ライフサイエンスコーパス: probe for

1 evelopment of nanomolar affinity fluorescent probes for 14 aminergic GPCRs.

2 A single split-ring resonator (SRR) probe for 2D surface mapping and imaging of relative die

3 a custom-designed exon microarray containing probes for 57 muscle-specific genes to assay the transcr

4 antibodies as the most widely used affinity probes for 5mC analysis, i.e., employed in the methylate

5 This study warrants future studies to probe for a possible role of cytotoxic extracellular his

6 titis B virus (HBV)-infected human livers to probe for a subset of T cells specialized to overcome lo

7 al set of acquisition parameters for a given probe for a variety of measures of resolution.

8 quitous ligand to afford rapidly fluorescent probes for a large set of GPCRs to be used for instance

9 s) are being investigated as multifunctional probes for a range of biomedical applications.

10 nating library of ultrasensitive luminescent probes for a range of biotechnology applications from bi

11 assay, using only one set of oligonucleotide probes, for a total analysis time of less than 10 min po

12 and cell-derived protein extracts were then probed for activation of signaling pathway molecules (ER

13 ating the first aptamer-based activatable PA probe for advanced molecular imaging in living mice.

14 crease access to wireless optofluidic neural probes for advanced in vivo pharmacology and optogenetic

15 nts were applied in combination with a lipid probe for affinity enrichment of myristoylated proteins

16 phorylation to design a turn-on fluorescence probe for ALP sensing.

17 umogallion as a direct-fluorescent molecular probe for aluminium, complemented with transmission elec

18 mbled monolayer (SAM) designed to attract or probe for analytes and then by grafting a non-fouling zw

19 sparse noise was presented dichoptically to probe for anomalous retinal correspondence.

20 ein families with single-cell resolution, 2) probe for antagonist specificity, and 3) allow the measu

21 s and increases the potential of fluorescent probes for applications in analytical chemistry and imag

22 ixture served as a highly specific detection probe for ascorbic acid (AA).

23 suggests that these measures could be useful probes for assessing circuit dysfunctions in the disorde

24 molar, selective and cell permeable chemical probe for ATAD2.

25 ly modified VLPs as selective nanostructured probes for autonomous sensor functionalization and enhan

26 Mutagenesis studies designed to probe for base-pairing interactions suggest that the add

27 serve in death mediation, thereby providing probes for better assessing its role in inflammation.

28 nostic Accuracy Studies-2 applet was used to probe for bias.

29 w and effective strategy for developing FRET probes for bioassays.

30 Identification of novel fluorescent probes for biofilm imaging will greatly facilitate diagn

31 novel BTD derivative to be used as a stable probe for bioimaging applications.

32 hore scaffolds in the development of new NIR probes for bioimaging.

33 are an attractive alternative to fluorescent probes for biological labeling because of their photosta

34 miconductor quantum dots (QDs) are promising probes for biological sensing because they offer multipl

35 nt challenges in the field of thiol-reactive probes for biomedical research and diagnostics, emphasiz

36 uranium may provide the sought-after tool to probe for biotic processes.

37 strated the usage of this dual-functionality probe for both flow cytometry and mass cytometry in a mi

38 egation-induced emission (AIE)-based turn-on probe for both inorganic mercury ions and organicmercury

39 Here we introduce a method to probe for broken detailed balance and demonstrate how su

40 -BRD9, the first selective cellular chemical probe for bromodomain-containing protein 9 (BRD9).

41 The utility of the probes for bulk measurements extends also to SECM studie

42 Now, a chemiluminescent probe for cathepsin B has been developed that provides a

43 To do this, we used multiple probes for cell mechanics including a microfluidic optic

44 te motif in order to construct a fluorescent probe for cellular sulfur species.

45 s expected to enable the future use of cFRET probes for cellular sensing and other imaging assays.

46 t-generation bio-derived microarchitectures, probes for cellular/biochemical processes, biomicrorobot

47 oefficients, which we find to be a sensitive probe for changes in the HB network structure as well as

48 se XUV radiation can be used as an effective probe for characterizing otherwise unresolved features o

49 to molecular details and then provide a poor probe for chemical information.

50 te how it can be used as a sensitive optical probe for chemically specific Raman imaging.

51 ative, we showed that the sensitivity of the probes for cholesterol can be tuned by modifications int

52 -2(CFTERD3) thus represents a simple turn-on probe for chymase detection, with real-time and direct r

53 To identify a more suitable probe for clinical dCK PET imaging, we compared the sele

54 ging properties make (64)Cu-CHS1 a promising probe for clinical use.

55 s validate small molecule cysteine cathepsin probes for clinical PET imaging and suggest that they ha

56 While the (5F)LOH acts as a molecular probe for CN(-), (2F)LOH, (1F)LOH, and (0F)LOH acts as c

57 een as a good candidate for development as a probe for cocaine in many contexts.

58 Tyr-Au NPs were successfully used as a dual probe for colorimetric and fluorescence turn-on assays o

59 developed that makes use of an irreversible probe for competitive assays run to completion against t

60 dings open the possibility of using UCNPs as probes for controlled localization of uncaging and imagi

61 To this end, we have developed acoustogenic probes for copper(II)-1 and -2 (APC-1 and APC-2, a water

62 ent quench dynamics can serve as a sensitive probe for correlations in delocalized fermionic quantum

63 the literature and have not been explored as probes for covalent conjugation to proteins, possibly be

64 queous soluble and a biologically acceptable probe for Cys-SeH.

65 inally, we demonstrated the utility of mEPIC probes for data exploration such as hierarchical cluster

66 d after therapy using MRI and a clinical PET probe for dCK.

67 PET probes for dCK have been developed and are effective in

68 C4 in R/S configuration is thus a versatile probe for delineating the triplex stabilizing factors an

69 high vacuum, has recently been proposed as a probe for demonstrating mesoscopic centre-of-mass superp

70 We hypothesized that PET probes for deoxycytidine kinase (dCK) could be used to d

71 e the development of an active site-specific probe for detecting a secreted peritumoral protease expr

72 e also investigated the utility of PllA as a probe for detecting alpha-galactosides.

73 ical biology of persulfides and the chemical probes for detecting them.

74 red as one of the most sensitive families of probes for detection and imaging applications.

75 te-responsive groups has resulted in turn-ON probes for detection and imaging of beta-galactosidase a

76 ymers were demonstrated as chemiluminescence probes for detection of different chemical analytes.

77 e that can use specifically circularized DNA probes for detection of target nucleic acids and protein

78 ical characterization as a live-cell imaging probe for different fungal pathogens.

79 eight were isolated using trimeric envelope probes for differential single B cell sorting.

80 ting and cytochemistry used Siglec-F-Fc as a probe for directed purification, followed by liquid chro

81 ue fluorescence features that may serve as a probe for disease detection.

82 een made in designing fluorescent sensors or probes for divalent metal ions.

83 developed and validated molecular inversion probes for DNA capture and deep sequencing of 28 drug-re

84 (dHis) Cu(2+)-binding motif as a rigid spin probe for double electron-electron resonance (DEER) dist

85 nc distributions in single cells: a chemical probe for dynamic live-cell fluorescence imaging and a c

86 ults also support the use of envelope trimer probes for efficient isolation of HIV-1 bnAbs.

87 ns and highlights the use of envelope trimer probes for efficient recovery of bnAbs.

88 lization on magnetic particles and a readout probe for electrochemical detection by square-wave volta

89 tes pi-electron-rich selective and sensitive probes for electron-deficient picric acid (PA).

90 a kinome-wide selective radioactive chemical probe for endogenous kinase PET neuroimaging in human.

91 Furthermore, we probed for enrichment within genetic pathways and of tra

92 on for long-term monitoring with submersible probes for environmental analysis are possible analytica

93 findings demonstrate that Rbins are powerful probes for eukaryotic ribosome assembly.

94 1-(13)C]-glycerate ([(13)C]-Glyc) as a novel probe for evaluating glycolysis using hyperpolarized (13

95 e of action suggests that it may be a useful probe for examining energy metabolism, particularly in B

96 ating insula function, and could be a useful probe for examining interoceptive dysfunction in psychia

97 Amyloid probes, for example, thioflavin T and Congo red, have be

98 ies for future rational drug development and probes for exploring the role of the kappa-opioid recept

99 ing systems; however, biocompatible chemical probes for FA are currently lacking.

100 In this context, fluorescence-based probes for FA imaging are emerging as potentially powerf

101 trigger by creating a series of fluorescent probes for FA with excitation and emission wavelengths t

102 indicate preclinical potential value of the probe for fluorescence-guided diagnosis of peritoneal me

103 in the form of a backpack MS with a sampling probe for forensic analysis or in the form of a compact

104 he developed in-tube SPME device as an ideal probe for forensic application, drug monitoring, and poi

105 its redox properties and providing excellent probes for FTIR spectroscopy.

106 13 represents an excellent chemical probe for functional studies of the BAZ2 bromodomains in

107 The availability of probes for functional studies of mammalian Nav is limite

108 on and also can be used as valuable chemical probes for further HSC biology research towards promisin

109 nt molecule, which can be used as an optical probe for G-quadruplexes.

110 nium derivatives that can be used as optical probes for G-quadruplexes.

111 GOx)-glucose system to design a colorimetric probe for glucose.

112 been made in the development of luminescent probes for Group I and Group II ions as well as protons.

113 Herein, we report a plasmonic probe for H2O2 based on 3-mercaptophenylboronic acid (3-

114 To demonstrate the efficacy of this probe for H2S detection, we demonstrate the ability of M

115 is growing chemical toolbox of new molecular probes for H2S and related RSS sets the stage for applyi

116 le compound 22 will be a useful experimental probe for helping to elucidate the role of ERbeta in can

117 activities and thus represent novel chemical probes for heterochromatin formation and function.

118 erformance and are evaluated as a diagnostic probe for high-grade serous ovarian cancer, typically di

119 ine blot hybridization with species-specific probes for high-throughput detection and simultaneous id

120 and cIAP1 and a structurally novel chemical probe for IAP biology.

121 s are demonstrated to be useful colorimetric probes for ice recrystallization inhibition, giving a vi

122 Ten species-specific probes for identifying these 10 psocid species were desi

123 [(18)F]-2-DFR is expected to be a useful PET probe for imaging and quantifying liver functions in viv

124 cterize a positron emission tomography (PET) probe for imaging DIPG in vivo In human histological tis

125 (18)F]FTrp represents a highly promising PET probe for imaging of Trp metabolism.

126 nthesis and application of smart fluorescent probes for imaging macrophage cellular activity, ranging

127 agging approach using a biotinylated capture probe for immobilization on magnetic particles and a rea

128 ins a locked nucleic acid (LNA) modified DNA probe for improving hybridization efficiency, while a si

129 Using a resistance temperature probe for in situ monitoring we demonstrate that the hot

130 dots (QDs) have become important fluorescent probes for in vitro and in vivo bioimaging research.

131 bacterial phytochromes attract attention as probes for in vivo imaging due to their near-infrared (N

132 erting nanocrystals as promising fluorescent probes for in vivo imaging in this spectral region.

133 In nanoscale magnetic resonance probes, for instance, finite sampling times greatly limi

134 plied a (2)H-edited NMR approach to directly probe for intermolecular interactions in the full-length

135 ons (MBs) have recently emerged as efficient probes for interrogating biomarkers in live cancer cells

136 rmationally selective inhibitors as chemical probes for interrogation of the structural and dynamic f

137 og pathway is expected to provide a valuable probe for investigating and targeting ligand-dependent h

138 er M17A2 shows the potential to act as a new probe for investigating this kind of intercellular conne

139 l compounds will serve as useful mechanistic probes for KLF10-mediated effects and T regulatory cell

140 evelopment of a positron emission tomography probe for live bacterial infection based on the small-mo

141 , and biological evaluation of a fluorescent probe for live-cell FA imaging that relies on a FA-induc

142 found to be a potent and selective chemical probe for liver inflammation and injury.

143 ored for use as alkyne-state-dependent Raman probes for living cell imaging due to synergetic enhance

144 Heavy-enzyme mass effects were probed for local or global contributions to catalytic si

145 quadruplex nucleic acids, providing valuable probes for local structure, dynamics, and ligand binding

146 e substrates for stem cells, and fluorescent probes for long-term tracking of cells and biomolecules

147 tures, allowing single atomic cavities to be probed for many minutes.

148 of the failure zone can be used as a direct probe for material rigidity.

149 high resolution in vivo using a fluorescent probe for matrix metalloproteinase-2/9 activity, fluores

150 (KO) mice were implanted with radiotelemetry probes for measurement of core body temperature.

151 programmable material building blocks and as probes for measuring and manipulating intracellular proc

152 To probe for mechanistic insight into how AC up-regulation

153 To identify novel chemotaxis inhibitors as probes for mechanistic studies and leads for development

154 stimulated Raman scattering (SRS) imaging to probe for metabolic differences between fluconazole-susc

155 thesized and used as a selective fluorescent probe for Metronidazole detection.

156 ic molecular targets have great potential as probes for microbial diagnostic applications.

157 analyses and are endowed with a fluorescent probe for miRNA detection.

158 directed against HER2 have been developed as probes for molecular imaging.

159 atural tRNA species, this fusion is a viable probe for monitoring tRNA stability in a cellular qualit

160 adly useful for the development of substrate probes for monitoring exo-glycosidases, as well as a ran

161 the N-terminal residues of apoA-I as useful probes for monitoring formation and remodeling of HDL pa

162 Probes for monitoring protein aggregation with a variety

163 illustrating their promise as nonperturbing probes for monitoring such events.

164 rts with little or no repetitive elements as probes for multicolor fluorescence in situ hybridization

165 d on Quantum dots (QDs) which acted as a bio-probe for NAD(+) dependent dehydrogenase catalyzed react

166 used fluorescent in situ hybridization with probes for nascent transcripts to determine how soon aft

167 Probes for neurotransmitter concentration enable monitor

168 -BF4 (-)) has shown promise as a PET imaging probe for NIS, the current synthesis method using isotop

169 We developed and tested a novel probe for noninvasive detection of A. fumigatus lung inf

170 ble imaging properties of 64Cu and Al18F PET probes for noninvasive imaging of thrombosis.

171 inical proof of concept for the use of ADAPT probes for noninvasive in vivo imaging.

172 -sensitive probes, and an ROS/pH-insensitive probe for normalization.

173 re be considered as an appropriate molecular probe for NTS1 imaging by PET.

174 s (Ln:NPs) hold promise as novel luminescent probes for numerous applications in nanobiophotonics.

175 for preparation of various chemiluminescent probes for numerous applications.

176 ing GTNPs@PANI nanoparticles as the contrast probes for OCT imaging, noninvasive and real-time molecu

177 EDs) and recording sites onto silicon neural probes for optogenetic applications in neuroscience.

178 ants and performed whole exome sequencing to probe for other rare, highly penetrant variants.

179 The recent generation of fluorescent probes for PA, by fusing GFP to PA-binding domains, has

180 ynthesis was optimized, providing an optimal probe for PET imaging of the tumor-promoting macrophage

181 each reporter using appropriate radiolabeled probes for PET or SPECT imaging.

182 is behavior enhances the selectivity of this probe for phase recognition, since the different environ

183 d membrane phases as a versatile fluorescent probe for phase recognition.

184 ion measurements, which provides a versatile probe for phase transition in an electric manner in minu

185 Variants of BTNL2 were analyzed using probes for polymerase chain reaction and high-resolution

186 New radiolabeled probes for positron-emission tomography (PET) are provid

187 es critically rely on bright and photostable probes for precise detection of biological molecules.

188 Although our facility supplies probes for preclinical imaging, the same workflow would

189 iched for VZV specificity were generated and probed for proliferative responses to every VZV protein

190 atic side-chain protons, which are important probes for protein structure and function.

191 While protein side chain dynamics have been probed for proteins in solution with nuclear magnetic re

192 ligand discovery can identify small-molecule probes for proteins that have proven difficult to target

193 comparable or even superior performance as a probe for PSMA-targeted RGS and also hint toward the une

194 vel dual-modality iodine-labeled fluorescent probe for quantitative mapping of polymyxin in kidney pr

195 ligands, represent a new class of molecular probes for quantitative imaging of endocytic receptor dy

196 NA functionalized silver nanoparticle (AgNP) probes for quantitative investigation of biorecognition

197 Affibody molecules constitute a new class of probes for radionuclide tumor targeting.

198 caffold proteins have attracted attention as probes for radionuclide-based molecular imaging.

199 design strategy toward the development of MR probes for ratiometric pH imaging.

200 iaturized multifunctional device, the single-probe, for reactive MS analysis of live single cells und

201 92 hemagglutinins (HAs) were constructed and probed for reactivity with ferret antisera against MN/10

202 The application of 2 as a fluorescent probe for real-time detection of cellular glucosamine at

203 We report a novel single neural probe for real-time simultaneous monitoring of multiple

204 e sampling and ionization device, the Single-probe, for real-time mass spectrometry (MS) analysis.

205 lity of SPNs for designing smart activatable probes for real-time in vivo imaging is also discussed.

206 e microscopy controlled nanothermal analysis probes for reproducible spatially resolved thermally ass

207 biosensing when using ultrathin fiber optic probes for research purposes.

208 An orthogonal approach is to probe for 'response signatures' that identify specific c

209 This sensor was applied as a probe for scanning electrochemical microscopy (SECM) in

210 This approach offers a novel chemical probe for selective VHL knockdown, and demonstrates the

211 as a simple and fast responding fluorescence probe for sensitive and selective determination of hemog

212 on of neutralized chimeric DNA oligomer as a probe for sensitive detection of single nucleotide polym

213 Fluorescent probes for signal generation were designed to consume pr

214 A small molecule probe for SMYD2 would allow for the pharmacological diss

215 ctly characterize these three glutamines and probe for sources of FXIIIa substrate specificity.

216 sed turn-on near-infrared (NIR) fluorescence probe for specific detection of beta-amyloid (Abeta) agg

217 The availability of high quality probes for specific protein targets is fundamental to th

218 the optimization of a collagen-targeted PET probe for staging pulmonary fibrosis.

219 4 h later and stimulated with LPS ex vivo to probe for stress-induced sensitization of proinflammator

220 eptide prove the attainability of (17)O as a probe for structure studies of biological systems.

221 triene (DPH) is a commonly used fluorescence probe for studying cell membrane-lipids due to its affin

222 s have accelerated the discovery of chemical probes for studying biological processes.

223 factors to consider in development of 2D IR probes for studying proteins.

224 e the unique capability of our SECM chemical probes for studying real-time metabolic interactions bet

225 rs and dual-color fluorescent activity-based probes for studying two of the three active catalytic su

226 and both yielded similar FRET profiles when probed for subunit adjacency, suggesting similar underly

227 The goal of the present study was to probe for such a candidate that may regulate exon IX in

228 s largely unexplored protein family as novel probes for super-resolution microscopy.

229 h small molecules both for the generation of probes for target exploration and for therapeutic purpos

230 tion of highly potent and selective chemical probes for target validation has emerged as a concept wh

231 We used the probes for targeted sequencing of a geographically diver

232 rategies to design selective and activatable probes for targets.

233 ermittently through the use of a fiber-optic probe (for the case of oxygen) and biochemical assays (f

234 ighly conserved BH residue T831 as a sensing probe for the 3'-terminal base paring of RNA:DNA hybrid.

235 trapping proof that: (i) EBN is an efficient probe for the analysis of glutathione thiyl radical (GS(

236 istidine was successfully used as an optical probe for the assessment of histidine in different serum

237 exible exchange of the DNA sequences used to probe for the autoantibodies.

238 propose that NI-42 (13-d) is a new chemical probe for the BRPFs suitable for cellular and in vivo st

239 nvestigation of a bifunctional nanocomposite probe for the detection of cancer biomarkers, demonstrat

240 brid, which allows for the construction of a probe for the detection of CN(-) in water samples and la

241 acetate) is the most widely used fluorogenic probe for the detection of general oxidative stress.

242 ratiometric photoacoustic molecular imaging probe for the detection of metal ions in vivo, but also

243 p water soluble, biocompatible nanocomposite probe for the detection of pyrophosphate (PPi) in physio

244 s work demonstrates that TMP is an effective probe for the determination of Rf,T and AQYT in whole wa

245 charge transport presents an ultrasensitive probe for the electronic perfection of interfaces, in th

246 linium-based magnetic resonance (MR) imaging probe for the enzyme myeloperoxidase (MPO), might be a m

247 ies (F = 29%), 8i is a high-quality chemical probe for the evaluation of TRIM24 and/or BRPF1 bromodom

248 Here, we probe for the first time the electronic band structure o

249 ve identified and validated a small-molecule probe for the first time.

250 y describes the synthesis of a dual emission probe for the fluorescent ratiometric sensing of hydroge

251 This study provides a valuable probe for the investigation of GAG biology and opens ave

252 of the analyzed sample and a microelectrode probe for the localized electrochemical analysis of the

253 Herein, we report GSK4027 as a chemical probe for the PCAF/GCN5 bromodomain, together with GSK40

254 s at a given applied force to quantitatively probe for the phase state as a function of RH and corres

255 Ds could be used as a sensitive fluorescence probe for the quantification of different concentrations

256 In this work, we designed a peptide-based probe for the rapid (<10 min) high-throughput survey of

257 oclusters (Cu NCs) and used as a fluorescent probe for the sensitive detection of thiram and paraquat

258 trifluoroacetophenone group was a sensitive probe for the study of DNA-protein interactions by (19)F

259 We fabricated a membrane-based CoOxH-GO probe for the visual detection of CN(-) by preparing a t

260 sorption spectroscopy (XAS), we were able to probe, for the first time to our knowledge, the crystall

261 energetic features of the reaction has been probed for the first time.

262 the potential imprint of bias in science, we probed for the most commonly postulated bias-related pat

263 designed species-specific primers and TaqMan probes for the above six Tribolium species.

264 ghlights the utility of viral suppressors as probes for the analysis of silencing pathways.

265 Methyl groups are powerful probes for the analysis of structure, dynamics and funct

266 st stone toward the development of drug-like probes for the dCTPase enzyme.

267 Developing probes for the detection of reactive oxygen species (ROS

268 olymorphism (SNP) array platform with custom probes for the JAK2 V617F mutation (V617F), we identifie

269 terostructures are presented as nanophotonic probes for the light-triggered photoelectrochemical dete

270 Pharmacological probes for the melanocortin receptors have been utilized

271 We designed novel PET imaging probes for the murine and human granzyme B isoforms that

272 elements such as antibodies/antigens and DNA probes for the proposition of immunosensors and genosens

273 When using consensus primers and probes for the quantification of HRV, RT-dPCR outperform

274 d through the preparation of two fluorogenic probes for the selective detection of biothiols.

275 strate the ability to synthesize fluorogenic probes for the sensitive and selective detection of inor

276 onto gold electrode and used as the capture probes for the specific recognition of target single-str

277 two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of alpha V beta 3 activi

278 synthesized and examined in vitro by in-line probing for the formation of G-quadruplex structures.

279 of the system utilized nanothermal analysis probes for thermolytic surface sampling followed by atmo

280 ingosine and diacylglycerol; uncaging of the probe for these two species triggered calcium signaling

281 transport via GLUT5, and the first chemical probe for this transporter.

282 As molecular probes for this study, derivatives of isopropyl 2-O-benz

283 hallenge in bioimaging is to design chemical probes for three-dimensional (3D) tissue imaging.

284 ecificity and represent useful PET and SPECT probes for thrombus detection.

285 tudy, the feasibility and potential of these probes for thrombus imaging was assessed in detail in 2

286 e form of a compact MS with an intrasurgical probe for tissue analysis.

287 s have been limited by the lack of sensitive probes for tracking Fe-S cluster synthesis and transfer

288 labeling method wherein a synthetic receptor probe for trimethyl lysine (Kme3), CX4-ONBD, is used to

289 ion qualifies the new tracers as interesting probes for tumor imaging worthy for further investigatio

290 We devise a probe for tunnelling, a computational primitive where cl

291 w Surface Enhanced Raman Spectroscopy (SERS) probe for U937 cells identification in vitro.

292 a distinct yet complementary set of imaging probes for understanding disease mechanisms in three dim

293 nique employing an efficient photo-activated probe for use with mass spectrometry.

294 radio-frequency analogues to optically based probes for use in basic chemical, biological, medical an

295 oughly investigated the suitability of these probes for use in electrochemical advanced oxidation pro

296 esigned a family of ratiometric endosomal pH probes for use in live-cell STED nanoscopy.Ratiometric f

297 luorophore, and suggests that development of probes for use in superresolution localization microscop

298 therefore represent important new molecular probes for Viridiplantae research.

299 ution in space and time requires microscopic probes for visualization.

300 ese results indicate [(64)Cu]-LLP2A is a PET probe for VLA-4, which when used in conjunction with [(1