ライフサイエンスコーパス: progressive hearing loss

1 natal Tmc1(Bth/+) mice substantially reduced progressive hearing loss.

2 t degenerated as hearing matured, leading to progressive hearing loss.

3 esponse, two had stable hearing, and one had progressive hearing loss.

4 about the genetic basis for its early onset, progressive hearing loss.

5 n an Iranian pedigree that is afflicted with progressive hearing loss.

6 causes outer hair cell defects, and leads to progressive hearing loss.

7 up of patients with pretreatment intractable progressive hearing loss.

8 e mutations in DSPP are also associated with progressive hearing loss.

9 dent elevated thresholds characteristic of a progressive hearing loss.

10 asement membrane and usually associated with progressive hearing loss.

11 ototoxic drugs or aging diseases, leading to progressive hearing loss.

12 nately found in outer hair cells, leads to a progressive hearing loss after 1 month, suggesting that

13 However, the progressive hearing loss and morphological defects of ha

14 s mellitus and optic atrophy and may include progressive hearing loss and other neurological symptoms

15 use low-frequency nonsyndromic hearing loss, progressive hearing loss, and isolated optic atrophy ass

16 P2RX2-null mice developed severe progressive hearing loss, and their early exposure to co

17 zygous Gfi1(Cre) mice exhibit an early onset progressive hearing loss as compared with their wild-typ

18 Csb(m/m) and Csa(-/-) mice manifested progressive hearing loss, as measured by an increase in

19 Progressive hearing loss associated with aging may resul

20 The KO-TgAC1 mice displayed delayed onset progressive hearing loss associated with deterioration o

21 Affected individuals experience progressive hearing loss beginning in the 2d-4th decades

22 The progressive hearing loss correlated with the accumulatio

23 Q4, which, when mutated, causes the dominant progressive hearing loss DFNA2.

24 man K(+) channel hKv7.4 lead to post-lingual progressive hearing loss (DFNA2), which affects world-wi

25 elayed onset autosomal dominant nonsyndromic progressive hearing loss, DFNA20/26.

26 missense allele linked to autosomal dominant progressive hearing loss (DFNA22), provide an allelic sp

27 profound congenital deafness (DFNB7/B11) and progressive hearing loss (DFNA36), respectively, caused

28 Dominantly inherited progressive hearing loss DFNA38 is caused by heterozygos

29 er, they suffer increased mortality and show progressive hearing loss during adulthood despite compen

30 DBA/2J (DBA) mice exhibit progressive hearing loss, evident for high frequencies (

31 ns between these mutations and the causes of progressive hearing loss have been elusive.

32 es of mutant genes responsible for inherited progressive hearing loss have suggested possible mechani

33 fully penetrant, nonsyndromic sensorineural progressive hearing loss in a large Costa Rican kindred

34 NA20, a gene causing dominant, nonsyndromic, progressive hearing loss in a three-generation Midwester

35 Using a mutant mouse model (Beethoven) for progressive hearing loss in humans (DFNA36), which harbo

36 Recently, dominant-progressive hearing loss in humans and mice was linked t

37 a missense change in LOXHD1, a gene causing progressive hearing loss in humans, as the sole variant

38 Here we show that progressive hearing loss in the ethylnitrosourea-generat

39 ied a mutation in the Usp53 gene that causes progressive hearing loss in the mambo mouse line.

40 age of 30 years (range, 14 to 79 years) and progressive hearing loss in the target ear (median basel

41 e in DFNA2, an autosomal dominant version of progressive hearing loss, involves degeneration of hair

42 In an extended Israeli family, nonsyndromic progressive hearing loss is caused by three different re

43 Progressive hearing loss is common in the human populati

44 Progressive hearing loss is very common in the populatio

45 a, which has been implicated in nonsyndromic progressive hearing loss, is localized at stereocilia ti

46 As is seen in humans, the mice had progressive hearing loss leading to profound deafness.

47 Late-onset and progressive hearing losses occur following congenital CM

48 , which has been identified in a pre-lingual progressive hearing loss patient in Taiwan, yielded cell

49 se that these events conspire to produce the progressive hearing loss phenotype in Tg-mtTFB1 mice.

50 ps8L2 null-mutant mice exhibit a late-onset, progressive hearing loss that is directly linked to a gr

51 haracterized typically by bilateral, rapidly progressive hearing loss that responds therapeutically t

52 ltransferase TFB1M (Tg-mtTFB1 mice) exhibits progressive hearing loss that we proposed models aspects

53 nse mutation (G321S) that has been linked to progressive hearing loss to further examine the inhibito

54 af, stdf ) leading to recessive, early-onset progressive hearing loss was detected and exome sequenci

55 Gene mutations that cause nonsyndromic progressive hearing loss with early onset may provide in

56 All participants showed progressive hearing loss within 3 months prior to the st