ライフサイエンスコーパス: prodynorphin

1 f the proNKB neurons were immunoreactive for prodynorphin.

2 evated GluR2 was accompanied by decreases in prodynorphin.

3 as c-fos, fos-related antigen-2 (fra-2), and prodynorphin.

4 s the opioid neuropeptide precursor protein, prodynorphin.

5 icotropin-releasing hormone, vasopressin, or prodynorphin.

6 in neural and cardiac tissues and represses prodynorphin and c-fos gene expression by binding to DNA

7 and regulates Ca2+-induced transcription of prodynorphin and c-fos genes.

8 ding protein that represses transcription of prodynorphin and c-fos genes.

9 of DREAM to DNA response elements (DREs) in prodynorphin and c-fos genes.

10 AM for specific DNA response elements in the prodynorphin and c-fos genes.

11 intake of the CHO diet resulted in levels of proDynorphin and Dynorphin A1-17 that were similar in th

12 Immunolabeling for prodynorphin and enkephalin revealed numerous immunoposi

13 In addition, we examined two genes (prodynorphin and FK506 binding protein 5) that are stron

14 CFA also induced an upregulation of prodynorphin and neurokinin-1 (NK-1) in dorsal horn neur

15 duced phospho-ERK primarily colocalized with prodynorphin and NK-1 in superficial dorsal horn neurons

16 transcriptional regulation of genes, such as prodynorphin and NK-1.

17 ding to DNA to activate the transcription of prodynorphin and other downstream genes in pain control.

18 There were no differences in proDynorphin and proEnkephalin mRNA levels in the ARC (0

19 ofluorescence to explore the distribution of prodynorphin and proNKB immunoreactivity in the rat hypo

20 alamic projections of fibers expressing both prodynorphin and proNKB provide evidence that these neur

21 othalamus where neuronal somata coexpressing prodynorphin and proNKB-immunoreactivity were identified

22 use and rat, including tyrosine hydroxylase, prodynorphin, and galanin.

23 localized in some puncta and fibers, but the prodynorphin antibody additionally labeled cell bodies.

24 n volunteers bearing the (T) allele of PDYN (prodynorphin) at rs1997794 showed reduced fear extinctio

25 date genes revealed by our screening, namely prodynorphin, BDNF, and MHC class I molecules, to the fa

26 Immunohistochemical analysis showed prodynorphin content increased in the nucleus accumbens

27 o study the basal and evoked release of this prodynorphin derived peptide in the spinal cord of ureth

28 NL induced a sustained release of endogenous prodynorphin-derived opioid peptides that activated an a

29 These observations suggest that prodynorphin-derived peptides have a much more pervasive

30 igators to contain perikarya that synthesize prodynorphin-derived peptides, except the pedunculoponti

31 LID, including overexpression of DeltaFosB, prodynorphin, dynorphin A, cyclin-dependent kinase 5, an

32 on, blocks swim stress-induced activation of prodynorphin (encodes dynorphin) in the NAc.

33 3 (SCA23) is caused by missense mutations in prodynorphin, encoding the precursor protein for the opi

34 s in the brain associated with inhibition of prodynorphin-expressing (Pdyn-expressing) and of proenke

35 ressor DREAM acts constitutively to suppress prodynorphin expression in spinal cord neurons.

36 onsistent with this result, mice lacking the prodynorphin gene did not show a stress-induced potentia

37 s have demonstrated that stress may increase prodynorphin gene expression, and kappa opioid agonists

38 esis, transgenic mice possessing a disrupted prodynorphin gene showed no increase in immobility or st

39 Here, mice lacking the prodynorphin gene were studied for sensitivity to non-no

40 Prodynorphin-immunopositive cell bodies consisted of two

41 Dynorphin and prodynorphin immunoreactivities colocalized in some punc

42 ts with an ShA history showed an increase in prodynorphin immunoreactivity in both the nucleus accumb

43 The localization of prodynorphin immunoreactivity to pyramidal cells suggest

44 calized with and decreased the expression of prodynorphin in nucleus accumbens medium spiny neurons,

45 al increases expression of pCREB, c-Fos, and prodynorphin in the superficial dorsal horn, changes tha

46 dditionally, we investigated whether arcuate prodynorphin-ir (immunoreactive) neurons expressed the n

47 cleus expressed NK3R, and nearly 100% of the prodynorphin-ir neurons contained nuclear ERalpha.

48 Interestingly, the majority of prodynorphin-ir neurons in the arcuate nucleus expressed

49 We found that the majority of prodynorphin-ir neurons in the rat arcuate nucleus expre

50 Prodynorphin is processed into the opioid peptides, alph

51 Prodynorphin knock-out (KO) mice had normal responses to

52 In addition, knock-out mice lacking prodynorphin, KOR, or G-protein receptor kinase 3 (GRK3)

53 Antibodies against dynorphin and prodynorphin labeled puncta and fibers in laminae I, II,

54 o true: 96% of neurons in the LHA containing prodynorphin mRNA also expressed prepro-orexin mRNA.

55 loss of the orexin neurons completely lacked prodynorphin mRNA in this area, further confirming that

56 Hypothalamic Dynorphin A1-17 and proDynorphin mRNA levels are stimulated by feeding a hig

57 O, ad libitum intake of Fat/Sucrose elevated proDynorphin mRNA levels in the arcuate and Dynorphin A1

58 real-time PCR was used to show that KOR and prodynorphin mRNA levels were decreased in the NAc, wher

59 ce and orexin knock-out mice showed abundant prodynorphin mRNA-expressing neurons in the LHA, but ore

60 expressing prepro-orexin mRNA also expressed prodynorphin mRNA.

61 brain regional levels of opioid peptides and prodynorphin mRNA.

62 in neurons are activated by fasting and that prodynorphin neurons restrain food intake during schedul

63 In contrast, neither prodynorphin nor GRK3 knock-out mice showed U50,488 tole

64 tream regulatory element (DRE) of either the prodynorphin or c-fos genes.

65 Potential candidates may include a prodynorphin- or other opioid-like gene.

66 t to its origin as a duplication of either a prodynorphin- or proenkephalin-like gene.

67 id were also examined on mRNA expression for prodynorphin (PDYN) and kappa-opioid receptors (KORs) in

68 These genes included prodynorphin (PDYN) and proenkephalin (PENK), among othe

69 Rodent models implicate amygdala prodynorphin (Pdyn) as a mediator of negative affect; ho

70 In human, prodynorphin (Pdyn) gene polymorphisms might be linked t

71 the relationship of genetic variants of the prodynorphin (PDYN) gene, which is enriched in the stria

72 ing mice with a targeted inactivation of the prodynorphin (Pdyn) gene.

73 strated significant increases in whole brain prodynorphin (Pdyn) mRNA in WSP mice only during EtOH wi

74 Because the tyrosine hydroxylase (TH), prodynorphin (PDYN), and proenkephalin (PENK) genes cont

75 ndothelial nitric oxide synthase (NOS3), and prodynorphin (PDYN).

76 alized with a subset of preproenkephalin and prodynorphin positive spiny neurons within the dorsomedi

77 The prodynorphin-positive neurons in the dorsal horn were di

78 Prodynorphin (ProDYN) in the anterior pituitary gland ap

79 Messenger RNA levels of ProDynorphin (proDYN), but not pro-opiomelanocortin (POM

80 ad libitum intake resulted in mRNA levels of proDynorphin, proEnkephalin and POMC, and Dynorphin A1-1

81 on of the same diet decreases mRNA levels of proDynorphin, proEnkephalin and POMC, as well as levels

82 f neuropeptides including those derived from prodynorphin, proenkephalin, proSAAS, and amyloid precur

83 Prodynorphin/proNKB fibers were also identified in the p

84 A dense plexus of double-labeled prodynorphin/proNKB-ir fibers was found within the arcua

85 and proopiomelanocortin, proenkephalin, and prodynorphin transcript levels in cortex, hippocampus, a

86 Axonal fibers immunolabeled for prodynorphin varied in size and were found in all lamina

87 ere was some colocalization of dynorphin and prodynorphin with CGRP and substance P, but not with iso

88 here was no co-localization of dynorphin (or prodynorphin) with enkephalin (or Phe-Arg-Met-enkephalin