ライフサイエンスコーパス: profound

1 ilities of these measurements were much more profound.

2 gical analysis of intestinal tissue revealed profound abnormalities in support of this conclusion.

3 ffects of the associated SMOC2 haplotype are profound, accounting for 36% of facial length variation

4 ofiling of whole blood by CyTOF demonstrated profound activation of cells of the innate immune system

5 Persistent DNA damage induces profound alterations in gene expression that, in turn, i

6 aining the New Zealand Black Slam locus have profound alterations in Ly108, CD150, and Ly9 expression

7 hogenic factor in Alzheimer disease, induces profound alterations in neurovascular regulation through

8 subtype-selective NaV1.7 inhibitors produced profound analgesia.

9 A unique pattern of profound anatomical change known as Dehnel's phenomenon

10 (betaT) is a genetic blood disorder causing profound and life threatening anemia.

11 ted major down-regulation of photosynthesis, profound and multifarious modulation of plant hormone le

12 S-causing mutations in its BEACH domain have profound and possible effects on the interaction with Do

13 ement, or dispersal, of individuals can have profound and predictable consequences on community assem

14 from osteoblastoid cells is associated with profound and selective reductions in the number and prop

15 AKI is associated with a profound and severe increase in morbidity and mortality

16 w modulations of synaptic gain can result in profound and sustained effects on neural activity.

17 with sustained sensory input, can result in profound and sustained effects on neural responses to pr

18 ent on to show that protein folding can have profound and unexpected biological effects on such diver

19 e interesting, more emotionally moving, more profound, and occasionally even more beautiful.

20 In this context we recently demonstrated profound anti-silencing properties for the small (679 bp

21 HuR inhibition has profound anticancer activity.

22 LS), and Alzheimer's disease (AD), and found profound apical dendrite degeneration of Betz cells in b

23 of oncogenic SS18-SSX fusion proteins caused profound ATRi sensitivity and a reduction in SS18 and SM

24 yed high levels of serum cytokines typifying profound autoinflammation.

25 es to enhance its nuclear expression induces profound autophagy in cultured renal epithelial cells.

26 The antibody also causes profound beiging, increases cellular mitochondrial densi

27 and therapies to counteract these might have profound benefits for health.

28 physiological changes that contribute to the profound benefits of these surgical procedures.

29 en sources; all of these parameters can have profound biological consequences, and were correlated to

30 to interact with multiple proteins, can have profound biological impacts on cells.

31 cancer that develops in the skeleton causing profound bone destruction and fractures.

32 Whereas damaged skeletal muscle has a profound capacity to regenerate, heart muscle, at least

33 Here, we use a model exhibiting the most profound case of pubertal suppression among mammals to e

34 CD73(+) BRAF(V600E)-mutant melanomas caused profound CD73 downregulation in tumor cells.

35 the pyruvate dehydrogenase complex, caused a profound cell growth inhibition in tumour cells harbouri

36 pression of thousands of genes, resulting in profound cellular changes.

37 Profound changes are occurring in the epidemiology of sc

38 he methionine-choline deficient (MCD) model, profound changes are seen in redox enzymes and key intra

39 Our results also reveal that there were profound changes during the production of the final viru

40 The mammalian sex chromosomes have undergone profound changes during their evolution from an ancestra

41 ctor for the spread of bronze technology and profound changes in burial practices as well as material

42 ese early patterning effects are manifest as profound changes in cell fates [short hair cells (HCs) a

43 munity-wide reorganizations, which result in profound changes in ecosystem functioning.

44 orylation in transformed CD8+ T cells led to profound changes in gene expression that were accompanie

45 treatment practices have been accompanied by profound changes in markers of resistance.

46 role in seizure onset, we propose that these profound changes in mEC neuron excitability associated w

47 Our data showed profound changes in skeletal shape, size and structure w

48 fatal fibrotic lung disease characterized by profound changes in stem cell differentiation, epithelia

49 The Myshkin model demonstrates profound circadian and light-responsive behavioral alter

50 ng their basic biological principles and has profound clinical implications.

51 ein kinase (MAPK) pathway antagonists induce profound clinical responses in advanced cutaneous melano

52 naplastic large cell lymphoma (ALCL) has had profound clinical success.

53 Sleep loss causes profound cognitive impairments and increases the concent

54 of leaving the European Union (EU) will have profound consequences for health and the National Health

55 Our results have profound consequences in the interpretation of transport

56 and enrichment of dynamic crosslinking have profound consequences on domain morphology.

57 Apathy has profound consequences, such as functional impairment, hi

58 ble events that nonetheless occur-often with profound consequences.

59 risk IPSS-R with poor-risk genetic features, profound cytopenias, and high transfusion burden are can

60 receptor profile (including CCR2 and CCR5), profound cytotoxicity (Granzyme B and CD107A), resistanc

61 that causes blindness, balance disorders and profound deafness, and studied a knock-in mouse model, U

62 temporal area in individuals with early and profound deafness.

63 a and other neurodegenerative diseases cause profound declines in functioning; thus, many patients re

64 creased by 1.5-fold and was accompanied by a profound decrease in proliferative potential.

65 In association with the profound defect in intestinal oxalate secretion, Cftr(-/

66 early foregut endoderm led to a specific and profound defect in lung development with lung buds faili

67 Upf3b-null mice also have a profound defect in prepulse inhibition (PPI), a measure

68 Larval fly hearts overexpressing miR-1 have profound defects in actin filament organization that are

69 quitylates replication protein A (RPA), show profound defects in ICL repair.

70 ete with NK cells for IL-15 thereby inducing profound defects in NK-cell reconstitution that compromi

71 ular, and olfactory systems, attributable to profound defects in sensory receptor terminal differenti

72 Profound defects in the normal counterregulatory respons

73 etectable consequences of SMN deficiency are profound defects of the neuromuscular junctions (NMJs).

74 Striatopallidal MSNs showed profound defects, including alterations in synaptic tran

75 These mice display profound deficits in synaptic plasticity without any eff

76 These effects resulted in a profound delay in tumor growth.

77 adenosine and prostaglandin E2, results in a profound delay of neutrophil apoptosis and concomitant u

78 ntal disorder characterized by microcephaly, profound developmental delays and/or intellectual disabi

79 hibitors of all MbetaLs, notwithstanding the profound differences between these enzymes' active site

80 This analysis revealed profound differences in heterozygote frequencies among p

81 Here, we found profound differences in hippocampal-cortical reactivatio

82 Our data suggest profound differences in regulation of imprinting in plac

83 to a melanomagenesis protocol, demonstrated profound differences in susceptibility to nevus initiati

84 broblasts and weak in HeLa cells, indicating profound differences in the regulation of biochemical pr

85 ials will help in understanding the observed profound differences in their electrochemical reactivity

86 rrests cerebral angiogenesis, resulting in a profound diminution of the brain microvasculature withou

87 In the absence of Ptchd1, we observed profound disruption in excitatory/inhibitory balance des

88 ants arrest development at midgestation with profound disruptions in the organization of the mesoderm

89 cal oscillations that are thought to reflect profound disruptions of activity in neuronal circuits th

90 DI-010976 is well tolerated and results in a profound dose-dependent inhibition of hepatic DNL in ove

91 This approach leads to profound dose-related adverse effects.

92 This modulation is attributed to a profound down-regulation of digestive enzyme genes and t

93 e are almost devoid of Dock7, resulting in a profound dysregulation of its signaling pathway, leading

94 xtreme droughts in the Nordeste region, with profound eco-hydrological and socioeconomic impacts.

95 Results suggest a predictable but profound effect of trophic position on fluctuations and

96 Different redox states have a profound effect on domain orientation in the enzyme and

97 Gravity has a profound effect on fluid distribution and pressure withi

98 Yeast extract has a profound effect on folding at protein concentrations 100

99 and AD, and these sequelae associate with a profound effect on patient and graft survival.

100 at the structure of the incoming plate has a profound effect on the extent of N subduction into the m

101 e fraction of the fine eutectic matrix has a profound effect on the flow strength.

102 nd DPPC for the gel phase), and these have a profound effect on the optical properties of the system,

103 ive to structural perturbations, which has a profound effect on the overall lifetime of the complex.

104 For the cooked starch/lipid complexes, more profound effect was evident (22.2-67.7%).

105 le LD environments, phase misalignment has a profound effect, with decreased metabolic efficiency and

106 AGE: Sugar regulation of gene expression has profound effects at all stages of the plant life cycle.

107 e in many physiological processes and exerts profound effects on behavior by regulating neuronal exci

108 esults add to mounting evidence that aSI has profound effects on brain areas that regulate affective

109 n event frequently observed in cancer, exert profound effects on genome stability via MRE11 with pote

110 he gut bacterial communities of mammals have profound effects on host fitness, but the processes that

111 observed in T2D and diabetic animals and has profound effects on insulin secretion, including reduced

112 ol of complex I-mediated respiration and its profound effects on oxygen utilization, energy homeostas

113 disulfide bond formation enzymes could have profound effects on pathogen virulence.

114 ges in personal vehicle ownership are having profound effects on public health.

115 asal congestion, and repeated sneezing, with profound effects on quality of life, work productivity,

116 pansion and mutation of those genes may have profound effects on scallop's phenotype and adaptation.

117 climate change and fire suppression may have profound effects on the balance between storage and rele

118 Posttranslational modifications can have profound effects on the biological and biophysical prope

119 nipulation of OL progenitor cells (OPCs) has profound effects on the establishment of functional cogn

120 ral variations (SVs) in genomic DNA can have profound effects on the evolution of living organisms, o

121 w that blockade of dopamine D2 receptors has profound effects on the functional connectivity patterns

122 uding exposure to drugs of abuse can produce profound effects on the physiology and behavior of offsp

123 Microbes can have profound effects on their hosts, driving natural selecti

124 Particularly, increased matrix stiffness has profound effects on tumor growth and metastasis.

125 ese data demonstrated that eCig exposure has profound effects upon gene expression in human lung epit

126 ine containing eCig vapor displayed the most profound effects upon miRNA expression.

127 erization are fundamental in chemistry, with profound effects upon physical properties, however their

128 -infiltrating T lymphocytes and results in a profound extension of the median survival of treated ani

129 t disease-modifying therapies, the impact is profound for patients and their families.

130 ces between individual cells that often have profound functional consequences.

131 STATEMENT Spinal cord injury (SCI) leads to profound functional deficits, though substantial numbers

132 outhwest Asia, and China, during a period of profound global environmental perturbations as the Pleis

133 und, MRL-Atp6v1b1vtx/vtx mutant mice exhibit profound hearing impairment, which is associated with en

134 in in hair cells, but not in neurons, causes profound hearing loss and outer hair cell degeneration i

135 Early onset profound hearing loss in KO mice and lack of information

136 Children with profound hearing loss were referred for CI assessment at

137 efects, cochlear hair cell degeneration, and profound hearing loss.

138 ic insulin signaling remained intact despite profound hepatic insulin resistance.

139 in D2R-MSNs (indirect pathway) resulted in a profound hyperlocomotor phenotype.

140 goal was to define the genetic cause of the profound hypomyelination in the taiep rat model and dete

141 rgic median preoptic area neurons produced a profound hypothermia due to cutaneous vasodilatation.

142 ture due to quantum confinement and are most profound if the underlying lattice symmetry changes.

143 These data reveal a profound, immediate and precise integration of nocicepti

144 expression, as observed here, may underpin a profound immune dysregulation, setting the stage for dis

145 ant clinical event/year, demonstrating their profound immunodeficiency.

146 high pressures and temperatures, have had a profound impact in a wider context.

147 in real time and at atomic level will have a profound impact in advancing our understanding of RNA fu

148 ety of proteins that contain disulfides, the profound impact of cross-linking on the behavior of the

149 This global approach revealed the profound impact of Hfq on gene and protein expression.

150 rriage against subsequent AUD, speaks to the profound impact of marriage on problematic alcohol use.

151 Electrical characterization reveals the profound impact of the presence of the n-doped ZnO layer

152 ops substantially during childhood and has a profound impact on achievement in school and in cognitiv

153 The TAIR10 annotation update had a profound impact on Arabidopsis research but was released

154 een parasites and the gut microbiota, with a profound impact on both host immunity and metabolic pote

155 nger RNAs and that non-AUG translation has a profound impact on cellular states.

156 during these processes can therefore have a profound impact on development.

157 vention by current control strategies, has a profound impact on fetal growth, pregnancy duration, and

158 CS disaccharides had a profound impact on gut microbial composition, affecting

159 mediated regulation of gene expression has a profound impact on immune cell development, function, an

160 mented in biological research and has made a profound impact on patient care.

161 st stage of filtering in the cochlea and its profound impact on perception.

162 phytochrome signaling mechanisms that have a profound impact on plant growth and development in respo

163 mon and widespread phenomenon that has had a profound impact on TE dynamics and, consequently, on the

164 pABLUF, modulation in the Tyr (Y8) pKa has a profound impact on the forward photoreaction.

165 stand an aberrant mitogenic activity, with a profound impact on the genetic history of tumorigenesis,

166 se mineral-depositing communities have had a profound impact on the habitability of the planet.

167 releasing drug on-demand at tumor site have profound impact on the improvement of the efficacy and t

168 rs of proteins and biomolecules, which has a profound impact on the nanoparticle's biological fate.

169 erials interface and interaction should have profound impact on the optimization and de novo design o

170 sic biology of neutrophils that might have a profound impact on tumor development and the function of

171 onal and nuclear beta-catenin activity has a profound impact on tumor progression in this basal model

172 orests of this region have a long history of profound impacts by phloem-feeding bark beetles, and spe

173 t high elevations around the world will have profound impacts on mountain biodiversity.

174 Atopic dermatitis has profound impacts on patient and family quality of life.

175 nse accompanying global warming and may have profound impacts on soil respiration (Rs) and its compon

176 a ubiquitous, ongoing global phenomenon with profound impacts on the growing conditions of the world'

177 n (ENSO) and other climate patterns can have profound impacts on the occurrence of infectious disease

178 on in PFC pyramidal cells, and we observed a profound impairment in mGlu3-LTD following a single, 20-

179 These findings have profound implications for cancer therapy, and provide ne

180 posts suggest that his presidency could have profound implications for health.

181 contacts are constrained by condensin, with profound implications for local chromatin function durin

182 These results have profound implications for lymphedema treatment as topica

183 s resulting from a changing climate can have profound implications for plant interactions in desert c

184 acts of climate change on soil systems, with profound implications for terrestrial ecosystem function

185 This theory has profound implications for the design and ethics of publi

186 een the dividing cell and its neighbours has profound implications for the integrity, arrangement and

187 s in the ocean-atmosphere system, likely had profound implications for the rate and magnitude of the

188 In cancer cells, a gain of stemness may have profound implications for tumour aggressiveness and clin

189 These findings have profound implications in the development of T cell-based

190 It has a profound imprint on the global climate system that resul

191 those with incident dementia, and again most profound in individuals with higher volume of white matt

192 This effect was more profound in multimodal associative areas in the frontal

193 This impairment was more profound in naive B cells from CVID 21low patients than

194 in osteoblasts and osteocytes, leading to a profound increase in bone volume.

195 ors disrupted this crosstalk and triggered a profound increase in granulocyte recruitment to tumors.

196 Inhibiting myostatin induced a more profound increase in muscle mass ( approximately 45%), d

197 cular trait similar to wild-type, but with a profound increase in phenotypic heterogeneity.

198 The underlying mechanism involves a profound increase in the hydrolysis of ATP/NAD and AMP,

199 ainst pathogen infection and correlated with profound increases in intestinal Th17 cells.

200 ed excess T lymphocytes, splenomegaly, and a profound inflammatory phenotype that was suppressed by g

201 In general, there is a profound influence of reducing physical dimensions of pa

202 of redox mediator in these solar cells has a profound influence on both the light harvesting and TTA-

203 e that the redox state of the apoplast has a profound influence on cellular metabolism.

204 The environment of a cell has a profound influence on its physiology, development and ev

205 tracation in the solid state, but also has a profound influence on the electrochemical and electronic

206 in all mammalian species investigated, has a profound influence on the in vivo ADME characteristics,

207 Temporal expectations had a profound influence on working memory performance, leadin

208 y reproduced in clinical pilot) and revealed profound influences of subtle changes in mt DNA backgrou

209 Changing precipitation regimes could have profound influences on carbon (C) cycle in the biosphere

210 r demographic change, both of which can have profound influences on future health burdens.

211 bolite secretion and signaling, and features profound influences on host immunity and physiology, inc

212 d in Apoa1bp(-/-) mice and associated with a profound inhibition of Notch activation and reduced expr

213 This profound insight has transformed our understanding of st

214 rresponding proteins in cancer, and provides profound insights into leukemogenesis and drug response.

215 e penultimate exon of ZSWIM6 who have severe-profound intellectual disability and additional central

216 igh early and sustained bacterial titers and profound intestinal inflammation associated with extensi

217 A tissue-centered analysis has revealed a profound loss of esophageal tissue differentiation (iden

218 example, embryonic lethality) or results in profound loss of fitness.

219 -ghrelin and fear memory formation, promotes profound loss of ghrelin binding sites in the amygdala a

220 not Ret(fx/fx) ; Phox2b-Cre mice, display a profound loss of Phox2b expression with subsequent chemo

221 absent or abnormal in Usher mice, indicating profound loss of vestibular function.

222 Motor neurons exhibit the most profound loss, but the mechanisms underlying disease pat

223 rase results in hydrolase hypersecretion and profound lysosomal storage.

224 Pregnancy is associated with profound maternal metabolic changes, necessary for the g

225 ion of IDH1/2 and accumulation of 2-HG cause profound metabolic and epigenetic dysregulation, includi

226 FGF21 exerts profound metabolic effects in Siberian hamsters exposed

227 med metabolic surgery because they result in profound metabolic improvements that often surpass the e

228 Overall, these findings suggest a profound misperception of and unfounded optimism regardi

229 circadian pattern of gene expression causing profound modulation of transcription of genes related to

230 he evolution of the eukaryotic cell marked a profound moment in Earth's history, with most of the vis

231 erimental endotoxemia model, a transient but profound monocytopenia was observed; restoration of circ

232 PA14 colony biofilms show a profound morphogenic response to phenazines resulting fr

233 the mammary gland is its ability to undergo profound morphological, physiological, and intracellular

234 on of cDCs in Relb(-/-) mice associated with profound myeloid expansion and perturbations in B and T

235 ciated with high parasitism, myocarditis and profound myocardial gene expression changes.

236 ing to damage and healing it, leading to the profound negative environmental impact of their continuo

237 Pcmt1 knock-out mice exhibit a profound neuropathology and die 30-60 days postnatal fro

238 These results provide profound new knowledge and will stimulate more theoretic

239 Defective eyelid formation correlated with profound ocular anomalies evident by postnatal days 1-4,

240 tor of bone acquisition that antagonizes the profound osteoanabolic capacity of activated Wnt/beta-ca

241 nd that pathogenic Htt expression leads to a profound overgrowth of synaptic connections that correla

242 he brain, but we have now found unexpectedly profound pathology in the human INCL spinal cord.

243 resulted in reduced nutrient transport and a profound perturbation of the endocytic machinery, despit

244 on programs, which are often associated with profound phenotypic changes.

245 conformeric strains of Abeta, which may have profound phenotypic outcomes.

246 mage to the lateral hypothalamus (LH) causes profound physical inactivity in mammals.

247 ng of nascent chains inside the ribosome has profound physiological consequences that bear on correct

248 scopy in mouse models of sepsis, we observed profound platelet aggregation, thrombin activation, and

249 two core Hippo pathway effectors, developed profound post-MI pericardial inflammation and myocardial

250 ce led to moderate salt wasting, low BP, and profound potassium wasting.

251 minant LCMV epitope L2062-2069, indicating a profound private specificity effect in heterologous immu

252 As expected, EBOV infection led to a profound proinflammatory response, including strong indu

253 1 gene expression in mature podocytes caused profound proteinuria, and with deep-etching freeze-fract

254 LSD induces profound psychedelic effects, including changes in the m

255 r and macrovascular complications that cause profound psychological and physical distress to both pat

256 -term effects of maternal obesity could have profound public health implications, there is an urgent

257 feature of our moral cognition represents a profound puzzle for evolutionary approaches to human mor

258 We identify profound rearrangement in cellular proteostasis occurrin

259 This is a critical gap given (i) profound reconfigurations in land use and land control o

260 y significantly reduces this risk, with more profound reduction among HCV-positive versus HCV-negativ

261 e anemia, reduced BM cellularity, and showed profound reduction in BM B cell lymphopoiesis associated

262 dose, with stabilization of hemostasis and a profound reduction in factor VIII use in all seven parti

263 After learning, there was a profound reduction in the overall strength and number of

264 covered that knocking down MYST3 resulted in profound reduction of ERalpha expression, while ectopic

265 Knockdown of ZEB1 resulted in more profound reduction of nonrisk allele promoter activity a

266 nd E2F2, however, repression of E2F3 elicits profound reduction of proliferation in the hematopoietic

267 d found that loss of alphaII spectrin causes profound reductions in all beta spectrins.

268 Profound reductions in neutrophil counts and chemotaxis

269 Postmortem human AD cortex shows profound reductions of NPTX2 and coordinate reductions o

270 ently, because PIK3CA mutant cells exhibit a profound reliance on glucose metabolism, malate-aspartat

271 (CP-AMPARs) after drug withdrawal results in profound remodeling of NAc neuro-circuits.

272 esioned toward the lesioned hemisphere and a profound reorganization of functional cortical hierarchi

273 s that hemiparkinsonism is associated with a profound reorganization of the hierarchical organization

274 se prostate model, Skp2 depletion leads to a profound repression of prostate tumor growth and distal

275 type 1C (USH1C/harmonin) is associated with profound retinal, auditory and vestibular dysfunction.

276 reactions, is hypothesized to have played a profound role in the evolution of eukaryotes.

277 gammadelta-T-cell-deficient mice developed profound RPE and retinal damage at doses that caused min

278 These data indicate profound sex differences in the impact of a genetic lesi

279 signals across lipid bilayer membranes is of profound significance in many biological processes, from

280 Radiography revealed profound skeletal defects in cKO mice, including rachiti

281 ABSTRACT: Severe burns result in profound skeletal muscle atrophy; persistent muscle atro

282 quality of life of millions worldwide, with profound social and economic implications.

283 ith the East Asian summer monsoon (EASM) has profound societal implications.

284 (MD) imposed early in postnatal life elicits profound structural and functional abnormalities through

285 ate, where channel closure is facilitated by profound structural rearrangements in the AMPAR extracel

286 gulation of TH signaling in their livers and profound suppression of adipose tissue lipolysis, which

287 hed early expression of IFN-gamma along with profound suppression of CCL2 and CCL7 chemokines, provid

288 diomyopathy were both distinct from and more profound than changes in messenger RNA levels in the hea

289 ic homeostasis, this study demonstrates that profound TJ-restructuring by organ and tissue-specific c

290 ver, differentiated monocytes presented with profound transcriptomic, phenotypic, and functional diff

291 Treg-restricted Nrp1 deletion results in profound tumor resistance due to Treg functional fragili

292 mechanical stretch were shown to induce the profound up-regulation of NGF in osteoblasts within 1 h

293 cell age-dependent and was associated with a profound upregulation of markers of non-mast cell lineag

294 lls isolated from the injured heart revealed profound upregulation of the enzymatic machinery for hyd

295 and the anterior chamber, where they caused profound uveal inflammation and release of proinflammato

296 nce with ASO-29 treatment at P15 despite the profound vestibular functional deficits that persist wit

297 He complained of sudden painless profound visual loss in the left eye (LE) two hours afte

298 postoperative infections repeatedly required profound voriconazole dose reductions whenever high-dose

299 ch (if not most) of life science research in profound ways.

300 ot to partial penetrance of treatment, but a profound yet hidden alteration to the animals' patternin