ライフサイエンスコーパス: probenecid

1 om a "chemical double" knockout (Oat3KO plus probenecid).

2 5-1 mg/kg per dose, every 2-3 weeks, without probenecid).

3 fibroblasts treated with the Panx1 blocker, probenecid.

4 nt, yet reversible manner in the presence of probenecid.

5 , and by pannexin blockers carbenoxolone and probenecid.

6 fects were reduced by the pannexin inhibitor probenecid.

7 exin1 (Panx1) mimetic peptide (10)Panx1, and probenecid.

8 urate-lowering drugs include allopurinol and probenecid.

9 ges pretreated with the pannexin-1 inhibitor probenecid.

10 ed with IFN-gamma that was also inhibited by probenecid.

11 by administration of non-radioactive ALA and probenecid.

12 ersed by cotreatment with the OAT6 inhibitor probenecid.

13 thiocyanatostilbene-2,2'-disulfonic acid and probenecid.

14 .v. infusion with VPA alone or with VPA plus probenecid.

15 f the efflux transporters are inhibitable by probenecid.

16 ically slowed and overshoot was abolished by probenecid.

17 nced with a 10-day course of amoxicillin and probenecid.

18 t had been preceded by prophylaxis with oral probenecid.

19 Probenecid (0.1 mM) or novobiocin (0.1 mM) added to the

20 Probenecid (1 mM), alpha-cyano-4-hydroxycinnamic acid (4

21 ely 0.25 muM) and pannexin channel inhibitor probenecid (10 mg/kg, IC50 approximately 11.7 muM), we s

22 or, % inhibition): 1.5 mM alphaKG, 80%; 1 mM probenecid, 100%; 1 mM piroxicam, 100%; 1 mM octanoate,

23 In contrast, a high intravenous dose of probenecid (250 mg/kg) only slightly inhibited SD elicit

24 Probenecid, a classic pharmacological agent for gout, ha

25 ansport of cGMP from colorectal epithelia by probenecid, a mechanism validated by studies in cultured

26 ockage of the tubular secretion pathway with probenecid, a necessary condition for establishment of c

27 inhibitors benzbromarone, sulfinpyrazone and probenecid all inhibit verinurad binding via a competiti

28 Probenecid also inhibited the regulatory volume decrease

29 The cytotoxic effects were fully reversed by probenecid (an OAT1 inhibitor) and partially reversed by

30 sma concentrations of non-radioactive ALA or probenecid (an organic anion transport inhibitor) and, t

31 of this study was to examine the effects of probenecid, an inhibitor of organic anion transport, on

32 s significantly inhibited in the presence of probenecid, an organic anion transporter inhibitor.

33 nction, or in the presence or the absence of probenecid, an organic ion transport inhibitor that appe

34 loromercuriphenylsulfonate and by the anions probenecid and 4,4'-diisothiocyanostilbene-2,2'-disulfon

35 To minimize nephrotoxicity, oral probenecid and intravenous hydration with normal saline

36 ministered and concomitant administration of probenecid and saline hydration appeared to minimize dru

37 tly by multiple Panx inhibitors (mefloquine, probenecid, and (10)Panx1), ectonucleotidase (apyrase),

38 isothiocyanatostilbene-2,2'-disulfonic acid, probenecid, and sulfinpyrazone, inhibitors of MRP1 and M

39 of the pannexin 1 blockers carbenoxolone and probenecid, and the HlyA-induced ATP release was found t

40 Since Panx1 inhibitors such as probenecid are already clinically tested in different se

41 At the CP, verapamil and probenecid (but not indomethacin) significantly increase

42 for some inhibitors (up to 4-fold), such as probenecid, but not for others (an inhibitor-dependent e

43 of uric acid-lowering agents allopurinol and probenecid can lower blood pressure in adolescents.

44 Probenecid co-infusion elevated the ICC-to-ECF concentra

45 Probenecid co-infusion elevated VPA concentration in the

46 t, inhibition of cyclic nucleotide efflux by probenecid did not affect the background Na(+) conductan

47 Co-infusion of probenecid did not have a significant effect on VPA effl

48 Enhanced treatment with amoxicillin and probenecid did not improve the outcomes.

49 Probenecid did not inhibit folate binding to FR, but inh

50 protein inhibitors, such as indomethacin and probenecid, effectively increased the accumulation of EG

51 vels of urate lowering, the uricosuric agent probenecid had no effect on endothelial function.

52 observed for inhibition of PAH transport by probenecid in renal basolateral membrane vesicles (5.2-f

53 In contrast, probenecid, in a concentration-dependent manner, inhibit

54 Transient reactions to probenecid, including mild to moderate constitutional sy

55 date putamen 3-5 times, and indomethacin and probenecid increased accumulation in ependyma 4-5 times.

56 Perfusion of 1-20 mM probenecid increased dose-dependently the dialysate leve

57 How probenecid inhibits SD deserves further investigation be

58 Therefore, probenecid may inhibit C. trachomatis growth by an as ye

59 apnia, we have examined the possibility that probenecid may inhibit SD through extracellular acidific

60 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/probenecid mouse model was used to examine the changes i

61 The organic anions probenecid, octanoate, and alpha-ketoglutarate reduced o

62 blocking pannexin/gap junction channels with probenecid or carbenoxolone significantly reduced extern

63 , whereas it was impaired in the presence of probenecid or carbenoxolone.

64 accumulation of adenosine was not blocked by probenecid or GMP, suggesting that neither extracellular

65 Release was blocked by carbenoxolone, probenecid or peptide (10)panx, implicating pannexin cha

66 ve mass treatment (SMT) with oral ampicillin-probenecid or tetracycline was then given to registered

67 cking pannexin-1 hemichannels with (10)Panx, probenecid, or carbenoxolone but not when connexin hemic

68 he selective activation of TRPV2 channels by probenecid promoted the sADP to generate a plateau poten

69 Before treatment with probenecid, RBF was linearly related to hippuran clearan

70 n after drug administration, confirming that probenecid readily penetrated the central nervous system

71 Inhibition of MRP4 in HTM cells by MK571 or probenecid resulted in cell shape changes and decreases

72 Depletion of PNX1 by siRNA or inhibition by probenecid resulted in significant blocking of extracell

73 The resulting CHOhOAT cells showed probenecid-sensitive and pH-dependent uptake of p-aminoh

74 t LTC4 is secreted by normal mast cells by a probenecid-sensitive mechanism that is independent of MR

75 Probenecid-sensitive transport of EC cGMP between AC fis

76 e-fractionated poly(A)+ RNA and screened for probenecid-sensitive transport of p-aminohippurate (PAH)

77 Probenecid-sensitive transport of the NAC-Hg(2+) conjuga

78 us laevis oocytes expressing hOAT1 supported probenecid-sensitive uptake of [(3)H]p-aminohippurate (K

79 n transporter 1 (rROAT1) mediated saturable, probenecid-sensitive uptake of cidofovir, adefovir, and

80 (203)Hg-uptake studies showed probenecid-sensitive uptake of mercury-thiol conjugates

81 p-aminohippurate (PAH) uptake was saturable, probenecid-sensitive, and inhibited by a wide range of o

82 hemichannels with CO(2)-saturated buffer or probenecid significantly reduced cell-cell signalling be

83 nsport inhibitors MK571, sulfinpyrazone, and probenecid, supporting a role for the MRP transporters i

84 inhibited by the pannexin 1 channel blocker probenecid, supporting a role of pannexin 1 in inflammas

85 broad-spectrum Panx1 blockers, mefloquine or probenecid, suppressed ATP release and reduced withdrawa

86 -stimulated by the organic substrates MK571, probenecid, taurocholic acid, estrone sulfate, and bromo

87 In contrast, sodium 4-phenylbutyrate and probenecid, the latter a uricosuric drug used clinically

88 SD was markedly reduced by perfusion of 5 mM probenecid through the microdialysis probe.

89 sured twice, before and after treatment with probenecid, to verify that RBF is not affected.

90 50% (P=0.03) to 2.01+/-0.08 mL/min/100 g in probenecid-treated rats.

91 gle-injection clearance method in normal and probenecid-treated rats.

92 Probenecid treatment significantly reduced hippuran clea

93 and placebo for the first study and 1000 mg probenecid versus placebo in the second study.

94 Probenecid was administered either directly through the

95 tive to inhibition by bromosulfophthalein or probenecid was observed for taurocholate, estrone sulfat

96 Moreover, probenecid, which blocks the export of cAMP, inhibited t

97 Treatment with carbenoxolone and probenecid, which directly and specifically block Panx1

98 e patient received intravenous hydration and probenecid with the infusions to reduce the nephrotoxici

99 in the US, we therefore investigated whether probenecid would have a direct effect on Chlamydia trach