ライフサイエンスコーパス: proerythroblast

1 urst-forming unit (BFU-E) differentiation to proerythroblast.

2 to the increased apoptosis of FLVCR-deleted proerythroblasts.

3 (+) progenitors, and in vitro-differentiated proerythroblasts.

4 macrophages and developmentally synchronous proerythroblasts.

5 the survival or proliferation of CFU-e's or proerythroblasts.

6 level of approximately 50 times the level in proerythroblasts.

7 survival factors are deployed in early-stage proerythroblasts?

8 at are later depleted as more differentiated proerythroblasts accumulate at hematopoietic sites exhib

9 ring short-term BM transplantation, stage E2 proerythroblasts additionally proved to be a predominant

10 The mutant proerythroblasts also aberrantly express genes of the my

11 ive to that of erythropoietin in stimulating proerythroblast and erythroblast proliferation.

12 od cells follows the sequential formation of proerythroblasts and basophilic, polychromatophilic and

13 Sox6 is highly expressed in proerythroblasts and erythroblasts in the fetal liver, n

14 teins from mutant Kit-driven murine leukemia proerythroblasts and identified Shp2 and Stat5 as proxim

15 ialomucin was discovered in Kit(+)CD71(high) proerythroblasts and was sustained at subsequent Kit(-)C

16 ncided with the apex in cell cycling and the proerythroblast-basophilic normoblast transition.

17 titative analysis revealed that the ratio of proerythroblasts:basophilic:polychromatic:orthromatic er

18 From the CFU-E/proerythroblast (CD71(+) Ter119(-) cells) stage onward,

19 ssion of Cul4A in a growth factor-dependent, proerythroblast cell line increased proliferation and th

20 Forced expression of Ldb1 in G1ER proerythroblast cells inhibited cellular maturation, a f

21 as performed specifically in mouse embryonic proerythroblast cells.

22 verall, findings reveal a novel transitional proerythroblast compartment that deploys unique expansio

23 differentiation is the process during which proerythroblasts differentiate to produce enucleated ret

24 Later liver proerythroblasts express low levels of gamma-globin, whi

25 w levels of gamma-globin, while adult marrow proerythroblasts express only beta-globin transcripts.

26 We observed that proerythroblasts expressed a broad tetraspanin phenotype

27 E11.5 definitive proerythroblasts from mice transgenic for the human beta

28 Extensive in vitro self-renewal of proerythroblasts from the earliest period of definitive

29 e results in rapid expansion of pre-leukemic proerythroblasts (FVA cells) dependent on erythropoietin

30 ient erythropoiesis has been developed using proerythroblasts isolated from the spleens of Friend vir

31 we chose nonerythroid COS-1 cells instead of proerythroblast-like K562 cells, which produce endogenou

32 bryonic erythroid cells arrested at an early proerythroblast-like stage of their development.

33 unophenotypically, and functionally resemble proerythroblasts, maintaining both cytokine dependence a

34 ally develop a severe macrocytic anemia with proerythroblast maturation arrest, which suggests that e

35 unique Kit(-)CD71(high)Ter119(-) "stage E2" proerythroblast pool first is described, which (unlike i

36 Transcriptome analysis of RHAU knockout proerythroblasts showed that a statistically significant

37 mbryonic stem cell cultures mature to a late proerythroblast stage and express at least certain genes

38 nitive) erythroid precursors arrested at the proerythroblast stage in vitro and fail to contribute to

39 committed erythroid precursors arrest at the proerythroblast stage of development and undergo apoptos

40 sible erythropoietin/erythropoietin receptor proerythroblast stage specific events were further inves

41 d intracellular complex composition from the proerythroblast stage to the enucleated reticulocyte.

42 failure occurs in these animals at the CFU-E/proerythroblast stage, a point at which the transferrin

43 ythroid precursors is already present by the proerythroblast stage.

44 tic anemia and differentiation defect at the proerythroblast stage.

45 fetal liver hematopoiesis was blocked at the proerythroblast stage.

46 s a heme export protein that is required for proerythroblast survival and facilitates macrophage heme

47 ility of erythropoietin signaling to promote proerythroblast survival and has an effect additive to t

48 ion starts from morphologically recognizable proerythroblasts that proliferate and differentiate to g

49 Hb Null ES cells generates viable definitive proerythroblasts that undergo apoptosis upon terminal di

50 om mutant mice arrest at the transition from proerythroblast to basophilic erythroblast.

51 The transition from proerythroblast to basophilic normoblast occurred later,

52 4 was noted during differentiation of murine proerythroblast to orthochromatic erythroblast.

53 ted a progressive and dramatic decrease from proerythroblast to reticulocyte; this enabled us to devi

54 As primitive erythroblasts mature from proerythroblasts to reticulocytes, they undergo a betaH1

55 ntibodies augmented or inhibited adhesion of proerythroblasts to Vascular Cell Adhesion Molecule-1 an

56 odies to CD81 and CD82 augmented adhesion of proerythroblasts to Vascular Cell Adhesion Molecule-1 bu

57 that during murine erythropoiesis in vivo, 1 proerythroblast undergoes 3 mitosis to generate sequenti

58 U/mL of erythropoietin, the folate-deficient proerythroblasts underwent apoptosis, whereas control er

59 The partial differentiation block of proerythroblasts was because of a proliferation defect.

60 Bcl-X expression in proerythroblasts was highly EP-dependent.

61 When these proerythroblasts were induced to terminally differentiat

62 Control proerythroblasts were obtained from Friend virus-infecte