ライフサイエンスコーパス: processing site

1 at bound RNA motifs nearby and in the Drosha processing site.

2 coded by daaP codons 49-51 downstream of the processing site.

3 ncoded by the region of daaP upstream of the processing site.

4 1E1 also reacted with peptides spanning the processing site.

5 frame, designated daaP, which flanks the daa processing site.

6 flexibility than by the conformation of the processing site.

7 re-specific signals at the earliest possible processing site.

8 polypeptide was identified flanking the daa processing site.

9 ith a mutation near the putative proteolytic processing site.

10 ide with the Gly(-2)-Gly(-1) sequence at the processing site.

11 23K polypeptide that contained a lipoprotein processing site.

12 by a ruler mechanism anchored at the primary processing site.

13 r the protein in the SQ state of the quinone processing site.

14 phobic trough and the C-terminal proteolytic processing site.

15 laced at unique positions surrounding the 3'-processing site.

16 oteolytic cleavage of AgrD at its C-terminal processing site.

17 s in vitro at a known in vivo gamma2 gamma2' processing site.

18 and cleaves only the C-terminal proTGF-alpha processing site.

19 east genes were analyzed to find probable 3'-processing sites.

20 putative pheromone sequence bordered by Kex2 processing sites.

21 ults confirm the specificity of endoprotease-processing sites.

22 7/p1 (P2 residue Ala to Val) gag proteolytic processing sites.

23 g the possibility of sequential unfolding of processing sites.

24 unts than transcripts that were not close to processing sites.

25 he appropriate dibasic or monobasic cleavage processing sites.

26 ition a mobile loop in the vicinity of these processing sites.

27 are 3808 are unique motifs, many residing in processing sites.

28 aining nuclear bodies may be miRNA precursor processing sites.

29 een semiquinones and Ndelta in other quinone-processing sites.

30 , compared to control sets of widely used 3'-processing sites.

31 mapping G-quadruplexes in the context of RNA processing sites.

32 tudying G-quadruplexes in the context of RNA processing sites.

33 G-quadruplexes, of which 54,252 are near RNA processing sites.

34 for their apparent counter selection in RNA processing sites.

35 sive effort to study G-quadruplexes near RNA processing sites.

36 ocessing at dibasic and monobasic prohormone-processing sites.

37 rRNA processing intermediates with 5-ends at processing site A2 in the internal transcribed spacer 1

38 The mutant with both processing sites abolished had 10% of the activity of wi

39 the three terminal base pairs, including the processing site adjacent to the conserved CA.

40 is of the N terminus of VirB1* localized the processing site after amino acid 172 of VirB1.

41 phosphoserine-15 form of p53 at presumed DNA processing sites after the induction of DNA breaks.

42 the rapid transfer of experimental data to a processing site allow efficient use of the facility and

43 The conservation of TETD downward arrowG processing sites among insect effector caspases, includi

44 process the trnD transcript at the normal 3' processing site and displayed a lower level of expressio

45 cted mutations within a predicted C-terminal processing site and mutants with C-terminal deletions fu

46 ereby initial cleavage within ITS2 at the C2 processing site and termination of subsequent exonucleas

47 ccessible database that catalogs putative 3'-processing sites and 3'-UTR sequences for multiple organ

48 The processing sites and a disulfide bridge between the 18-

49 e to CTLs: a paucity of predicted proteasome processing sites and an enrichment for amino acids that

50 differential utilization of typical dibasic processing sites and atypical processing sites C-termina

51 ta support a model in which the selection of processing sites and the order of precursor processing a

52 hain lengths determined according to deduced processing sites and with relaxin-like cross-links.

53 , CPAMD8 contains a signal sequence, an RXXR processing site, and a thioester motif.

54 Endosomes are highly active APP processing sites, and endosome anomalies associated with

55 nsistent with the lack of the internal HCF-1 processing sites, and exhibits a predominantly nuclear l

56 ein, contains multiple consensus proteolytic processing sites, and functions efficiently in the assem

57 ) fusion proteins containing a natural RT/IN processing site are cleaved by the viral protease and (i

58 m nor the sequence of the mature rRNA at the processing sites are required for processing.

59 the possibility of additional ADAMTS-cleaved processing sites are unknown.

60 addition to two previously identified furin-processing sites (Arg74 downward arrow and Arg287 downwa

61 ic motif, reminiscent of furin-like protease processing sites, as the Ebo-GP cleavage site.

62 2 processes pro-Mch2alpha at three aspartate processing sites (Asp23, Asp179, and Asp193) to produce

63 ctive conformation of human proinsulin, both processing sites assume positions that are relatively fa

64 at MT6-MMP cleaves not only the known MT-MMP-processing site at Asn(66)-Leu but also the previously u

65 in the mature AGPR domain revealed a second processing site at position -20.

66 is revealed Lys(147) to be an intramolecular processing site at which cleavage is required for full a

67 unique motifs were identified in human miRNA processing sites, binding to which could inhibit miRNA m

68 duction of bioactive opioids occurred in all processing site blockade mutants examined; these results

69 Known alternative 3'-processing sites, both within the 3'-untranslated region

70 Analysis of the complete set of 3'-end-processing sites by means of a discrimination function s

71 f cleavage of mono- and paired-basic residue processing sites by YAP3p was determined in vitro for a

72 ypical dibasic processing sites and atypical processing sites C-terminal to leucine residues.

73 The lack of an apparent 3'-processing site calls into question the validity of some

74 amino acids Tyr, Met, and Leu suggests that processing sites can be placed into two groups and that

75 ll structure with the N-terminal proteolytic processing site close to the C-terminal glycosyl phospha

76 mary processing is ordered, with the primary processing site closest to the C-terminal end of MSP1 be

77 d to drive the formation of gene promoter-3' processing site contacts through the cleavage stimulatio

78 ignals, a set of 1352 unique pre-mRNA 3'-end-processing sites, corresponding to 861 different genes,

79 peptide (cox2-20) or the leader peptide and processing site (cox2-21) without altering either the pr

80 Mutations at or near the processing site did not affect protein stability or pack

81 ily members reveals two non-equivalent furin processing sites differentiated by the presence of eithe

82 defined sites is in fact required for proper processing, site-directed mutagenesis was performed to b

83 To determine whether this ORF is involved in processing, site-directed mutagenesis was used to genera

84 ate five residues from the presumed prepilin processing site eliminated this autoregulation, as did a

85 the sequence and structure changes from the processing site for both enzymes.

86 N-terminal sequencing revealed the typical processing site for cysteine proteases of the papain fam

87 uires an intact lipoprotein modification and processing site for full activity.

88 ure and specific contacts with the viral DNA processing site for inhibition by integrase inhibitors.

89 myelin basic protein, MBP(85-99)--contains a processing site for the cysteine protease asparagine end

90 HopK1 is processed in planta at the same processing site found in AvrRps4.

91 Promoters and processing sites have not been maintained in identical p

92 nslation through RNA located upstream of the processing site; however, processing did not depend on t

93 A in an unprocessed state by blocking the 5'-processing site, impeding an early step in the pathway.

94 TS) leader segment upstream from the primary processing site in 47S pre-rRNA.

95 d in the extract were cleaved at the histone processing site in a reaction which was dependent both o

96 We mapped an Mpl-dependent processing site in ActA between amino acid residues 207

97 r than peptide NF derived from the major MMP-processing site in aggrecan.

98 position -21 to +18 surrounding the natural processing site in pre-tRNA substrates.

99 The Asp-X sequence at the putative processing site in proIGIF suggests that a protease such

100 he sequences around the Kex2 endoproteolytic processing site in the expressed fusion protein can comp

101 e uncovered a novel functionally relevant PC processing site in the N-terminal part of the pro-domain

102 receding Ala38 serves as a posttranslational processing site in the PTHrP precursor, 2) to determine

103 results indicate that: 1) Arg37 is indeed a processing site in the PTHrP precursor; 2) three distinc

104 the vicinity of the KEX2-like endopeptidase processing site in the XPR2 pro-region might play a crit

105 The processing site in Vif was characterized both in vivo an

106 ted to slower cleavage at the A0, A1, and A2 processing sites in 35S pre-rRNA, delayed processing of

107 Multiple proteolytic processing sites in Glass bottom boat (Gbb), the Drosoph

108 includes the 5.8S region and its surrounding processing sites in ITS1 and ITS2.

109 sition and locations of QGRS relative to the processing sites in the pre-mRNA sequence, QGRS Mapper f

110 trained in its ability to cleave some of the processing sites in the precursor.

111 elp to explain the location of the secondary processing sites in the pro-domains of the PC family, an

112 te ore from Libby, Montana, occurred in many processing sites in the United States, including a dense

113 own to undergo ADAM17 shedding and where the processing sites included Ser/Thr residues within +/- 4

114 dicted sites with experimentally verified 3'-processing sites indicates good agreement.

115 groove two or three nucleotides from the 3'-processing site inhibited both 3'-processing and strand

116 yzes site-specific hydrolysis at an internal processing site (IPS) after a G residue that immediately

117 whereas an RKPL peptide representing the Gc processing site is cleaved at negligible levels.

118 how that an RRLL peptide representing the Gn processing site is efficiently cleaved by SKI-1 protease

119 a hexahistidine tag, we determined that the processing site is likely to be between residues D304 an

120 Interestingly, the Vif processing site is located in a domain that is highly co

121 The putative substrate binding and processing site is located on the face of the beta-helix

122 also had a promoter, but the fdxH gene had a processing site just upstream of the gene.

123 ial transcription start points or transcript processing sites located at positions -727, -545, -208,

124 presence of a dibasic protease (Kex2/furin) processing site motif 6-8 residues upstream from the LAP

125 urthermore, substitution of other classes of processing site motifs did not perturb DCG structure or

126 ed the extent to which each of the HIV-1 Gag processing sites must be cleaved by substituting the P1-

127 activity previously described for IN at the processing site near viral DNA termini.

128 cessed into at least five shorter RNAs using processing sites near known functional elements of C/D b

129 Replacement of the secondary processing site, normally refractory to PfSUB1, with a P

130 cally significant, corresponding to protease processing sites observed in vivo.

131 The amino acid sequence surrounding the processing site of AvrRpt2 and two related sequences fro

132 single point mutation at the intramembranous processing site of Notch1, Val1,744-->Gly, resemble the

133 therwise double-stranded region at the Dicer processing site of pre-let-7g.

134 in 2 also cleaved a peptide derived from the processing site of presenilin 1, albeit with poor kineti

135 rom the C-terminus, predicted from the known processing site of the Paracoccus denitrificans oxidase,

136 d that they all start at Ser(11), the normal processing site of the subunit 6 precursor.

137 The expected processing site of this alpha-zein reveals a putative mu

138 We also explored the cellular processing sites of gamma-secretase for amyloid precurso

139 relative accessibilities of multiple dibasic processing sites of PE by peptide amide hydrogen-deuteri

140 guide RNAs specifically targeting biogenesis processing sites of selected microRNAs; and we find that

141 al bodies are believed to be the storage and processing sites of several ribonucleoproteins.

142 dentifying sRNA targets in vivo and defining processing sites of the regulated transcripts.

143 that disabled one or both of the interdomain processing sites of the zymogen.

144 cated 32 to 35 nucleotides downstream of the processing site on the H4, H2b, and H3 genes.

145 ovide evidence for the existence of distinct processing sites or modifications in the extracellular d

146 a peptide representing the HTLV-I retroviral processing site P19/24 (APQVLPVMHPHG) yielded Km and kca

147 while cleavage of a peptide representing the processing site P24/15 (KTKVLVVQPK) yielded Km and kcat

148 iral DNA +1 and -1 bases, which flank the 3'-processing site, play a critical role for 3'-processing

149 n the P3 positions of the two major internal processing sites, positions 143 and 209, in the mature H

150 Site-directed mutagenesis of the normal RKRR processing site prevented cleavage.

151 d transcripts and mapped the genome-wide RNA processing sites (PSSs) in a methanogenic archaeon.

152 MTS-9 zymogen has many proprotein convertase processing sites, pulse-chase analysis, site-directed mu

153 allele that disrupts a probable proteolytic processing site required for insulin maturation.

154 that changes in the position of the primary processing site result in extended or diminished maturat

155 omoter with either proximal or distal 3'-end processing sites, resulting in the synthesis of short an

156 ficiency (rnc) or a mutation in the RNaseIII processing site (rIII) located between NUTL and the begi

157 n nutL and nutR is the presence of RNase III processing sites (rIII) located immediately promoter dis

158 erated in vitro also serves to define the PR processing site separating the p2a and p2b peptides, Asn

159 Replacing the natural processing site sequence (AHAY) with a good furin substr

160 A proper prodomain/catalytic domain processing site sequence is also required to free the ma

161 ate, Ac-RPLE-SNAV, which is identical to the processing site sequence, was cleaved at the E-S bond by

162 hose sequences were derived from the natural processing site sequences of HIV-1.

163 We found that mutating this major processing site (site 3) resulted in a form of proNGF th

164 Of these processing sites, site 3, adjacent to the N terminus of

165 yses showed that using Mn(2+) as a cofactor, processing site specificity of these substrates was also

166 so appeared to remove the P30 signal peptide processing site, suggesting a larger leader peptide than

167 splice acceptor site, and analysis of native processing sites suggests that selection of this site is

168 ition, the addition of specific neurological processing sites that correspond to each of the processe

169 of nascent transcripts cleaved at the early processing sites that generate the 20S precursor to the

170 Downstream of the processing site, the fidelity of processing decreased in

171 aining multiple introns and many alternative processing sites, they are usually processed co-transcri

172 function in regulating recognition of 3'-end processing sites through competition with the Rna15 (yea

173 uted a methionine for an alanine at a likely processing site to allow selective chemical cleavage wit

174 ologous to mouse PPT-C and contains the same processing sites to generate predicted HK-1.

175 erential rates of cleavage at the five major processing sites to give characteristic processing inter

176 the amino acid sequence upstream of the KEX processing site, to study the fidelity of processing.

177 d from mouse testicular cells to identify 3'-processing sites used at various stages of spermatogenes

178 The specific processing site was determined and used to divide the pr

179 The caspase-processing site was mapped to aspartate-135 in the centr

180 city and reduced processing at the gag NC-p1 processing site was noted.

181 Finally, determination of the processing site was shown to involve its location relati

182 ursor RNA that included the upstream poly(A) processing site was used to test the hypothesis that non

183 een the X alpha T14 3' flank and upstream 3' processing sites, we have developed a modified oocyte as

184 published reports, mutations disrupting this processing site were present in 0.88% of subjects with e

185 With some constructs, a range of processing sites were apparent and the relative proporti

186 The polypeptide sequence at the processing site, which is highly conserved, adopts a spe

187 accumulated, suggesting a post-Golgi complex processing site, while the 16.5-kDa C-terminal intermedi

188 esponding to TNF-alpha and both proTGF-alpha processing sites, while the other lacks detectable TACE

189 amma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating

190 stituting the P1-position amino acid at each processing site with Ile.

191 gate the structural properties of the 3' end processing site within the Moloney murine leukemia virus

192 lly abolished N-glycosylation or proteolytic processing sites within the NGF precursor.

193 Insertion of Dicer and Drosha RNase processing sites within the shRNA allows generation of s

194 A mutation that blocks cleavage at the MA/CA processing site (Y132I) displayed a strong transdominant

195 Mutation of the processing site yields membrane-associated intermediate-