OSTs in

255 ucose and glutamine as metabolic tracers, we probed the phenotypic changes in metabolism following a

256 We present a new LFA design that probes the dissociation of aptamers from the surface of

257 tude pulse made prior to the FSCV sweep that probes the impedance of the system.

258 in both the insulating and metallic phases, probes the subsequent relaxation in the metallic phase,

259 Probing the array with several glycan-binding proteins u

260 first study describing ToF-SIMS imaging for probing the brain-wide accumulation of supplemented Li i

261 Tn-Seq is an experimental method for probing the functions of genes through construction of c

262 ming self-assembly chemistries and processes.Probing the growth pathways of quasicrystalline material

263 come among the most promising strategies for probing the underpinnings of human health and disease.

264 X-ray scattering and photoluminescence (PL) probes, the NC-SL structural transformations are correla

265 es tools that can selectively and intimately probe these biomolecules.

266 We probed these interactions genetically and identified sec

267 dy, primarily due to technical challenges in probing these materials in situ.

268 ow; when combined with available fluorescent probes, this palette provides 24 resolvable colours, wit

269 charge transfer between a QD and a molecular probe to even low-affinity binding events at the QD/solv

270 Used as a probe to identify Thy-1(+) CAF-enriched tumors in a comp

271 demonstrate the capability of the miniature probe to map the biomechanical properties in phantom and

272 show that tactoids can also serve as optical probes to delineate the role of temperature and concentr

273 atic assays, potent inhibitors, and chemical probes to detect, track, and characterize the role of Ty

274 y for ALDH1A1 or ALDH2 and generate chemical probes to examine the unique and overlapping functions o

275 y, but it has proven valuable to prepare and probe transition-state dynamics by the photodetachment o

276 ultrasonic bath (UB) at 40kHz and ultrasonic probe (UP) at 24kHz were tested for the determination of

277 buffers, the concentration of detection DNA probe used in the preparation of FCN-DNA conjugates, the

278 Its synthesis and crystallization was probed using an active machine-learning algorithm develo

279 ia photoluminescence, these states are often probed using photocurrent methods that require efficient

280 of analogue precursor chondrite material was probed using state of the art dynamic X-ray radiography.

281 We calculate the exposures needed to probe various contributions to the total geo-neutrino fl

282 affording highly reactive nitrile imines, is probed via a monochromatic wavelength scan at constant p

283 onsible for a large interfacial nonlinearity probed via second harmonic generation that is sufficient

284 Spontaneous Raman microscopy probes vibrational transitions with much narrower resona

285 To test this hypothesis, a near infrared probe was fabricated to have high affinity to apoptotic

286 No probe was identified for AST levels.

287 This oligonucleotides detection probe was observed to detect target oligonucleotides spe

288 Using pyridine as a nucleophilic probe, we have demonstrated both experimentally and comp

289 g control without risking damage to the SECM probe, we implement cyclic voltammetry probe approach su

290 Using anti-T. brucei ABQs as chemical probes, we demonstrated that these exhibit different try

291 INGS, and 408 bacterial species and 84 genus probes were assigned.

292 Different probes were examined in bulk solutions, and dihydrorhoda

293 Moreover, the new SPME probes were used to validate an analytical method for de

294 solvent-assisted desorption, these new SPME probes will properly suit various metabolomics applicati

295 bits an extraordinary lifestyle, and further probing will answer exciting basic microbiological and c

296 ion efficacy and detection capacity of a DNA probe with two inserted UNA monomers (UNA2), and compare

297 monomers (UNA2), and compared it to the DNA probe with two purposefully inserted mutations (DNAM2) a

298 y irradiating the photocleavable DNA capture probe with ultraviolet (UV) light.

299 Herein, we described a novel type of smart probes with tunable reaction rates, high fluorescence tu

300 orm from 2-12 wk, whereas flexible thin-film probes yield a marked accumulation of astrocytes and mic