ライフサイエンスコーパス: progress through

1 involved both apoptosis and necrosis, which progressed through 12 to 14 hours after exposure.

2 We found that RGPs progress through a coherent program in which their proli

3 n that, in vivo, human CD56(bright) NK cells progress through a continuum of differentiation that end

4 The treated cells progress through a first S phase with kinetics similar t

5 ow that flat CRCs do not develop de novo but progress through a flat adenomatous stage to invasive ca

6 that rhabdomyosarcomas represent an arrested progress through a normal transitional state that is reg

7 munodeficiency virus (SIV) has been shown to progress through a number of changes that lead to the em

8 The method delays fluid progress through a porous channel by diverting fluid int

9 er treatment cessation, autoreactive B cells progress through a series of activation steps before the

10 Lymphocyte development requires cells to progress through a series of stages, each associated wit

11 The organoid hair cells also progress through a similar dynamic developmental pattern

12 Hepatocellular carcinoma (HCC) is known to progress through a step often called tumor promotion.

13 uate organ mass, the daughters of stem cells progress through a transit-amplifying phase displaying r

14 s a multistep process where oligodendrocytes progress through a well coordinated differentiation prog

15 slet cells expanded in monolayers for months progressed through a reversible epithelial-to-mesenchyma

16 cancer occurs only after a cell lineage has progressed through a series of stages.

17 polarity reversals, and the field direction progresses through a 180 degrees change while the field

18 n a tightly controlled microbial environment progresses through a choreographed succession of bacteri

19 Tumor development progresses through a complex path of biomechanical chang

20 is ablated, Purkinje cell heredodegeneration progresses through a mechanism not significantly affecte

21 Here, a given site progresses through a sequence of resource and species st

22 The bacterial microbiota of biopsy specimens progresses through a systematic series of changes that c

23 ld, beginning with philosophy of science and progressing through a series of substantive research and

24 Secondary structure elements are progressing through a small number of discrete states in

25 Assembling Gag forms immature capsids by progressing through a stepwise pathway of assembly inter

26 Untreated HIV-1 infection progresses through acute and asymptomatic stages to AIDS

27 Subsequently, T cell behavior progressed through additional distinct stages, including

28 ng continue to develop new disorders as they progress through adolescence.

29 le differentiation, produce a hair shaft and progress through all stages of the hair follicle cycle.

30 from seeds obtained from regenerated plants progressed through all developmental stages and had the

31 The assembly process is believed to progress through an alternating series of RNA conformati

32 The origin of life is believed to have progressed through an RNA world, in which RNA acted as b

33 hat for small initial viral load the disease progresses through an asymptomatic course, for intermedi

34 The APC is essential for cells to progress through anaphase, exit from mitosis, and preven

35 Research has progressed through application of molecular techniques i

36 Each subunit sequentially progresses through ATP, ADP and apo states while the ass

37 We used an in vitro cell system that progressed through basophilic, polychromatic, orthochrom

38 These effects evolved as monkeys progressed through behavioral sessions, because increasi

39 tiates from multiple replication origins and progresses through bidirectional replication forks to en

40 f p53 restored the ability of these cells to progress through both G1/S and mitosis, leading to their

41 ofilament structure as the tip spontaneously progresses through both catastrophe and rescue.

42 emale -UNmale = 27.5%, P < 0.05), and 3) IGT progresses through both parental lineages (glucose toler

43 TR-mediated checkpoints and allowed cells to progress through cell cycle in the presence of DSBs.

44 erosis is a chronic inflammatory process and progresses through characteristic morphologic stages.

45 fections became less frequent as individuals progressed through childhood and young adulthood, they o

46 As monkeys progressed through choice sequences toward rewards, amyg

47 tical question as to how DNA replication can progress through chromatin, which is inhibitory to all D

48 them will provide great insight as vaccines progress through clinical trials.

49 e crucial in evaluating JNJ-Q2 potency as it progresses through clinical trial development.

50 urate evaluation of GSK2140944 potency as it progresses through clinical trial development.

51 cial for evaluating GSK1322322 potency as it progresses through clinical trials.

52 roneedles and thermal ablation are currently progressing through clinical trials for delivery of macr

53 to the development of new compounds that are progressing through clinical trials.

54 ace validity in this system as most patients progress through consecutive stages, and none revert to

55 e it will be very important to monitor their progress through continued surveillance.

56 The CDH progresses through continuous growth of the liver into t

57 were overexpressed in trt1(-) cells as they progressed through crisis.

58 in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integrat

59 ression of HEF1 leads to failure of cells to progress through cytokinesis, whereas depletion of HEF1

60 romosome segregation, procyclic trypanosomes progressed through cytokinesis to produce one nucleated

61 Ameloblasts progress through defined stages of development as enamel

62 The development of the cerebral cortex progresses through defined stages including neural proli

63 ng idiopathic infantile nystagmus, which has progressed through determining the role of the FRMD7 gen

64 It has made significant technical progress through developments in source, algorithm and i

65 nship between gaze and locomotion as the bat progresses through different phases of insect pursuit.

66 ronic infection with hepatitis B virus (HBV) progresses through different phases.

67 Dendritic cells (DCs) progress through distinct maturational phases; immature

68 of the urinary bladder appear to evolve and progress through distinct molecular pathways.

69 Thus, germ cells progress through distinct, sequential regulatory states,

70 n the infected cytoplasm, have been shown to progress through disulfide-bonded Vp1 folding intermedia

71 eiosis that persist unrepaired as germ cells progress through DNA repair-competent phases of spermato

72 m-up material design have been significantly progressed through DNA-based approaches.

73 Adult marrow progressed through double-positive and single-positive s

74 ractions between T cells and dendritic cells progress through dynamic contact stages in vivo consisti

75 itude of molecular pathways are necessary to progress through each cellular milestone, yet the underl

76 between a protein's characteristics and its progress through each stage of the structural genomics p

77 elopment of peripheral B cells and failed to progress through early B-cell development at the pro-B-

78 called modified Blalock-Taussig shunt allows progress through early life to an age and weight at whic

79 t human oocytes enter meiotic prophase I and progress through early recombination events in a similar

80 eripheral subcutaneous tumors, tumorigenesis progresses through early reversible stages, and Tax is s

81 al pathways are involved, and these pathways progress through elements of "native" structure.

82 China has rapidly progressed through epidemiological and demographic trans

83 or maternal-perinatal health; and accelerate progress through evidence, advocacy, and accountability.

84 ge IV non-small-cell lung cancer (NSCLC) who progress through first-line therapy have poor progressio

85 Animals that possess MSR typically progress through four stages of behavior when facing a m

86 ed that IBCs formed by uropathogenic E. coli progressed through four distinct developmental stages th

87 is it required for the normal human cell to progress through G1 and the remainder of interphase.

88 Second, normal cells can progress through G1 in its entirety without centrioles.

89 cell acquires most of the cell cytoplasm and progresses through G1 into the next mitotic cell cycle.

90 ter begin G1 simultaneously, the mother cell progresses through G1 more rapidly.

91 Using CENP-F as a marker for progress through G2, we also show that sustained inhibit

92 the knock-in mutation (Tcf3(DeltaN/DeltaN)) progress through gastrulation without apparent defects,

93 tablish the anteroposterior axis but fail to progress through gastrulation.

94 The SA/- mice progressed through gestation, showing 10 to 15% reduced

95 DC as diverging from a common progenitor and progressing through grades in parallel.

96 f hematopoietic progenitors from fibroblasts progresses through hemogenic precursors that are Prom1(+

97 MD although various promising approaches are progressing through human clinical trials.

98 t retinal disease in the diabetic milieu may progress through inflammatory and neuroretinal stages lo

99 e-associated molecular patterns (DAMPs), and progressing through innate and adaptive immune responses

100 The tobacco addiction treatment field is progressing through innovations in medication developmen

101 ontinuously monitor research investments and progress, through international platforms such as a Glob

102 Cells treated with ZM447439 progress through interphase, enter mitosis normally, and

103 ) reformation and into an intact NE as cells progress through interphase.

104 the secretion of surface-active proteins to progress through its life cycle.

105 en exchange rates as phosphoglycerate kinase progresses through its catalytic cycle have been measure

106 parum, the parasite slows its metabolism and progresses through its developmental cycle at a reduced

107 ally all the tissues of the body, and tumors progress through many different stages during their deve

108 Nevertheless, when autophagy progressed through maturation stages, HIV was degraded.

109 round and support reproductive cells as they progress through meiosis and pollen maturation.

110 infertility due to failure of germ cells to progress through meiosis I and hypogonadism.

111 phosphorylated on multiple residues as cells progress through meiosis.

112 d DNA damage and apoptosis, yet collectively progressed through meiosis and spermiogenesis and genera

113 ls is set early in development, with oocytes progressing through meiosis later in life.

114 on leaving the niche, enter into meiosis and progress through meiotic prophase [1].

115 ristem identity and determinacy in which the progress through meristem identities is mediated by a do

116 e II alpha-dependent mitotic decatenation to progress through metaphase.

117 Subsequently, these cells progress through metaplasia and dysplasia to intraepithe

118 ence for a role for Ca2+ in MI since oocytes progress through MI in the absence of detectable Ca2+ tr

119 Rates of decline and progress through milestones measured using the scale var

120 DN3 thymocytes to exit the G2/M checkpoint, progress through mitosis and further differentiate.

121 e rises during G(2)-phase and falls as cells progress through mitosis and G(1).

122 ulation of mitosis, allowing mutant cells to progress through mitosis at the expense of genomic integ

123 d an increase in the time taken for cells to progress through mitosis from nuclear envelope breakdown

124 However, after the doubly transfected cells progress through mitosis in the presence of rapamycin, w

125 Cultures of snf2Delta yeast were found to progress through mitosis slowly.

126 urveillance enables BRCA2-deficient cells to progress through mitosis with under-replicated DNA, whic

127 e checkpoint complex fails to form and cells progress through mitosis without proper arrest in respon

128 stimulated in synchronous HeLa cells as they progress through mitosis, and these proteins are activat

129 FoxM1 null or depleted cells fail to progress through mitosis, as expression of several mitot

130 pho-H2AX-positive and BrdUrd -positive cells progress through mitosis, demonstrating a link between p

131 of the reduced ability of cardiomyocytes to progress through mitosis.

132 overexpressed and is essential for cells to progress through mitosis.

133 ntromere cannot be stretched; however, cells progress through mitosis.

134 Although viable, these cells are slow to progress through mitosis.

135 ay underlie the inability of PTIP mutants to progress through mitosis.

136 tic actin-dependent changes in shape as they progress through mitosis; they round up upon mitotic ent

137 the single-stranded recombinant AAV2 vectors progressed through mitosis in the absence of the helper

138 Cells treated with AZD1152 progressed through mitosis with misaligned chromosomes a

139 Most irradiated cells progressed through mitosis without significant delay, bu

140 Developing hGOs progressed through molecular and morphogenetic stages th

141 Sp1(-/-) cells progress through most embryonic stages of blood cell dev

142 hat as epidermal progeny differentiate, they progress through multiple spatiotemporal transition stat

143 Human embryonic stem cells progress through multiple stages in their path to neural

144 system, biofilm development was observed to progress through multiple stages, including attachment o

145 endrocytes, the myelinating glia of the CNS, progress through multiple transitory stages before termi

146 fteen passes generated an adapted virus that progressed through multiple cycles in cultured D2F2/E2 c

147 genic differentiation but disappear as cells progress through myogenesis, concomitant with the destru

148 ous cause of morbidity and mortality despite progress through neurobiological research in identifying

149 inhibition, to helping the replication fork progress through non-nucleosomal protein-DNA complexes.

150 completely blocked in cortex hydrolysis and progresses through outgrowth to produce colonies at a fr

151 Aged apoE4 TR mice progressed through pentylenetetrazol-induced seizure sta

152 into human clinical trials and successfully progressed through phase 1 studies.

153 undergone extensive clinical testing and has progressed through phase III clinical trials, continued

154 a transitory apoptotic response and the skin progressed through phases of hyperplasia and dysplasia.

155 public-company-sponsored clinical trials are progressing through phases 1-3.

156 All patients had progressed through platinum-based chemotherapy.

157 Many drugs have progressed through preclinical and clinical trials and h

158 he identification of AT13387 (35), which has progressed through preclinical development and is curren

159 expression analysis suggests that the hESCs progress through primitive streak or mesendoderm to meso

160 Postnatal spermatogonial stem cells (SSCs) progress through proliferative and developmental stages

161 Although many tumor cells did not progress through Ptx-induced mitotic arrest, tumor signi

162 pic hypogonadism characterised by failure to progress through puberty, indicating the involvement of

163 was rapid compared with Fg, but both cargoes progressed through Rab4(+), Rab11(+), and von Willebrand

164 As ecosystems progress through recovery, it is important to estimate a

165 Chk1 S301 phosphorylation increases as cells progress through S and G2 and that both Cdk1 and Cdk2 ar

166 ests at the G(1)/S transition, skp1-3f cells progress through S phase and instead display two distinc

167 The ability to inappropriately progress through S phase during drug treatment is a key

168 vely sensitive HT29 cells, which continue to progress through S phase during drug treatment.

169 that fail to interact with Skp2 and cyclins progress through S phase with similar kinetics as wild t

170 inue to synthesize DNA slowly and eventually progress through S phase, suffering severe DNA damage th

171 e same group of E2F1-3 target genes as cells progress through S phase.

172 nal effectors that commit cells to enter and progress through S phase.

173 ional program that commit cells to enter and progress through S phase.

174 eriments show that ORC disassembles as cells progress through S phase.

175 nds to MBF to repress transcription as cells progress through S phase.

176 inue to synthesize DNA slowly and eventually progress through S-phase, suffering severe DNA damage th

177 Here we show that HTLV-I-transformed T cells progress through S/G(2)/M phases of the cell cycle with

178 synthesis, decreases in the number of cells progressing through S phase and cell proliferation, wher

179 Cells lacking miR-155 are inefficient in progressing through S phase and spontaneously undergo ap

180 nscript-based markers were used to track the progress through senescence, and indicated that limiting

181 ical neurons responded to sensory stimuli by progressing through sequences of states, identifiable on

182 Diseases normally progress through several stages.

183 erobic conditions did not become dormant and progressed through several developmental stages until da

184 Their research has progressed through several evolutionary cycles, beginnin

185 ercent volume per ameloblast) as ameloblasts progress through six defined developmental stages.

186 ction of these lesions increases as children progress through staged surgical reconstruction, with mu

187 These diseases progress through stages.

188 follicle is a cyclic biological system that progresses through stages of growth, regression, and qui

189 We employed a rat liver cancer model that progresses through stages similar to those of human live

190 ) undergo lifelong cyclical transformations, progressing through stages of rapid growth (anagen), reg

191 generally believed that tumours develop and progress through stepwise accumulation of mutations in d

192 r discovery the beta-lactam antibiotics have progressed through structural generations, each in respo

193 itial reaction were characterized, and their progress through subsequent washing with diethyl ether a

194 Here we show that burrowers can progress through such sediments by using a mechanically

195 opriately regulate the Notch program as they progress through T cell development.

196 ne programs that change dynamically as cells progress through T cell differentiation.

197 The alternative replication cannot progress through the A/T-rich FRA16B fragile site, while

198 rmediate states these proteins adopt as they progress through the ATP hydrolysis cycle is key to unde

199 d protein modification and that infected ECs progress through the autophagosome pathway by LC3 dual f

200 of the Trp195 loop and are linked to enzyme progress through the catalytic cycle, including donor su

201 ize and age distributions: these cells still progress through the cell cycle and although we do not s

202 cells are unable to replicate their DNA and progress through the cell cycle and that the NASP(-/-) n

203 cleation, whereas megakaryocytes continue to progress through the cell cycle but skip late stages of

204 role of the CaM-Ks on cell proliferation and progress through the cell cycle in breast cancer cells.

205 results indicate that endothelial cells must progress through the cell cycle in order to be radiosens

206 rest in S-phase but defective cells can also progress through the cell cycle leading to nucleosome de

207 lls expressing low levels of p21 immediately progress through the cell cycle upon release from S phas

208 s represent different G1 subpopulations that progress through the cell cycle with distinct temporal p

209 comprise the conserved machinery that drives progress through the cell cycle, but how they do this in

210 marks" genes for rapid reactivation as cells progress through the cell cycle.

211 p in promoting that arrest declines as cells progress through the cell cycle.

212 bility to return to quiescence and decide to progress through the cell cycle.

213 n FLS leads to S-phase arrest and failure to progress through the cell cycle.

214 uction and the ability to synthesize DNA and progress through the cell cycle.

215 to direct observation and 273 patients whose progress through the clinic stations was timed.

216 l ensembles robustly encoded conjunctions of progress through the current route, position in the larg

217 e to multi-step protocols, with major recent progress through the elegant ligand design in heterobime

218 hannels and secreted trophic factors as they progress through the endoplasmic reticulum and the Golgi

219 a striking decrease in fertility, failing to progress through the estrous cycle normally, show any si

220 Each species' rate of progress through the event scale, described by a regress

221 ation of these substrates and arrays as they progress through the fabrication process.

222 salivary glands, we observed B. burgdorferi progress through the feeding tick via what we believe to

223 y depleted of all miRNAs, and they failed to progress through the first cell division, probably becau

224 re CD4(+) T follicular helper (Tfh) cells to progress through the germinal center and provide protect

225 eciation of how these networks vary as cells progress through the haematopoietic cell hierarchy.

226 tomatic bacteriuria, or pyelonephritis could progress through the IBC cascade in a well-characterized

227 ired sensitization to NK cell killing, while progress through the late lytic cycle is associated with

228 replicating the virus decreases as the cells progress through the lytic cycle such that only a tiny f

229 a subset of membrane-spanning cargo as they progress through the medial Golgi.

230 Our results show that the failure to progress through the meiotic pathway is not the result o

231 disease changes considerably as the lesions progress through the morphological stages identified.

232 rs with fewer academic resources and tend to progress through the ranks slower than men.

233 posed to cWnts, Bmp2-deficient cells fail to progress through the Runx2/Osx1 checkpoint and thus do n

234 promotes H2B synthesis that allows cells to progress through the S phase.

235 The ability to study live cells as they progress through the stages of cancer provides the oppor

236 rmation on target sequences and tracks their progress through the various stages of protein productio

237 ion, virion composition and infectivity, and progress through the virus life cycle under perturbation

238 EGF-stimulated goblet cells progressed through the cell cycle expressing pERK in the

239 As these cells progressed through the contraction of the immune respons

240 the last few decades, quantum chemistry has progressed through the development of computational meth

241 We previously showed that these two proteins progressed through the Golgi with distinct kinetics.

242 itory synaptic transmission as adult gerbils progressed through the process of associative learning a

243 was a smooth ramp-like change as the animal progressed through the sequence toward the reward.

244 g gastric processing, which emptied into and progressed through the small intestine.

245 a closed, ordered conformation as the enzyme progresses through the catalytic cycle.

246 We first find that as the 8-cell embryo progresses through the cell cycle, the nuclei of most -

247 rces in estimating how a population of cells progresses through the cell cycle.

248 the point of sperm entry, which subsequently progresses through the entire egg cortex.

249 ve a multisynaptic pathway that sequentially progresses through the entorhinal and perirhinal regions

250 rovide continuous coordination of urea as it progresses through the filter, and well-placed alpha-hel

251 sity is generated during the reaction, which progresses through the formation of fractures.

252 Virion assembly progresses through the formation of immature virions (IV

253 mic models of the AAA(+) ATPase module as it progresses through the functional cycle.

254 Previous studies have shown that the enzyme progresses through the kinetic cycle by modulating the d

255 male -UNmale = 1.60 g, P < 0.05), 2) obesity progresses through the maternal line (percent body fat:

256 is because HPV-18-associated disease rapidly progresses through the preinvasive stages of neoplasia.

257 rtions imposed on the cofactor as the enzyme progresses through the reaction cycle.

258 r to stably associated dimer as the spidroin progresses through the silk extrusion duct.

259 on of the transcriptome of V. cholerae as it progresses through the stages in biofilm development.

260 Spermatogenesis in Tex14(-/-) mice progresses through the transit amplification of diploid

261 mpleted in 1 d, with an additional 1-2 d for progressing through the analysis procedure.

262 n of telomerase subunits in cells blocked or progressing through the cell cycle as synchronized by mu

263 mained unchanged in human cells entering and progressing through the cell cycle from G(0), despite dr

264 Cells progressing through the cell cycle must commit irreversi

265 iling of synchronously growing cell cultures progressing through the cell cycle.

266 t pathways that prevent cells with DSBs from progressing through the cell cycle.

267 ducibility of FTIR spectra recorded of cells progressing through the cell cycle; (3) insights into th

268 me-point "snapshot" of a population of cells progressing through the cycle asynchronously.

269 it, with several new diagnostic technologies progressing through the development pipeline.

270 n entering the S phase, and are deficient in progressing through the early M phase.

271 o be more prevalent and abundant in patients progressing through the esophageal adenocarcinoma cascad

272 inhibited p130 downregulation in T98G cells progressing through the G1/S transition and S phase and

273 s of molecularly targeted anti-cancer agents progressing through the late stages of clinical developm

274 is examination begins at the N3 lymph nodes, progressing through the N2 and N1 lymph node stations, u

275 unchanged in cells exiting from mitosis and progressing through the next cell cycle.

276 Ovol1-deficient germ cells were defective in progressing through the pachytene stage.

277 rate of DNA replication, blocked cells from progressing through the S phase, and inhibited prolifera

278 spore and deletion of cmpA resulted in cells progressing through the sporulation programme more quick

279 ng" cisternae that carry cargo forward while progressing through the stack.

280 f both IgH-mu- and IgL-kappa-chains, without progressing through the stage of IgH-mu-chain alone.

281 the aging process and age-related disease is progressing through the use of model organisms, how to a

282 parasites within a host - millions of them - progress through their cell cycle synchronously.

283 s undergo several cellular decisions as they progress through their life cycles inside host cells(2).

284 stocysts enter biosynthetic dormancy but can progress through their normal developmental program afte

285 Despite these advances, some patients progress through therapy and succumb to their disease.

286 ignaling, yet little is understood as to how progress through these events is regulated.

287 Little is known about how replication progresses through these regions in human cells.

288 tely, studies show that many patients do not progress through this continuum.

289 m to cause anthrax depends on its ability to progress through this life cycle in a regulated manner.

290 As cells progress through this protocol, they express genes in a

291 Wild-type cells progress through three distinct phases: a quiescent phas

292 FepA-mediated transport of FeEnt progressed through three distinct phases with successive

293 Biofilm growth progresses through three genetically programmed stages:

294 On its activation pathway, Hsp33 progresses through three major conformations, starting a

295 ints caused by variation in gene copy number progressed through tissue development and resulted in st

296 We found that TFH cells progressed through transcriptionally and functionally di

297 d by multiple scaffold morphing steps, which progressed through tricyclic pyrimido[2,3-b]azaindoles t

298 Colorectal cancer (CRC) can progress through two pathways of genomic instability: ch

299 eveals how classical Red Queen conflicts can progress through unrecognized intermediates.

300 d genomic instability, Atm(KD/-) lymphocytes progressed through variable, diversity, and joining reco