ライフサイエンスコーパス: prodromal

1 s ability to detect treatment effect in aMCI/prodromal AD (pAD) clinical trial populations.

2 prospectively enrich a study population with prodromal AD (PDAD) defined by cerebrospinal fluid (CSF)

3 c patients with a positive amyloid scan have prodromal AD and a poor prognosis for dementia within 3

4 ever, the status of this receptor in mild or prodromal AD has remained the subject of controversy.

5 pal gyrus, and precuneus) in highly educated prodromal AD patients but not in poorly educated prodrom

6 C partly overlapped those of highly educated prodromal AD patients but were less extended.

7 resent findings suggest that highly educated prodromal AD patients can cope better with the disease t

8 compared between highly and poorly educated prodromal AD patients in both directions to identify reg

9 e severe hypometabolism than poorly educated prodromal AD patients in the left inferior and middle te

10 Highly educated prodromal AD patients showed more severe hypometabolism

11 poorly educated subgroup (42 controls and 36 prodromal AD patients) and a highly educated subgroup (4

12 highly educated subgroup (48 controls and 28 prodromal AD patients).

13 romal AD patients but not in poorly educated prodromal AD patients.

14 However, during the preclinical or prodromal AD stages (i.e. in amyloid positive controls,

15 n interregional correlation analysis in each prodromal AD subgroup to explore metabolic connectivity.

16 rimination tasks related to the diagnosis of prodromal AD than did standard clinical reconstruction p

17 heimer's disease (AD) and may be a marker of prodromal AD that can be used to identify individuals wi

18 CSF samples, including 309 with AD, 287 with prodromal AD, 399 with stable mild cognitive impairment,

19 erlying neuropathological changes, including prodromal AD, and may be a potentially useful clinical m

20 he observations of neuronal hyperactivity in prodromal AD, we propose that this APOE4-driven hyperact

21 irment (MCI), a condition that may represent prodromal AD.

22 ical stage which in most subjects represents prodromal AD.

23 ta imaging facilitates accurate detection of prodromal AD.

24 Prominent subtypes included prodromal Alzheimer disease (8.2%) and cerebrovascular d

25 selection of individuals at preclinical and prodromal Alzheimer disease (AD) will depend on the prac

26 ve reserve) in highly educated patients with prodromal Alzheimer disease (AD).

27 tia annually, whereas those with subtypes of prodromal Alzheimer disease and stroke progressed at ann

28 changes in the brain regions associated with prodromal Alzheimer disease.

29 rimination tasks related to the diagnosis of prodromal Alzheimer's disease (AD) was compared with the

30 with Alzheimer's disease were classified as prodromal Alzheimer's disease (n = 38) and Alzheimer's d

31 available biomarkers to classify subjects as prodromal Alzheimer's disease according to International

32 t studies have explored ASL MRI in early and prodromal Alzheimer's disease and have reported areas of

33 n of disease-specific language impairment in prodromal Alzheimer's disease could enhance clinicians'

34 d group or the International Working Group-2 prodromal Alzheimer's disease group could be considered.

35 subtle brain changes can be detected during prodromal Alzheimer's disease stages.

36 magnetic resonance imaging) in patients with prodromal Alzheimer's disease via spatial correlations i

37 The trial enrolled individuals with prodromal Alzheimer's disease, defined according to the

38 was 50% compared to 21% for subjects without prodromal Alzheimer's disease.

39 ing Group-1 criteria, 850 (53%) subjects had prodromal Alzheimer's disease.

40 impairment, which is often considered to be prodromal Alzheimer's disease.

41 on the NTB primary endpoint over 2 years in prodromal Alzheimer's disease.

42 al volume in late-life depression are due to prodromal Alzheimer's disease.

43 Connect on cognition and related measures in prodromal Alzheimer's disease.

44 of the earliest in vivo imaging evidence of prodromal Alzheimer's disease.

45 r how these same nuclei appear vulnerable in prodromal Alzheimer's disease.

46 on for the treatment of mild to moderate and prodromal Alzheimer's disease.

47 was 61% compared to 22% for subjects without prodromal Alzheimer's disease.

48 ing Group-2 criteria, 308 (40%) subjects had prodromal Alzheimer's disease.

49 This study describes prodromal and AMI symptoms in women.

50 oted increased regional CBF of patients with prodromal and early stage clinical Alzheimer's disease,

51 esting the preservation of nAChRs during the prodromal and early stages of AD.

52 d that the GRK abnormality in vivo occurs at prodromal and early stages of AD.

53 data support the use of diazepam in treating prodromal and early warning signs of symptom exacerbatio

54 , focusing on these issues in the context of prodromal and early-stage Parkinson's disease.

55 roved by about 100% during treatment in both prodromal and first-episode patients, changes that achie

56 aging helps detect functional changes in the prodromal and more advanced stages of AD and is a marker

57 Microglial activation appears at the prodromal and possibly at the preclinical stage of Alzhe

58 w trials are indeed evaluating treatments at prodromal and preclinical stages.

59 Prior substance use and ages at onset of prodromal and psychotic symptoms were determined by stan

60 e associated with an earlier age at onset of prodromal and psychotic symptoms.

61 ectivity in cognitively normal, preclinical, prodromal, and AD dementia individuals.

62 Such prodromal astrocyte dysfunctions may represent novel the

63 and depressive disorder onset may involve a prodromal buildup of symptoms.

64 Because high pulsatility could represent prodromal cerebrovascular changes that damage the brain

65 Such prodromal changes in astrocytes may represent novel ther

66 Recognition of these prodromal changes may be important in future management

67 scent male patient originally presented to a prodromal clinical research program with severe obsessiv

68 s, may represent a paraviral exanthem with a prodromal coryzal phase, sudden eruption of fairly monom

69 he lifespan is integral to understanding the prodromal course of many neuropsychiatric illnesses and

70 ence of DNH on high-field SWI could identify prodromal degenerative parkinsonism in iRBD.

71 except tau were elevated in individuals with prodromal dementia, while none except Abeta were elevate

72 dementing process and may be associated with prodromal dementia.

73 l patients had pleocytosis, and 3 had severe prodromal diarrhea of unknown etiology.

74 ndings are in accordance with a hypothesized prodromal disease phase spanning 10 to 20 years.

75 patients contributed tissues obtained in the prodromal disease phase, whereas 18 Parkinson disease pa

76 in their sleep quality resembling signs of a prodromal disease stage.

77 bserved that sustained GH expression reduced prodromal disease symptoms and eliminated progression to

78 e, motor, and psychiatric changes (so-called prodromal disease).

79 rium may, in some cases, represent early or 'prodromal' DLB.

80 ore feature of schizophrenia that is seen in prodromal, drug-naive, and chronic schizophrenic patient

81 ere excluded, indicating that this was not a prodromal effect.

82 rs following conscription to reduce possible prodromal effects of schizophrenia on smoking.

83 ikely than the TAU psychiatrists to identify prodromal episodes before patients met objective relapse

84 stic performance, disability/impairment, and prodromal factors.

85 ical visual orienting may represent an early prodromal feature of an ASD, and abnormal functional spe

86 sults suggest that depressive symptoms are a prodromal feature of dementia or that the 2 share common

87 The prodromal features had converted to schizophrenic psycho

88 These mice developed all the prodromal features of type 2 diabetes but, despite the c

89 All had a prodromal febrile illness preceding neurological symptom

90 Although the prodromal females had smaller intracranial volume measur

91 F CXCL13 was associated with the presence of prodromal fever or headache (P = .01), limited response

92 trol in individuals deemed to be potentially prodromal for psychotic illness.

93 Agreement in differentiating prodromal from nonprodromal patients was 93%.

94 This pathway might be involved in the prodromal gastric dysmotility observed in patients with

95 Performance of the three prodromal HD groups was characterised by insidious and s

96 longitudinal studies of cognitive decline in prodromal HD have not stratified samples based on diseas

97 This work identifies a specific prodromal HD phenotype associated with a prominent and p

98 ate that clinical trials may be conducted in prodromal HD using the outcome measures and methods spec

99 hed and clinically relevant endophenotype of prodromal HD.

100 In severe cases, the painful prodromal hemorrhagic colitis is complicated by potentia

101 Four prodromal high-risk adolescents and six first-episode pa

102 In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in m

103 feasibility of preventive clinical trials in prodromal Huntington disease (HD).

104 Prodromal Huntington's disease (prHD) is associated with

105 Cognitive, motor and psychiatric changes in prodromal Huntington's disease have nurtured the emergen

106 isted of gene-negative controls (n = 16) and prodromal Huntington's disease individuals (n = 48) with

107 xpanded but not yet manifesting the disease (prodromal Huntington's disease) are compared with subjec

108 l magnetic resonance imaging connectivity in prodromal Huntington's disease, despite the spectrum of

109 function (Stroop Test, Trail Making Test) in prodromal Huntington's disease, which instead were relat

110 al reorganization of whole-brain networks in prodromal Huntington's disease.

111 l magnetic resonance imaging connectivity in prodromal Huntington's disease.

112 This patient had a prolonged nonspecific prodromal illness before developing respiratory symptoms

113 onal anthrax is difficult during nonspecific prodromal illness.

114 ikely to be related to regional variation in prodromal illnesses.

115 Both patients had nonspecific prodromal illnesses.

116 measurements of sleep and cAMP/PKA could be prodromal indicators of disease, and serve as therapeuti

117 of neutrophils (PMN), as may occur during a prodromal infection, is an important trigger for mobiliz

118 It evolves through 4 phases: prodromal, initial, established, and resolving.

119 ommended in human STEC infections during the prodromal intestinal phase, and the toxicity of polymyxi

120 The prodromal males had significantly smaller intracranial v

121 efine a subtype of depression representing a prodromal manifestation of Alzheimer disease.

122 motor enactment of dreams and is a potential prodromal marker of Parkinson's disease (PD).

123 ehavior in preadolescent children and may be prodromal markers of risk for dysphoria.

124 acute (mean, 7.3+/-4.8; range, 0 to 29) than prodromal (mean, 5.71+/-4.36; range, 0 to 25) symptoms.

125 established DLB and AD, as well as in their prodromal, mild cognitive impairment (MCI) phases.

126 nd entorhinal cortex was only observed among prodromal (mildly amnestic) individuals.

127 Our HD OVT73 sheep are a prodromal model and exhibit minimal pathology and no det

128 Using the McSweeney Acute and Prodromal Myocardial Infarction Symptom Survey, we surve

129 approach was applied to assess patients with prodromal (n = 28) and mild (n = 7) AD.

130 Firstly, operational criteria now exist for prodromal or at risk mental states which predict transit

131 In patients with prodromal or mild AD, one year of monthly intravenous in

132 the model can also identify individuals with prodromal or preclinical Parkinson's disease in prospect

133 ounter minor depressive disorder either as a prodromal or residual phase of illness in major depressi

134 chosis symptoms (ie, no longer qualifying as prodromal) or clinical judgment that the reported sympto

135 Prodromal pain was significantly associated with higher

136 time of blood sampling, having a history of prodromal pain, or the extent of acute pain.

137 ence was seen in the positivity rate between prodromal Parkinson disease patients and controls when u

138 uclein positivity was seen in 22 of 39 (56%) prodromal Parkinson disease subjects and 30 of 67 (45%)

139 tructural imaging biomarkers associated with prodromal Parkinson's disease dementia may allow for the

140 One such manifestation of prodromal Parkinson's disease is rapid eye movement (REM

141 disease', 'Stress and Parkinson's disease', 'Prodromal Parkinson's disease', 'Non motor symptoms and

142 potentially provides a cognitive marker of 'prodromal' Parkinson's disease that might be useful in t

143 Prodromal participants from PREDICT-HD were stratified b

144 ed to schizophrenic psychosis for 46% of the prodromal patients at 6 months and for 54% at 12 months.

145 mine whether antipsychotic drug treatment of prodromal patients can delay or prevent onset or attenua

146 notype, which might reflect vulnerability of prodromal patients to substance abuse.

147 udies in differential diagnosis, identifying prodromal patients, and the evaluation of treatment effe

148 lls, and refined animal models to argue that prodromal PD can be defined as a disease of impaired int

149 dopamine transporter density consistent with prodromal PD.

150 tive dysfunction can be considered a sign of prodromal PD.

151 llectively, we have created a mouse model of prodromal PD.

152 re investigations into treatment targets for prodromal PD.

153 k of TBI was greater in PD patients in their prodromal period across all age and sex groups, with HRs

154 mine the time-to-TBI in PD patients in their prodromal period compared to population-based controls.

155 sociation between PD and a recent TBI in the prodromal period of PD.

156 sible that the risk of TBI is greater in the prodromal period of PD.

157 ington's disease mutation, starting from the prodromal period prior to motor diagnosis.

158 compared time-to-TBI in PD patients in their prodromal period to controls.

159 a placebo when they first met criteria for a prodromal period.

160 ore likely to receive antibiotics during the prodromal phase (64% vs. 13%; P < 0.001), multidrug regi

161 There has been much interest in the prodromal phase and the possibility of preventing SZ by

162 sible to identify Parkinson's disease in its prodromal phase and to promote neuroprotective intervent

163 The concept of a long, intermediary, prodromal phase between the first appearance of amyloid

164 There is a long prodromal phase between the formation of protein aggrega

165 of frank psychosis is usually preceded by a prodromal phase characterized by attenuated psychotic sy

166 t risk for Parkinson disease (PD) during the prodromal phase could clarify disease mechanisms and all

167 Aborting the acute painful episode at the prodromal phase could potentially prevent or minimize ti

168 established and suggests the existence of a prodromal phase for the disease.

169 otic or anthrax antiserum therapy during the prodromal phase is associated with markedly improved sur

170 n increase in depressive symptoms during the prodromal phase of AD.

171 urements to determine whether persons in the prodromal phase of Alzheimer's disease (AD) could be acc

172 avioural symptoms in the mildly symptomatic, prodromal phase of autosomal dominant Alzheimer's diseas

173 antibiotics or anthrax antiserum during the prodromal phase of disease, multidrug antibiotic regimen

174 siologic events operate in unison during the prodromal phase of the crisis: vaso-occlusion, inflammat

175 ased antipsychotic medication use during the prodromal phase reduced relapse and rehospitalization ra

176 C4 depletion started at prodromal phase, and C4 was lowest after the maximum sev

177 hology of AD may affect the brain during its prodromal phase.

178 ssues from Parkinson disease patients in the prodromal phase.

179 However, the long biochemical and cellular prodromal phases of the disease suggest that dementia is

180 pe 2 diabetes are both characterized by long prodromal phases, challenging the study of potential ris

181 During treatment, the mean score for prodromal positive symptoms improved more in the olanzap

182 ophrenia was correlated with the severity of prodromal psychopathologic and neuropsychological impair

183 e onset of schizophrenia in individuals with prodromal psychotic symptoms, is predominantly localized

184 associated with longer duration of untreated prodromal psychotic symptoms.

185 uals 12-35 years old who meet criteria for a prodromal risk syndrome convert to psychosis within 2 ye

186 atter loss has been observed in patients and prodromal samples.

187 The average prodromal score, symptom weighted by frequency and inten

188 After controlling for risk factors, prodromal scores accounted for 33.2% of acute symptomato

189 A prodromal stage characterized by psychiatric disturbance

190 Because mild cognitive impairment (MCI) is a prodromal stage for dementia, we sought to evaluate whet

191 n in language integrity, detectable from the prodromal stage in a subset of patients with Alzheimer's

192 Early assessment at the preclinical or prodromal stage is in a great demand since treatment aft

193 ith AD and mild cognitive impairment (MCI, a prodromal stage of AD) with a meta-analytical technique.

194 lend support to the hypothesis that MCI is a prodromal stage of AD.

195 irment who are at-risk for or already in the prodromal stage of Alzheimer's disease.

196 at the semantic variant can be preceded by a prodromal stage of focal left anterior temporal atrophy

197 histories from normal cognition through the prodromal stage of mild cognitive impairment (MCI) to cl

198 der, and constipation may develop during the prodromal stage of PD and precede PD diagnosis by years.

199 n PD, with mild cognitive impairment being a prodromal stage of PD with dementia (PDD).

200 lation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies.

201 he symptoms that accompany migraine from the prodromal stage through the headache phase suggest that

202 oups compared to controls, especially at the prodromal stage, involving the temporo-parietal cortex.

203 cortices (FC) as a biomarker for AD and its prodromal stage, mild cognitive impairment (MCI).

204 from the identification of biomarkers at the prodromal stage.

205 subtle abnormalities may be apparent in the prodromal stages of AD and in subjects who carry suscept

206 changes in language were evident during the prodromal stages of Alzheimer's disease, with two-thirds

207 hat can be used to identify pre-clinical and prodromal stages of disease in addition to fully symptom

208 ture T1D risk can only be identified at late prodromal stages of disease indicated by markers such as

209 hese regions may be affected earliest during prodromal stages of FAD, while cortical atrophy may occu

210 hich tau induces neuronal dysfunction during prodromal stages of tauopathy and define tau-driven path

211 g and affects neuronal function during early prodromal stages of tauopathy remains unclear.

212 are of great interest for understanding the prodromal stages of the disease process.

213 n) dimensions in Alzheimer's disease and its prodromal stages.

214 n in those with mild cognitive impairment, a prodromal state for Alzheimer's disease, and dementia.

215 Postpartum blues (PPB) is often a prodromal state for postpartum depression (PPD), with se

216 d of detecting Alzheimer disease (AD) in its prodromal state is needed for patient stratification in

217 ted clinical progression to psychosis from a prodromal state.

218 the impact of cognitive-behaviour therapy on prodromal states, acute schizophrenia, negative symptoms

219 prevent transition to psychosis in high-risk prodromal states.

220 s moving toward prevention strategies during prodromal states.

221 ere significantly correlated with concurrent prodromal symptom severity (r = 0.27, P < 3.6 x 10(-8),

222 Olfactory deficits are a common (often prodromal) symptom of neurodegenerative or psychiatric d

223 viduals with either familial risk factors or prodromal symptomatology.

224 total score of more than 20 on the Scale of Prodromal Symptoms (SOPS), and had an interest in partic

225 Interview for DSM-IV Personality Disorders), prodromal symptoms (Structured Interview for Prodromal S

226 isperidone was evaluated in adolescents with prodromal symptoms and a family history of schizophrenia

227 rds increased stress sensitivity, leading to prodromal symptoms and eventually psychosis.

228 h the story of an oncologist, we discuss the prodromal symptoms and signs leading to burnout and comp

229 infarction to explore their experiences with prodromal symptoms and their decision-making process to

230 It remains unknown whether prodromal symptoms are predictive of future events.

231 Movement abnormalities were correlated with prodromal symptoms at each time period, and for several

232 Data remain sparse on women's prodromal symptoms before acute myocardial infarction (A

233 Most women have prodromal symptoms before AMI.

234 Olanzapine was efficacious for positive prodromal symptoms but induced weight gain.

235 cluded 256 individuals meeting the Scale for Prodromal Symptoms criteria and 141 control subjects, al

236 re associated with ALS risk and may serve as prodromal symptoms decades before ALS diagnosis.

237 Women with more prodromal symptoms experienced more acute symptoms.

238 The most frequent prodromal symptoms experienced more than 1 month before

239 However, these prodromal symptoms have not been consistently associated

240 disorders (ASD); however, it is not clear if prodromal symptoms in this area are already present in t

241 Prodromal symptoms included fever, hematuria, and flank

242 ude the possibility of misdiagnosis bias, if prodromal symptoms of AMI were mistaken for respiratory-

243 Prodromal symptoms of ASD at 6 months include a diminish

244 , apathy and anxiety are risk factors for or prodromal symptoms of incipient Alzheimer's disease.

245 The PRP was effective in detecting prodromal symptoms of relapse early in an episode.

246 )F-dopa uptake was elevated in patients with prodromal symptoms of schizophrenia (effect size, 0.75)

247 Individuals experiencing prodromal symptoms of schizophrenia (ultra-high-risk gro

248 striatal (18)F-dopa uptake in patients with prodromal symptoms of schizophrenia was correlated with

249 Twenty-four patients having prodromal symptoms of schizophrenia were compared with 7

250 ognitive impairment seen in individuals with prodromal symptoms of schizophrenia.

251 ychosis and reducing symptoms in people with prodromal symptoms of schizophrenia.

252 ventions, such as D-serine, for treatment of prodromal symptoms of schizophrenia.

253 Prodromal symptoms often occurred many years before the

254 years; P < .001), presented more often with prodromal symptoms or active infection (33% vs 13%; P =

255 Patients with prodromal symptoms or moderate or severe pain at present

256 that depression could be one of the earliest prodromal symptoms or risk factors associated with the p

257 tin-associated protein-like 2 (CASPR2)], the prodromal symptoms or types of presentations often sugge

258 he conversion-to-psychosis rate and Scale of Prodromal Symptoms scores.

259 themes characterized their experiences: (1) prodromal symptoms varied substantially in both nature a

260 fects were observed when onset of illness or prodromal symptoms was the outcome.

261 on of psychoeducation, active monitoring for prodromal symptoms with clinical intervention when such

262 prodromal symptoms (Structured Interview for Prodromal Symptoms), and movement abnormalities (Dyskine

263 .e., recognition and early intervention with prodromal symptoms), communication enhancement training,

264 Advancing age, prodromal symptoms, and acute pain severity at presentat

265 ocumentation of heart disease or experienced prodromal symptoms, and two had previously completed thr

266 ounced in subjects with briefer durations of prodromal symptoms, contributing factors may predominant

267 to antidepressant medication, recognition of prodromal symptoms, monitoring of symptoms, and developm

268 ain activities, promptly evaluating possible prodromal symptoms, training fitness personnel for emerg

269 escribing people presenting with potentially prodromal symptoms.

270 may hasten the onset of psychotic as well as prodromal symptoms.

271 an age, 66+/-12), with 95% (n=489) reporting prodromal symptoms.

272 Because RBD is a prodromal syndrome of Parkinson disease (or related diso

273 luation because of a suspected schizophrenia prodromal syndrome.

274 hose with low total Structured Interview for Prodromal Syndromes scores.

275 ic prodrome and the Structured Interview for Prodromal Syndromes showed promising interrater reliabil

276 h risk based on the Structured Interview for Prodromal Syndromes, 176 had at least one follow-up asse

277 psychosis using the Structured Interview for Prodromal Syndromes, and for attention-deficit/hyperacti

278 atients with schizophrenia and patients with prodromal syndromes.

279 s when based on the Structured Interview for Prodromal Syndromes.

280 arkinson disease subjects and 30 of 67 (45%) prodromal tissue blocks.

281 Prodromal tissues were obtained on average 7.0 years pri

282 regulation in childhood may be understood as prodromal to adult psychopathology.

283 brain injury, implying that vasculopathy is prodromal to most forms of brain injury in hemoglobin SS

284 such as gastroparesis and constipation, are prodromal to the cardinal motor symptoms of the disease.

285 ical and mechanistic findings supporting the prodromal value of RBD for PD, incorporating clinical an

286 y of active drug supplementation at the time prodromal worsening of psychotic symptoms was first obse