ライフサイエンスコーパス: prodigiosin

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1 39006 produces the red-pigmented antibiotic prodigiosin.

2 -2-em-3-carboxylic acid and the red pigment, prodigiosin.

3 lved in the biosynthesis of the red pigment, prodigiosin.

4 S. marcescens expresses prodigiosin, a bright red and cell-associated pigment wh

5 In exhibiting this capability, prodigiosin and its analogue provide lead compounds to r

6 Prodigiosin and its structural analogue (compound R) ind

7 f mutant p53/p73 interaction was specific to prodigiosin and not related to mTOR inhibition.

8 Other possible functions for prodigiosin as a mediator of cell death at population st

9 Finally, we describe a new prodigiosin-based bioassay for detection of some N-acyl

10 xpression of the pig cluster responsible for prodigiosin biosynthesis in two Serratia sp. In this art

11 Regulation of prodigiosin biosynthesis involves a complex hierarchy, w

12 ating, for the first time, that the complete prodigiosin biosynthetic gene cluster had been cloned an

13 Mutations in pigS reduced production of prodigiosin by decreasing the transcription of the biosy

14 here a kinetic model relating cell, ATP, and prodigiosin concentration changes for S. marcescens duri

15 e accompanied by large decreases in cellular prodigiosin concentration; low growth rates were associa

16 er suggesting a negative regulatory role for prodigiosin in cell and energy production under aerobic

17 Moreover, prodigiosin increased levels of the transcription factor

18 Mechanistic studies revealed that prodigiosin increased the levels of p73 and reduced leve

19 Consistently, prodigiosin induced activation of a p53-responsive lucif

20 Prodigiosin induced the expression of p73 and disrupted

21 [Aldefluor(+)] CRCSCs in vitro Furthermore, prodigiosin inhibited the growth of xenograft tumors ini

22 Prodigiosin is one of the most potent anion transporters

23 kdown or DeltaNp73 overexpression suppressed prodigiosin-mediated inhibition of colonosphere formatio

24 c-Jun knockdown attenuated prodigiosin-mediated p53-reporter activation, DeltaNp73

25 ical activity is distinct from other related prodigiosin natural and unnatural products and is even m

26 PigS-mediated control of prodigiosin occurred via binding directly to a short inv

27 squid pen powder (SPP)-containing medium on prodigiosin (PG) production by Serratia marcescens TKU01

28 zes several secondary metabolites, including prodigiosin (Pig) and a carbapenem antibiotic (Car).

29 The strain ATCC39006 makes the red pigment, prodigiosin (Pig), and the beta-lactam antibiotic carbap

30 3-carboxylic acid (Car) and the red pigment, prodigiosin (Pig).

31 beta-lactam) and a red pigmented antibiotic, prodigiosin (Pig; a tripyrrole), which are controlled by

32 ndary metabolites, carbapenem antibiotic and prodigiosin pigment, is under pheromone-mediated transcr

33 3 activation, on CRCSCs in vitro and in vivo Prodigiosin prevented colonosphere formation independent

34 tic pathway of the red-pigmented antibiotic, prodigiosin, produced by Serratia sp. is known to involv

35 onal regulator of multiple genes involved in prodigiosin production.

36 etermined their importance in the control of prodigiosin production.

37 P) was shown to be equivalent to the rate of prodigiosin production.

38 (PKSs) found in the biosynthetic pathways of prodigiosin, pyoluteorin, mycosubtilin, nikkomycin, ente

39 e natural products, metacycloprodigiosin and prodigiosin R1.

40 f the literature, these results suggest that prodigiosin reduces ATP production by a process termed e

41 Prodigiosin restored p53 signaling in cancer cells harbo

42 this study, we report the identification of prodigiosin that can reactivate p53 family-dependent tra

43 Prodigiosin was induced most strongly during limited gro

44 vestigated the effects of the small-molecule prodigiosin, which restores the p53 pathway in tumor cel

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