ライフサイエンスコーパス: progressive

1 t is generally regarded as static and slowly progressive.

2 neurodegenerative disorders characterized by progressive accumulation of alpha-synuclein (alpha-syn)

3 Tauopathies are characterized by the progressive accumulation of hyperphosphorylated, aggrega

4 entatorubral-pallidoluysian atrophy (DRPLA), progressive acquirement of an ataxic phenotype is linked

5 ce is effectuated through adaptive rewiring: progressive adaptation of structure to use, creating sho

6 iations in fullerene cage stability with the progressive addition of chemical species.

7 xed lysozyme concentration (0.714g.L(-1)) by progressive addition of LM pectin (from 0 to 4g.L(-1)).

8 Both models recreate the progressive adult-onset dysfunction and degeneration of

9 hronic social defeat stress in mice produces progressive alterations in sleep and circadian rhythms t

10 The progressive and early onset of these defects suggest a p

11 Huntington's disease (HD) is a progressive and fatal degenerative disorder that results

12 athic pulmonary fibrosis (IPF) is a chronic, progressive and fatal fibrotic lung disease characterize

13 Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease.

14 Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial pneumonia.

15 ted macular degeneration (AMD) that leads to progressive and irreversible loss of visual function.

16 d feature of the SRD5A3-CDG disorder that is progressive and may lead to serious visual impairment.

17 Idiopathic pulmonary fibrosis (IPF) is progressive and rapidly fatal.

18 mmetrical cerebellar atrophy, which appeared progressive, and a prominent corpus callosum.

19 ulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease.

20 chenne muscular dystrophy (DMD) is a severe, progressive, and rare neuromuscular, X-linked recessive

21 Primary progressive aphasia (PPA) refers to a disorder of declin

22 s in a large cohort of patients with primary progressive aphasia (PPA) variants defined by current di

23 a, including the semantic variant of primary progressive aphasia (svPPA), is strongly associated with

24 of these impacted neural networks in primary progressive aphasia are lacking.

25 Primary progressive aphasia is a syndrome characterized by progr

26 al patients in both semantic variant primary progressive aphasia samples.

27 cortical atrophy, logopenic variant primary progressive aphasia, and corticobasal syndrome).

28 ophy and eight for logopenic variant primary progressive aphasia.

29 eliorated disease scores in MOG35-55-induced progressive, as well as PLP138-151-induced relapsing-rem

30 present an important mechanism to ensure the progressive assembly of primitive embryonic tissues.

31 iling to undergo branching morphogenesis and progressive atrophy of the proximal lung endoderm with c

32 FUS pathology, hypoexcitability, as well as progressive axonal transport defects.

33 frequency of B-cell subsets associated with progressive B-cell maturation and IgE class-switching.

34 xus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes.

35 s associated with developmental aberrations, progressive BMF with myelodysplastic features, and incre

36 cular features in 2 siblings presenting with progressive bone marrow failure (BMF), immunodeficiency,

37 different clinical syndromes (both acute and progressive), brain parenchymal lesions seen on neuroima

38 ows between fixed poles, is modulated by the progressive breakdown of the dorsal mesocardium.

39 scosity is thus a macroscopic witness of the progressive breaking of the tetrahedral hydrogen bond ne

40 Fibrosis in lung and skin leads to progressive bronchiolitis obliterans (BO) and scleroderm

41 represents an important mechanism underlying progressive CD4(+) T cell depletion in vivo.

42 This cellular movement is driven by progressive cell-matrix contacts and actively translocat

43 hy (cALD) is a fatal disease associated with progressive cerebral demyelination and rapid, devastatin

44 city of current definitions used to identify progressive change of the average peripapillary retinal

45 ongitudinal bacterial series that manifested progressive changes in liquid media growth, motility, bi

46 T2D induced progressive changes in retinal histology.

47 anges are of direct clinical relevance, with progressive changes on OCT often preceding functional lo

48 ns are binary, while rheostat positions show progressive changes.

49 ) in 27 unrelated individuals with a complex progressive childhood-onset dystonia, often associated w

50 ns and the midlife onset of debilitating and progressive chorea, dementia, and psychological disturba

51 Progressive clinical course was observed in 45%, carotid

52 9 patients (10.7%), in 8 of 10 patients with progressive CLL, and in 1 patient with prolymphocytic tr

53 on tyrosine kinase inhibitors were active in progressive CLL, but outcomes were mixed.

54 , we show that stressful experiences lead to progressive, clustered loss of dendritic spines along th

55 Alzheimer's disease (AD) is characterized by progressive cognitive decline, increasingly attributed t

56 MENT Alzheimer's disease is characterized by progressive cognitive decline, mainly attributed to syna

57 nd vertical saccades, dysphagia, apathy, and progressive cognitive decline, which led to her death 2

58 Whereas some contribute to progressive cognitive deterioration, others lower the le

59 Early and progressive colonization of the healthy brain is one hal

60 mes, to explore the hypothesis that DED is a progressive condition that has substantive and measurabl

61 MiR-211 knockout (-/-) mice exhibited a progressive cone dystrophy accompanied by significant al

62 n MYPN in 2 unrelated families with a slowly progressive congenital cap myopathy.

63 ation processes emphasizes the importance of progressive control strategies and measures to evaluate

64 Given the highly recurrent and progressive course of bipolar disorder sometimes even in

65 The progressive death of retinal ganglion cells and resultin

66 ses in gene expression could contribute to a progressive decline in cellular function, understanding

67 g an in-vitro laser axotomy model, we show a progressive decline in the ability of cut CNS axons to f

68 file of 1 (critical cardiogenic shock) or 2 (progressive decline) were assessed with the EQ-5D-3L vis

69 blunted hypertrophy accompanied by a rapid, progressive decrease in cardiac function.

70 -frontal region, which was associated with a progressive decrement of the functional connections betw

71 ies are a rare group of disorders leading to progressive degeneration of cerebral white matter.

72 son's disease (PD) is characterized by slow, progressive degeneration of dopaminergic neurons in the

73 These CERKL-/- animals showed progressive degeneration of photoreceptor outer segments

74 d by organic sleep related symptoms, rapidly progressive dementia and sympathetic symptoms.

75 erular water permeability, in the context of progressive depletion of all VEGF-A isoforms from the po

76 linical benefit in patients with refractory, progressive desmoid tumors who receive long-term treatme

77 Intravenous MSCs eliminated the progressive deterioration in LV end-diastolic volume and

78 or acute myocardial infarction attenuate the progressive deterioration in LV function and adverse rem

79 couples primary beta-cell dysfunction to the progressive deterioration of beta-cell mass in diabetes.

80 This article reviews the progressive development of currently available and next-

81 phy until the end stage of the disease, when progressive dilation begins, right ventricular volume is

82 eability, cyclical abolition of preload, and progressive dilation of the right ventricle.

83 inued in 54 (44%) patients, primarily due to progressive disease (39 [31%]) and adverse events (seven

84 98 [39%] of 252; five related to treatment), progressive disease (43 [17%]), sepsis (36 [14%]; two re

85 o change in symptoms attributed to ECD), and progressive disease (worsening of symptoms attributed to

86 as associated with worse PFS ( P < .001) and progressive disease at first restaging ( P < .001).

87 ned positive for HER1/2 and who did not have progressive disease during chemotherapy (four to eight c

88 ry endpoint was time to progression (time of progressive disease or death from any cause), with inten

89 Study patients were treated until progressive disease or unacceptable adverse effects occu

90 ated with greater brain atrophy in secondary progressive disease over a period of short term follow-u

91 ) were significantly higher in patients with progressive disease than in patients with stable disease

92 te and partial response, stable disease, and progressive disease were defined according to the 2014 N

93 Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a prevalence of 1 million perso

94 bevacizumab monotherapy was continued until progressive disease without significant treatment-relate

95 ponders (n = 6) (stable metabolic disease or progressive disease) showed a median OS of 4.4 mo (1-y a

96 s were nonresponders (stable disease, n = 9; progressive disease, n = 2).

97 isease progression (clinical or radiological progressive disease, relapse, or death from any cause).

98 this category than for those with stable or progressive disease.

99 % (3 of 17) stable disease and 30% (5 of 17) progressive disease.

100 response, minor response, stable disease, or progressive disease.

101 This method identifies 41% of the later progressive diseases on CT, with no false-positives.

102 Cholangiopathies are a diverse group of progressive diseases whose primary cell targets are chol

103 Alzheimer disease (AD) is a progressive disorder that affects cognitive function.

104 Patients with BVMD demonstrated progressive disorganization and thinning of the submacul

105 euterium exchange mass spectrometry, we show progressive disruption of individual orthosteric contact

106 it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.

107 Rb family protein inactivation triggers the progressive E2f-mediated transactivation of Socs3, a pot

108 We document progressive EBOV dissemination into the eyes, brain and

109 iods of simulated microgravity did not cause progressive elevations in ICP (supine, 15 +/- 2 vs. 24 h

110 Progressive enrichment of both delta(13)C-CH4 and deltaD

111 n have the potential to significantly affect progressive entrustment in training paradigms.

112 ative interactions, which support or inhibit progressive entrustment leading to operative autonomy.

113 These results reveal a progressive expansion of vertebrate viral infections ove

114 or dysregulation of ANTs is associated with progressive external ophthalmoplegia, cardiomyopathy, no

115 D and that affects endosomes and induces the progressive failure of lysosomes, each of which are dire

116 neurodegenerative disease, characterised by progressive failure of the neuromuscular system.

117 MYO5B should be considered as an additional progressive familial intrahepatic cholestasis gene.

118 ible for several biliary diseases, including progressive familial intrahepatic cholestasis type 3 (PF

119 ailure of these phases to occur in a timely, progressive fashion promotes pathologic wound healing.

120 Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease traj

121 Maladaptive repair after AKI may lead to progressive fibrosis and decline in kidney function.

122 and that Ly6C(low) MPs may contribute to the progressive fibrosis and dysfunction of mdx(5cv) diaphra

123 nsform the management of patients with other progressive fibrotic lung diseases.

124 IRT1 activation as a therapeutic strategy in progressive, fibrotic kidney disease.

125 Early onset XLRS is associated with a more progressive form of the disease, characterized by large

126 osure times to a ferrous solution showed the progressive formation of a triiron cluster on the inner

127 sability, which accrues predominantly during progressive forms of the disease.

128 re 2.33 times more likely to develop rapidly progressive glaucoma disease despite significantly lower

129 approved for the treatment of patients with progressive glioblastoma on the basis of uncontrolled da

130 atment with lomustine alone in patients with progressive glioblastoma.

131 search efforts due to their association with progressive glomeruli damage in disease states.

132 erum to induce crescentic nephritis (rapidly progressive GN), this genetic inactivation of the GR in

133 ained stable, consistent with the absence of progressive graft injury.

134 natal Tmc1(Bth/+) mice substantially reduced progressive hearing loss.

135 on individuals worldwide and causes severely progressive hepatitis.

136 tory chain complex III (CIII) deficiency and progressive hepatopathy due to mutated BCS1L, a CIII ass

137 and Texas Children's Hospital, patients with progressive HER2-positive glioblastoma were enrolled bet

138 rent high-frequency epileptic seizures cause progressive hippocampal sclerosis, which is associated w

139 Medical, surgical, and progressive ICUs of three academic hospitals.

140 A- and b-waves showed progressive impairment later from 2 and 3 months of age

141 In HD patients, LV SUV showed a progressive increase during doxorubicin treatment that p

142 The progressive increase in diagnostic claims for secondary

143 a graded fashion, and consequently evoking a progressive increase in locomotor output.

144 al conduction velocity, which manifests as a progressive increase in response latency.

145 IV-infected adults receiving ART resulted in progressive increases in malaria parasitemia prevalence

146 enerative disease with severity ranging from progressive infantile paralysis and premature death (typ

147 Rapid progressive infections are associated with a severe impa

148 Thus, FtsZ treadmilling guides the progressive insertion of new cell wall by building incre

149 pathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with unknown etiol

150 esting helped to distinguish stationary from progressive IRD subtypes and to establish a precise diag

151 s-linking (standard CL) for the treatment of progressive keratoconus 12 months after the operation.

152 s of corneal collagen crosslinking (CXL) for progressive keratoconus from the healthcare payer's pers

153 Corneal collagen crosslinking for progressive keratoconus is cost effective at a willingne

154 Most forms of chronic, progressive kidney disease are characterized by fibrosis

155 ly or 5/6 nephrectomized rats) that develops progressive kidney disease in association with TGF-beta

156 e UmodC147W/+ mice developed spontaneous and progressive kidney disease with organ failure over 24 we

157 In two other models of progressive kidney disease, global Mif deletion or MIF i

158 imited by a lack of animal models exhibiting progressive kidney disease.

159 Progressive kidney diseases are often associated with sc

160 that mediates these metabolic effects during progressive kidney injury by inhibiting TGF-beta type 1

161 Of the 10 patients, 4 had a progressive late-onset rod-cone dystrophy, with a mean (

162 infiltration of CD4(+) T cells and prevented progressive left ventricular dilatation and hypertrophy,

163 DCP is typically caused by non-progressive lesions to the basal ganglia or thalamus, or

164 Heavy alcohol use can lead to progressive liver damage, especially in individuals with

165 ct of aerobic capacity on susceptibility for progressive liver disease following a 16-week 'western d

166 lting in hepatocyte death, inflammation, and progressive liver fibrosis.

167 rats were submitted to RT (ladder climbing, progressive load, 3 times a week for 12 weeks).

168 tion in children living in endemic settings; progressive loss and dysfunction of these cells may repr

169 al hallmark of PD and is associated with the progressive loss of dopaminergic neurons over the course

170 Likewise, TgF344-AD rats displayed progressive loss of hippocampal norepinephrine levels an

171 ing white matter, although they did not show progressive loss of integrity over time.

172 levels associate with nephrotic syndrome and progressive loss of kidney function, thereby encouraging

173 ssive aphasia is a syndrome characterized by progressive loss of language abilities with three main p

174 and that recapitulate the human disease-with progressive loss of motor neurons in heterozygous animal

175 Progressive loss of mutated SAMD9 through the developmen

176 expected white matter development but also a progressive loss of tissue integrity.

177 er syndrome type III (USH3) characterized by progressive loss of vision and hearing is caused by muta

178 e brain tumors characterized by slow growth, progressive loss of vision, and limited therapeutic opti

179 e eased the selection pressure, resulting in progressive loss or truncation of tas3 and chp1 genes in

180 nic airway infection by Pseudomonas leads to progressive lung destruction ultimately requiring lung t

181 sarcoidosis-affected individuals experience progressive lung disease or cardiac and nervous system i

182 pathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncertain

183 ized by platelets lacking alpha-granules and progressive marrow fibrosis.

184 laxed state after fertilization, followed by progressive maturation of higher-order chromatin archite

185 aM-CaMKII delineates the importance of CaM's progressive mechanism of target binding on its Ca(2+) bi

186 uclear RNAi and morc-1(-) mutants revealed a progressive, met-1-dependent enrichment of H3K36me3, sug

187 In total, 101 patients with treatment-naive progressive metastatic clear cell renal cell carcinoma w

188 tients presenting at ages 2 to 4 months with progressive microcephaly, spastic quadriparesis, and glo

189 t of early hippocampal neurodegeneration and progressive microstructural changes in the dentate gyrus

190 the Rev1Xpc bone marrow was associated with progressive mitochondrial dysfunction and consequent exa

191 To investigate a progressive mobility program in a neurocritical care pop

192 An ongoing progressive mobility program in the neurocritical care p

193 LK in Pkd1(fl/fl) ;Pkhd1-Cre mice, a rapidly progressive model of ADPKD, decreased renal Akt/mTOR act

194 , in the modulation of CSPGs deposition in a progressive model of multiple sclerosis, the Theiler's m

195 a neurodegenerative disease characterized by progressive motor neuron loss and caused by mutations in

196 MENT Parkinson's disease is characterized by progressive motor symptoms due to the selective loss of

197 ondary progressive MS [SPMS], and 40 primary progressive MS [PPMS]) from C1 to T10.

198 relapsing-remitting MS [RRMS], 17 secondary progressive MS [SPMS], and 40 primary progressive MS [PP

199 that differentiates relapsing-remitting from progressive MS achieved a validated AUROC of 0.91.

200 e extent and distribution of fibrin(ogen) in progressive MS cortex and elucidate its relationship wit

201 he development of therapeutic strategies for progressive MS.

202 or and cognitive disability in patients with progressive MS.

203 the failure of remyelination associated with progressive MS.

204 hout causing John Cunningham virus-dependent progressive multifocal encephalomyelitis.

205 course of patients with natalizumab-related progressive multifocal leukoencephalopathy (PML) and ful

206 and the evolution of JC polyomavirus-induced progressive multifocal leukoencephalopathy over three di

207 opathy; lymphoma, hepatic encephalopathy and progressive multifocal leukoencephalopathy were seen mor

208 logies with prominent myelin injury, namely, progressive multifocal leukoencephalopathy, metachromati

209 One patient died of progressive multifocal leukoencephalopathy.

210 out mechanisms that drive the development of progressive multiple sclerosis (MS), although inflammato

211 ole brain atrophy in patients with secondary progressive multiple sclerosis (SPMS).

212 randomly assigned 732 patients with primary progressive multiple sclerosis in a 2:1 ratio to receive

213 Effective therapies for progressive multiple sclerosis that prevent worsening, r

214 uscular dystrophy, which is characterised by progressive muscle wasting and the discovery of reliable

215 ses infantile-onset multisystem disease with progressive muscle weakness.

216 ork measures spinal cord thinning in chronic progressive myelopathies, including human T-lymphotropic

217 by immune-mediated destruction of myelin and progressive neuroaxonal loss.

218 The rapid and progressive neurodegeneration in MoCD presents a major c

219 up of neurodegenerative disorders defined by progressive neurodegeneration of the corticospinal tract

220 lysosomal storage disorder characterised by progressive neurodegeneration.

221 ssive supranuclear palsy (PSP) is a rare and progressive neurodegenerative condition characterised pa

222 Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition primarily involv

223 Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease that is the leadin

224 rs of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease, we measured elect

225 Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterised by

226 Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder.

227 ide repeats are known to cause 10 late-onset progressive neurodegenerative disorders as the repeats e

228 encephalopathies (TSEs), are a group of rare progressive neurodegenerative disorders caused by an abn

229 s disease and Parkinson disease, are rapidly progressive neurodegenerative disorders caused by misfol

230 ur unrelated families with HPA who exhibited progressive neurodevelopmental delay, dystonia, and a un

231 tigating a Ttc19(?/?) mouse model that shows progressive neurological and metabolic decline, decrease

232 n sickness (CMS) in our clinic who developed progressive neurological deterioration (encephalopathy)

233 he data was investigated for trait and state progressive neuropathologies in MDD using both unbiased

234 s or remission, in the absence of detectable progressive neuropathology.

235 stablished nodal complexes leads to slow but progressive nodal destabilization over 10 months, primar

236 ral dementia, and ARHGAP35 and SERPINA1 with progressive non-fluent aphasia.

237 ile and antitumour activity in patients with progressive or treatment-resistant NSCLC, providing a ra

238 breast radiation treatment, she experienced progressive painful pruritic breast fullness, skin dimpl

239 Progressive pancreatic beta cell failure underlies the t

240 the presence of a persistent and potentially progressive pathology.

241 The Reep6-/- mice exhibited progressive photoreceptor degeneration from P20 onwards.

242 tions formed in meiotic interphase undergo a progressive polarization (clustering) at the nuclear per

243 acific NW region of the U.S. (representing a progressive populace facing stringent water quality regu

244 blished a feline HFpEF model induced by slow-progressive pressure overload.

245 Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging and i

246 rgic agonists did not alter cocaine SA under progressive ratio or seeking/taking chained reinforcemen

247 self-administer cocaine as measured using a progressive ratio reinforcement schedule and to enhanced

248 Animals were tested for fixed and progressive ratio responding for cocaine and stress-indu

249 Conversely, ACC dopamine release by progressive ratio responding to reward, during which ani

250 ession, heightened relapse vulnerability and progressive ratio responding, and resilience to punishme

251 ated with increased motivation measured on a progressive ratio schedule of food reinforcement, yet an

252 male Sprague-Dawley rats responding under a progressive ratio schedule to quantify the reinforcing e

253 t could lever press similar to controls on a progressive ratio schedule.

254 n sessions using fixed ratio 1, 3, and 5 and progressive ratio schedules.

255 cocaine self-administration rats displayed a progressive reduction in CTDP-32476 self-administration

256 nly a contraction of the lattice, leading to progressive reduction of the band gap.

257 ly increase in (18)F-FDOPA uptake and then a progressive reduction over time.

258 The progressive relation among metabolic syndrome, insulin r

259 t abduction was associated with significant, progressive relative posterior displacement of the tempo

260 nce), tai chi, yoga, motor control exercise, progressive relaxation, electromyography biofeedback, lo

261 Progressive remodelling appears to be gradual, but not u

262 Progressive resident autonomy is also limited.

263 speed at endoluminal CT colonography led to progressive restriction of visual search patterns.

264 The diagnosis of early-onset progressive retinal atrophy (PRA) was supported by reduc

265 blindness worldwide, and is characterized by progressive retinal ganglion cell (RGC) death.

266 Age-related macular degeneration (AMD) is a progressive retinal neurodegenerative disorder character

267 thy woman presented with a 2-year history of progressive right blepharoptosis.

268 e show that several sensory patches arise by progressive segregation from a common prosensory domain

269 ng behind electrophysiological changes was a progressive, selective decline in neural connectivity, a

270 A progressive sequence truncation procedure is then used f

271 ous ONI is rare and characterized by rapidly progressive severe visual impairment.

272 therapies and their practical application in progressive/severe pulmonary arterial hypertension with

273 passage P1 to P4, and was associated with a progressive shedding of procoagulant MPs.

274 epetitive stimulation (>/=1 Hz) results in a progressive slowing of action potential conduction veloc

275 ntrolling for sperm concentration, increased progressive sperm motility generated more pyruvate conve

276 lowing a stereotypic pattern consistent with progressive spreading along anatomical pathways.

277 cted transcription factor networks that link progressive stages.

278 There is now substantial evidence that progressive structural changes are of direct clinical re

279 on make relapsing MS more resilient than the progressive subtype.

280 erosis (ALS), multiple system atrophy (MSA), progressive supranuclear palsy (MSP)).

281 Progressive supranuclear palsy (PSP) is a rare and progr

282 pecific binding was, however, found on human progressive supranuclear palsy and corticobasal degenera

283 tive diseases including Alzheimer's disease, progressive supranuclear palsy and corticobasal degenera

284 anguage variants of frontotemporal dementia, progressive supranuclear palsy and corticobasal syndrome

285 er's disease, dementia with Lewy bodies, and progressive supranuclear palsy).

286 Fifteen subjects (4 controls, 6 AD, 3 progressive supranuclear palsy, 2 cortico basal syndrome

287 urodegeneration causing Alzheimer's disease, progressive supranuclear palsy, chronic traumatic enceph

288 sease, to relatively little loss, as seen in progressive supranuclear palsy.

289 escribed recessive Mendelian disorder in the progressive symmetric erythrokeratoderma spectrum.

290 ntricular mass, 86+/-41 [46-195] g/m(2)) was progressive, systolic function mainly preserved (cardiac

291 In lung allografts, progressive terminal airway fibrosis leads to an irrever

292 In this study, we describe an approach of progressive unfolding of a target protein using a gradie

293 Implementation of Progressive Upright Mobility Protocol Plus.

294 f residual shunts, anomalous vessel anatomy, progressive valvulopathy, hypertension, and atrial scars

295 SCT) is a skeletal disorder characterized by progressive vertebral, carpal and tarsal fusions, and mi

296 ent in PCNSL and clinically marked by slowly progressive visual deterioration, lymphomatous ONI is ra

297 haracterized by motor neuron dysfunction and progressive weakening of the neuromuscular junction (NMJ

298 is characterized by muscle degeneration and progressive weakness.

299 Structural dysfunction in ARVD/C is progressive with substantial interpatient variability.

300 continued exposure to a causative agent and progressive worsening of disease; conversely, diagnosing