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1 Astrocytes are profoundly activated during AD and may lose their capaci

2 illustrate how these genomic approaches have profoundly advanced our understanding of individual tumo

3 itories is crucial as misexpression here has profoundly adverse consequences.

4 are not only observed during aging but also profoundly affect cellular function and stress resistanc

5 n results in heterogeneous mixtures that can profoundly affect clinical safety and efficacy.

6 ved in forests around the globe, which could profoundly affect ecosystem functioning and services pro

7 (GLP-1R) activity selectively in the LH can profoundly affect food reward behavior, ultimately leadi

8 Gut microbiota profoundly affect gut and systemic diseases, but the mec

9 eep cycles are consequences of aging and can profoundly affect health.

10 r products of gut microbial fermentation and profoundly affect host health and disease.

11 Gut commensals profoundly affect host immunity and intestinal homeostas

12 Our work reveals that hydrodynamics can profoundly affect how bacteria compete and evolve in por

13 Social networks can profoundly affect human behavior, which is the primary f

14 ika virus (ZIKV), and West Nile virus (WNV), profoundly affect human health.

15 from resource defence and collective action profoundly affect insider-outsider conflict resolution,

16 However, these modifications can profoundly affect interactions between ASOs and intracel

17 ecently recognized signalling molecules that profoundly affect metabolism.

18 mass cytometry by time-of-flight (CyTOF) can profoundly affect our knowledge of cell population heter

19 Environmental conditions profoundly affect plant disease development; however, th

20 Changes in body temperature can profoundly affect survival.

21 ed in a wide array of pulmonary diseases may profoundly affect symptoms and progression.

22 spontaneous release, such as nicotine, could profoundly affect synaptic maturation.

23 including mutations and polymorphisms, which profoundly affect the cells in which they appear and con

24 We demonstrate that patterns of charges can profoundly affect the charge-charge associations that dr

25 Renal disease can also profoundly affect the colonic microenvironment and has b

26 at specific influenza HA-NA combinations can profoundly affect the critical role played by HA during

27 Aerosol interfaces can profoundly affect the fate of condensable organic compou

28 Neo-adjuvant chemotherapy can rapidly and profoundly affect the oesophageal adenocarcinoma genome.

29 be carefully considered, as this choice can profoundly affect the output.

30 imits the size of the reservoir but does not profoundly affect the proviral landscape.

31 relatively insensitive to mild knockdown but profoundly affected by depletion of gene function, revea

32 e transport of cytoplasmic components can be profoundly affected by hydrodynamics.

33 These sensory functions may be profoundly affected by the states of primary afferent ne

34 s forming the stromal tumor microenvironment profoundly affected lung tumor growth in three different

35 Pleistocene glaciations have profoundly affected patterns of genetic diversity within

36 Altering the living conditions of mice profoundly affected the cellular composition of the inna

37 n electrostatically mismatched A86K mutation profoundly affected the DNA binding properties of the WT

38 The Zika virus (ZIKV) epidemic has profoundly affected the lives of children and families a

39 phingolipid and phospholipid metabolism were profoundly affected, showing an increase in ceramide (Ce

40 stresses impact negatively on plant growth, profoundly affecting yield and quality of crops.

41 regularity that signals environmental change profoundly affects adaptive behavior.

42 mand on the rate of protein synthesis, which profoundly affects cellular resource allocation.

43 Microbial colonization after birth profoundly affects development of the host.

44 otein inactivates their target enhancers and profoundly affects epidermal stem cell function.

45 Salmonella infection profoundly affects host erythroid development, but the m

46 ital microscopy showed that CYTH1 deficiency profoundly affects HSPC mobility and localization within

47 tightly bound component of the complex that profoundly affects its activity and architecture.

48 e of Apps running on smartphones and tablets profoundly affects medicine.

49 allocated to each option and its variability profoundly affects performance.

50 hosite, Y192, within the Lck SH2 domain that profoundly affects the amount of active Lck in cells.

51 We show that FKBP12 profoundly affects the calcineurin-dependent phosphoprot

52 Sleep profoundly affects the emotional and motivational state.

53 ntaminates the extracellular miRNA pool, and profoundly affects the levels of miRNAs detected.

54 Our study reveals that mutualistic strategy profoundly affects the pace of morphological change in t

55 for charge generation.Molecular orientation profoundly affects the performance of donor-acceptor het

56 on the status of pectin methylesterification profoundly affects the properties of pectin and, thereby

57 fference in VP1 known to shift viral tropism profoundly affects the quantity and quality of the anti-

58 uperconductors, strong confinement potential profoundly affects their spatial distribution eventually

59 of intraspecific trait variation, which can profoundly alter community dynamics [1].

60 Prior heat activation can profoundly alter its subsequent temperature responsivene

61 how conformational changes in CCL3 N termini profoundly alter its surface properties and dimer-dimer

62 Internal states can profoundly alter the behavior of animals.

63 kinetically distinct synaptic processes that profoundly alter the discharge rate and sensitivity of f

64 sing from the internally-generated field can profoundly alter the Feynman relation and result in a ne

65 ironmental variation within a population can profoundly alter the strength of selection on phenotypic

66 ng declines in vertebrate seed dispersers to profoundly alter tropical forest composition.

67 is shaped by the maternal microbiota, and is profoundly altered by antibiotic treatment.

68 positive] and 1.29 [HCV-negative]), and more profoundly altered in HCV-positive men by lipid lowering

69 antly, the beta cell subtype distribution is profoundly altered in type 2 diabetes.

70 CCR7-deficient mice have profoundly altered lymphocyte recirculation and display

71 tes blocked astrocytic Ca(2+) signalling and profoundly altered olfactory-driven chemotaxis and touch

72 These demographic shifts have profoundly altered the coevolved relationship between ho

73 r current results indicated serum starvation profoundly altered the gene expression and metabolism of

74 using the CRISPR/Cas9 genomic-editing system profoundly altered transcriptional profiles of prolifera

75 aily alcohol binges, synaptic plasticity was profoundly altered.

76 e of oxygen on Earth 2.3 billion years ago, profoundly altering the course of evolution by facilitat

77 Loss of PC1 expression profoundly alters cellular energy metabolism.

78 RATIONALE: Pregnancy profoundly alters maternal physiology.

79 On the single-neuron level, surround input profoundly alters response amplitude and modulates spati

80 TGF-beta1 profoundly alters the electrophysiological phenotype of

81 he activation of the AP of complement, which profoundly alters the phenotype of microvascular endothe

82 e DNA repair and associated events has grown profoundly, although major questions remain unanswered.

83 Administration of D-4F or E06 to rats profoundly ameliorated mechanical hyperalgesia and infla

84 prostate and breast cancers, CHD1 depletion profoundly and specifically suppressed cell proliferatio

85 t, long-acting PEGylated TRAIL (TRAILPEG) is profoundly anti-rheumatic against two complementary expe

86 ar oscillations (resonance "strength") rises profoundly as loop gain rises toward 1.

87 actor of activated T-cell (NFAT) activity is profoundly attenuated if Ca(2+) clearance is not inhibit

88 Although trehalose profoundly attenuated mTORC1 signaling, trehalose-induce

89 Similar to BCL6 silencing, depletion of AXL profoundly attenuates GBM proliferation both in vitro an

90 r in vivo protected against kidney injury by profoundly attenuating tissue injury, activation, and di

91 Instead, the low-affinity anti-IgE mAbs profoundly block human peanut- and cat-allergic IgE-medi

92 We show here that MEK inhibition did profoundly block naive CD8(+) T cell priming in tumor-be

93 Remarkably, overexpressing Hdac1 profoundly blocks, whereas deleting Hdac1 significantly

94 e nitrifier population structure was altered profoundly by management.

95 pected compounds, the emergence of which can profoundly change models of planetary interiors, where h

96 ly from the nucleus accumbens to the PFC and profoundly change PFC structural and functional developm

97 His most recent electrocardiogram was profoundly changed from previous tracings, with marked a

98 The agricultural transition profoundly changed human societies.

99 xpression networks, but these activities are profoundly changed in GF mice.

100 cate that evolutionary innovation via HGT is profoundly constrained by epistasis and historical conti

101 Collectively, our results reveal that BCL-W profoundly contributes to B cell lymphoma, and its expre

102 ects induced by radiation or chemotherapy to profoundly control tumors.

103 Heparin-induced thrombocytopenia is a profoundly dangerous, potentially lethal, immunologicall

104 temporal cortex to visual speech in the same profoundly deaf adults both before and 6 mo after implan

105 at without early childhood cochlear-implant, profoundly deaf children do not develop intact, high-lev

106 Many profoundly deaf people wearing cochlear implants (CIs) s

107 mice lacking myosin IIIa and myosin IIIb are profoundly deaf, whereas Myo3a-cKO Myo3b(-/-) mice lacki

108 is and cardiomyopathy, and was found to have profoundly decreased activity of respiratory chain compl

109 ntrol of TFH cell differentiation because of profoundly decreased CTLA4 expression on regulatory T ce

110 herpes simplex virus 1 (HSV1) infection was profoundly decreased despite normal immune cell developm

111 The patients had profoundly decreased proprioception leading to ataxia an

112 loidogenic processing of APP, but not Abeta, profoundly decreased respiration and enhanced glycolysis

113 cardial ischemia, myeloperoxidase deficiency profoundly decreased vulnerability for ventricular tachy

114 coenzyme Q (ubiquinone, Q) and Q levels are profoundly decreased, pointing towards novel possibiliti

115 Moreover, Bcl-w loss profoundly delayed MYC-mediated B cell lymphoma developm

116 methylation so that age-related changes are profoundly delayed, while changes at loci involved in li

117 dborne, and airborne allergenic molecules is profoundly dependent on the route of allergen exposure a

118 gular-spiking and burst firing patterns were profoundly depressed in the mouse with global deletion o

119 tinct from that in thicker medium due to the profoundly different atomic kinetics.

120 Despite their profoundly different cellular composition, size, and fun

121 rroelectrics reveals that their behaviour is profoundly different from that in bulk ferroelectrics, w

122 ntelligence, tailored to the challenges of a profoundly different kind of society and lifestyle.

123 n, wetting of a confined pore proceeds via a profoundly different mechanism compared with wetting of

124 tem cells continuously replicate, suggesting profoundly different regulatory mechanisms within distin

125 of isoprene emission and photosynthesis are profoundly different, with photosynthesis increasing and

126 d-type receptors, A-867744 was found to have profoundly differing effects on mutated receptors compar

127 as driven by multiple genomic subclones with profoundly differing growth dynamics and hence different

128 ty.SIGNIFICANCE STATEMENT Schizophrenia is a profoundly disabling psychiatric illness with a devastat

129 rediction error to regulate this learning is profoundly disrupted, leading to formation of inappropri

130 s therapy, which is both life-sustaining and profoundly disruptive to their quality of life.

131 Hippocampal damage profoundly disrupts the ability to store new memories of

132 Reverberation profoundly distorts the sound from a source, yet humans

133 Culture on PEOT/PBT and polysulfone profoundly disturbed function of islets, and induced sev

134 ila melanogaster and Caenorhabditis elegans) profoundly diverged.

135 ed to fatty acid oxidation in the heart were profoundly down-regulated in both wild-type and Ppara mi

136 n of past environments and a future changing profoundly due to human influence becomes possible.

137 the localization of H1 in chromatin changes profoundly during the endocycle.

138 IFN-alphabetagammaR(-/-) mice manifested as profoundly elevated aspartate transaminase (AST) and ala

139 emonstrate that collective cell migration is profoundly enhanced by the addition of contract guidance

140 583 mutants show increased cell death due to profoundly enhanced Ca(2+) influx, resulting from altere

141 However, a profoundly enhanced motility in aligned collagen matrice

142 enerative angiogenesis in skeletal muscle is profoundly flawed in both structure and function, with n

143 sexual issues with patients in general, and profoundly for anal sex.

144 Human fitness dynamics are uniquely and profoundly governed by the flow of capital to subsequent

145 physical health during imprisonment but has profoundly harmful effects on physical and mental health

146 These contributions are profoundly heterogeneous but may converge on common path

147 cant functional consequences as indicated by profoundly higher deformation in real-time deformability

148 or source of freshwater for California and a profoundly human-impacted environment.

149 lar, rich in pro-inflammatory cytokines, and profoundly hypoxic.

150 itive optical molecular imaging approach can profoundly impact a wide range of surgical and noninvasi

151 cing viral mRNA translation, these processes profoundly impact host cell-intrinsic immune defenses at

152 , but fairly simple structural modifications profoundly impact its pharmacology and result in large n

153 teases with a wide functional diversity that profoundly impact multiple biological processes.

154 equent global change-type drought events may profoundly impact terrestrial ecosystems by triggering w

155 co data can direct ADMET experimentation and profoundly impact the progression of hit series.

156 amics of structurally similar substrates can profoundly impact the rate of catalysis.

157 We identify the variables that profoundly impact this event and allow control to be lev

158 sis (Mtb) and HIV in coinfected patients has profoundly impacted global mortality because of tubercul

159 ate glial filopodia or impair glial motility profoundly impacted synaptogenesis and circuit maturatio

160 Mass extinctions have profoundly impacted the evolution of life through not on

161 The mutation profoundly impacts helical structure stability of D25V-v

162 Environmental desynchrony (e.g. shift work) profoundly impacts human health, increasing cardiovascul

163 elective disruption of Munc13 autoinhibition profoundly impacts nervous system function in vivo.

164 Since local variation in air quality profoundly impacts public health and environmental equit

165 The affinity of a TCR binding to peptide:MHC profoundly impacts the phenotype and function of effecto

166 les is difficult to measure and control, yet profoundly impacts their quality and performance.

167 verely impaired (N=181; 3rd percentile), and profoundly impaired (N=74; 1st percentile) functioning b

168 T recruitment and MYC repression by GFI1 are profoundly impaired for SUMOylation-resistant GFI1 deriv

169 culomotor function in wild-type mice but are profoundly impaired in BK channel-null mice.

170 plasticity expressed by the LPP (lppLTP) was profoundly impaired in Fmr1-KOs relative to wild-type mi

171 re to achieve ubiquitous knockdown of BCL11A profoundly impaired long-term engraftment of both human

172 ctivity: while inactivation of neurons in MT profoundly impaired psychophysical performance, inactiva

173 Loss of T-bet specifically in NKp46(+) ILCs profoundly impaired the ability of myelin-reactive TH17

174 OX40 deficiency in Tfh cells profoundly impaired the acquisition of germinal center (

175 icating that while some older physicians are profoundly impaired, others retain their ability and ski

176 treated patients whose T cells functions are profoundly impaired.

177 onses, with targeted depletion of ILC2 cells profoundly impairing TH2 cell localization to the lungs

178 USP9X depletion profoundly impairs the progression of DNA replication fo

179 at Ube2o deletion in MMTV-PyVT or TRAMP mice profoundly impairs tumor initiation, growth, and metasta

180 transcription factors and coregulators, can profoundly improve understanding of mechanisms underlyin

181 A profoundly improved understanding of the behavior of fra

182 plasmonic behaviour of rhodium nanoparticles profoundly improves their already excellent catalytic pr

183 Despite profoundly inactivating somatic and proximal axon Na(+)

184 tic or pharmacological targeting of the A2AR profoundly increased CAR T cell efficacy, particularly w

185 The profoundly increased CHD risk conferred by maternal preg

186 We found that IRI tolerance is profoundly increased in female mice compared with that o

187 activation (i.e. mutant PIK3CA) resulted in profoundly increased migration where extracellular multi

188 The profoundly increased output voltage of a lateral PNG bui

189 thyroxine levels ( approximately 50-80%) and profoundly increased thyroid-stimulating hormone levels

190 Trace Zn(2+) levels profoundly influence Abeta assembly even at concentratio

191 Here we show how this sensory input can profoundly influence an animal's ability to locate the s

192 Internal states of the brain profoundly influence behavior.

193 igh-dimensionality in ecological systems can profoundly influence cycling, and so can demographic str

194 action potentials (DAPs) in vitro, which can profoundly influence neural computation and plasticity.

195 behavior is critically important, and could profoundly influence our current understanding of how gr

196 robes associated with plants and insects can profoundly influence plant-insect interactions.

197 Social processes profoundly influence speech and language acquisition.

198 cascades, and other correlated actions that profoundly influence system-level function.

199 shown that these atomic-scale processes can profoundly influence the architecture and composition of

200 f nucleic acids and resulting ion atmosphere profoundly influence the conformational landscape of RNA

201 This will profoundly influence the natural environment, including

202 )T cell responses, suggesting that HLA genes profoundly influence the nature of responses.

203 hat frequencies of CpG and UpA dinucleotides profoundly influence the replication ability of echoviru

204 he environmental dependency of epistasis can profoundly influence the response to selection, shaping

205 chromosome complement in phenotypic females profoundly influenced aortic gene expression profiles an

206 te matter development-domains that should be profoundly influenced by deprivation through the learnin

207 rate of atherosclerotic lesion formation is profoundly influenced by innate and adaptive immunity, w

208 s, and the energetics of these processes are profoundly influenced by the ion atmosphere that surroun

209 exported from terrestrial ecosystems and are profoundly influenced by the land use of the surrounding

210 in 2016, the West Africa Ebola epidemic has profoundly influenced discussions and practice concernin

211 eam of basic and clinical insights that have profoundly influenced modern understanding of human heal

212 The presence of SRHA (2.5 mg TOC/L) profoundly influenced the aggregation behavior by stabil

213 These redox fluctuations could have profoundly influenced the course of eukaryotic evolution

214 ril and intertwining architecture of the ECM profoundly influences cell behavior and development.

215 interrelated, and dense nanoenvironment that profoundly influences chemical interactions.

216 The timing of ETBF clearance profoundly influences colon adenoma formation, defining

217 r of physiological processes within the gut, profoundly influences gut microbiota composition.

218 act, collectively called the gut microbiota, profoundly influences many aspects of host physiology, i

219 s to aqueous interfaces is a phenomenon that profoundly influences vital processes in many areas of s

220 onal mutualisms are ancient, widespread, and profoundly influential in biological communities and eco

221 eparanase-neutralizing monoclonal antibodies profoundly inhibit tumor load in the mouse bones, associ

222 erile 20-like kinase 1 (Mst1), but not Mst2, profoundly inhibited cytosolic nucleic acid sensing.

223 Our decoy receptor, MYD1-72, profoundly inhibited disease progression in aggressive p

224 to a complete block in nuclear division and profoundly inhibited DNA replication.

225 es of TNT009 at 3 to 100 mg/kg uniformly and profoundly inhibited HLA antibody-mediated C3d depositio

226 er IV injection in mice, but the former more profoundly inhibited LPS-induced pulmonary inflammation

227 re adverse events were reported, and BIVV009 profoundly inhibited overall and DSA-triggered CP activa

228 istically significant inhibition, AGN 211377 profoundly inhibited S-antigen-induced uveitis and laser

229 Akt2 deficiency profoundly inhibited the development of liver lesions in

230 Loss of TNC function in Ewing sarcoma cells profoundly inhibited their migratory and metastatic pote

231 s were unaffected by doses of SH-BC-893 that profoundly inhibited tumor growth.

232 Ex vivo serum CP activity was profoundly inhibited when TNT009 concentrations exceeded

233 ndent of its transcriptional function, NOTCH profoundly inhibits GSK-3beta activity.

234 conclusion, exposure to inflammatory stimuli profoundly inhibits human Treg differentiation HIF-1alph

235 SET profoundly inhibits p53 transcriptional activity in unst

236 knockdown of FOXE1 in primary thyroid cells profoundly interferes with the p53 pathway.

237 stump after delayed peripheral nerve repair profoundly limits nerve regeneration.

238 Dysgonomonas spp. and Helicobacter spp., was profoundly lower in Rb3/Rd-treated mice.

239 aspartyl proteases, notably cathepsin D, and profoundly lowers CSF and brain Abeta levels in rats and

240 ey are intended to monitor, sometimes giving profoundly misleading results.

241 UF1 profoundly mitigated induced NEC-like injury in neonatal

242 bolic end-products, including H(+) ions that profoundly modulate biological activities.

243 Microgravity and 3D culture can profoundly modulate cell proliferation and survival.

244 diverse nature of EVs and their abilities to profoundly modulate host cells, this series puts particu

245 response, reactive oxygen species (ROS) can profoundly modulate T cell adaptive immune responses.

246 dynamics and associated selection rules are profoundly modulated.

247 Nanostructured ceria becomes profoundly more active due to its enhanced surface area

248 Bed rest has a profoundly negative effect on muscle metabolism, mass, a

249 Cooling and hypothermia are profoundly neuroprotective, mediated, at least in part,

250 but that the degree of heritability depends profoundly on the quality of instruction.

251 show that tau-deficient (tau(-/-)) mice are profoundly protected from excitotoxic brain damage and n

252 G-CSF- and G-CSF receptor-deficient mice are profoundly protected in several models of rheumatoid art

253 on, we show that depletion of gut microbiota profoundly protects against renal I/R injury by reducing

254 itylation in a variety of cell lines and can profoundly reduce the generation of cytosolic peptides.

255 We report that pDC survival was profoundly reduced during different nonviral inflammator

256 InDel mutations into exon 2 of the ICP0 gene profoundly reduced HSV-1 infectivity in permissive human

257 the rate of LLC metastasis to the lungs was profoundly reduced in ALCAM(-/-) mice.

258 insulin secretion and calcium responses were profoundly reduced in beta-arrestin-2 (barr2) deficient

259 Implanted tumor growth was profoundly reduced in CLEC14A-KO mice compared with that

260 Importantly, GPR182 expression was profoundly reduced in numerous human carcinomas, includi

261 This procedure profoundly reduced mechanical pain behaviors induced by

262 RO5256390 profoundly reduced rapid eye movement sleep in wild-type

263 Different side chains replacing Cys(93) profoundly reduced RD3 affinity for the cyclase, irrespe

264 We found that exploration profoundly reduced spatially selective, choice-predictiv

265 ZIP profoundly reduced spontaneous hippocampal local field p

266 cytotoxicity, or serum resistance, though it profoundly reduced the ability of the mutant to colonize

267 ynamitin or another dynein regulator, NudEL, profoundly reduced the efficiency of infection by ecotro

268 ment of atherosclerotic coronary plaques but profoundly reduced the incidence of premature deaths, th

269 Decline of ARSB, in the presence of oxygen, profoundly reduced the oxygen consumption rate and incre

270 gation and spreading of washed platelets and profoundly reduced their capacity to promote endothelial

271 combination with KCS1 (ipk1Deltakcs1Delta), profoundly reduced virulence in mice.

272 f the unfolded protein response (UPR), which profoundly reduces FGF signaling in cardiac progenitor c

273 mokine (C-C motif) ligand 26 in cancer cells profoundly reduces MDSC recruitment, angiogenesis, and t

274 es, including brain, heart, and kidneys, are profoundly refractory to pro-apoptotic signaling, leadin

275 or, temporally staggered turnover event that profoundly reorganized marine ecosystems during the Ceno

276 sed IL1B-induced ZFP36 expression at 2 h and profoundly repressed TNF mRNA at 6 h.

277 of Snail in cancer cell lines lacking Snail profoundly represses 4E-BP1 expression, promotes cap-dep

278 ies demonstrate that high-risk HPV oncogenes profoundly reprogram the tumor microenvironment independ

279 gles, both inversion and outline masking can profoundly reshape this orientation sensitivity profile.

280 nt study demonstrated that Sts(-/-) mice are profoundly resistant to systemic infection by Candida al

281 Nelfinavir profoundly sensitizes BRAF and NRAS mutant melanoma cell

282 al PTM codes on histones and coregulators is profoundly shaped by regulatory interplays between PTMs.

283 igenetics, as well as gene transcription are profoundly shaped by serine/threonine and tyrosine signa

284 onclude that electrical compartmentalization profoundly shapes both synaptic function and how that fu

285 therefore conclude that high-order epistasis profoundly shapes evolutionary trajectories through geno

286 , suggesting that fungal communities on skin profoundly shift during puberty.

287 Additionally, we noted a profoundly significant increase in taxa from Proteobacte

288 Early institutional care can be profoundly stressful for the human infant, and, as such,

289 tions of ZIP that can impair memory actually profoundly suppress spontaneous brain activity directly

290 dentified here, Smad5, Ywhag and Crtap, also profoundly suppressed cell invasion.

291 o human hepatoma cell lines, HepG2 and Huh7, profoundly suppressed cell proliferation and colony form

292 on of miR-92a-3p or inhibition of miR-26b-5p profoundly suppressed metastasis.

293 The cytoprotectant glycine profoundly suppressed NG and TcdB-induced lysis but not

294 along with talin and LFA-1, and loss of RIAM profoundly suppresses Ag-dependent conjugate formation i

295 f evidence that anti-TAA mAbs are capable of profoundly synergizing with T cell-directed immunotherap

296 LNs, and gene expression changed in pDC more profoundly than in conventional DC.

297 only impairs DNA replication checkpoint more profoundly than inhibition of ATR or CHK1, but also defe

298 LB100 profoundly upregulates miR-181b-1, which we show directl

299 Clinically, affected female newborns are profoundly virilized (Prader score of 4/5), and both gen

300 genetic activation of LH VGAT(+) neurons was profoundly wake promoting, whereas acute inhibition incr