ライフサイエンスコーパス: profile

1 arkov motif profile and polypyrimidine tract profile.

2 demonstrated a clinically acceptable safety profile.

3 ient SCID, with an excellent clinical safety profile.

4 formed the best, followed by DNA methylation profile.

5 ically characterized based upon their immune profile.

6 sessment, PSI had the best decision-aid tool profile.

7 the eribulin arm, with a manageable toxicity profile.

8 on of leaf nitrogen and the light absorption profile.

9 ytosis imprinted a distinct antiinflammatory profile.

10 acteria (40.8%)-were identified in 688 women profiled.

11 Both treatments had similar safety profiles.

12 with greater efficacy and/or improved safety profiles.

13 g to their transcription factor and cytokine profiles.

14 genitors do not exhibit different expression profiles.

15 as well as alteration of the transcriptional profiles.

16 r physiology, structure, and gene expression profiles.

17 expressed as different brain phosphoprotein profiles.

18 h a new dataset of 265 ccRCC gene expression profiles.

19 tent anti-inflammatory and immune modulatory profiles.

20 roach and summarized the results in evidence profiles.

21 have repeatedly revolutionized transcriptome profiling.

22 al disease biomarkers through transcriptomic profiling.

23 7 thereafter and subjected to lipid mediator profiling.

24 chromatin immunoprecipitation, and ribosome profiling.

25 Based on the expression profiles, 19 genes were further analysed by qPCR.

26 Here, we have profiled 2 repressive epigenetic marks, H3K9me2 and H3K2

27 CVD.With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of

28 single-cell MAB-seq (scMAB-seq), capable of profiling 5fC and 5caC at genome scale using approximate

29 ferent subclones with heterogeneous mutation profiles accumulating in GPCR, PI3K-Akt and FGFR signali

30 COSMIC v78 contains wide resistance mutation profiles across 20 drugs, detailing the recurrence of 30

31 probably contributes to a concentration-time profile after oral administration in the cynomolgus monk

32 We conclude that plasma profiling after STEMI may help identify patients with a

33 lly significant differences in the metabolic profile among uninfected I. scapularis nymphal ticks, B.

34 We identified 4 host gene expression profiles, among which catabolic remodeling, associated w

35 Unsupervised gene expression profiling analysis, including principal component analys

36 resented a dose-proportional pharmacokinetic profile and a half-life of 12 days.

37 TATION: Avelumab showed an acceptable safety profile and antitumour activity in patients with progres

38 caused a muted innate immune gene expression profile and decreased immune cell infiltration in an int

39 hibitor displaying excellent pharmacokinetic profile and efficacy in a human PTEN-deficient LNCaP pro

40 modulation of the host urinary metabolomics profile and intestinal energy absorption.

41 position weight matrix profile, Markov motif profile and polypyrimidine tract profile.

42 The safety profile and risk of systemic toxic effects when brimonid

43 TATION: Gilteritinib had a favourable safety profile and showed consistent FLT3 inhibition in patient

44 espondent profile sheet assessed demographic profile and social media use profile in terms of the mod

45 zed the fatty acid composition, the phenolic profile and the sensory analysis of the oils from these

46 Cell-specific labeling of RNA can be profiled and imaged using bioorthogonal chemistry.

47 hA3R) antagonists to determine their kinetic profiles and affinities.

48 ations between altered cerebellar metabolite profiles and brain injury topography, severity of injury

49 on through comprehensive analyses of release profiles and cellular-uptake and cell viability studies.

50 mately contribute to their unique behavioral profiles and potential for development as cocaine use di

51 g nutritional needs to individual biomedical profiles and the issues surrounding them.

52 e further extended to problems in metagenome profiling and cell type inference.

53 Chemical profiling and gene expression studies showed that solana

54 Basal lineage-specific profiling and genetic loss-of-function experiments revea

55 ectum using microarray based transcriptional profiling and identified several novel candidate retinot

56 of CD8 T-cell activation, combining polysome profiling and microarray analysis.

57 Advances in genome profiling and next-generation sequencing have led to the

58 A dopamine neurons, their mRNA translational profile, and basic electrophysiological characteristics

59 of insulin resistance, serum ferritin, lipid profile, and liver function tests improved irrespective

60 with short reaction times, increased safety profile, and potential to scale up.

61 wild-type mice maintain a distinct cytokine profile, and, unlike eosinophils isolated from IL5tg mic

62 of various strengths and temporal expression profiles, and 10 protein-localization, degradation and s

63 d DPD, PH-LHD subclassification, hemodynamic profiles, and mortality.

64 uring 2002 to 2005, had complete risk factor profiles, and were free of clinical CVD, were included i

65 developed a population-level microsatellite profiling approach, SID (Saccharomyces cerevisiae IDenti

66 BMI) and offspring systemic cardio-metabolic profile are causal, via intrauterine mechanisms, or due

67 sms that shape and regulate their expression profiles are largely unknown.

68 Both perturbation and response profiles are stratified into stabilizing and destabilizi

69 on, although the grand canonical free energy profiles are uphill for HTT exon 1 fragments having 20 o

70 fibers with enhanced Rayleigh backscattering profiles as distributed temperature sensors, we demonstr

71 ation and an altered locomotor sensitization profile, as well as increased responding for and intake

72 d approach to map the complete glycosylation profile at every site in multiple HIV-1 Env trimers, acc

73 he variables that impact Env's glycosylation profile at sites with divergent glycosylation.

74 Single-cell transcriptional profiling at E9.5 reveals that endocrine-committed cells

75 ng the occurrence of 30-day MACE and CV risk profile based on information from national registries.

76 ecular assays and has resulted in resistance profiles being reported to physicians an average of 9 da

77 icant correlations between AC and polyphenol profile, being hydroxybenzoic acid diglucoside, tryptoph

78 synovial fluid showed significantly distinct profiles between groups with 125 differentially expresse

79 ve feedback, shape the temporal ERK activity profile but are dispensable for oscillations.

80 ex DNA sequences are difficult to detect and profile, but are important contributors to human health

81 to neonatal mice enabling longitudinal TFAR profiling by continued bioimaging throughout the lives o

82 mRNA profiling by microarray analysis revealed that the expre

83 messenger RNA was subjected to transcriptome profiling by microarray.

84 A "dome-shaped" profile can form at the upper boundary of the urban heat

85 In addition, we show copy number profiles can also be obtained from the same data, all at

86 However, how the protein profile changes to facilitate the cells differentially p

87 siderable advantages compared to traditional profiles collected as curtains, although this new approa

88 the normal faults interpreted in 3-D seismic profiles collected from adjacent areas.

89 em with large data sets of normal expression profiles compiled from public sources, in regard to the

90 ic liver disease, but comprehensive cytokine profiling data across different clinical characteristics

91 by integrating gene and microRNA expression profiling data from hearts of T. cruzi infected mice.

92 signal when applied to low-quality chromatin profiling datasets across individuals, cell types and sp

93 number of publicly available transcriptional profiling datasets.

94 Despite similar 1D-gel profiles, defatting with n-hexane resulted in significan

95 archical clustering based on gene expression profiles delineated brain regions into structurally tier

96 Results of miRNA profiling demonstrated that miR-30a was markedly downreg

97 on sequence-derived features, such as sparse profile, dinucleotide profile, position weight matrix pr

98 cteristics, microbial population and flavour profile during storage.

99 However, we observe distinct kinetic profiles, even for proximal sites, and this suggests tha

100 Genetic studies and transcriptional profiling experiments show that this single protein is i

101 ypes, to generate a representative reference profile for miscanthus cell wall biomass.

102 ng transcriptomic, genomic and/or epigenomic profiles for any given cancer sample.

103 roach, we investigate the unique transhesive profiles for breast cancer cells that are adapted to col

104 s to carefully balance efficacy and toxicity profiles for each individual patient.

105 l regions studied by ENIGMA, gene expression profiles for three pathways were significantly correlate

106 mRNA and miRNA expression profile frequently performed the best, followed by DNA m

107 reover, curcumin exhibited sustained release profile from crosslinked nanogels in simulated gastroint

108 (-/-) mice had a very different inflammatory profile from infected Il1r1(-/-) and Pycard(-/-) mice.

109 The profile from larger iodine clusters deviates from a sing

110 and present whole-genome replication timing profiles from cells in early, mid, and late S phase of t

111 ow that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages.

112 OA patients possess a respiratory metabolic profile fully divergent from those obtained in the other

113 omatically generated RN with gene expression profiles (GEP) from a cohort of multiple myeloma (MM) pa

114 highly sensitive software pipeline based on profile hidden Markov models constructed from manually c

115 Whole genome mRNA expression profiling identified nicotinamide N-methyltransferase (N

116 stion, epigenetic changes, abnormal microRNA profiles, immunosenescence, and a low-grade chronic infl

117 g protocol and uncovered a different poly(A) profile in esp5.

118 formed comparison of the whole transcriptome profile in isolated fibres and other portions of the fla

119 Lyme disease, modulates its gene expression profile in response to the environments encountered thro

120 sed demographic profile and social media use profile in terms of the mode, frequency, and duration of

121 le of a specific immune/inflammatory patient profile in the improved response to sorafenib.

122 ast, two additional compounds with PLTX-like profile in the Palythoa canariensis sample.

123 suitable biomarker due to its high stability profile in wastewater.

124 J pathogenesis and help delineate an altered profile in wound-healing markers during ONJ development.

125 roved interim outcomes and acceptable safety profiles in adults.

126 atography was employed to analyze fatty acid profiles in egg samples.

127 ) in urine samples confirmed that metabolite profiles in mdr1a (-/-) mice were remarkably unaffected

128 We analyzed lncRNA expression profiles in mouse hearts at postnatal day (P) 1, P7 and

129 ed lysine 9 in histone), and gene-expression profiles in naive, effector memory (EM), and terminally

130 rked differences in specific peanut allergen profiles in peanut butter and flour and peanut preparati

131 tumors showed altered primary and metastatic profiles in previous studies, depending upon nuclear and

132 changes of genome-wide blood DNA methylation profiles in relation to the development of PTSD symptoms

133 f variation for the antennal transcriptional profiles in the adult and developing olfactory system of

134 pplying this antibody for protein expression profiling in 44 normal and 21 malignant human tissues, w

135 Ribosome profiling in ER-stressed cells lacking these factors rev

136 miRNA profiling in the human brain has revealed miR-132 as one

137 We performed comparative ribosome profiling in yeast and mice with various ribonucleases i

138 The rogue waves show similar profiles, in agreement with the theory of extreme wave g

139 induced genes identified in transcriptional profiling include those for putative enzymes and a carbo

140 Our multi-layer proteomics profiling, integrative network analysis, and functional

141 Here, we report that the human skin odour profile is affected by malaria infection.

142 This dopamine profile is specific to behavioral choice, scalable with

143 f multiple NAbs with distinct neutralization profiles is likely to enhance the breadth and potency of

144 d assay and also shows a very favorable ADME profile leading to favorable predicted human pharmacokin

145 Lipid profile levels were statistically significant on compari

146 h an unfavorable cardiometabolic risk-factor profile [lower high-density lipoprotein (HDL) cholestero

147 in vitro properties and a promising mouse PK profile, making it suitable for in vivo testing.

148 needed that can extensively and controllably profile many individual cells.

149 trate through metabolomic and transcriptomic profiling marked suppression of glucocorticoid biosynthe

150 dinucleotide profile, position weight matrix profile, Markov motif profile and polypyrimidine tract p

151 This study used PA of different MW profiles (mean degree of polymerization 8.3 and 19.5) to

152 ped a sensitive and accurate multiplex miRNA profiling method using modified isothermal EXPAR combine

153 mic analysis showed greater phosphoproteomic profile modification(s) in response to combined MEK/mTOR

154 biomechanical behavior and vascular healing profile of a novel thin-walled (115 microm) sirolimus-el

155 Transcriptional profile of ABA receptor genes revealed a different induc

156 Characterizing blood profile of alopecia areata (AA) is important not only fo

157 mental design, we quantified the ontogenetic profile of bite-force performance in post-metamorphic Ce

158 The proteoform profile of C9 was acquired by high-resolution native mas

159 h was further enlightened through Cu release profile of Cu-chitosan NPs.

160 igated in human islets to develop a detailed profile of early ischemia induced changes and targets fo

161 y mixture of lipids, the modulated-intensity profile of elastic back-scattered light from an opticall

162 t provides the first consensus glycosylation profile of Env trimers, which should serve as a useful b

163 a clearer idea of how to improve the safety profile of GCs, recent studies have investigated the com

164 By fitting the transmission profile of grain boundaries, we obtain excellent agreeme

165 egy is reported for improving the resistance profile of HCV NS3/4A protease inhibitors.

166 riptional level manifests in the physiologic profile of individual cells in the context of disease pr

167 cs of the sample from the measurement of the profile of its refractive index in the vicinity of molec

168 lly, as with ventral pathway, the activation profile of posterior dorsal regions was correlated with

169 on the functional properties and isoflavone profile of soy protein concentrate.

170 Pathway analysis of the transcriptomic profile of the injured nociceptors revealed oxidative st

171 the overall structure and the charge density profile of the two biopolymers.

172 We reviewed the climate health profiles of 16 states and two cities participating in th

173 We examined serum cytokine profiles of 411 patients with HCC (n = 102: 32% HBV, 54%

174 edominant peaks were observed in the RP-HPLC profiles of all protein fractions.

175 average avalanche shapes, i.e., the temporal profiles of avalanches of fixed duration.

176 ed differences in the fatty acid selectivity profiles of cellular zDHHC enzymes and mapped molecular

177 At the same cell the molecular profiles of different organelles can strongly correlate,

178 imulations that characterize the free-energy profiles of explicit proton transport through several im

179 Lipid profiles of fatm and ram2 suggested that FatM increases

180 he intracellular and extracellular metabolic profiles of four prostate cancer cell lines with varying

181 We then analyzed gene expression profiles of human breast cancer patients and patient-der

182 on network analyses revealed transcriptional profiles of individual cell populations distinct from bu

183 ever, it has been challenging to use genetic profiles of individual patients in identifying the most

184 We examined the transcriptional profiles of macrophages that reside in the islets of Lan

185 Metabolite profiles of mcrA deletant, mcrA overexpressing, and pare

186 The metabolic profiles of microtissues derived from normal organs (hea

187 s; and (2) RNA sequencing-derived expression profiles of nasal cells, before and after HDM exposure.

188 The relative composition profiles of PFASs in blood matrices differed.

189 sed for the first time to determine spectral profiles of tryptophan, reduced nicotinamide adenine din

190 cit similar nasal proteome responses and the profiles of welders and healthy controls were alike.

191 We performed (epi)genomic profiling of 138 IMs from 148 cancer-free patients, recr

192 g cell subpopulations based on transcriptome profiling of 144 single LNCaP prostate cancer cells trea

193 Systematic profiling of a larger portion of circulating plasma prot

194 loped a novel assay that allows for parallel profiling of activity on all modified cytosines.

195 Ribosome profiling of an eIF5A-depleted strain reveals a global e

196 Profiling of cardiomyocyte and nonmyocyte transcriptiona

197 Transcriptional profiling of cDKO HSPCs revealed the activation of p53 a

198 novel image processing pipeline, for the 4D profiling of chemoconvulsant action in multiple brain re

199 Thus, proteomic profiling of cilia from diverse eukaryotes defines a con

200 Here, we performed epigenetic profiling of human resting naive, central and effector m

201 Dynamic proteome profiling of individual proteins in human skeletal muscl

202 Previous cardiac transcriptional profiling of LmnaH222P/H222P mouse, a small animal model

203 Using unbiased proteomic profiling of over 100 different cytokines, we found that

204 .6L, MYB59, and ANAC055, using transcriptome profiling of overexpressors and mutants, provided insigh

205 develop a new method for total transcriptome profiling of plasma-derived EVs by next generation seque

206 cal research relies on the fast and accurate profiling of specific biomolecules and cells in a non-in

207 on and post-translational modification (PTM) profiling of targeted protein in biofluid.

208 The complete profiling of the bio/nanomaterials interface and interac

209 for high-throughput structural and molecular profiling of the diverse populations of synapses that co

210 Spatial profiling of the iron-laden infiltrates further demonstr

211 Profiling of the OFC synaptome identified alcohol-sensit

212 High-throughput genomic and molecular profiling of tumors is emerging as an important clinical

213 We show that a cylindrical flight profile offers considerable advantages compared to tradi

214 the role of prenatal cytokine and chemokine profiles on neurodevelopmental outcomes in humans.

215 Methods We performed digital gene expression profiling on a cohort of 245 formalin-fixed, paraffin-em

216 ng embryogenesis, we performed transcriptome profiling on whole mouse embryos.

217 idence of PTDM and a manageable tolerability profile over 24 weeks of treatment.

218 ids and to the monitoring of its degradation profile over time.

219 ments in islet (epi)genome and transcriptome profiling (particularly single cell analyses) are provid

220 for Personalized Therapeutics (ADEPT) study profiled patients with mild, moderate, and severe asthma

221 have been found to exhibit remarkable "motif profiles", patterns in the relative prevalences of all p

222 ore >/=25), but not in those with lower risk profiles (pinteraction=0.007), and exerted a significant

223 jectory of incorporation of global molecular profiling platforms into the routine clinical classifica

224 including differential expression analysis, profiling plotting, correlation analysis, patient surviv

225 atures, such as sparse profile, dinucleotide profile, position weight matrix profile, Markov motif pr

226 dent pituitary growth hormone (GH) secretory profiles-pulsatile in males and persistent in females-re

227 Comparative proteome profiling regarding other cells demonstrated cell-type-s

228 Hierarchical clustering of the profile reliably predicted pre- and postoperative status

229 The origin and significance of these profiles remain largely unknown.

230 y associations are used along with intensity profiles, retention time characteristics, mass defect, a

231 participants based on global gene expression profiles revealed that participants with significantly h

232 Gene expression profiling revealed primary and metastatic cells as two d

233 Transcriptional and epigenomic profiling revealed that IFE and HF tumor-initiating cell

234 Cell-specific transcriptional profiling revealed that microglia selectively enhanced C

235 Intracellular metabolic profiling revealed that PknG is necessary for efficient

236 r inhibition evidenced only context-specific profiles, revealed in the static connectivity patterns l

237 ution mapping of m(6)A coupled with ribosome profiling reveals that m(6)A promotes the translation of

238 nnotation, RNA-protein interaction, ribosome profiling, RNA-seq analysis and RNA target prediction.

239 reading frames (ORFs) from regular ribosome profiling (rRibo-seq) data and outperform several establ

240 e (MTD), pharmacokinetic and pharmacodynamic profiles, safety, and clinical activity of enasidenib in

241 ERA transcatheter heart valve (THV) is a low-profile, self-expanding nitinol valve made from bovine p

242 ochemical factors that control the retention profile shape.

243 a two-part survey composed of the respondent profile sheet and the Social Skills Inventory.

244 The respondent profile sheet assessed demographic profile and social me

245 Finally, analysis of neurotransmitters profile showed a significant effect on cholinergic and d

246 zyme assays and customized (13) C metabolite profiling showed that both targets are functionally impa

247 pab1 deletion brings about a transcriptional profile similar to TORC1 inactivation, and deletion of p

248 er of CGIs consistently detected from all 16 profiled single cells was 20 864 (72.7%), with 12 961 pr

249 Gene expression profile status was class 1 in 247 tumors (70%) and class

250 ession analyses and unbiased gene expression profiling studies offer a molecular explanation for the

251 Recent genome-wide ribosome profiling studies suggest that thousands of uORFs initia

252 is inactivated by looking at gene expression profiling studies.

253 functions associated with a proinflammatory profile such as bactericidal capacity and the ability to

254 tiple biochemical biomarkers and metabolomic profiles suggested that MPs exposure induced disturbance

255 ect of hDBR1 on RNA splicing, and metabolite profiling supported the observation that neoplasm is tri

256 flow-nanospray mass spectrometry nontargeted profiling technique to identify changes in the exposome

257 he advent of high-throughput DNA methylation profiling techniques has enabled the possibility of accu

258 Unbiased, "nontargeted" metabolite profiling techniques hold considerable promise for bioma

259 Cell wall profiling techniques showed that the pretreatment led to

260 rodactylus and had different gene expression profiles than lake sticklebacks.

261 eptors (TLRs) may offer superior therapeutic profiles than that of single TLR activation.

262 n coefficients, and better canonical loading profiles than the competing methods.

263 by RT-qPCR, often showed opposite expression profiles than the related miRNAs.

264 gazing' by identifying features of the SHAPE profile that human experts agree 'looks' like a riboSNit

265 We aimed to profile the microbiota at different stages of Barrett's

266 Profiling the expression patterns of snoRNAs is the init

267 By profiling the transcriptomes of individual cells, single

268 nantly CN-52/60 and CN-42) dominated the PCN profile, the hexa-CNs (mainly CN-66/67) accounted for th

269 gonal ubiquitin transfer (OUT) technology to profile their ubiquitination targets in mammalian cells.

270 simulations also predict the adhesion force profile to be distinct for CaCl2 compared with the other

271 ed with placebo, and showed a similar safety profile to currently available GLP-1 receptor agonists,

272 analysis of IFN-gamma transcript and protein profile to simultaneously study the responsiveness of di

273 vast amount of high-throughput data has been profiled to understand the mechanism of complex diseases

274 Here we use exometabolomic profiling to examine the time-varying substrate depletio

275 Therefore, we have used cellular expression profiling tools to define the distinct miRNA expression

276 ETATION: Avelumab has an acceptable toxicity profile up to 20 mg/kg and the maximum tolerated dose wa

277 2 cycles) for epigenomic and transcriptomic profiling using the Infinium HumanMethylation450 BeadChi

278 The solvent retention capacity profile was also affected by jet milling.

279 An annular magnetic field profile was observed 5 ps after the interaction, indica

280 The arsenobetaine depth profile was related, albeit weakly, to that of chlorophy

281 RVA profile was the easiest way of identifying this characte

282 When a stationary voltage profile was used in the ST region, ions are blocked at t

283 (1)H HR-MAS NMR metabolite profiling was achieved from a small sample of intact sau

284 Activity-based protein profiling was applied to pooled plasma samples to enrich

285 Biochemical profiling was conducted to confirm a CDG type I defect.

286 otype microarrays and comparative metabolite profiling we demonstrate the impact of the well-characte

287 e defined using gene expression and mutation profiles, we identify a unique subpopulation based on ad

288 Through transcriptomic profiling, we determined that low expression of the ergo

289 g whole-exome sequencing and transcriptional profiling, we found that the long non-coding RNA MIR100H

290 By global proteomic and phosphoproteomic profiling, we show that, in BL, HSP90 inhibition comprom

291 Tolerability profiles were comparable between arms.

292 enotypic analyses of FCGR3A/CD16 Fc-receptor profiles were compared in CAV-positive (n=52) and CAV-fr

293 of variance was used for comparison of lipid profile, whereas Kruskal-Wallis test was used for compar

294 clinical circumstances, their in vivo safety profiles (which are being incorporated into their chemic

295 uce the human 28-day menstrual cycle hormone profile, which controls human female reproductive tract

296 ature of the inserted pore, yielding a force profile with barriers for membrane exit due to the membr

297 elopment, each resulted in a gene expression profile with significant overlap.

298 s that PDAC and IPMN have differential miRNA profiles with respect to C, with a large number of dereg

299 we term functionally-relevant morphological profiling with great potential to improve our understand

300 we present dimethyl sulfate (DMS) mutational profiling with sequencing (DMS-MaPseq), which encodes DM