ライフサイエンスコーパス: problematic

1 entifying this characteristic as potentially problematic.

2 ake an etiologic nosologic system inherently problematic.

3 as used today in biomedicine seem especially problematic.

4 nal bedform models at various scales remains problematic.

5 Estimation of dietary sodium intake is problematic.

6 However, chemoresistant disease is still problematic.

7 ty is difficult, and published scores remain problematic.

8 en simple estimates of the burden of disease problematic.

9 ication, background DNA from WGA kits can be problematic.

10 ity, and other reporting measures, may prove problematic.

11 nto high- and low-risk groups for IC risk is problematic.

12 er CD4(+) T follicular helper (GC Tfh) cells problematic.

13 s are used for model parameterization can be problematic.

14 configurational integrity of the products is problematic.

15 overs makes the quantification of their role problematic.

16 causality from observational designs can be problematic.

17 eages, and their long-term culturing remains problematic.

18 sing these models outside of MATLAB is often problematic.

19 d N-terminal position proved to be much more problematic.

20 account with specific demographic models are problematic.

21 lity improvements in surgery are notoriously problematic.

22 of iodine status, although such use is often problematic.

23 , identifying functional dark matter remains problematic.

24 ater delta(18)O values-a process known to be problematic.

25 sing chemical or temperature perturbation is problematic.

26 by cytokine production has been particularly problematic.

27 ells to Bcl-xL-targeting strategies, remains problematic.

28 on collisions are thought to be particularly problematic.

29 se makes the study of the underlying physics problematic.

30 on of prions as infectious agents has become problematic.

31 e direct injection is not possible, has been problematic.

32 of calcium-sensitive probes in vivo remains problematic.

33 l terms to understand their influence can be problematic.

34 catter, imaging deep into a tissue volume is problematic.

35 edictions on their effect in agro-ecosystems problematic.

36 plication-transcription conflicts are highly problematic.

37 clinical use of GSK3 inhibitors potentially problematic.

38 lishing causality from observational data is problematic.

39 g in a clade as biodiverse as the insects is problematic.

40 nstant with age, but the data are scanty and problematic.

41 their stability in the presence of water is problematic.

42 in consumer products is very challenging and problematic.

43 otion and cognition; yet, such models remain problematic.

44 size three-dimensional photonic crystals are problematic.

45 ions, and drug interactions are particularly problematic.

46 nt in simultaneous intracellular recordings, problematic.

47 tion and scan tolerance were not reported as problematic.

48 art failure guidelines to the NMD population problematic.

49 Early nonadherence is especially problematic.

50 imental timelines where blood degradation is problematic.

51 Yet truly quantitative TIRF remains problematic.

52 infection (LTBI) treatment regimens has been problematic.

53 tric studies using the Nicholson approach is problematic.

54 onal GABA release, this lack of knowledge is problematic.

55 pes, but imputation of rare variants remains problematic.

56 ecently, rendered their expression profiling problematic.

57 titration or thermal gravimetric analysis is problematic.

58 dentifying primary sources of fish tissue Hg problematic.

59 r sexual risk taking, mental ill health, and problematic alcohol use (ORs of more than three to six),

60 We aimed to investigate well-being and problematic alcohol use in ayahuasca users, and ayahuasc

61 mographics, current well-being and past-year problematic alcohol use of past-year ayahuasca users and

62 speaks to the profound impact of marriage on problematic alcohol use.

63 electrochemical reaction products is clearly problematic and bears further investigation.

64 to effectively resolve MG activation can be problematic and can lead to chronic inflammation, a cond

65 coagulation factor VIII (FVIII) is the most problematic and costly complication of FVIII replacement

66 of the available pan-specific antibodies are problematic and do not provide a standard, reliable plat

67 the target price and opportunity costs were problematic and formal negotiations ended in 2002.

68 determining susceptibility to polymyxins is problematic and lengthy.

69 dult neurons, in vitro or in vivo, have been problematic and not translatable to human patients.

70 lving pacemakers, inhibition or bursting are problematic and that simplifying assumptions commonly ma

71 opose that the focus on linguistic status is problematic, and a shift to focus on the processes that

72 onal roles to myeloid cell subtypes has been problematic, and the potential for peripheral myeloid ce

73 Results show potentially problematic areas in nearshore environments, where colla

74 This is not necessarily problematic as diagnostic criteria are meant to index ra

75 r, quantifying this over-estimation has been problematic as existing methodologies introduce a series

76 This method has proved problematic as it has led investigators to conflate iron

77 This is problematic as the default assumption is that FPs origin

78 Furthermore, reaction scale up is often less problematic as this is addressed at the inception of the

79 orally neutral as toward insects or flowers, problematic as toward race or gender, or even simply ver

80 The preparation of larger iptycenes is often problematic, as a result of their limited solubility and

81 This presentation is problematic, as many data distributions can lead to the

82 One problematic aspect of this wastewater was the very high

83 ning early dinosaur evolution and highlights problematic aspects of current cladistic definitions.

84 lopment, our approach can explain previously problematic aspects of large-scale forest mortality, suc

85 h a shared commitment to alleviate ethically problematic aspects of the environments within which the

86 ut our research reveals that this apparently problematic association forms a pathway by which mutatio

87 Firestone & Scholl (F&S) rely on three problematic assumptions about the mind (modularity, refl

88 Patients with problematic asthma follow distinct illness trajectories

89 Problematic asthma patients with unfavorable long-term d

90 ectories of severe exacerbation rates among "problematic asthma" patients and develop a risk score to

91 exacerbation rates over five years for 177 "problematic asthma" patients presenting to a specialist

92 erdispersion in mutation count, resulting in problematic background rate estimation.

93 robials appeared to be effective on reducing problematic bacteria and microbiome can be utilized to i

94 A relevant example of problematic bacterial colonization within UV-inaccessibl

95 This finding is problematic because broadening the participation of unde

96 ortance in biomedicine but quantification is problematic because current methods depend on indirect m

97 This is problematic because differential growth is a crucial ele

98 anism by administration of GR antagonists is problematic because GR is essential for life.

99 , popularly known as 'reverse inference', is problematic because it does not take into account other

100 explain experiences of aesthetic pleasure is problematic because it is founded on a mechanistic Enlig

101 s of such specific organization is extremely problematic because it is frequently obstructed by rando

102 ptor (CAR) T cells to T-cell malignancies is problematic because most target antigens are shared betw

103 ng the roles of individual NSPs in humans is problematic because neutrophils are end-stage cells with

104 sis of the condition in individual humans is problematic because of (a) test reliability and (b) lack

105 Simulating such large-scale changes is problematic because of a strong hysteresis effect, which

106 tic relationships in Rosaceae have long been problematic because of frequent hybridisation, apomixis

107 ls in countries such as India is potentially problematic because of high antibiotic use, overcrowding

108 Studies in animals are problematic because of species-specific differences in h

109 iagnosis of neurocysticercosis (NCC) remains problematic because of the heterogeneity of its clinical

110 Phenotypic classification is problematic because small samples are ubiquitous; and, f

111 pted this manifestly beneficial strategy and problematic because the comparative methods of evolution

112 This seems problematic because the reaction of CH4 and water to gen

113 This is problematic because there is little support that species

114 ctions following bacteremia are particularly problematic because they can occur at any time in a prev

115 This can be problematic because toxicological characterization is la

116 cal samples containing >10(4) lymphocytes is problematic, because immune receptors comprise two polyp

117 Patient-reported outcome measures are problematic, because low response rates may cause bias.

118 Testing can be problematic, because the CLSI does not recommend the tes

119 a role in the generation or exacerbation of problematic behaviors.

120 r in drug development are widely regarded as problematic, but the failure of well-designed studies be

121 Incomplete clinician reporting, problematic case definitions, limitations of diagnostic

122 cascade reaction demonstrates that the often problematic competing C-H activation pathways in the pre

123 ectroscopy as a method for identification of problematic compounds and as a valuable aid toward revea

124 g rigid and planar electrode combined with a problematic conductive electrolyte and adhesive pad.

125 Technetium is a problematic contaminant at nuclear sites and little is k

126 Fe(II) -catalyzed oxidation accomplished the problematic conversion of indole into 2-indolinone.

127 CPS using S. pneumoniae serotype 5 (ST-5), a problematic CPS component of Prevnar13.

128 on the basis of serological tests, with the problematic cross-reacting antibodies of the Flavivirus

129 r focus on incorporation of the historically problematic cytochrome P450 mono-oxygenases.

130 the final maps with less manual work even on problematic datasets.

131 Ayahuasca users reported less problematic drinking than classic psychedelic users, alt

132 r well-being than comparison groups and less problematic drinking than classic psychedelic users.

133 users, although both groups reported greater problematic drinking than the other respondents.

134 Drinks may be indicative of greater risk for problematic drinking.

135 iable QC filter that can be used to identify problematic drug combinations matrices and prevent furth

136 f more than three to six), and strongest for problematic drug use and interpersonal and self-directed

137 ng of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses

138 uring reward anticipation at age 14 predicts problematic drug use at age 16.

139 in response to anticipated rewards predicts problematic drug use.

140 escents may increase vulnerability to future problematic drug use.

141 t analog registration of cold temperature is problematic due to impaired analog-to-digital conversion

142 Deciphering the carbohydrate alphabet is problematic due to its unique complexity among biomolecu

143 ver is one form of communication that can be problematic due to lost or omitted information.

144 scertained newly acquired phenotypes remains problematic due to low DNA recombination efficiency.

145 s have relied on PCR amplification, which is problematic due to primer design, and transcriptome sequ

146 yleigh scattering (RRS) is limited and often problematic due to the complex interplay of the fluoroph

147 this organism on a routine basis, which were problematic due to the fastidious nature of the bacteriu

148 s of myelodysplastic syndromes (MDS) remains problematic due to the subjective nature of morphologic

149 Acanthamoeba infections has been considered problematic due to the very low incidence of disease, de

150 tion of peptide array phosphorylation remain problematic, due to the absence of "housekeeping" kinase

151 ose synthesis and/or stability is apparently problematic during H(2)O(2) stress.

152 nt treatments are stage-dependent and can be problematic during the meningoencephalitic stage, where

153 the macronutrients are viewed as potentially problematic (e.g., contribute to disordered eating).

154 unders, we observed positive associations of problematic eating attitudes at age 11.5 y with new-onse

155 However, the link between problematic eating attitudes in early adolescence, which

156 Problematic eating attitudes in midchildhood seem to be

157 ontrolling for body mass index at age 6.5 y, problematic eating attitudes remained positively associa

158 EAT scores >/=85th percentile (indicative of problematic eating attitudes) compared with scores <85th

159 ggest that the utility of programs to modify problematic eating behaviors and eating patterns should

160 isite geometrically defined enamides remains problematic, especially for highly substituted and Z-ena

161 nts in these regions makes sequence assembly problematic, especially when using short-read sequencing

162 Some of these targets were problematic even without any tag; thus, the fact that al

163 munities become cohesive and why this can be problematic (even dangerous)--and in this way provides s

164 Technetium ((99)Tc) is a problematic fission product for the long-term disposal o

165 ghlighted the potential for treatment of the problematic fluoroquinolone-resistant MRSA, VRE, and S.

166 ence and evaluating impact on folding can be problematic for amyloid aggregates because a single sequ

167 t of custom scripts and pipelines, making it problematic for biomedical researchers.

168 n time for overall molecular tumbling can be problematic for biomolecules containing areas of disorde

169 ts, surgeons recognize that the model can be problematic for determining the value of an operation.

170 portance, data from an oscillatory system is problematic for existing methods of regularized supervis

171 goal of RNA-seq experiments, yet it remains problematic for genes with low expression or several iso

172 This is problematic for HCMV because clinical strains mutate rap

173 This is problematic for identifying sites of hydrophobic ligand

174 y children, the decreased sensitivity may be problematic for immunocompromised patients, in whom low

175 This is particularly problematic for lone-pair-rich, semiconducting materials

176 interest followed by complementation remains problematic for obligates and is a highly sought-after g

177 It may also be problematic for other base-sensitive reactions involving

178 tient reviews posted on online sites appears problematic for periodontal practices, the author urges

179 line media than in acidic environment may be problematic for practical application.

180 rturbs the near field, which is particularly problematic for sensitive high quality factor resonances

181 articles (1-10 nm), which are often the most problematic for the commonly used techniques such as ele

182 selectivity, which renders these approaches problematic for the purpose of fingerprinting large biol

183 preactivation, which has become particularly problematic for the study of large macromolecular protei

184 o-dynamic Therapy (PDT/SDT), hypoxia is also problematic for the treatment of solid tumours using the

185 t key functional features of bnAbs often are problematic for their elicitation in mice by classic vac

186 infections in high transmission settings is problematic for traditional genotyping approaches.

187 positive feedback mechanisms that can prove problematic for traditional probe positioning methods.

188 ausal or benign can be error prone, which is problematic for training supervised learning algorithms

189 ds carry high risks of complications and are problematic for use in clinical practice.

190 The problematic fossil taxa Halkieria and Orthrozanclus (gro

191 Problematic fossils, extinct taxa of enigmatic morpholog

192 electrolysis completely avoids generation of problematic fugitive emissions (CO2, CO and SO2), signif

193 ant number of the reported compounds contain problematic functional groups, suggesting that enzyme in

194 Carnufex bridges a problematic gap in the early evolution of pseudosuchians

195 The resulting report identifies problematic gene predictions and includes extensive stat

196 GeneValidator (GV) to automatically identify problematic gene predictions and to aid manual curation.

197 Problematic gene predictions are flagged and can be rean

198 comparisons with CCZ and DISCOL datasets are problematic given the lack of standardised methods and t

199 It is problematic given the nature of the patient-physician re

200 rgeted and potent antibiotics active against problematic Gram-negative pathogens.

201 The solution to problematic group behavior is therefore not to individua

202 Wiwaxiids are a problematic group of scale-covered lophotrochozoans know

203 include echinoderms, hemichordates and more problematic groups such as vetulicolians and vetulocysti

204 olidation provide opportunities to alleviate problematic human memories, we lack a detailed mechanist

205 63 years) with high glycemic variability and problematic hypoglycemia received intraportal islet graf

206 dolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse.

207 human subjects with histories of recurrent, problematic, impulsive aggressive behavior and in nonagg

208 s, making functional assessment of autophagy problematic in a clinical setting.

209 We find that Glaser coupling is not problematic in ARGET-ATRP of alkyne-terminated polymers

210 many successes, the case-control approach is problematic in biomedical science.

211 This increase is especially problematic in children who bear the greatest burden of

212 rug-resistant pathogens that are notoriously problematic in hospitals: Pseudomonas aeruginosa, Acinet

213 These requirements are problematic in industrial settings; currently, no scalab

214 hiolitis and pneumonia and can be especially problematic in infants and the elderly.

215 imate change, yet its reconstruction remains problematic in many regions.

216 arget effects associated with this drug were problematic in MM patients.

217 health, whereas some foliar diseases can be problematic in organic agriculture.

218 Vaccine development has been problematic in part due to the high degree of diversity

219 s with well-ordered structures, but could be problematic in small peptides because the labeling may c

220 T scan or MRI; however, these techniques are problematic in terms of sensitivity and specificity, and

221 This phenomenon is particularly problematic in the biotechnology industry, as production

222 quences in biopolymers, but this is somewhat problematic in the formation of synthetic polymers.

223 n the cobalt-catalyzed process, which can be problematic in the palladium-catalyzed counterpart.

224 of pairwise distance estimates, which can be problematic in the presence of fragmentary sequences.

225 elivery of postoperative adjuvant therapy is problematic in this disease because of the magnitude of

226 This is problematic in tropical Africa, where records of ecosyst

227 This is particularly problematic in ultrafast nanophotonics, including optica

228 ) to multiple chemistries being particularly problematic in weed control.

229 In eukaryotes, such screens have proven more problematic, in part because of the lack of a sensitive

230 ng Limited Data (MELD) that can harness such problematic information in a physics-based, Bayesian fra

231 We conclude that a significant source of problematic interpretations in photobiomodulation report

232 For these corneas, problematic issues are quantifying anterior corneal powe

233 electrolytes are considered able to inhibit problematic Li dendrites and build safe solid Li-metal b

234 , and 4-hydroxybenzoic acid (HBA), which are problematic lignocellulose-derived byproducts, on exoele

235 pproximately 1.6 V versus Li(+)/Li, avoiding problematic lithium plating at the expense of reduced ce

236 ly used analgesic known for its particularly problematic mechanical behavior under compression (i.e.

237 Problematic microfossils dominate the palaeontological r

238 gand-centric approach taken here overcomes a problematic molecular redundancy of CspC and CspE that l

239 Translation of aberrant or problematic mRNAs can cause ribosome stalling which lead

240 erspective article is to briefly explain the problematic nature of current practices and to offer a p

241 dmirably in peak picking, they also detect a problematic number of false positive EIC peaks and can a

242 protocol does not require time-consuming and problematic off-chip probe conjugation and washing.

243 t can impart treatment resistance, and cause problematic off-target effects.

244 pecies also are among the most important and problematic, opportunistic nosocomial pathogens.

245 long fragments are able to extend paths into problematic or repetitive regions.

246 units worldwide, with the potential to cause problematic outbreaks and acquire high-level resistance

247 olid catalysts cannot adequately address the problematic overpotentials when the surfaces become pass

248 agnosing coccidioidal meningitis (CM) can be problematic owing to its infrequency and/or a delay in t

249 f these results using standard techniques is problematic, owing to the practical difficulty in establ

250 an important subtype of kidney cancer with a problematic pathological classification and highly varia

251 For these problematic pests, promising approaches include using la

252 Accordingly, partial 'un-scoring' of the problematic phylogenetic characters was proposed.

253 conomic benefits of controlling densities of problematic plant species using biological control agent

254 Recent evidence places the problematic Polypodium, a parasite of fish eggs, firmly

255 For some individuals, problematic pornography use (PPU) is a reason for seekin

256 f organisms under investigation, potentially problematic probes can now be identified a priori.

257 centre that facilitate the translation of a problematic protein sequence.

258 s criticised due to its low reproducibility, problematic quantification of results, differences in re

259 sion products (99)Tc and (90)Sr are found as problematic radioactive contaminants in groundwater at n

260 and an adaptive confidence metric highlights problematic regions.

261 ith broad substrate scope, circumventing the problematic regiospecific acylation of free 2-aminoimida

262 eatening malaria in the United States, has a problematic safety profile and is often unavailable in h

263 s further shows that mQC is able to identify problematic screens whereas plate-level QC was not able

264 ic research, the digestion kinetics of these problematic sequences is not well-known.

265 population structure in these studies can be problematic since both selection and neutral demographic

266 This method is problematic, since it cannot rule out the influence of g

267 This is potentially problematic, since prior immunity to a scaffold may inhi

268 releasing the anti-inflammatory drug to the problematic site, eventually protecting against joint de

269 yping array manifest file and can detect all problematic SNPs, including SNPs with wrong RS ID and SN

270 ge of science to lend false credibility to a problematic sociocultural discourse.

271 metastases from prostate cancer, but it has problematic specificity, mainly because of tracer accumu

272 er, in settings in which renal background is problematic, strategies for reducing its kidney uptake m

273 t proteins of known structure for which such problematic structural data are available, including a s

274 vailability of research on interventions for problematic substance use in young people indicates the

275 dicated that among VL+ YMSM, those reporting problematic substance use were more likely to report CAI

276 The method allowed incorporation of problematic substrates: aminopyrazoles bearing protected

277 as improved, but some crucial aspects remain problematic, such as the absence of HRQOL research hypot

278 bs against glycan epitopes is generally more problematic than against proteins.

279 els that are both central to modern life and problematic: their use increases atmospheric levels of g

280 fusing to define religion and for relying on problematic theoretical concepts.

281 It remains particularly problematic to define the structures of native macromole

282 However, it has proven problematic to genotype STRs from high-throughput sequen

283 ressing ATP-gated P2X4 receptors have proven problematic to identify and study in brain slice prepara

284 with massive genomic instability, making it problematic to identify driver genes using human tumors

285 However, it has been problematic to test this proposal in living cells becaus

286 ical development of viral vectors expressing problematic transgenes.

287 the genomes of four cacti in the especially problematic tribe Pachycereeae, which contains most of t

288 rs having improved performance and minimizes problematic untwist during weaving nanotube yarns.

289 Repeated drug consumption may progress to problematic use by triggering neuroplastic adaptations t

290 problems, weight control practices, and the problematic use of alcohol, smoking, and illegal drugs i

291 problems, weight control practices, and the problematic use of alcohol, smoking, and illegal drugs.

292 abuse have an essential role in perpetuating problematic use, yet effective connectivity or the causa

293 equipment (WEEE) constitutes one of the most problematic waste streams worldwide, and accurately esti

294 , simple odds ratio (OR) calculations can be problematic when dealing with large numbers of subjects

295 Missing covariate data are particularly problematic when the probability that a value is missing

296 single-site measurements and cooling remain problematic, while only ensemble measurements have been

297 Klebsiella pneumoniae (CR-Kp) are especially problematic, with a 50 % average survival rate.

298 itation following hemorrhagic shock is often problematic, with development of prolonged hypotension a

299 thermal transport in Earth's core have been problematic, with predictions of high thermal conductivi

300 side hydrolases, including GCase, has proven problematic within live mammalian cells.