ライフサイエンスコーパス: proficient

1 lly sterile, whereas opaque cells are mating-proficient.

2 a1 activate Chk1 normally and are checkpoint proficient.

3 the 193 tumors with < 20 mutations were MMR-proficient.

4 s unique among eukaryotic polymerases in its proficient ability for error-free replication through ul

5 bic environment that when fused together are proficient activators.

6 terior brain areas of the left hemisphere in proficient adult readers.

7 osms amended with alginate particles and the proficient alginolytic bacterium Alteromonas macleodii s

8 The use of DEK-proficient and -deficient breast cancer cells in orthoto

9 Using NER-proficient and -deficient cells and in vitro PARP-1 assa

10 g recruited to chromosomal DSBs in both H2AX-proficient and -deficient cells, suggesting that the Rad

11 biochemical characterization of these FIP1C-proficient and -deficient tumor models revealed that FIP

12 on of representative glycohydrolase activity-proficient and -deficient variants was conducted.

13 s in developing lymphocytes from both c-NHEJ-proficient and c-NHEJ-deficient mice, demonstrating that

14 e NHEJ (aNHEJ), which operates in both cNHEJ-proficient and cNHEJ-deficient cells.

15 air in nuclear extracts from mismatch repair proficient and deficient cells.

16 emonstrated by using synthetic CsgA peptides proficient and deficient in fiber formation, respectivel

17 valuated by using superoxide dismutase (SOD) proficient and deficient strains of S. cerevisiae.

18 Thus, spatially uniform inhibition allows proficient and flexible coding in hippocampal CA1 by sup

19 th a very long linker was less recombination-proficient and less sensitive to variations in Z-site le

20 The evaluation of proficient and less-proficient readers points to differe

21 nvolved in priming replication, are also TLS proficient and therefore may play important roles in dam

22 virulence in NOS2(-/-) mice but were growth-proficient and virulent in IFN-gamma(-/-) mice, suggesti

23 It is puzzling however, that swarming-proficient and virulent strains of Vibrio parahaemolytic

24 ging to know whether a NICU is becoming more proficient, and it is not usually apparent whether concu

25 transient telomere dysfunction in telomerase-proficient animals is a potent stimulus of tumor formati

26 or-infiltrating CD8(+) T cells in TNF/TNF-R1-proficient animals.

27 Highly proficient Arabic-English bilingual individuals particip

28 LigD POL is proficient at adding templated and nontemplated deoxynuc

29 We show NHEJ is uniquely proficient at bypassing subtle terminal mispairs and rad

30 A3A is, by contrast, highly proficient at C/mC deamination.

31 ke other species in the Acidovorax genus, is proficient at catalyzing NDFO.

32 of the bacterium Myxococcus xanthus that is proficient at cooperative fruiting body development to e

33 Microorganisms proficient at degrading insoluble polysaccharides posses

34 donuclease, which is sufficient to make them proficient at degrading their chromatin into oligonucleo

35 siveness to proinflammatory stimuli but were proficient at endocytosis of particulate and soluble mat

36 Tgo-Pol Z1 is also proficient at extending from primers that terminate oppo

37 e frequent because APOBEC3A itself is highly proficient at generating DNA breaks, whose repair can tr

38 Skeletal muscles are proficient at healing from a variety of injuries.

39 axonomic profiling and binning programs were proficient at high taxonomic ranks, with a notable perfo

40 Nevertheless, Prdm9 knockout mice are proficient at initiating recombination.

41 The resulting Tgo-Pol Z1 variant is proficient at initiating replication from base mismatche

42 Highly variable subpopulations are more proficient at metastatic colonization and chemotherapeut

43 experience of agonistic encounters to become proficient at mutual assessment.

44 similarity with which an observer has become proficient at rapid individuation.

45 ction Service, clinical laboratories must be proficient at rapidly recognizing isolates suspicious fo

46 ing in their natural environments need to be proficient at recognizing and responding to changes in f

47 Second, subjects become more proficient at reversing choice preferences as they exper

48 the prototype foamy virus (PFV) intasome is proficient at stable capture of nucleosomes as targets f

49 Yellow variants are proficient at swarming (++) and tend to lyse in liquid d

50 citly assumes that task specialists are more proficient at their jobs than generalists and specialist

51 Human subjects are proficient at tracking the mean and variance of rewards

52 Many cells are remarkably proficient at tracking very shallow chemical gradients,

53 Although anergic B cells in the IRF8-proficient background were blocked at the transitional s

54 ducible telomere dysfunction on a telomerase-proficient background, in telomerase knockout mice with

55 oss-language activation is present even when proficient bilinguals perform a task only in one languag

56 d Diels-Alderase was converted into the most proficient biocatalyst for [4+2] cycloadditions known.

57 nds of mutagenesis and screening to afford a proficient biocatalyst for enantioselective cleavage and

58 bacterium Klebsiella pneumoniae, which is a proficient biofilm former and a commonly isolated nosoco

59 air and genomic stability not only in c-NHEJ-proficient but also -deficient human G1-phase cells.

60 ect cell viability by leading to restriction proficient but modification deficient cell phenotypes.

61 itized DNA-dependent protein kinase (DNA-PK)-proficient but not DNA-PK-deficient glioblastoma cells,

62 increased by knockdown of DDX41 only in p53-proficient but not in p53-deficient cells.

63 antigen (PCNA) monoubiquitination in Poleta-proficient but not in Poleta-deficient XPV (Xeroderma pi

64 YloA-proficient, but not YloA-deficient, Bsn specifically bou

65 olog)-independent break-repair and resection-proficient by physical assay.

66 Because the DNA binding-proficient C-terminal domain of AccR is monomeric, we pr

67 BRG1-deficient cancer cells relative to BRG1-proficient cancer cells, inducing senescence via activat

68 of CDK4/6 and Akt inhibitors in treating Rb-proficient cancer.

69 e Amsterdam criteria and had mismatch repair-proficient cancers with no previously associated mutatio

70 imization and drug development to target p53-proficient cancers.

71 nding the utility of PARP inhibitors to BRCA-proficient cancers.

72 t morbidities, emphasizing whole cultures of proficient care rather than the traditional emphasis on

73 Finally, unlike nuclease-proficient Cas9 in human cells, the specificity of trunc

74 Triosephosphate isomerase (TIM) is a proficient catalyst of the reversible isomerization of d

75 Organophosphate hydrolases are proficient catalysts of the breakdown of neurotoxic orga

76 Natural enzymes are incredibly proficient catalysts, but engineering them to have new o

77 e transfer of activated TNF-R1-deficient or -proficient CD8(+) T cells in CD8-deficient mice bearing

78 We found that A(2A)R-proficient CD8(+) T cells specific for melanoma cells di

79 ce in each of 16 retinoblastoma protein (Rb)-proficient cell lines regardless of other genetic lesion

80 ction donors are used, COIN enriches for HDR-proficient cells among heterogeneous cell populations.

81 present in both repair-defective and repair-proficient cells and was strongest and highly significan

82 ally lethal in XRCC1-deficient compared with proficient cells as evidenced by hypersensitivity to DSB

83 nges alone mediated chemotaxis in adaptation-proficient cells but exhibited altered sensitivity to se

84 In contrast, HSulf-1 proficient cells exhibit more AVs and reduced LDs.

85 ressed how telomere losses within telomerase-proficient cells have an impact on carcinogenesis.

86 Deletion of MTAP in MTAP-proficient cells rendered them sensitive to PRMT5 deplet

87 Knockdown of Poltheta in HR-proficient cells upregulates HR activity and RAD51 nucle

88 Interestingly, ATG7-deficient and -proficient cells were equally sensitive to the antiproli

89 apoptosis-necrosis continuum, apoptotically proficient cells were screened facing several apoptotic

90 ated by the incubation of fumarate hydratase-proficient cells with cell-permeable fumarate.

91 e, cells with defects in MMR exist among MMR-proficient cells, as observed in healthy intestinal tiss

92 Compared with BRCA1-proficient cells, PARPi-resistant BRCA1-deficient cells

93 xaliplatin treatment in comparison with MSH3-proficient cells, suggesting that MSH3 plays an importan

94 1-deficient cells but had no effect in ERCC1-proficient cells, supporting the hypothesis that PARP1 m

95 r resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt inhib

96 smatch repair (MMR)-deficient cells over MMR-proficient cells.

97 ed with DCIS-like lesions developing from RB-proficient cells.

98 e differentially sensitive to Pu-27 than ATM proficient cells.

99 impact on cell growth and viability in BRCA2-proficient cells.

100 ed in UM and PD20 cells compared with FANCD2-proficient cells.

101 ells, with minimal effect in BRCA1- or PALB2-proficient cells.

102 is highly selective for MMR-deficient versus proficient cells.

103 ase-6 in XPC-deficient cells, but not in XPC-proficient cells.

104 city, targeting MMR-deficient cells over MMR-proficient cells.

105 drives extinction of haploid and diploid MMR-proficient cells.

106 ased number of UFBs compared with FA pathway-proficient cells.

107 3, in turn, inhibits mTORC1 activity in Tsc2-proficient cells.

108 Here we examine the effect of PARPi on HR-proficient cells.

109 se to chromosomal triplex formation than NER-proficient cells.

110 esting enrichment of a sub-population of HDR-proficient cells.

111 and enables subtle gene modification in MMR-proficient cells.

112 f CPT cytotoxicity in Tdp1 deficient but not proficient cells.

113 linically, we evaluated XRCC1-deficient and -proficient Chinese hamster and human cancer cells for sy

114 nd dozens of clinical criteria tidying up by proficient clinicians.

115 ectively, in the cohort with mismatch repair-proficient colorectal cancer (hazard ratio for disease p

116 ective cytotoxicity for MMR-deficient versus proficient colorectal cancer cells.

117 ectal cancers, patients with mismatch repair-proficient colorectal cancers, and patients with mismatc

118 d 11% (2 of 18 patients) for mismatch repair-proficient colorectal cancers.

119 nd a molecular mechanism by which DNA ligase proficient complexes are assembled during NHEJ in mammal

120 Thus, PADT-proficient complexes undergo a conformational change tha

121 hibition compared with corresponding NEDD4-1-proficient control cells.

122 allowed the subject to consistently achieve proficient control.

123 reas expression of MIR34A was induced in p53-proficient CRC cells exposed to hypoxia.

124 in PDA cell lines that are either DNA repair proficient (DDR-P) or deficient (DDR-D).

125 Proficient deaf readers activated left inferior frontal

126 The question of what differentiates proficient deaf readers from less-proficient readers is

127 LCs possess many of the properties of highly proficient dendritic cells, recent studies have indicate

128 grated transgenes, transgene removal enabled proficient differentiation of iPS cells into functional

129 strophe, revealing a new role for Myc in the proficient division of glioma cells.

130 A well-organized rapid damage response and proficient DNA repair, therefore, become critically impo

131 reast cancer cells with functional BRCA1 and proficient DSB repair, a transient nuclear depletion of

132 e fertility of oocytes containing a synapsis-proficient, DSB repair-defective mutation in a gene (Tri

133 e patient cells are homologous recombination proficient due to the low ratio of mutant to wild-type R

134 e, although only actively growing cells were proficient eDNA donors.

135 Surprisingly, the pol gamma exonuclease-proficient enzyme excised the incorrectly incorporated g

136 The YT mutant is the most proficient enzyme reported thus far for the detoxificati

137 lectric field in the active site of a highly proficient enzyme, Delta(5)-3-ketosteroid isomerase (KSI

138 (AP), which is one of the most catalytically proficient enzymes known.

139 Additionally, in MMR-proficient Escherichia coli, LNA modification of the ssO

140 nted demonstrating that use of an especially proficient 'extended FMDV 2A' coding region allows produ

141 y ATR-independent, as a HUS1 mutant that was proficient for ATR-induced checkpoint kinase 1 phosphory

142 ient chemistry and stabilize conformers most proficient for catalysis.

143 The UmuD N41D monomer is proficient for cleavage and interacts physically with DN

144 Both Fml1(K99R) and Fml1(D196N) are proficient for DNA binding but totally deficient in DNA

145 utants unable to interact with nsp14 are not proficient for ExoN activation.

146 ctp1Delta, these mutants were recombination-proficient for Rec12 (Spo11 homolog)-independent break-r

147 is study we show that mammalian cells become proficient for spontaneous gene amplification when the f

148 AD-51-ssDNA filaments to a conformation more proficient for strand exchange.

149 The Msh6-S cyclin fusion was proficient for suppressing mutations at three loci that

150 R are sensitive to oxidative DNA damage, but proficient for TC-NER.

151 ut abrogate its ability to activate Mec1 are proficient for the replication checkpoint, but they are

152 requency 4 logs lower than that of integrase-proficient FV vectors.

153 processing as a possible contributor to more proficient hearing in noise.

154 Twenty limited English proficient Hmong (n=10) and Spanish-speaking participant

155 rous growth when transplanted into autophagy-proficient hosts.

156 eterochromatin maintenance in p21 checkpoint-proficient human cells.

157 ays and suggest that Hyd-1 can function as a proficient hydrogen oxidase.

158 roduced within the brain, that microglia are proficient immune cells shaping neuronal circuitry and f

159 CD8alpha(+) DCs are also highly proficient in amplifying GC levels, leading to impaired

160 ed mutants, which retain the CtpA pilin, are proficient in attachment and adherence.

161 h small hydrophobic side chains are the most proficient in attracting CO2, indicating a significant c

162 Humans, by contrast, are highly proficient in auditory long-term memory (LTM).

163 in a concentration-dependent manner and were proficient in biofilm formation.

164 can theoretically allow a trainee to become proficient in both domains and to navigate the complexit

165 ons with dominant transactivation ability is proficient in DDR and insensitive to PARP inhibition.

166 the environment of liquid water is uniquely proficient in delocalizing positive charge.

167 n cells, we show each polymerase is uniquely proficient in different contexts.

168 We show that a Ku complex proficient in DNA loading but impaired in translocation

169 Tumors deficient or proficient in DNA mismatch repair (MMR) were identified

170 All three variants are proficient in DNA strand exchange, but G151D is slightly

171 eal that MtRecG but not MtRuvAB or MtRecA is proficient in driving the fork reversal.

172 ation, despite the fact that these cells are proficient in DSB repair by homologous recombination (HR

173 oleta) or the E3 ubiquitin ligase RAD18 were proficient in DSB repair following exposure to IR indica

174 east cancers carry wild-type BRCA1/2 and are proficient in DSB repair.

175 nd cognitively capable of participating, and proficient in English, participants were randomly select

176 but instead survived to become memory cells proficient in generating recall immunity.

177 cally reduces transcript production in cells proficient in global NER but lacking TCR, indicating tha

178 The use of a ruvB mutant proficient in homologous recombination but not in replic

179 We demonstrate that BRCA2(Delta105) is proficient in homologous recombination-mediated DNA repa

180 Face recognition is highly proficient in humans and other social primates; it emerg

181 te channeling for steps in vitro BER and was proficient in in vitro repair of substrates mimicking a

182 e brain endothelium in vitro, they were more proficient in induction of permeability and pro-inflamma

183 enesis and find that RNF8-deficient mice are proficient in meiotic sex chromosome inactivation (MSCI)

184 detectable effect on transcription in cells proficient in NER but lacking TCR, indicating that NER c

185 pressing the less severe Mtnip-3 allele were proficient in nitrate transport.

186 DNA polymerase gamma is also proficient in performing single-nucleotide reverse trans

187 splenocytes depleted of known APCs were most proficient in presenting nuclear autoantigens from apopt

188 on activities and the purified HOP2 alone is proficient in promoting strand invasion.

189 n activities, and the purified HOP2 alone is proficient in promoting strand invasion.

190 pombe ctp1 mutants deficient in clipping but proficient in resection during meiosis.

191 ast, cells expressing phospho-mimic EXO1 are proficient in resection even after CDK inhibition and fa

192 reasingly technological society, a workforce proficient in science, technology, engineering, and math

193 h a contemporary view of what it means to be proficient in science.

194 ele identified in this work, recA(Q300R), is proficient in SOS induction and repair of UV-induced DNA

195 ble from wild-type fibroblasts and they were proficient in the fusion of short telomeres.

196 The human motor system is remarkably proficient in the online control of visually guided move

197 esistance can occur, however, when cells are proficient in the removal of drug-induced damage.

198 After monkeys became proficient in this task, we tested their ability to gene

199 n is recruited to 5S rRNA genes as a part of proficient initiation complexes and the activity persist

200 Multisensory calibration is fundamental for proficient interaction within a changing environment.

201 -pdg-NLS-TAT protein was delivered to repair-proficient keratinocytes and fibroblasts, and to a human

202 is only a limited ability to survive and are proficient killers of chlamydiae.

203 VmoLac is a native, proficient lactonase with promiscuous, low phosphotriest

204 Proficient language use requires speakers to vary word o

205 tients with CMMRD and 5 individuals with MMR-proficient LCs (controls).

206 municating digitally may come with a cost in proficient learning of written Chinese.

207 lity of more than 0.7, which is considered a proficient level.

208 children have unexplained problems acquiring proficient linguistic skills despite adequate intelligen

209 l/fl) LysM-Cre(+) mice relative to autophagy-proficient littermates resulted in increased bacillary b

210 on, confirming that a small number of enzyme-proficient liver-engrafted cells can improve phenotype.

211 response was similar in IRF-1-deficient and -proficient macrophages during gammaherpesvirus infection

212 ng hepatocarcinogenesis, but only telomerase-proficient mice exhibited significantly increased rates

213 Notably, only rods in melatonin-proficient mice were affected by this daily visual cycle

214 instability and carcinogenesis in telomerase-proficient mice.

215 ein antigens in both TACI-deficient and TACI-proficient mice.

216 h patients who have microsatellite-stable or proficient mismatch repair (pMMR) tumors.

217 s of endonuclease-deficient and endonuclease-proficient Mlh1-Mlh3.

218 that patients whose tumors had deficient vs proficient MMR had significantly better SAR (adjusted ha

219 Favorable DFS was observed for dMMR versus proficient MMR proximal tumors (HR, 0.71; 95% CI, 0.53 t

220 Compared with mismatch repair proficient (MMR-P) POLE wild-type tumours, POLE-mutant c

221 Adoptive transfer of Cx3cr1-proficient monocyte-enriched bone marrow cells into sept

222 was deleted by targeted mutation in the CSR proficient mouse B-cell line, CH12F3.

223 allowed 1-, 2-, or 3-bp substitutions in MMR-proficient mouse embryonic stem cells as effectively as

224 s observed only for wild-type YscO and a T3S-proficient mutant of YscO but not for the several T3S-de

225 21), comparing proficient (N = 11) and less proficient (N = 10) readers' performance in a widely use

226 tivation in deaf readers (N = 21), comparing proficient (N = 11) and less proficient (N = 10) readers

227 7/8-deficient neoplasms compared with E2f7/8-proficient neoplasms.

228 ctivating enzyme Ube1, which is required for proficient NER.

229 gression in rat ERBB-2 (neu) transgenic, pfp-proficient (neu(+)/pfp(+)) or pfp-deficient (neu(+)/pfp(

230 ontrol or indirectly involved, we found that proficient neuroprosthetic control is associated with la

231 Those initially not proficient on a given day were immediately prompted to p

232 h early transient hypoglycemia would be less proficient on fourth-grade achievement tests compared wi

233 Less proficient operators derive greater benefit from simulat

234 er benefit from simulator training than more proficient operators.

235 n-Smad1 and Atm-p38MAPK-Atf2 pathways in p53-proficient or -deficient cells and requires the Smad1-At

236 2 (APE2) has no effect on CSR in either APE1-proficient or -deficient cells.

237 uorescence between those cell lines that are proficient or deficient in mismatch repair.

238 signaling was preserved in models that were proficient or deficient in p53, resembling standard or h

239 e in PriA that renders it less catalytically proficient or prevents conformational changes in PriA th

240 However, proficient organophosphatases such as serum paraoxonase

241 sis in regulating gene pathways required for proficient osteoclastogenesis.

242 Conversely, cells with a proficient p53 allele could better cope with the mitotic

243 that significantly affected limited English proficient patients' ability to access language services

244 ally attempted to engineer IcmF to be a more proficient PCM by targeting two active site residues pre

245 Transfer of Nr4a1-proficient PMo into Nr4a1-deficient mice prevented tumor

246 delity than bulk replication by proofreading-proficient Pol delta or Pol epsilon.

247 escape proofreading by 3' --> 5' exonuclease-proficient Pol epsilon, indicating that ribonucleotide i

248 but still detectable when using exonuclease-proficient pol gamma.

249 0) compared with six (range, 0 to 17) in MMR-proficient/POLE wild-type tumors (P < .001).

250 ock the swarming behavior of a large gliding-proficient population.

251 beta' subunit and inhibits transcriptionally proficient promoter-complex (RPo) formation.

252 the open-reading frame, encodes a DNA repair proficient protein and is expressed in IVS7+2T>G carrier

253 These remarkably proficient proteins also provide noncanonical functions

254 al splice variants, are expressed as editing-proficient proteins in mammalian cells.

255 Furthermore, in reaching-proficient rats, reaching accuracy was reduced and forel

256 In contrast, the less-proficient readers exhibited a pattern of response chara

257 erentiates proficient deaf readers from less-proficient readers is poorly understood but topical, as

258 The evaluation of proficient and less-proficient readers points to different modes of processi

259 been used to study disassembly of hydrolysis-proficient RecA protein filaments.

260 Thus, RecA K72R inhibits hydrolysis-proficient RecA proteins by interacting with them in sol

261 n the leading strand results from their more proficient removal.

262 at the global genome level while maintaining proficient repair of constitutively expressed genes.

263 ither repair protein is combined with the CT-proficient repair partner, no relocalization occurs.

264 spite having normal amounts of catalytically proficient Rubisco, the hybrid mutant strains display re

265 Proficient SIN activity requires the asymmetric distribu

266 d Cdc11 hyperphosphorylation correlates with proficient SIN activity.

267 group of English monolinguals and a group of proficient Spanish-English bilinguals were presented wit

268 of targeting BRCA1 location to convert BRCA1-proficient sporadic tumors to be susceptible to the synt

269 tive to the energy charge in the acetylation-proficient strain (0.71).

270 ning these improvements in a mismatch repair proficient strain reduced counter-selection escape frequ

271 ismatch repair-deficient and mismatch repair-proficient strains.

272 iour of acetylation-deficient or acetylation-proficient strains.

273 ation apparatus tip protein Bsp22 in all Bvg-proficient strains.

274 As subjects became proficient, strong initial task-related activation was f

275 single-stranded DNA to form a catalytically proficient structure able to promote homology recognitio

276 and characterizes Poltheta as among the most proficient terminal transferases known.

277 Spiked swipe and water samples as well as proficient testing water standards were analyzed to vali

278 an N,N-dibenzylammonium moiety appeared more proficient than a hydroxyl group at directing the stereo

279 3' primer terminus, and is surprisingly more proficient than terminal deoxynucleotidyl transferase.

280 In comparison, growth on PUT was more proficient than that on CAD, and this observed growth ph

281 Three subtypes were MMR proficient: those with mutations in BRAF (6.9% of sample

282 t training, or social input from adults; and proficient tool use is a species-wide capacity.

283 mors, as compared with 73 in mismatch repair-proficient tumors (P=0.007), and high somatic mutation l

284 ly in hypermutated DNA mismatch repair (MMR)-proficient tumors and appear to be responsible for the b

285 Patients with MMR-proficient tumors and BRAF or KRAS mutations had statist

286 These individuals had mismatch repair-proficient tumors and each carried nonsense variant in t

287 for 5 years compared with patients whose MMR-proficient tumors lacked mutations in either gene.

288 A higher percentage of MMR-proficient tumors with BRAF(V600E) were proximal (76%),

289 cantly lower proportion of patients with MMR-proficient tumors with mutant BRAF (hazard ratio = 1.43;

290 es was similar to those of patients with MMR-proficient tumors without BRAF or KRAS mutations.

291 d detected in women (59%), compared with MMR-proficient tumors without BRAF(V600E) or KRAS mutations

292 Four hundred two patients (89.3%) had MMR-proficient tumors, and 32 patients (8%) had at least 1 g

293 1 as a potential therapeutic target in BRCA2-proficient tumors.BRCA2 is essential for the repair of D

294 rget therapy-resistant hypoxic cells in ASS1-proficient tumours and ASS1-deficient tumours.

295 leads to increased self-confidence and more proficient use of the direct ophthalmoscope.

296 ere required to both abolish activity of the proficient version and restore full activity to the defi

297 -mediated degradation and still inhibits vif-proficient viral infection.

298 In these studies, we examine a swarming-proficient, virulent strain and identify an altered-func

299 uiting body development by a developmentally proficient wild-type strain under high-nutrient conditio

300 ound in nearly half of the study cohort (MMR-proficient without BRAF(V600E) or KRAS mutations) had si