ライフサイエンスコーパス: programmable

1 ses in materials fabrication are not readily programmable.

2 Such programmable 2D protein lattices should enable new appro

3 he design of new structural motifs to create programmable 3D DNA lattices with atomic spatial resolut

4 This system, referred to as RNA Editing for Programmable A to I Replacement (REPAIR), which has no s

5 predictable and tractable for generation of programmable allelic series with a range of expression l

6 assembly information to building blocks in a programmable and efficient way.

7 as) constitutes a next-generation method for programmable and high-throughput functional genomics.

8 We demonstrate programmable and multiplexed memory storage in human cel

9 nded DNA rotaxane for its ability to undergo programmable and predictable conformational changes.

10 medicine and material science by introducing programmable and responsive behaviour to diverse molecul

11 Printed droplet microfluidics provides a programmable and robust technology to construct arrays o

12 y arbitrary planar and 3D motifs in a highly programmable and seamless manner.

13 rotein binders at each locus are eluted in a programmable and selective fashion.

14 For these dual-loaded microcapsules, a programmable and sequential release of hydrophobic and h

15 Here, we use the programmable and specific binding of dye-labeled DNA pro

16 By taking advantage of the programmable and specific interactions of DNA, 11 distin

17 ction because complementary DNA duplexes are programmable and structurally predictable.

18 the potential to build increasingly complex, programmable, and efficient gene circuits in the future.

19 Here we use a programmable annealer for the information decoding probl

20 hysical systems, we perform experiments on a programmable annealer with superconducting flux technolo

21 -mediated DNA strand displacement, and their programmable applications range from medical diagnosis t

22 computing, bio-inspired robotics, and shape-programmable architectures.

23 was applied to muPADs for multiple and time-programmable assays for metal ion determination.

24 DNA-programmable assembly has been used to deliberately synt

25 nts on RNA/DNA substrates or can function as programmable assembly lines.

26 n and rapid fabrication approach enables the programmable assembly of multiple materials within this

27 dded crystalline nanoparticle sheets via DNA programmable assembly provides independent control over

28 Here, we designed a DNA-directed programmable assembly strategy to fabricate a halo-like

29 eep subwavelength size regime by using a DNA-programmable assembly technique.

30 he most sophisticated architectures made via programmable assembly, and their formation can be unders

31 icle architectures are synthesized using DNA-programmable assembly, unveiling exquisitely tunable opt

32 smonic superlattice microcavities, made from programmable atom equivalents comprising gold nanopartic

33 DNA-grafted nanoparticles have been called "programmable atom-equivalents": Like atoms, they form th

34 PER synthesis happens in a programmable, autonomous, in situ and environmentally re

35 Here, we report a programmable "base editing" system to induce precise bas

36 eview recent work showing the versatility of programmable biochemical reaction networks (BRNs) in ana

37 This work offers design principles for programmable biochemical reactions with potential applic

38 We present a programmable bioengineered 3-dimensional silk-based bone

39 Polypeptides and polynucleotides are natural programmable biopolymers that can self-assemble into com

40 DNA surface ligands can be used as programmable "bonds" to control the arrangement of nanop

41 d nanostructures in one step by triggering a programmable cascade of events that is autonomously exec

42 ect structure-activity relationships between programmable cell surface models and human lectins in a

43 grated analysis system that utilizes a light-programmable, cell-permeable reporter deliverable simult

44 The acoustofluidic-based programmable chemical waveform generation and switching

45 tion system in which CO2 is introduced using programmable CO2 pressures across a membrane into a flow

46 Programmable colloidal assembly enables the creation of

47 iber/polymer hybrid materials having locally programmable complex electrical, thermal and mechanical

48 nanoparticles will allow a new generation of programmable composites for tunable metamaterials, data

49 daptable platform for optical alignment-free programmable-contrast imaging, offers the potential to t

50 findings demonstrate that DNA can allow for programmable control of bimetallic nanoparticle morpholo

51 nding goal of synthetic biology has been the programmable control of cellular functions.

52 versatile regulatory toolsets that allow for programmable control of gene expression.

53 an unlimited readout resolution and enabled programmable control of instrument parameters as well as

54 any individually accessible memory cells and programmable control of its addressing and readout makes

55 terial 3D printing of viscoelastic inks with programmable control of local composition.

56 Programmable control of the cell cycle has been shown to

57 ration, fast response, and possibilities for programmable control.

58 e lens of a commercial DSLR camera and a USB programmable controller board to sequentially control th

59 , a genome-editing approach that enables the programmable conversion of one base pair into another wi

60 Here, we describe the development of a programmable CRISPR system capable of specifically visua

61 Here we describe a programmable, CRISPR-Cas9-based acetyltransferase consis

62 ins designed to secrete multiple proteins on programmable cues in an integrated, benchtop, millilitre

63 Here we engineered programmable cytidine deaminases and test if we could in

64 The easily programmable dCas9 toolkit allowed precise control of ep

65 This programmable de novo MTase tool might be used for studyi

66 Our programmable deaminases effectively convert specific cyt

67 Therefore programmable deaminases represent a promising genome edi

68 J function that highlights its potential for programmable demyristoylation in vivo.

69 Yu et al. show programmable, densely packed clusters using thermally ex

70 trapped on the microelectrode surface using programmable dielectrophoretic manipulations.

71 es in sub-microliter reaction droplets using programmable digital microfluidics.

72 manufacturing technologies to create highly programmable discontinuous fibre composites.

73 with a commercially available acousto-optic programmable dispersive filter (AOPDF).

74 vator-like effectors (TALEs) contain modular programmable DNA binding domains.

75 Programmable DNA cleavage using CRISPR-Cas9 enables effi

76 Here we develop a programmable DNA origami nanospring that overcomes these

77 Herein we report the use of programmable DNA sequences to control AuNR overgrowth, r

78 The use of CRISPR-Cas9 as an RNA-programmable DNA targeting and editing platform is simpl

79 We have designed programmable DNA-based nanoswitches whose closing/openin

80 The creation of restriction enzymes with programmable DNA-binding and -cleavage specificities has

81 Here we show that by fusing a programmable DNA-binding domain (pDBD) to Cas9 and atten

82 Nucleases containing programmable DNA-binding domains can alter the genomes o

83 These molecules are composed of programmable DNA-binding ligands flexibly tethered to a

84 In this study we utilized a programmable DNA-binding methyltransferase to induce tar

85 er at the endogenous genomic locus through a programmable DNA-binding module.

86 chemical synthesis with the specificity of a programmable DNA-binding protein by using protein trans-

87 like effector (TALE) proteins are a class of programmable DNA-binding proteins for which the fundamen

88 Recent advances in the field of programmable DNA-binding proteins have led to the develo

89 t the core p300 domain can be fused to other programmable DNA-binding proteins.

90 This programmable EIS structure was fabricated with silicon o

91 e ribose dependency of Cas9 to develop a XNA-programmable endonuclease.

92 plex as a unique example of a protein-guided programmable endoribonuclease.

93 report a protocol on DNA-nanostructure-based programmable engineering of the biomolecular recognition

94 rapid prototyping and explicitly introduces programmable environments as an experimental variable.

95 These new programmable epigenetic editors allow unprecedented cont

96 We demonstrate programmable fabrication of three-dimensional (3D) mater

97 nofilms designed to drug release profiles in programmable fashion are promising new and alternative w

98 A programmable field effect-based electrolyte-insulator-se

99 echanism is readily realised by an in-cavity programmable filter the dispersion and bandwidth of whic

100 This programmable flexibility enables the fabrication of prec

101 iplexed microfluidic cell culture, automated programmable fluid handling for cell perturbation, quant

102 nique properties of redox-MHD pumping (i.e., programmable fluid speeds and flow patterns without the

103 Adaptive liquid repellency and programmable fog harvesting are demonstrated as applicat

104 ndle yields monodisperse macromolecules with programmable folding and self-assembly properties.

105 Therefore, the oligonucleotide bond can have programmable function beyond dictating the structure of

106 intelligent devices with reconfigurable and programmable functionalities that may lead to advances i

107 latform for developing robust materials with programmable functions, demonstrating the potential of u

108 For the sake of efficiency, we use a field programmable gate array for strictly hardware-based comp

109 those achieved in other fields such as field-programmable gate arrays (FPGA).

110 sign to accelerate pre-alignment using Field-Programmable Gate Arrays (FPGAs), which can perform pre-

111 ferent approach inspired by electronic Field Programmable Gate Arrays is the programmable photonic pr

112 as3 gene converted this immune system into a programmable gene regulator capable of reversible gene s

113 ble effective library design and genome-wide programmable gene repression in many genetic backgrounds

114 ery cell in the human body contains a set of programmable gene-silencing proteins named Argonaute.

115 system provides a new opportunity to create programmable gene-specific antimicrobials that are far l

116 ary to the guide RNA and has been applied to programmable genome editing.

117 ependent manner and has been widely used for programmable genome editing.

118 te the potential of glycodendrimersomes with programmable glycan displays as a model system to reveal

119 owth engine uses binding site perception and programmable growth capability to create drug-like molec

120 The system is completely programmable, has an intuitive user interface, and can b

121 The current study describes a method using programmable, implantable peristaltic pumps to chronical

122 Programmable in situ amplifiers based on the mechanism o

123 id prototyping of complex gene circuits, and programmable in vitro diagnostics, including glucose sen

124 olecular array exhibits transformations with programmable initiation, propagation, and regulation.

125 d, smart immuno-technologies with 'built-in' programmable interactions of antigen-antibody upon recei

126 As a demonstration, programmable interconnects and an interdigitated electro

127 atomical utility (e.g., breast only), or non-programmable interfaces.

128 We also show that the octahedra can serve as programmable interparticle linkers, allowing one- and tw

129 tion due to its predictable conformation and programmable intra- and intermolecular Watson-Crick base

130 evious base editors, ABEs enable the direct, programmable introduction of all four transition mutatio

131 We realize a programmable Ising-type quantum spin model with tunable

132 ines, from one DNA template, and demonstrate programmable kinase activity.

133 Programmable kirigami metamaterials with controllable lo

134 A programmable ligand display system can be used to dissec

135 Here, we use DNA as a programmable ligand to show that two- and three-dimensio

136 Moreover, the use of a chemically programmable ligand, such as DNA, would allow for the ma

137 conjugated via a DNA linker that allows for programmable linker geometry and protein spatial configu

138 e of geometry and mechanics, we manufactured programmable liquid wires that present previously uniden

139 imple PHE device, hold promise for realizing programmable logic elements in magnetic electronics.

140 ays of photosensors on plastic and paper and programmable logic memory devices.

141 ved multidomain multicomponent gels based on programmable low-molecular-weight gelators, with one net

142 DNA origami represents a class of highly programmable macromolecules that can go through conforma

143 All-electrical and programmable manipulations of ferromagnetic bits are hig

144 as a means to track RNA in living cells in a programmable manner without genetically encoded tags.

145 lls can communicate and process signals in a programmable manner, are reported.

146 ion of one target DNA base into another in a programmable manner, without requiring dsDNA backbone cl

147 ability to precisely modify genomic DNA in a programmable manner.

148 s to repress or derepress a target gene in a programmable manner.

149 nipulate, sort, and electroporate cells in a programmable manner.

150 rchical micro/nanofibers in a continuous and programmable manner.

151 change the way a prodrug is activated in a "programmable" manner.

152 oparticle conjugates, which may be useful as programmable material building blocks and as probes for

153 These results suggest a path towards voltage-programmable materials based on solid-state switching of

154 computational systems, smart actuators, and programmable materials.

155 Shape-programmable matter is a class of active materials whose

156 xternal stimuli are critical to soft robots, programmable matter, and smart medicine.

157 with sentinel capabilities, which provides a programmable means to cull infected cells.

158 biocompatibility, nonthrombogenic features, programmable mechanical properties, and surface binding

159 The programmable mechanical response of these materials coul

160 The use of programmable meganucleases is transforming genome editin

161 and pollen grains to wrinkled membranes and programmable metamaterials.

162 ucidate the rules of synthetic, functionally programmable microbiome assembly, (4) determine function

163 sed on these observations, we developed cPPA programmable microcapsules whose payload release rates d

164 lop a method of cellular interrogation using programmable microfluidic devices which exploits the add

165 sing sequencing (ATAC-seq) integrated into a programmable microfluidics platform.

166 Using electronically programmable microfluidics, the measurement is in turn u

167 ated micropumps controlled by an inexpensive programmable microprocessor.

168 eation of versatile compressible solids with programmable microstructure, customizable shapes, and tu

169 recise patterning that can be used to create programmable molecular machines and arrays of functional

170 We anticipate that future generations of programmable molecular machines may have significant rol

171 ction and have been creatively repurposed as programmable molecular scalpels for surgical manipulatio

172 Programmable molecular self-assembly of siRNA molecules

173 multi-stimuli response can form the basis of programmable molecular systems, wherein specific input s

174 with nanoscale geometric controls provide a programmable molecular toolbox for engineering complex n

175 Our results demonstrate programmable motion of 2D and 3D DNA origami mechanisms

176 ated resealable chip interface (RCI) allowed programmable multiple injection protocols.

177 chnology to enable high-density fluorescent, programmable, multiplexed biorecognition in a compact an

178 surfaces, thus facilitating the creation of programmable multistable materials with fast actuation c

179 In contrast, two-dimensional (2D) programmable nanoparticle (NP) systems are not well expl

180 Here, we report a programmable nanoreplica molding process to fabricate a

181 as a unique class of compounds that combine programmable nanoscale building blocks and atomic precis

182 Synthetic DNA is a highly programmable nanoscale material that can be designed to

183 rrays, with each cross-point consisting of a programmable nanowire transistor node.

184 The programmable nature of DNA makes it an ideal system for

185 The programmable nature of DNA-DNA interactions used in this

186 The programmable nature of these minimal systems has enabled

187 suggest a simple, robust approach to realize programmable neuromorphic chips compatible with large-sc

188 Here we demonstrate electrically programmable nonvolatile memory metadevices realised by

189 he recent discovery of a bacterially derived programmable nuclease termed clustered regularly intersp

190 e discuss current progress toward developing programmable nuclease-based therapies as well as future

191 nd broadly applicable methods for delivering programmable nucleases and donor templates for homology-

192 Genome engineering with programmable nucleases depends on cellular responses to

193 Genome editing using programmable nucleases has revolutionized biomedical res

194 Programmable nucleases have revolutionized zebrafish gen

195 ment of genome editing technologies based on programmable nucleases have substantially improved our a

196 A particularly tantalizing application of programmable nucleases is the potential to directly corr

197 ATIONALE: Targeted genetic engineering using programmable nucleases such as transcription activator-l

198 ansformation brought about by the ability of programmable nucleases to manipulate the genome.

199 Programmable nucleases, such as Cas9, are used for preci

200 CRISPR-Cas systems are efficient and easily programmable nucleic acid-targeting tools, with uses rea

201 microRNA imaging inside live cells based on programmable oligonucleotide probes, which self-assemble

202 Herein we demonstrate the programmable one-pot dehydration-hydration condensation

203 he microfluidic immunosensor chip to achieve programmable operations of the immunoassay including bea

204 Specifically, we developed Programmable Order Polymerization (POP), Microfluidic Co

205 Here we report stable non-volatile programmable p-n junctions fabricated from the verticall

206 atic biases between the actual values of the programmable parameters and their user-specified values.

207 reduces the magnitudes of the biases in the programmable parameters but also enhances the performanc

208 be significantly impaired by noise in their programmable parameters, effectively misspecification of

209 rticle recycling in sustainable processes to programmable particle delivery in lab-on-a-chip applicat

210 e is safely resorbed into the body, within a programmable period.

211 technology platform for direct expression of programmable phosphoproteins containing multiple phospho

212 Programmable photoactuation enabled by graphene: Graphen

213 tronic Field Programmable Gate Arrays is the programmable photonic processor, where a common hardware

214 Programmable plasmon modes offer a robust way to achieve

215 e foundation for a new generation of active, programmable plasmonic metamaterials with major implicat

216 architectures are designed and printed with programmable Poisson's ratios ranging from -0.8 to 0.8 o

217 d be used to design folding of other knotted programmable polymers such as RNA or proteins.

218 bility of DNA nanostructures will enable the programmable positioning of components in 2D and 3D spac

219 licone gel particles that display a range of programmable properties and narrow size distributions.

220 Based on the non-volatile programmable properties controlled by gate voltages, the

221 in microarrays fabricated using nucleic acid programmable protein array (NAPPA) technology, which ena

222 novel Rac1 interactions using a nucleic acid programmable protein array and discovered that Rac1 bind

223 Programmable protein phosphorylation is poised to help r

224 the door to a new generation of genetically programmable protein-based molecular machines.

225 With the introduction of the D-Wave programmable quantum annealer, a considerable amount of

226 computational role in a currently available programmable quantum annealer.

227 evelopment and manufacturing of experimental programmable quantum annealing optimizers that contain h

228 recently been shown to physically implement programmable quantum annealing.

229 The challenge is to achieve a fully programmable quantum device featuring coherent adiabatic

230 a way of exploring many-body phenomena on a programmable quantum simulator and could enable realizat

231 Our device can generate programmable radio-frequency bursts or continuous wavefo

232 sking moiety, the substrate sequence enabled programmable reaction times within the cell cytoplasm.

233 RNAs (sRNAs) are increasingly being used as programmable regulators of gene expression.

234 e endow E. coli with a system for efficient, programmable replacement of genomic DNA with long (>100-

235 bolometric-effect-based photodetectors with programmable response spanning from visible to near-infr

236 for incorporation into systems with complex, programmable responses to different sets of stimuli.

237 operation of ribocomputing devices based on programmable RNA interactions suggests that systems empl

238 Programmable RNA-guided CRISPR/Cas9 has recently emerged

239 This work represents a step toward programmable, scarless genome editing in unmodified cell

240 ned DNA sequences from the human genome with programmable selectivity for both canonical and epigenet

241 otides as a molecular building block for the programmable self-assembly of nanostructured systems-was

242 In particular, although the programmable self-assembly of oligonucleotides and prote

243 ecular polymer has been a great challenge in programmable self-assembly of organic molecules.

244 the synthetic manifestation of a temporally programmable self-assembly.

245 les with grafted hydrocarbon ligands and DNA programmable self-assembly.

246 Programmable, self-assembled DNA nanoswitches serve both

247 y controllable residual stresses that enable programmable, self-bending behavior.

248 n technique also has the added advantages of programmable sensor surface generation based on the need

249 yamides bind to the minor groove of DNA with programmable sequence specificity and high affinity.

250 Programmable sequence-specific genome editing agents suc

251 complementary nucleic acid targets, enabling programmable sequence-specific targeting with minimal ma

252 Here, we develop programmable, sequence-specific antimicrobials using the

253 atory devices depends on the availability of programmable, sequence-specific, and effective synthetic

254 We show measurements wherein a user-programmable set-point precisely alters the protein conc

255 Soft materials capable of programmable shape change require localized control of t

256 x, multi-material architectures that exhibit programmable shape changes with temperature and time.

257 Herein we demonstrate programmable shape-memory materials that perform a seque

258 However, synthesis of such chains with programmable shapes outside a liquid environment has pro

259 rays with controllable spatial organization, programmable signalling pathways and higher order collec

260 Type VI CRISPR-Cas systems contain the programmable single-effector RNA-guided ribonuclease Cas

261 The widespread availability of programmable site-specific nucleases now enables targete

262 Programmable stiff sheets with a single low-energy foldi

263 joint were activated transcutanously using a programmable stimulator, and the resultant finger flexio

264 n assembly (CHA) amplification coupling with programmable streptavidin aptamer (SA-aptamer).

265 ge DNA origami rotaxanes that are capable of programmable structural switching.

266 ign of future nanoparticle assemblies having programmable structures and properties.

267 r electronics because of their versatile and programmable structures.

268 generate tailored chemical contrast based on programmable supercontinuum pulses.

269 ctional self-assembly of nanoparticles using programmable surface adapters.

270 Glycodendrimersomes with programmable surface display of glycan, together with ar

271 stiffening, 3D structures with gradient and programmable swelling properties, all printed with a sin

272 ith important implications for the design of programmable synthetic systems.

273 Short ncRNAs underlie a programmable system of chromatin modification that silen

274 ruct fused to the nuclease-inactivated dCas9 programmable targeting domain to introduce DNA methylati

275 Given the wide applicability of TALEs for programmable targeting of DNA sequences in vitro and in

276 m-up hybrid nanofabrication process based on programmable temperature control and parallel chemical s

277 vely coupled plasma-mass spectrometry with a programmable temperature cyclonic spray chamber, attaine

278 uent analysis on a thermal-desorption system programmable-temperature vaporization gas chromatograph

279 The possibility of designing programmable thin-film supramolecular structures with sp

280 As a consequence, nanostructures of programmable three-dimensional shapes and tunable compos

281 eighboring memory cells and read out after a programmable time with high fidelity.

282 iad array of applications in drug screening, programmable tissue engineering, drug delivery, and biom

283 op-mediated isothermal amplification (LAMP), programmable toehold-mediated strand-exchange signal tra

284 As a programmable tool orthogonal to any native proteins, the

285 RNA binding activity, which we leveraged for programmable tracking of transcripts in live cells.

286 Cas9, and highlight the utility of Cas9 for programmable transcript recognition without the need for

287 Here, we report a modular system based on programmable transcription activator-like effector (TALE

288 uided nuclease Cas9 can be reengineered as a programmable transcription factor.

289 Programmable transcription factors drive lethal gene exp

290 Several programmable transcription factors exist based on the ve

291 We report engineered, programmable transcription-activator-like effectors (TAL

292 Here we study a programmable transcriptional oscillator system that is c

293 canonical forms of genome-editing agents and programmable transcriptional regulators are constitutive

294 stem in Escherichia coli can be co-opted for programmable transcriptional repression.

295 oped synthetic tissue groupings that allowed programmable transformation of two-dimensional (2D) stre

296 orescence microscopy technique that exploits programmable transient oligonucleotide hybridization-on

297 ucleotides have been used extensively as the programmable units in this paradigm, proteins, which exh

298 e that targets unmodified RNA sequences in a programmable way.

299 ferent commercial mass spectrometers using a programmable XYZ stage.

300 We fuse 223 yeast CRs to programmable zinc finger proteins.