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1 c and theoretical chemists (cf. the cerocene problem).
2 een language and gesture is a categorization problem.
3  organization in the Z-ring is an unresolved problem.
4    We now provide a general solution to this problem.
5 on statistic (LT-Fam) that is robust to this problem.
6 h stochasticity is an intriguing fundamental problem.
7 evidence-based interventions to address this problem.
8 ems is a long standing and difficult inverse problem.
9 ychological intervention for a mental health problem.
10  metallo-beta-lactamases (MBLs) is a growing problem.
11 ion, or oncologic burden) is a global health problem.
12  populations therefore remains a challenging problem.
13 is suggests that operative volume is not the problem.
14 ty for solving the difficult protein folding problem.
15 branches remains a challenging computational problem.
16 ning procedure is a common solution for this problem.
17 e study provides a great chance to solve the problem.
18  antibiotics has become a global health-care problem.
19 an immediate and simple solution to an overt problem.
20 iterature suggests that AXO is a substantial problem.
21  secondary oven is often the solution to the problem.
22 dwide representing an emerging public health problem.
23  beneficial for this important public health problem.
24 -dimensional tracking into a one-dimensional problem.
25 owing injury represents a central biological problem.
26 ce MS2LDA+ that tackles both above-mentioned problems.
27  this area, CARP sheds new light on some old problems.
28 NSF results in all studied cases of rarefied problems.
29 lant clinical trial experts to address these problems.
30 propose specific measures to alleviate these problems.
31 le experiments and application to real world problems.
32 een developed as a solution to energy access problems.
33 s or those in frail patients are challenging problems.
34 es associated with behavioural and emotional problems.
35 ctice, and automatically adapts to different problems.
36 o inner-planet atmospheres are long-standing problems.
37  telomeres representing telomere replication problems.
38 ew users to adopt 2D-LC for their analytical problems.
39  speed-up for certain types of computational problems.
40 ecomes important in correlated matter-photon problems.
41  with ED use for nonurgent and urgent ocular problems.
42 ion of data from other biological networking problems.
43 ment, specifically to solve network querying problems.
44  in their ability to solve complex reasoning problems.
45 nce-related, ecologically based conservation problems.
46 atients presenting with diverse neurological problems.
47 ost common DSM-IV-oriented scale was anxiety problems (13%, 12-14).
48    The most common CBCL syndrome was somatic problems (21%, 20-23), whereas the most common DSM-IV-or
49 ate-of-the-art approaches developed for this problem, a superiority that is reflected particularly in
50 ortant basis for answering many evolutionary problems, a large number of algorithms have been develop
51 ial for prediction of preterm birth (PTB), a problem affecting 15 million newborns annually.
52                      Sleep apnea is a common problem affecting daily functioning and health.
53  practical solution to the bryostatin supply problem also opens broad, facile, and efficient access t
54 tinues to remain a significant public health problem among Europeans.
55                               Unfortunately, problems among meta-analyses such as the misapplication
56                                To solve this problem and also to increase circulation time, we synthe
57  methodologies to more directly address this problem and as a result in the development of more highl
58 an ultrathin CTE buffer layer mitigates this problem and can help achieve band-like transport on a wi
59 ere we take a novel approach to address this problem and establish a causal link between the power fl
60 t heterogeneity as a latent class allocation problem and present a covariate free class allocation ap
61             Periodontitis is a global health problem and the 6(th) most common infectious disease wor
62         We aimed to assess the scale of this problem and whether it is associated with the intiation
63                                    Potential problems and biases in quantitative and qualitative anal
64 es the natural analogue between optimization problems and energy minimization processes in highly par
65 A were assessed for physical and psychiatric problems and followed up for one year from adjustment of
66 h high incidence of learning and behavioural problems and is associated with neurodevelopmental disor
67 ollen exposure and associated methodological problems and limitations were considered to achieve a co
68 ion and conjugation, resulting in production problems and lower efficacy.
69  offers an efficient solution to cooperation problems and promotes prosocial behavior between group m
70 ciated software package that addresses these problems and provides novel cluster quality metrics.
71 preschool children at higher risk for vision problems and the effectiveness of some treatments for im
72  be reconfigured as needed to solve specific problems and to anneal the system at room temperature.
73 is remains a major global infectious disease problem, and a more efficacious vaccine is urgently need
74  compare when applied to the same biological problem, and what differences in behaviour are due to di
75  ICU and hospital stay, persistent cognitive problems, and higher mortality rates.
76 haviour towards employees with mental health problems, and its effect on employee sickness absence.
77 ng with absence of disability, mental health problems, and major chronic diseases.
78 ed chronic liver disease is a serious health problem around the world and often causes fibrosis/cirrh
79  and solves the constant-column biclustering problem as a maximal clique finding problem in a multipa
80 ciations of mode of delivery with behavioral problems assessed from parent-reported Rutter score at
81                        However, for gelatin, problems associated with false-positive and false-negati
82 nt onset of maternal and child mental health problems associated with first transition into poverty,
83 otein interactions can be used to combat the problems associated with latent HIV virus re-emergence i
84                  However, there are multiple problems associated with polymer based approaches: The p
85                  The prevalence of reporting problems at 36-months postinjury was 37% for mobility, 2
86  and measured coparenting and child behavior problems at 6 years.
87 e followed up families without mental health problems at baseline and estimated odds ratios for subse
88   Food allergy is an important public health problem because it affects children and adults, can be s
89  energy source is a particularly challenging problem, because folding intermediates are predicted to
90  sequencing (NGS) can overcome some of these problems but has limited application in the detection of
91 entimetres) and so does not suffer from this problem, but weak signals make many bio-imaging applicat
92 an algorithm that solves the high error rate problem by combining long, high-error reads with shorter
93                We provide a solution to this problem by combining quantitative proteomics with a syst
94                            We addressed this problem by developing a TCR-transgenic (Tg) mouse with C
95 escribe a promising step toward solving this problem by identifying and describing a radiotracer, [11
96  requiring a solution to the cue combination problem by mapping sensory estimates from continuous dim
97           A new study seeks to overcome this problem by sampling more species and data cleansing.
98                                     We solve problems by applying previously learned rules.
99 more, it is expected that many other related problems can be also studied by this approach.
100 research field, what kinds of new scientific problems can be tackled in the short term, and what long
101 show how difficult synthetic and theoretical problems can eventually be solved through newly designed
102                      Counselling for Alcohol Problems (CAP), a brief intervention delivered by lay co
103 r key applications, and the various unsolved problems, closing with a perspective on the prospects an
104     Yet mechanisms that solve the free-rider problem-critical for sustaining cooperation as a viable
105 he adjusted relative risk (ARR) of reporting problems decreased from 6 to 12 (ARR 0.87, 95% CI: 0.83-
106 y for Children-Second Edition), and behavior problems (defined as a Total Problem T score >/=2 SD abo
107  clear, present and increasing public health problem, despite being a potentially preventable tragedy
108  (PAR) represents a global and public health problem, due to its prevalence, morbidity, and impact on
109 roblem into a set of independent SV assembly problems, each of which can be effectively solved to enh
110 rradiation, while avoiding the phototoxicity problems encountered with many UV-absorbing photocages.
111 ANCE STATEMENT Among the most basic survival problems faced by animals is balancing the need to seek
112 gnized as a leading public health and social problem for adolescents in the United States.
113                                    This is a problem for aesthetic psychology.
114 e prospect of a solution to the "cold chain" problem for biological materials, in particular for vacc
115  and spatial filtering can solve the inverse problem for free-flowing aerosol particles in the sense
116               Bleeding remains a significant problem for many thrombocytopenic hematology/oncology pa
117 tochondrial and nuclear genomes could pose a problem for mitochondrial replacement therapy (MRT).
118 to-nuclear interactions are likely to pose a problem for MRT.
119 re and dynamics of segregation is a pressing problem for sociology and urban planning, but existing m
120 ion to future climates is likely to become a problem for spruce and beech by the end of this century,
121                  Studies have addressed this problem for static networks, but this is a first step st
122 molecule of peptidoglycan (PG), pose a major problem for the release of progeny virions.
123              Haze formation is a significant problem for the wine industry.
124                     Amongst many fascinating problems for future research, the data revealed a YtfE o
125 biotoxic, and bioaccumulative metal presents problems for the management of soil-plant-animal systems
126      Here we review studies that tackle this problem from a diverse set of approaches, from anatomy t
127  contamination of nanomaterials is a serious problem hampering their widespread use in biomedical pro
128 ite its importance, the structural alignment problem has not been formulated, much less solved, in a
129                                          The problem has previously been applied in epidemiology and
130          Decades of study of the RNA folding problem have revealed that diverse and complex structure
131                                        A key problem here is a general understanding of the molecular
132 o successfully address practical separations problems, however, a guest cannot simply be isolated fro
133 ustering problem as a maximal clique finding problem in a multipartite graph.
134  (TPS) method that solves this combinatorial problem in a principled and practical way.
135 ng methods have been employed to tackle this problem in a purely data-driven manner.
136             Medication nonadherence, a major problem in cardiovascular disease (CVD), contributes yea
137   How cells position their proteins is a key problem in cell biology.
138                                      A major problem in diagnosing reactions to FCs is identification
139  scientific experiments to solve a difficult problem in genetics.
140 rge diabetes-associated costs are not only a problem in high-income settings but also affect poorer w
141 eading benchmark and long-standing challenge problem in imperfect-information game solving.
142               Metal contamination is a major problem in many estuaries.
143                                A fundamental problem in neuroscience is understanding how sequences o
144  a combinatorial approach to the RNA folding problem in order to compute all possible non-pseudoknott
145  acceleration continues to be an outstanding problem in solar-astrophysics.
146  These sparse but robust observations pose a problem in that the coesismic uplifts of the footwall ar
147 tte (ABC) transport proteins remains a major problem in the chemotherapeutic treatment of cancer and
148                       We have addressed this problem in the context of plant cell division in which a
149                              We explore this problem in the context of self-motion and object motion,
150  near-surface wind speed, is a long-standing problem in tropical meteorology that has been approximat
151 ood allergy is an increasingly common health problem in Western populations.
152 uals) and shared genetic origin with conduct problems in a population-based sample (394 male individu
153 h could inform and prevent disordered eating problems in adolescence.
154           These findings suggest that weight problems in adulthood may be rooted partially in early c
155 ral abnormalities) and increasingly reported problems in basic daily activities.
156 ategies may help to remedy some of the major problems in cancer targeting: heterogeneity, change in p
157 s for innovation and optimization to solving problems in chemistry and engineering.
158         This is causing significant workflow problems in ICUs nationally.
159 onlinear patterns can be further extended to problems in metagenome profiling and cell type inference
160 ponents is essential to solving contemporary problems in modern biology, especially in domains such a
161 ons) remains one of the greatest outstanding problems in modern nuclear physics.
162 form of results, chemical tools, or unsolved problems in return for valuable insights and ideas.
163 with these pathways, and also examine sample problems in the engineering of these pathways.
164                                      Serious problems in the experimental design and data interpretat
165 raft survival, graft losses due to technical problems in the first 60 days were excluded.
166              Resources for addressing health problems in these animals are not on the priority list o
167 nction that may be related to neurocognitive problems in this devastating disorder.
168 cy, this process fails when we encounter new problems in which past experience leads to a mental rut.
169               Approaches for addressing such problems include multisector decision-making, institutio
170 e usage of the server for various biological problems including protein-cofactor, domain-domain, prot
171         This prompted actions to address the problem, including surveys of current and former fellows
172 , they are commonly accompanied by cognitive problems, including memory impairments that contribute t
173   The other 5 experienced ongoing autoimmune problems, including thyroiditis (3), hemolysis (1), thro
174 , our approach turns a whole genome assembly problem into a set of independent SV assembly problems,
175                        A particularly common problem involves clustering entities characterized by a
176 eral, modeling oil-recovery is a challenging problem involving detailed fluid flow calculations with
177                                         This problem is especially significant for small research gro
178 eloped to study virus-host associations, the problem is significantly understudied.
179                                       A core problem is that there is no sufficiently fast diagnostic
180                   A strategy to address this problem is the development of crops that are efficient i
181              Another important and difficult problem is the discovery of molecular disease subtypes c
182                              Central to this problem is the mechanism by which a brain region adjusts
183                            Exacerbating this problem is the overprescription of antibiotics as well a
184                               However, a key problem is their short half-life and low bioavailability
185                         One solution to this problem is to use two-photon microscopy to target fluore
186           Solving combinatorial optimization problems is challenging.
187 clean label options to overcome such quality problems is currently of high interest.
188 formulated as an approximate string matching problem, is the computational bottleneck because: (i) it
189                To address this computational problem, it is important to optimize the variant analysi
190  when associated with comorbid mental health problems, it quadruples the costs.
191 tomatic at birth but, we assume, may develop problems later in life.
192 agriculture is causing serious environmental problems like eutrophication of lakes and rivers.
193                              To address this problem, many journals have implemented new policies tha
194 rder Checklist [PCL]), personally identified problems (measured by Psychological Outcome Profiles [PS
195               Caregivers completed the Brief Problem Monitor-Parent Form to report on adolescent's be
196 pproximately 43 superfamilies, with unsolved problems now yielding to much larger data sets from high
197                                To solve this problem, numerous methods of countermeasure have been pr
198 ive fractures, implant failures or loosening problems occurred; mean Musculoskeletal Tumor Society sc
199 AS methods, it is still remains an important problem of addressing calculation an effect size and cor
200                 Easi-CRISPR solves the major problem of animal genome engineering, namely the ineffic
201                               To combat this problem of computational complexity, a plethora of heuri
202                            Given the serious problem of drug resistance and the adverse side effect p
203                                  The generic problem of extracting information on intrinsic particle
204 e quest to tackle the increasingly important problem of hearing loss in our aging population.
205 nal variation in scientists' approach to the problem of HIV/AIDS.
206    Recent findings provide insights into the problem of how epigenetic states are inherited through c
207 bly in water-based solutions is an important problem of interdisciplinary character that impacts the
208 stry, these species may help to overcome the problem of lethal resistance.
209 ly, we speculate that, if repurposed for the problem of neural systems identification, AMA may be abl
210 cellent biocompatibility and circumvents the problem of particle agglomeration.
211 ism may provide a widespread solution to the problem of size control in eukaryotes.
212                            Once considered a problem of Western nations, obesity (body mass index >/=
213                                We classified problems of asthma patients into biological, psychologic
214  use of bioorthogonal labeling strategies to problems of clinical relevance.
215 of edges in the knowledge graph representing problems of function prediction, finding candidate genes
216 w and promising way to address the intrinsic problems of lithium metal anodes.
217 ith or without seizures, gait abnormalities, problems of social behavior, and other variable features
218 croscopy (cryoEM) can circumvent some of the problems of x-ray crystallography as a pipeline for obta
219                    Behavioural and emotional problems often start in early childhood, and this might
220 rain injury (TBI) is a serious public health problem, often with devastating consequences for patient
221 ting the solution of the optimal percolation problem on a multiplex network with solutions valid for
222 sser et al. provide a novel approach to this problem, performing a phylogenetic analysis indicating t
223 le populations is representative of systemic problems plaguing the regulation of chemicals in food.
224 n as reported by adolescents and behavioural problems reported by their caregivers.
225                                         This problem requires changes to prescribing guidelines and p
226 ecent promising way to possibly resolve this problem, requires a long preparatory period for stem cel
227                             To overcome this problem, rock phosphate fertilisers are heavily applied,
228 essed, and any pending dental or oral health problems should be dealt with prior to starting treatmen
229  the means to abrogate the ensuing cognitive problems.SIGNIFICANCE STATEMENT Whereas seizures have be
230 on kinetics-based technique that solves this problem, significantly increasing the dynamic range of t
231          This is a challenging yet important problem since such a prediction could be used to deduce
232 ent properties represents a huge theoretical problem since the presence of SOC implies that the spin
233 s, the significance of their contribution to problem solving is debated within the field of biology.
234 (MCCB), especially focusing on reasoning and problem solving, and social cognition in schizophrenia p
235 uting follow-up data found no differences in problem-solving skills across groups.
236  positively associated with the relationship problems subscale at 3 y [incidence rate ratio (IRR): 1.
237     In the modified houses, major structural problems such as leaking roofs were repaired, windows sc
238 doption has been challenged by manufacturing problems, such as compromised integrity of coated pellet
239 also allows researchers to tackle real-world problems, such as multilingualism, the role of ever-chan
240 itional voting, the principle accepts unique problems, such as panel decisions about scientific or ar
241 ), and behavior problems (defined as a Total Problem T score >/=2 SD above the mean on the Child Beha
242 lassification of Diseases and Related Health Problems, Tenth Revision [ICD-10] codes F20 to F29 and I
243 lassification of Diseases and Related Health Problems, Tenth Revision primary admission diagnoses), a
244                Malaria is a worldwide health problem that affects two-thirds of the world population.
245 te to reach a desired outcome is a difficult problem that has been studied in great detail using stea
246 rovides an easy and affordable solution to a problem that has limited resolution and brightness when
247           Chronic liver disease is a growing problem that has substantial effects on public health.
248 mate change - a quintessential intertemporal problem that implicates inequities and extrinsic mortali
249 ophication of coastal ecosystems is a global problem that often results in bottom water oxygen defici
250                                              Problems that arise during DNA replication can drive gen
251 t continue to expand the scope of scientific problems that can be accessed in the biomedical sciences
252        This methodology resolves a number of problems that have rendered ECA ineffective for biosensi
253                        Addressing the common problems that researchers encounter when designing and a
254 n (AF) and stroke are important major health problems that share common risk factors and frequently c
255 ail, elderly individuals survive with health problems, that is, costs of success.
256  to evaluate and weigh the importance of the problem, the confidence in the evidence, the certainty a
257 isk), was used to assess exposure, breathing problems, tiring easily, and acute respiratory illnesses
258 king conversations from an isolated surgical problem to a discussion about treatment alternatives and
259 exactly map the complex utility maximization problem to the classic K -means clustering problem, whic
260 y discussed, highlighting new opportunities, problems to be solved and technological advances.
261 r what it means for two ostensibly unrelated problems to be the same, and how such sameness can provi
262 nd the evident success, there are still many problems to solve, on the way to the manufacturing of bi
263      We have implemented DNNs to handle both problem transformation and algorithm adaption type multi
264 cidence of mental disorders or mental health problems, use of mental health services, and resilience.
265                      One way to resolve this problem uses the fact that fast species regulated by fas
266 resulting time-dependent resource allocation problem using constraint-based analysis.
267 es of animals appear to have solved foraging problems using a shared set of mechanisms.
268 ms was 13% (95% CI 12-14), for externalising problems was 10% (9-11), and for internalising problems
269 revalence of total behavioural and emotional problems was 13% (95% CI 12-14), for externalising probl
270 oblems was 10% (9-11), and for internalising problems was 22% (21-24).
271                              To address this problem, we developed a data-driven approach to integrat
272                              To address this problem, we developed a highly multiplexed single-cell D
273                              To solve such a problem, we developed a new method called Optimistic Pro
274                              To address this problem, we generated myeloid cell-specific Nrp1-knockou
275                             To overcome this problem, we have developed a novel Single Cell Represent
276                              To address this problem, we have developed a procedure based on informat
277                              To address this problem, we mapped the anatomy, modeled the function, an
278                                To solve this problem, we propose a method based on matrix-assisted la
279                              To address this problem, we propose a new method: Genomic Mediation anal
280                              To address this problem, we use SPR spectroscopy correlated with surface
281                              To tackle these problems, we present an interpretable and efficient web-
282 ity and any mental disorder or mental health problems were 0.06 (95% CI 0.01-0.11) for any mental dis
283 n problem to the classic K -means clustering problem, which can then be efficiently solved with linea
284  the fruit fly olfactory circuit solves this problem with a variant of a computer science algorithm (
285         Tuberculosis remains a global health problem with an enormous burden of disease, estimated at
286 th congenital heart disease is a challenging problem with substantial morbidity and mortality.
287                                          One problem with this hypothesis is that, while some hotspot
288                         A common and serious problem with this therapy is the patient's immune respon
289                       These findings suggest problems with decision-making and information integratio
290 use of its wide use, publications indicating problems with generic switches, and complaints to the US
291 ot reaction allowed us to overcome potential problems with individual steps during the synthesis.
292                                        While problems with interpretation of this standard calculatio
293 se has focused on measuring solutions to the problem, with considerably less attention paid to its gl
294 r breast cancer surgery is a well-recognized problem, with moderate to severe pain affecting 15% to 2
295              This is a nontrivial clustering problem, with neither subgroups nor subgroup-specific ne
296  apply the described workflows to food fraud problems, with an objective of identifying key markers t
297 ct solution to the Robinson-Foulds Supertree problem within a constrained search space.
298                     Osteomyelitis is a major problem worldwide and is devastating due to the potentia
299 types of cancer and represent a major health problem worldwide.
300 s reported poor social integration, economic problems, worrying about family or friends overseas, and

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