ライフサイエンスコーパス: prochiral

1 n chains are fabricated by polymerization of prochiral 1,3,5-tris(3-bromophenyl)benzene (mTBPB) direc

2 use of 20 different substrates, including 17 prochiral 1,3-dienes and 3 acrylates, this hetero-dimeri

3 ctive asymmetric cross metathesis (ACM) of a prochiral 1,4-diene was demonstrated.

4 logy of monolayers formed upon adsorption of prochiral 1,5-substituted anthracene derivatives on high

5 is the rhodium(I)-catalyzed rearrangement of prochiral 1,6-heptadienes into [2,2,1]-cycloheptane deri

6 ion about the in-cage motions of the singlet prochiral 1-naphthoxy/1-phenylethyl radical pairs (radic

7 This alkylative desymmetrization of prochiral 2,2-disubstituted cyclopentene-1,3-dione is ca

8 (syn or anti) when prochiral radicals add to prochiral acceptors is of fundamental interest.

9 electivity in prochiral radical additions to prochiral acceptors.

10 egation at the molecular level by chiral and prochiral adsorbates on surfaces.

11 lysts for the enantioselective alkylation of prochiral aldehydes has been determined by simultaneous

12 f reaction of diethyl acetylphosphonate with prochiral aldehydes in the presence of a catalytic syste

13 lting vinylzinc reagents add to a variety of prochiral aldehydes to produce racemic (Z)-trisubstitute

14 of (Z)-trisubstituted vinylzinc reagents to prochiral aldehydes with a (-)-MIB-based catalyst has al

15 and N-bromosuccinimide efficiently converts prochiral alkenes into a readily separable 1:1 mixture o

16 ilized asymmetric hydroformylation (iAHF) of prochiral alkenes.

17 s the cyclizations of 4-allen-1-ols into one prochiral allene face.

18 hanisms involving prochiral nucleophiles and prochiral allyl fragments.

19 f enantioenriched chiral allylic amines from prochiral allylic alcohols.

20 s-coupling was investigated with substituted prochiral allylic boronates.

21 sized and evaluated for the rearrangement of prochiral allylic N-(4-methoxyphenyl)benzimidates.

22 tive rhodium-catalyzed allylic alkylation of prochiral alpha,alpha-disubstituted aldehyde enolates wi

23 ectivity, while the Pro242 residue locks the prochiral alpha-CH2, thereby leading to hydroxylation of

24 enzymatic oxidative desymmetrization of the prochiral amine substrate.

25 c gelatin and kappa-carrageenan gels and the prochiral and chiral isotopomers.

26 The adsorption orientation of these prochiral anthracene derivatives positions one of their

27 alytic asymmetric alpha-functionalization of prochiral barbituric acids, a subtype of pseudosymmetric

28 NMR spectra of mixtures of racemic mono- and prochiral bis-deuterated glycine-2-(13)C were resolved a

29 Combining the desymmetrization of a prochiral bis-hydroxymethyl group with the epimerization

30 ed heterogeneous asymmetric hydrogenation of prochiral C horizontal lineO and C horizontal lineC bond

31 -Boc aldehyde 32 and then converted into the prochiral C(16)-quaternary diol 12 via the practical Tol

32 t enable asymmetric palladium insertion into prochiral C-H bonds on a single methylene carbon center.

33 reactions often rely on desymmetrization of prochiral C-H bonds on the same achiral molecule, using

34 for the presence of two chemically identical prochiral C-H bonds represents an inherent limitation in

35 ot be accessible through desymmetrization of prochiral C-H bonds.

36 including an identification of homotopic and prochiral carbon atoms; and a bijective map relating the

37 Effective differentiation of prochiral carbon-hydrogen (C-H) bonds on a single methyl

38 cycle shuttling between different sides of a prochiral center, creating point chirality in the vicini

39 In reactions at a prochiral center, modest diastereoselectivities were obs

40 s within molecules that are removed from the prochiral centers by long distances presents special cha

41 mbined with simultaneous desymmetrization of prochiral cyclic anhydrides (1).

42 ved primary amine organocatalyst, a range of prochiral cyclohexanone derivatives possessing an alpha,

43 tween N-phenacylbenzothiazolium bromides and prochiral cyclopentene-1,3-diones.

44 propylcarboxaldehydes from readily available prochiral cyclopropenes.

45 to direct the addition of thiophenolate to a prochiral dichloropyrimidine by a tandem desymmetrizatio

46 se the first catalytic desymmetrization of a prochiral dienoic acid by enantioselective bromolactoniz

47 highly functionalized scaffolds containing a prochiral dienone system, a quaternary carbon center con

48 The desymmetrization of prochiral diesters with a chiral phosphoric acid catalys

49 The pendant, prochiral difluoride groups R-N=(O=)SF2 , in turn, offer

50 ctive enzymatic desymmetrization reaction of prochiral diol 12 using a commercially available Pseudom

51 In some cases, a prochiral directing group is not required and the first

52 ric induction are achieved from a mixture of prochiral (E)- and (Z)-enolates, which provides an excit

53 luated as catalysts for the rearrangement of prochiral (E)-allylic trichloroacetimidate 19 (eq 2) and

54 y trapping the lithiated intermediate with a prochiral electrophile (e.g., pivaldehyde or tBuPCl(2)).

55 enolate resulting from Michael addition with prochiral electrophiles, such as aldehydes or N-sulfonyl

56 ium-catalyzed allylic alkylation reaction of prochiral enolates to form an all-carbon quaternary ster

57 = 1-alkylimidazole, pyridine, PMe3, arene is prochiral) exist as a dynamic equilibrium of coordinatio

58 The ACs in this site have the same prochiral face protected by the protein, and this protec

59 at the energetic preference toward the alpha prochiral face stems from reduced skeletal distortions o

60 s compared to that in the corresponding beta prochiral face.

61 ement, which is selective with regard to the prochiral faces of the intermediate enolate.

62 Alkenes are the most ubiquitous prochiral functional groups--those that can be converted

63 The chemical shifts of the prochiral hydrogens of authentic (3R)-beta-phenylalanine

64 Enantioselective reductions of two prochiral ketones have been carried out using the origin

65 that purpose a series of racemic amines and prochiral ketones have been synthesized from commerciall

66 s used as catalysts for the hydrogenation of prochiral ketones in water at room temperature and 4 bar

67 Catalytic asymmetric reduction of prochiral ketones of type 4-alkylidene cyclohexanone wit

68 ymmetric reduction of phenyl ring-containing prochiral ketones to yield the corresponding optically a

69 shown to be applicable to a wide variety of prochiral ketones.

70 allows stereocontrol in the self-assembly of prochiral ligand scaffolds.

71 ere the generalized order parameters of both prochiral methyl groups were determined, the pro-R methy

72 tion into the C(sp(3))-H bonds of one of the prochiral methyl groups.

73 reaction of o-sulfinylbenzyl carbanions with prochiral Michael acceptors, such as differently sized c

74 r spectrum corresponds to that of an average prochiral molecule and may exhibit enantiotopic sites.

75 reveal enantiotopic discrimination in guest prochiral molecules are also described and compared with

76 nantiomers, of enantiomeric mixtures, and of prochiral molecules on chiral and achiral model surfaces

77 terms of adsorption-induced chirality in the prochiral molecules on the silver nanoparticles.

78 ectra originating from enantiotopic sites in prochiral molecules when dissolved in chiral solvents is

79 The chemisorption of prochiral molecules, such as adenine, on a metal surface

80 bond formation between a benzyl group and a prochiral nucleophile to generate a quaternary center.

81 of the asymmetric Tsuji allylation involving prochiral nucleophiles and nonprochiral allyl fragments,

82 hed allylation reaction mechanisms involving prochiral nucleophiles and prochiral allyl fragments.

83 ion has been demonstrated with azlactones as prochiral nucleophiles in the presence of chiral bisphos

84 conducting diastereoselective reactions with prochiral nucleophiles in the presence of metallacyclic

85 benzylic alkylation with 3-aryl oxindoles as prochiral nucleophiles.

86 catalytic enantioselective hydrogenation of prochiral olefins is a key reaction in asymmetric synthe

87 In this scenario, both faces of the prochiral oxocarbenium ion are subject to nucleophilic a

88 approaches to enantioselective additions to prochiral oxocarbenium ions.

89 of intermediates containing vinylgold(I) and prochiral oxocarbenium moieties.

90 l to their preparation was conversion of the prochiral parent bisphosphonic acids to the P,C-dimorpho

91 iral PCB metabolites are formed from axially prochiral PCB congeners, a fact that should be considere

92 owever, the formation of chiral OH-PCBs from prochiral PCBs has not been demonstrated experimentally.

93 ditionally, the oxidation of certain axially prochiral PCBs, such as 2,2',4,6'-tetrachlorobiphenyl (P

94 A concise preparation of the prochiral pentacyclic core of (+)-salvileucalin B is pre

95 ties that can be used to identify one of the prochiral phosphate oxygens as a critical site for compl

96 y to probe for interactions to either of the prochiral phosphate oxygens as illustrated by their use

97 ologs containing deuterium at C-6 or the two prochiral positions at C-7.

98 The two prochiral primary alcohols in diol 17 were differentiate

99 e, the allylic rearrangement of both E and Z prochiral primary allylic N-(4-methoxyphenyl)benzimidate

100 C-N bond formation and desymmetrization of a prochiral quaternary center are independently controlled

101 ary to achieve high levels of selectivity in prochiral radical additions to prochiral acceptors.

102 mpact on the levels of stereoinduction, as a prochiral radical intermediate is planar, with two ident

103 stereochemical preference (syn or anti) when prochiral radicals add to prochiral acceptors is of fund

104 ween stereochemical states and find that the prochiral reagent can sample several complexation geomet

105 uctures of complexes formed between adsorbed prochiral reagents and chiral molecules yield informatio

106 ctive lipase-catalyzed acrylation along with prochiral selection of 4-C-hydroxymethyl-1,2-O-isopropyl

107 genic centers are created by functionalizing prochiral sites under thermodynamic control, and remote

108 The assignment of the prochiral sites was derived from chiral analogues.

109 , thereby converting these readily available prochiral starting materials into highly enantiomericall

110 Oxidation of the prochiral substrate cumene by CYP4B1, but not CYP2B1 or

111 c, coplanar conformation with respect to the prochiral substrate, and reaction occurs preferentially

112 Prochiral substrates may undergo diastereoselective hydr

113 ther generating new stereogenic centres from prochiral substrates or resolving racemic mixtures of en

114 Our data suggest that for prochiral substrates, the step that determines the enant

115 lectivity in the asymmetric sulfoxidation of prochiral thioethers.

116 metathesis (ARCM) of a challenging class of prochiral trienes has also been achieved.

117 ve synthesis of branched allylic esters from prochiral (Z)-2-alkene-1-ols has been developed.

118 )2' allylic substitution of acetic acid with prochiral (Z)-allylic trichloroacetimidate 23.