ライフサイエンスコーパス: productively

1 ssive motors are predicted to cooperate more productively.

2 nsitions that allow them to continue folding productively.

3 to abstract subject matter, and combine them productively.

4 c S1 site, only Lys11-linked chains can bind productively across the active site and stimulate cataly

5 ls, subsequently inhibiting their ability to productively activate T lymphocytes.

6 variability, suggesting that researchers may productively adopt a systems-level approach to conceptua

7 targets substrates to the proteasome can be productively amplified at the proteasome.

8 similarity metrics are increasingly used to productively analyze genome-wide data.

9 understand how reovirus inclusions differ in productively and abortively infected MDCK cells, we used

10 Bovine trypsin productively and correctly processed proHD5 in vitro but

11 This allows Kif15 dimers to productively and efficiently generate forces that could

12 on of its conduct in ways that respectfully, productively and equally involve local partners.

13 ins, nonstructural proteins produced by both productively and nonproductively (and potentially transf

14 try as well as the fates of HIV-1 genomes in productively and nonproductively infected macrophages.

15 late strong IFN responses, fail to replicate productively, and can become WT revertants.

16 Biostatistics can be productively applied to cardiovascular research if inves

17 lso known as Markov random fields, have been productively applied to diverse problems in biology, inc

18 Autism is therefore most productively approached using a combination of biologica

19 ognition were first being fashioned and used productively, are revisited.

20 folding efficiency, R264C molecules that do productively assemble into heterodimers are capable of c

21 different combinations, with a given B cell productively assembling only one combination.

22 the regulatory domain of one primase subunit productively associates with nucleic acid that is bound

23 unclear whether these existing models could productively be combined.

24 e area in which evolutionary information can productively be exploited is in aligning a new sequence

25 stead de novo enzymatic reactions could more productively benefit from optimization of the electrosta

26 ed on the assumption that the enzymes should productively bind DNA substrate first, followed by templ

27 ts showed that although RNA-binding proteins productively bind specific RNAs to control their functio

28 on of FSPP directly mimics that expected for productively bound FPP, with the exception of the precis

29 le to determine the crystal structure of SOX productively bound to a 31 nucleotide K12-2 fragment.

30 d coils and erection of a 1000 A scaffold to productively bridge DNA ends.

31 insight into how to use this biomarker more productively by distinguishing subsets of patients and b

32 likely assist mutant Aer proteins to signal productively by forming collaborative signaling teams.

33 TPase activity, support yeast viability, and productively chaperone the Hsp90 client glucocorticoid r

34 ce topography is removed, and results can be productively compared with those previously observed for

35 s suggests that different sample sets can be productively compared.

36 this process can be prevented in disease and productively controlled by design.

37 of dynamic conformational fluctuations that productively couple into the reaction coordinate.

38 e that the flexible linkers may allow PKR to productively dimerize upon interaction with RNA activato

39 ata reveal that MeV polymerase is capable of productively docking directly to the nucleocapsid core.

40 Polymerases already productively elongating at the time of P-TEFb inhibition

41 gering an inactive polymerase at CYC1 into a productively elongating form.

42 r from those by which AP-1 and AP-2 adaptors productively engage clathrin in vesicle biogenesis.

43 tic receptor binding domain architecture can productively engage hACE2, but only the Urbani mutationa

44 In many cases, the ability to productively engage host translational components can de

45 To make informed decisions and to productively engage in public discourse, citizens need t

46 (100-fold less potent than DCs) and fail to productively engage KRN T cells at steady state and duri

47 PPARs and other metazoan nuclear receptors productively engage several distinct LXXLL motif-contain

48 rapidly boosted the capacity of NK cells to productively engage target cells and enabled NK cell res

49 d TLR4 ligand, lipopolysaccharide (LPS), but productively engage the mouse TLR4 (mTLR4)/myeloid diffe

50 ycosylated IgG variants can be engineered to productively engage with FcgammaRIIIA, as well as the hu

51 e, CD8-dependent spread of signal from a few productively engaged TCR to many other TCR can explain t

52 e Notch-dependent transcriptional complex is productively engaged.

53 interacts with extranucleosomal DNA when it productively engages its nucleosome substrate.

54 e a TCRalphabeta heterodimer's likelihood of productively engaging autoantigen, because they are perv

55 the likelihood of a TCRalphabeta heterodimer productively engaging autoantigen, because they are wide

56 Given that cytosolic CA represents "productively" entered cores, whereas vesicular CA repres

57 iant segregation cannot be verified could be productively explored with the combined approach illustr

58 weak promoter activity but that most are not productively expressed because other features needed to

59 eactive immune process is present in IPF can productively focus efforts toward identifying the respon

60 R crosstalk pathways can, therefore, be used productively for tailored therapeutic approaches, such a

61 idged Fe(II)-OO-pterin intermediate in WT to productively form Fe(IV)=O, which is responsible for hyd

62 rmational flexibility, such that the peptide productively forms both extended-chain and helical state

63 Further, the half-life of productively HCV-infected cells, estimated from the seco

64 ERV-K HML-2 expression profiles specific for productively HIV-1-infected primary human CD4(+) T cells

65 in the C57BL/6J mouse, but failed to infect productively human corneal epithelial cells.

66 Such virions were able to infect productively human dendritic cells located beneath the e

67 sed to (i) use the water sources of SSA more productively, (ii) improve nutritional outcomes and rura

68 rgeting pericyte differentiation in vivo may productively impact fibrotic kidney disease.

69 All H1N1 viruses replicated productively in airway cells; however, in contrast to se

70 8-Br-L-cIDPR potentially binds non-productively in an upside-down fashion.

71 ow that gamma34.5 deletion viruses replicate productively in and induce cellular damage in infected e

72 The fact that bovine FLUDV replicated productively in both the upper and lower respiratory tra

73 Inspired by the dynamic clamp used so productively in cellular neuroscience, the HDC allows a

74 These viruses replicated productively in HIV-1 receptor-expressing CrFK cells and

75 r HIV-1 clone allowed the virus to replicate productively in human cells that expressed rhA3G or hA3G

76 e to the inability of the virus to replicate productively in mammalian hosts.

77 HPIVs replicate productively in respiratory epithelial cells and do not

78 helial cell rearrangements are being studied productively in several tissues, the ventral epidermis i

79 al base within these pockets, (ii) interacts productively in the Michaelis complex with the substrate

80 tertiary amine of the catalyst are involved productively in the rate-limiting cyanide addition step.

81 ng on the circumstances, M. tuberculosis can productively infect cells using different modes of entry

82 1 was severely debilitated in its ability to productively infect cells via CEACAM1a, while the invers

83 e in determining the extent to which JCV can productively infect cells.

84 of murine norovirus (MNV) and its ability to productively infect cultured murine macrophages and dend

85 34 downregulated by OrfA) cells but fails to productively infect either 104-C1 (CD134-positive) cells

86 f Salmonella enterica serovar Typhimurium to productively infect either cultured mammalian cells or m

87 Here, we report that SARS-CoV can productively infect human bronchial epithelial Calu-3 ce

88 emonstration that although SARS-CoV does not productively infect human Mphi or DC, it appears to exer

89 Nine polyomavirus (PyV) species are known to productively infect humans.

90 frequencies are less fit in vivo and fail to productively infect important target organs, such as the

91 Here we report that hantaviruses productively infect LECs and that LEC infection by HPS c

92 ly cleared under normal conditions, begin to productively infect macrophages in a "self-amplifying" c

93 s, human cytomegalovirus (HCMV) is unable to productively infect most cancer-derived cell lines.

94 fects macrophages and microglia and does not productively infect neurons or astrocytes.

95 owever, it is not clear how viruses adapt to productively infect new hosts.

96 y to traverse an intact nuclear envelope and productively infect nondividing cells is a salient featu

97 The failure of AAV2 to productively infect normal keratinocytes could be clinic

98 eduction of the ability of wild-type SV40 to productively infect permissive monkey cells, even when t

99 om canine, equine, avian, and seal origin to productively infect pigs.

100 ly synthesizing DNA; however, VZV is able to productively infect them and use their machinery to repl

101 xplore whether primary X4 HIV-1 isolates can productively infect tissue macrophages that have termina

102 We were able to productively infect with MDV B cells isolated from splee

103 The virus productively infected alveolar epithelial and mesenchyma

104 wed that the population of Ki-67+ cells were productively infected and expanded proportionally with l

105 Therefore, FoxP3(+) Treg cells are productively infected and play an important role in acut

106 principal targets of HIV-1 infection, become productively infected and survive long enough to return

107 , is not readily detectable in the nuclei of productively infected bovine cells during the late stage

108 trikingly, >95% of these dying cells are not productively infected but instead correspond to bystande

109 XS52 cells were productively infected by a vaccinia virus mutant lacking

110 ysiology as they are the principal cell type productively infected by C. trachomatis.

111 that 30-90% of circulating naive cells were productively infected by day 10 after inoculation.

112 gocytes (macrophages and microglia) that are productively infected by HIV in brains play a pivotal ro

113 Macrophages and microglia are productively infected by HIV-1 and play a pivotal role i

114 The number of cells in the brain that are productively infected by HIV-1 is relatively small and c

115 ident central nervous system (CNS) cell type productively infected by HIV-1, and play a key role in t

116 While macrophages are another cell type productively infected by HIV-1, few studies have examine

117 Our data show that even though DCs are productively infected by HIV-1, infection does not induc

118 stem for establishing cell lines that can be productively infected by human T-lymphotropic virus type

119 rikingly, lung migratory CD103+ DCs were not productively infected by influenza virus and thus were a

120 re recruited to the granuloma where they are productively infected by M. marinum.

121 However, the skin cell type productively infected by MCPyV remains a central questio

122 that primary human osteoblasts (hOBs) can be productively infected by RRV.

123 DCs are productively infected by RSV, and during RSV infections,

124 CD4+ and CD8+ T cells were productively infected by RSV.

125 Here, we report that CNCCs are productively infected by ZIKV, but not by the related de

126 n of cytotoxic effector cells and killing of productively infected CD4 T cells.

127 described here we compared the frequency of productively infected CD4(+) T cells and macrophages in

128 le mechanisms may contribute to the death of productively infected CD4+ T cells and innocent-bystande

129 g (and thus latently infected) T cell when a productively infected cell attempts cell-to-cell transmi

130 t women may either produce fewer virions per productively infected cell or more effectively clear ext

131 ith latent envelope genomic fragments in the productively infected cell population.

132 rotein of HIV is expressed on the surface of productively infected cells and can be used as a target

133 trate that IL-7 enhances viral production in productively infected cells but does not disrupt viral l

134 target cell population size on the number of productively infected cells generated.

135 el significantly overestimates the number of productively infected cells generated.

136 This is demonstrated by reduced levels of productively infected cells in lymphoid organs and lower

137 emia decay post-ART indicates a half-life of productively infected cells ranging from 4 to 9.5 h, i.e

138 We show that CTLs kill productively infected cells significantly faster (P = 0.

139 with cell extracts, viral DNA replication in productively infected cells utilizes additional viral an

140 ntribution of CD8 T cell-mediated killing of productively infected cells was earlier and much greater

141 Prevalence of virus with latent fragments in productively infected cells was observed in only 2% of s

142 y transcribing, EdU-labeled HIV-1 genomes in productively infected cells, and immunofluorescence anal

143 In productively infected cells, E1B-55K and E4orf6 assemble

144 ter in blood, BrdU+ B cells greatly exceeded productively infected cells, indicating that new BLV inf

145 to capture interactions among target cells, productively infected cells, latently infected cells, vi

146 ients reflects immune-mediated death/loss of productively infected cells, the second-phase decline in

147 he expression patterns differed from that in productively infected cells, with the rat neuron pattern

148 f virions and with detection of viral RNA in productively infected cells.

149 cella-zoster virus (VZV) in the cytoplasm of productively infected cells.

150 ption occurs in a subset of HIV-1 genomes in productively infected cells.

151 ve transcriptionally active HIV-1 genomes in productively infected cells.

152 and GlucII, and to operate in the context of productively infected cells.

153 ace of effective immune control measures for productively infected cells.

154 -dependent recruitment of Hsc70 to nuclei of productively infected cells.

155 Herein, we show that the JHM strain also productively infected DCs.

156 hages residing in human tonsil blocks can be productively infected ex vivo by primary X4 HIV-1 isolat

157 ing RNAs was also verified by TaqMan qPCR in productively infected fibroblasts and ARPE19 cells.

158 EHV-1 productively infected four of these cell lines, and the

159 Sporozoites productively infected hepatocytes with high EphA2 expres

160 rs, and it is unclear how these cells become productively infected in vivo We investigated the mechan

161 the probability that a CD8(+) T cell will be productively infected is almost six times higher than fo

162 e protein transport during HIV-1 assembly in productively infected Jurkat CD4+ T cells and primary CD

163 Anx2-Gag binding was confined to productively infected macrophages and was not detected i

164 A better understanding of the number of productively infected macrophages is crucial to further

165 , high levels of viremia are maintained from productively infected macrophages.

166 has already crossed the species barrier and productively infected mammals.

167 A ChIP assay using productively infected MeWo cells revealed that VZV ORFs

168 gorously assessed; however, the frequency of productively infected monocytes and macrophages in vivo

169 To assess the contribution of productively infected monocytes and macrophages to HIV-

170 eport the composition of small RNAs in HIV-1 productively infected MT4 T-cells.

171 resulting chimeric virus construct, EcoHIV, productively infected murine lymphocytes, but not human

172 Productively infected myeloid cells were detected in blo

173 In productively infected neuronal cultures, epinephrine tre

174 The MAC387(+) cells were not productively infected nor did they express detectable CC

175 We demonstrate that HIV productively infected primary CD4(+) T cells express 12-

176 cells progress from the eclipse stage to the productively infected stage, the more likely that a vira

177 egree of protection against apoptosis in the productively infected subpopulation.

178 We find that most productively infected T cells migrate robustly, resultin

179 arly cloned viral genomes or by expansion in productively infected T cells.

180 cell follicles prevents their elimination of productively infected TFH cells.

181 fectious virus to CD4+ T cells without being productively infected themselves, and we point to a path

182 C. muridarum productively infected these macrophages at low MOIs but

183 cal and endocervical epithelial cells become productively infected with cell-free HIV-1 in a CD4-inde

184 use epithelial cells are the major cell type productively infected with Chlamydia during genital trac

185 with subtype A, B, C, or D SHIVs all became productively infected with different Env375 variants-S,

186 d, and only 45% of cultured neurons could be productively infected with either HSV-1 or HSV-2.

187 activated blood and tonsillar B cells can be productively infected with HHV-8, as measured by an incr

188 eLCs were productively infected with HIV, whereas Mutz-3 LCs were

189 estimating the rate at which CTLs kill cells productively infected with HIV-1 in humans in vivo.

190 Cells productively infected with HIV-1 release virions along w

191 However, Rag-gammac(-/-) mice were not productively infected with MNV by the oral route, in whi

192 NKT cells responded specifically to rare DCs productively infected with Nef- and Vpu-defective HIV-1.

193 asites owing to neonatal tolerization become productively infected with the filarial parasites.

194 we showed that the migrating monocytes were productively infected with the virus, documenting that t

195 s of NGS of RNA from fibroblasts and neurons productively infected with VZV using TaqMan quantitative

196 l particles than typically observed in cells productively infected with VZV.

197 posed to HTLV-1, both before and after being productively infected, can rapidly, efficiently and repr

198 porter mice to identify cells that have been productively infected, that have been rhoptry injected b

199 To determine whether tissue macrophages are productively infected, we used 3 different but complemen

200 , a significant fraction of these cells were productively infected.

201 normally nonpermissive mouse cells to become productively infected.

202 e killing immune effector cells that are not productively infected.

203 ins determines whether or not a cell becomes productively infected.

204 ual HSV-infected neurons will be latently or productively infected.

205 ponding to those that are both activated and productively infected.

206 The virus productively infects a small fraction of the blood DCs t

207 in the kidney and after entering the brain, productively infects and destroys oligodendrocytes.

208 We found that dengue virus productively infects approximately 80% of primary human

209 above observations, OrfA-negative FIV-34TF10 productively infects CrFK (CD134-negative) and 104-C1-Or

210 ich the OrfA reading frame is open (OrfArep) productively infects CrFK, GFox, 104-C1, and 104-C1-OrfA

211 68 efficiently completes the lytic phase and productively infects cultured cells.

212 have previously shown that dengue virus (DV) productively infects immature human dendritic cells (DCs

213 gerhans cells and that EBV both latently and productively infects oral epithelium-resident cells that

214 Moreover, ZIKV productively infects stem-cell-derived human neural cres

215 We found that vaccinia virus productively infects XS52 cells, yet this infection disp

216 introduction of fluorine into a molecule can productively influence conformation, pKa, intrinsic pote

217 e amino-terminal cytosolic portion of PLB to productively inhibit the Ca-ATPase.

218 uction in a receptor-independent manner, and productively interact with a GPCR in isolated membranes.

219 of CFTR's second membrane-spanning domain to productively interact with amino-terminal domains.

220 Thus, B cells can productively interact with DC displaying their cognate A

221 Our data indicate that Sf6 can productively interact with other bacterial OmpAs as long

222 ie T-cell activation, specifically that they productively interact with signaling microclusters at th

223 assay, suggesting that H77 NS4B is unable to productively interact with the Con1 replication machiner

224 ance to a viral oncoprotein can nevertheless productively interact with the same cellular target.

225 ability to collect human genetic data and to productively interpret and apply it.

226 ersal and the mechanism by which sporozoites productively invade hepatocytes will be highlighted in t

227 x nature of diet and its associations can be productively investigated with disease-specific studies.

228 o calculate the percentage of cells that are productively, latently, or abortively infected.

229 of helicase are employed, Y122A is unable to productively load the helicase onto forked DNA substrate

230 lymph node, where the cells must be able to productively lodge and grow.

231 s that otherwise neurotoxic glutamate can be productively metabolized by glutamate oxaloacetate trans

232 ssue, tumor cells appear rounded and fail to productively migrate.

233 As such, they provide targets by which to productively mobilize resident progenitor cells of the a

234 and Myt1l do not access fibroblast chromatin productively on their own; instead, Ascl1 recruits Brn2

235 targets for HIV infection, that they become productively or latently infected at low levels, and tha

236 system revealed that T(SCM) cells can become productively or latently infected, although the vast maj

237 me-wide association studies (GWAS) cannot be productively performed using inbred mouse strains.

238 the substrate for the OSBS reaction is more productively positioned vis a vis the active site cataly

239 the substrate for the OSBS reaction is more productively presented to the conserved acid/base cataly

240 Normal B cells that have failed to productively rearrange immunoglobulin V region genes enc

241 nt elimination of pre-B cells that failed to productively rearrange immunoglobulin VH-DJH gene segmen

242 ely essential role in the transcription of a productively rearranged Ig VDJCalpha transcription unit.

243 does not regulate L chain expression from a productively rearranged Igk allele.

244 gel immunodiffusion assays, and inability to productively reassort with ICV led to the proposal that

245 BAP1 outside the UCH domain, each failing to productively recruit ASXH to the wild-type BAP1 catalyti

246 This allows both viruses to productively replicate in distinct sets of dividing cell

247 the dogma that mouse cytomegalovirus cannot productively replicate in human cells and found that mou

248 mian immunodeficiency virus (SIV) infect and productively replicate in macrophages and T lymphocytes.

249 The ability to productively replicate in macrophages is unique to H5N1

250 high morbidity and mortality in mammals, can productively replicate in macrophages, as measured by th

251 bility of certain influenza virus strains to productively replicate in macrophages.

252 small subset can overcome cellular blocks to productively replicate in murine and primary human macro

253 an (HPAI) H5N1 influenza virus strains could productively replicate in murine macrophages through a h

254 n resting, circulating memory B cells and to productively replicate in plasma cells.

255 stigated the ability of H1 to H16 viruses to productively replicate in primary murine alveolar macrop

256 the viruses with unprocessed polyprotein to productively replicate in the IFN-competent cells and in

257 ssociated with a strain-specific capacity to productively replicate in type II pneumocytes and to cop

258 to recruit factors to viral genomes that can productively replicate viral DNA in a recombination-depe

259 host species and the cell type in which they productively replicate.

260 orne B lymphocytes, while EBV intermittently productively replicates in mucosal epithelia.

261 and smaller than those formed by T3-T1M1, a productively replicating reovirus strain, and contained

262 ure localization of recombination factors to productively replicating viral genomes.

263 , unlike cells found in lymphoid organs that productively respond to acute infections, immune cells i

264 nly ones that can stimulate naive T cells to productively respond to Ags.

265 a marked reduction in their ability to glide productively, resulting in marked reduction in malaria t

266 periments have revealed that thymocytes must productively signal in response to self antigens to matu

267 ma viremia and a more rapid disappearance of productively SIV-infected cells from the lymph node comp

268 istinct from the free drug in its ability to productively stimulate antitumor immunity.

269 4 is stable, nonubiquitylated, and unable to productively stimulate transcription.

270 In addition to amino acids, which have been productively studied for years, sugar-like molecules, ac

271 pes mutations in these specific genes may be productively studied to clarify ASD pathophysiology.

272 nalogs of HNP2 in their pro-forms all folded productively, suggesting that the Arg5-Glu13 salt bridge

273 multiple myosinVa motors can cooperate more productively than collections of kinesins in COS-7 cells

274 he ability of multiple kinesins to cooperate productively, the spatial and temporal properties of app

275 es was highly sensitive to disruption by non-productively titrating lattice-forming self-interactions

276 ies demonstrate that murine PBLs can be used productively to identify potential correlates of protect

277 ensuring that switching occurs primarily and productively to the opposite type, called directionality

278 eatly enhances the amount of substrate bound productively to the thylakoids.

279 pproach presented to help clinicians respond productively to women who request intervention.

280 ctively capture the cargo in the cytosol and productively unload the cargo at the membrane.

281 g animals' ability to extract, identify, and productively use proportion information across a range o

282 that the systematic review approach could be productively used to inform the development of reference

283 st report of a virus evolving a mechanism to productively utilize an antiviral agent to stimulate its

284 torsion angle for assembly, mutants that can productively utilize the altered external scaffolding pr

285 In many cases of productively utilized frameshifting, the proportion of r

286 t at slippage-prone sequences also generates productively utilized products encoded trans-frame with

287 ly flexible C terminus allows La to interact productively with a diversity of noncoding RNA precursor

288 e showed the adenovirus proteinase interacts productively with its protein substrates in vitro and in

289 occurs in nature whenever a host is infected productively with more than one influenza A virus.

290 rmation, which is not predicted to associate productively with or activate downstream effectors.

291 addition, stage E2 cells proved to interact productively with primary BM stromal cells in ways that

292 and N-hydroxylamines were shown not to react productively with the alpha-ketophosphonic acids under t

293 tions within beta-strands, fail to associate productively with the Bam complex.

294 rase IV, not DNA polymerase II, could engage productively with the Escherichia coli replisome to bypa

295 To connect productively with the high resolution achieved by cognat

296 usions (FLPs), which enable them to interact productively with the surrounding extracellular matrix;

297 a traptamer determined whether it associated productively with the TMD of the human EPOR, the mouse E

298 the N-lobe must be Ca(2+)-bound to interact productively with this site.

299 t the N-lobe must be Ca(2+)-free to interact productively with this site.

300 at T cells also have the ability to interact productively with variant ligands, indicating a flexibil