ライフサイエンスコーパス: progressively

1 deposition of fibrillar collagens) increased progressively.

2 que and a longitudinal protocol applied on a progressively 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridi

3 Parkinson's disease (PD) patients progressively accumulate intracytoplasmic inclusions for

4 mance in an APP/PS1 mouse model of AD, which progressively accumulates amyloid-beta.

5 The impact of obesity on HSC function is progressively acquired but persists after weight loss or

6 tion stages of an immune response identified progressively acquired heritable de novo methylation pro

7 North America in the early 20th century and progressively acquired the USA300 characteristics Panton

8 tose-1,6-bisphosphate (FBP), with AMPK being progressively activated as extracellular glucose and int

9 presence of inorganic phosphate, it will be progressively activated by the inorganic phosphate itsel

10 d provides new insight into how Hh morphogen progressively activates Smo.

11 CMR-measured infarct size declined progressively after reperfusion in all groups.

12 itrating gamma2 or delta subunit cDNA levels progressively altered GABA-evoked currents, revealing mo

13 ge in a critical phosphorylation site, S318, progressively amplifies OPS activity.

14 ortality, and 1 month readmissions decreased progressively and consistently during the study period.

15 Replication timing was thereafter progressively and continuously remodeled across the majo

16 ytes paced at cycle lengths (CLs) decreasing progressively and incorporating stochastic variations.

17 at the levels and activity of DUX4 increased progressively and were associated with its enhanced recr

18 n size, while concentration of EVs decreased progressively as follicle size increased.

19 proteins, the narrower scope having evolved progressively as lycophytes, ferns and flowering plants

20 C statistics for DSVE decreased progressively as RFs accumulated (0.776 for </=1 RF, 0.7

21 st of a hydrophobic rigid core surrounded by progressively assembling amphiphilic and polar molecules

22 Each outcome measure improved progressively at 1, 3, 6, and 12 months after surgery, b

23 alpha-Tocopherol levels increased progressively at increasing altitudes, which paralleled

24 rm normally in the cus2 mutant, but are lost progressively at later stages of sepal development, indi

25 ich naive IL-7Ralpha(+) CD57(-) PD1(-) cells progressively became the predominant subset.

26 implications on, amongst others, how tumors progressively become more genetically unstable due to in

27 creases in prevalence and atrial arrhythmias progressively become permanent as the population ages.

28 Microglia, the macrophages of the brain, are progressively becoming the main focus of the research in

29 olves complex allosteric mechanisms that are progressively being revealed in atomistic detail.

30 al distribution of the tribe as forests were progressively broken up by the mid-continent aridificati

31 e magnetoresistance at B = 0.3 T is shown to progressively change from positive to negative with incr

32 granulomas, demonstrating the HIV infection progressively changes these granulomas.

33 le of DCs and will discuss how their use has progressively clarified our understanding of the unique

34 ational unit of the brain and it is becoming progressively clearer that network dysfunction is at the

35 During kidney development, progressively committed progenitor cells give rise to th

36 onstrated that the fibrin network of thrombi progressively compacts over a 2-hour period.

37 t the dendritic stalk, labeling that becomes progressively conspicuous by P10, as it is in maturity.

38 he precise changes that occur as fibroblasts progressively convert to the target cell fates remain un

39 inside the female, geranylgeranyl acetate is progressively converted to geranylgeraniol then external

40 we demonstrate non-enzymatic chemistry that progressively converts 2',5'-linkages into 3',5'-linkage

41 have shown that the central auditory system progressively converts temporal representations of time-

42 The surfaces progressively crystallized to predominantly (but not exc

43 cone photoreceptors in the outer retina and, progressively, death of cells in the inner retina.

44 c mutations in vinculin suffer from chronic, progressively debilitating DCM that ultimately leads to

45 ndance (displaying high postdusk levels that progressively decline during the long night), our data s

46 Visual acuity progressively declined from stage 1 through stage 4 (P <

47 ned on a high sodium balance, renin activity progressively declined with older age, whereas serum and

48 g representations of the two odorants became progressively decorrelated, enhancing the robustness.

49 found that the expression of proteasomes was progressively decreased during aging.

50 -1beta, and IL-6) rapidly increased and then progressively decreased during the 30-day period post-CL

51 The HRs showed progressively decreased rates of mortality in women with

52 obally sclerotic glomeruli per kidney, which progressively decreased to 520,410 nonsclerotic glomerul

53 utcomes; whereas anti-inflammatory cytokines progressively decreased with lower JAK2 expression, proi

54 skeletal muscle, we have found that PGC1beta progressively decreases skeletal muscle mass predominant

55 treatment and after its cessation, with risk progressively decreasing as tamoxifen therapy duration i

56 treatment and after its cessation, with risk progressively decreasing as tamoxifen therapy duration i

57 xonemes gradually shorten and outer segments progressively degenerate.

58 verall, the proportion of aneuploid cells is progressively depleted from the blastocyst stage onwards

59 Here, we show that substrate shortening progressively destabilizes the consecutive enzyme-substr

60 rdless of posture, whole-body representation progressively deteriorates proportionally to SCI complet

61 Starting from the highest ranked gene, we progressively determine the minimum length of the gene s

62 stiffness and storage modulus increased with progressively developed fibrosis and portal hypertension

63 y reversible by PD-1 ligand blockade, but it progressively developed into an irreversible state.

64 Thus, TFH cells in the B cell follicle progressively differentiate through stages of localizati

65 , molecular, and solid-state physics and are progressively directing their footsteps toward problems

66 ST progressively disabled a host mechanism of protection by

67 During flood events, AREE anomalies progressively disappeared and gave way to the geogenic c

68 The gliadins structure appeared to be progressively disorganized with the temperature increase

69 This robust self-organizing system is progressively disrupted during tumor development.

70 feeding groups found that methylation levels progressively diverged with age, with pointwise differen

71 tion, the antigen-specific TCR repertoire is progressively diversified by staggered clonotypic expans

72 pression of the phagocytic receptor Bai1 was progressively downmodulated.

73 S1PR1 was progressively downregulated during T cell differentiatio

74 by CD4(+)CD8(+) pre-selection thymocytes is progressively downregulated following both MHC and CD1d-

75 generally considered to have evolved towards progressively drier conditions over the past few million

76 within a mucilaginous matrix, both of which progressively dry before sporophyte dehiscence.

77 mouse model system, Nestin levels increased progressively during medulloblastoma formation, resultin

78 omerular mesangial cells, which deteriorated progressively during postnatal development.

79 Channel relief and flow confinement increase progressively during subsequent flows.

80 cells, we found that KCNK3 current decreased progressively during the development of monocrotaline-in

81 on and pulmonary arterial pressure both rise progressively during the first few hours of human acclim

82 DNT in ENCHANTED declined progressively during the trial, especially in China.

83 ioalveolar lavage fluid adenosine levels are progressively elevated in association with pulmonary fib

84 Over the past decade, foldamers have progressively emerged as useful architectures to mimic s

85 ed in the STN and PFC, and this decrease was progressively enhanced as more items were stored into wo

86 ut AChRs assemble into ectopic clusters that progressively enlarge during development.

87 nriched in NMIIA, but over time, they become progressively enriched with NMIIB because of faster NMII

88 The DHS landscape is progressively established with a drastic increase at the

89 ojects triggered an activist opposition that progressively expanded and became influential at both th

90 slow structural relaxation, where the system progressively explores lower free-energy minima which ar

91 at the periphery of the pulmonary lobule and progressively extend toward the core of this anatomic lu

92 ion of cellular growth and proliferation, is progressively extinguished as SCs differentiate during n

93 ntration, we observe a range of motifs, that progressively favor tile-tile packing over duplex-end pi

94 ions underlie phonemic perceptual narrowing, progressively favoring mapping of native over non-native

95 examined, it controls the differentiation of progressively fewer enteroendocrine cell populations whe

96 ysregulated, the wound can become chronic or progressively fibrotic, with both outcomes impairing tis

97 s following hospitalization for MI increased progressively from 2011 through 2014.

98 on with mepolizumab versus placebo increased progressively from 52%; 0.48, 0.39-0.58) in patients wit

99 emporal cortices, these dimensions fall away progressively from posterior to anterior temporal cortic

100 lian orogen thus has been rising and growing progressively from the boundaries to the center, squeeze

101 nal constraints on the conformational space, progressively funneling the molecule to the native state

102 time, thermogenic-competent beige adipocytes progressively gain a white adipocyte morphology.

103 ransfer operating over small distances which progressively gives way to hopping transport over larger

104 ctin filaments and myosin motors, generating progressively greater contraction forces that resist fur

105 Tumors showed progressively greater DOX extent (sham, 0%; 0 mg, 0%; 12

106 at reductions in gap junction coupling allow progressively greater glucose-stimulated [Ca2+] and insu

107 range of pre- and stage 1 hypertension, with progressively greater reductions at higher levels of bas

108 casses, as well as demand for lean meat from progressively health conscious consumers, are considered

109 Clusters D and E exhibited progressively higher asthma and rhinitis symptoms and al

110 monotherapy is ineffective and selects for a progressively higher BRAF copy number.

111 ng RAES ratings and milestone ratings showed progressively higher correlations across training years,

112 Recent theories suggest that progressively higher level rules are encoded along an an

113 cident cardiovascular disease increases with progressively higher levels of glucose, low-density lipo

114 in herbal infusions' consumption, there's a progressively higher need of suitable plant material, as

115 e a search model against a series of maps of progressively higher resolutions, which ends with the or

116 Hypertension was linearly associated with progressively higher sodium and lower potassium excretio

117 Advancing age progressively impacts on risk and severity of chronic di

118 idence: (i) water flow through xylem that is progressively impaired as xylem water potential drops an

119 uiescence by hematopoietic stem cells (HSCs) progressively impairs their homeostasis in the bone marr

120 Male, but not female rats, progressively improved their advantageous option respond

121 phosphonates (3.6% at <2 years) and declined progressively in both women and men without these treatm

122 Intermediates are long lived and accumulate progressively, in contrast with conventional metabolic p

123 ood discharge is predicted as the canyon was progressively incised, which is at odds with the dischar

124 d sequential analyses in three prespecified, progressively inclusive cohorts: patients with an elevat

125 ls of piliation and TFP activity, which both progressively increase as the cells sense the presence o

126 c-Fos- and Arc/Arg3.1-immunoreactive neurons progressively increase in neighboring visual cortical ar

127 These aberrations progressively increase over time and may compromise the

128 We found that integrated HIV DNA levels progressively increase over time in the absence of ART,

129 ure gradually open up the structure to allow progressively increased access to the ribosome binding s

130 non-lesional, normal-appearing white matter progressively increased after clinical presentation, sug

131 without any of these factors, their addition progressively increased AT burden.

132 onological age at baseline (+3.36 years) and progressively increased during follow-up (+1.24 years in

133 t, amplitude and dV/dtmax of field potential progressively increased during the course of maturation.

134 as particularly evident in long bone shafts, progressively increased from Binet stage A to Binet stag

135 lic (SBP), diastolic (DBP) and mean (MAP) BP progressively increased from KOP, to KOM, and peaked amo

136 reater in smokers than in nonsmokers, and it progressively increased from mild to severe chronic obst

137 predominated in thymus, while stage 3 cells progressively increased in abundance extrathymically.

138 The pathologic disulfide HMGB1 isoform progressively increased in blood before epilepsy onset a

139 exocytotic events in secretory animal cells progressively increased in frequency, reaching steady st

140 The percentage of Treg1 cells progressively increased in kidneys of nephritic wild-typ

141 Conversely, endothelial-derived vasodilators progressively increased over 18 months and then abruptly

142 hts a temporal trend of incidence of NC that progressively increased over time and confirms a strong

143 easing frequency of RVP is associated with a progressively increased risk of appropriate ICD shocks u

144 deletion of individual glutamates in GC-A-8E progressively increased the Km Double Ala substitutions

145 The Maillard conjugation progressively increased the radical-scavenging activity

146 Total energy intake progressively increased to reach 1240 +/- 87 kcal/d at 1

147 , A2G2S[3,6]2, 12 hours after surgery, which progressively increased until 48 postoperative hours.

148 tively), ET (13 or 15 kidneys, respectively) progressively increased urine cAMP levels, water and sod

149 the degree of local neural synchronization, progressively increased with burst duration.

150 Extravascular hemolysis after transfusion progressively increased with increasing storage time (P

151 of band removal and revisional surgeries has progressively increased.

152 demonstrate that the translocation velocity progressively increases as the DNA exits from confinemen

153 4 inhibits MG extension but the cleaved form progressively increases during MG development with a con

154 The number of PNNs progressively increases during postnatal development unt

155 enous nicotine-associated cues in adult rats progressively increases or incubates after withdrawal.

156 eplenishment rate of the ParA-depletion zone progressively increases relative to the cargo speed, evo

157 rly visual information processing stages and progressively increases throughout the visual cortical h

158 Epigenetic drift progressively increases variation in DNA modification pr

159 PDI oxidation progressively increases with age.

160 tic history, and functional interaction with progressively increasing accuracy.

161 rse or nonexistent in areas 32 and 32V, with progressively increasing connections observed in more ca

162 regulatory evolution in cancer cells with a progressively increasing mutation burden.

163 irety of the follow-up duration, there was a progressively increasing number of mesh-related complica

164 of a 9 year-old male child with a history of progressively increasing swelling over the right eyebrow

165 roportion to burst duration, consistent with progressively increasing synchronization.

166 During serial passage at progressively increasing temperature, a CPD RSV containi

167 Here, we use genome editing to progressively introduce and accumulate diverse mutations

168 e, step-wise peptide Phe-to-Ala changes were progressively introduced and shown to raise the Kd from

169 with a loss of epithelial characteristics in progressively invasive cancer.

170 n is not required for Syk recruitment but is progressively involved in the recruitment of LAT and PLC

171 red with increasing storage duration and was progressively irreversible.

172 ity of a cancer therapeutic by administering progressively larger molecules until cutoff is observed

173 s genome-scale sequencing data accumulate in progressively larger sample sizes, our method will enabl

174 assembled punctate elements that cluster in progressively larger spherical structures and associates

175 repaired endogenous DNA lesions intensifies, progressively leading to genomic instability.

176 tion of interlobular biliary ductules, which progressively leads to cholestasis, hepatic fibrosis, ci

177 how that the mechanism of expansion involves progressively lengthening periods between cell divisions

178 ss sampled a dissolved Cu reservoir that was progressively less fractionated relative to the continen

179 , however, environmental variation explained progressively less GEP variability: At monthly timescale

180 iation, we conclude that ice streams exerted progressively less influence on ice sheet mass balance d

181 h of initiation of colonization; pups become progressively less susceptible to infection over the P2-

182 the germline-targeting prime is followed by progressively less-mutated design intermediates and, las

183 l, besides increasing fungal competition for progressively limited resources.

184 We further find that Ska is progressively loaded onto bioriented kinetochore pairs a

185 e in nystagmus as the set point changes over progressively longer time courses.

186 However, thousands of loci in euchromatin progressively lose DNA methylation between generations a

187 yonal and undifferentiated small cells (SCU) progressively lose EGFR and ASAP1 expression.

188 yer where, on terminal differentiation, they progressively lose organelles and convert into anucleate

189 whereas those processing higher frequencies progressively lose precision by integration of multiple

190 s HSCs accumulate a divisional history, they progressively lose regenerative potential.

191 ly early in the third larval instar (L3) but progressively lose this ability.

192 lonal complexity of adult stem cell pools is progressively lost during homeostatic turnover in severa

193 mbrane affinity, but phosphorylated K-Ras is progressively lost from the plasma membrane via endocyti

194 s present in the normal mammary gland and is progressively lost in patients with metastatic BC.

195 tudy, we demonstrate that IL-9 production is progressively lost in Th9 cultures during several rounds

196 candidates at status 1A more frequently with progressively lower doses.

197 We aimed to explore the relationship between progressively lower LDL-cholesterol concentrations achie

198 Progressively lower levels of long-chain lysophosphatidy

199 e skeleton in primitive erythroblasts, which progressively mature while circulating in the embryonic

200 cognitive performance is not inherited, but progressively matures in relationship with the establish

201 We show that the miRISC progressively matures on the target mRNA from a scanning

202 uild upon the successor representation while progressively mitigating its limitations.

203 nically achievable concentrations (1 microM) progressively mobilized cellular iron from hepatocyte, c

204 When UV was applied at progressively more depolarized preopen holding potential

205 sis and resulted in concomitant formation of progressively more differentiated hepatocytes and bile d

206 ytic inflammation in affected tissues became progressively more fibrinous and necrotizing over time.

207 olecule chemical probes or tools have become progressively more important in recent years as valuable

208 The direct effect of AUD becomes progressively more important later in life and with long

209 revealed that in early auditory regions, and progressively more in surrounding regions, temporal modu

210 progression analysis also are incorporating progressively more information and will be improved as d

211 tered, modified immunogens (designed to bind progressively more mature bnAb precursors) to initiate a

212 er, in human breast cancer cells that become progressively more metastatic, CPEB1 is reduced while MM

213 tuned hair cells ( approximately <2 kHz) to progressively more microdomain in high-frequency cells (

214 lowered stepwise from 280 mg/dL to 80 mg/dL, progressively more MK-2640 was cleared via MR, reducing

215 ine neutrophils, but not monocytes, generate progressively more MPs with high interleukin (IL)-1beta

216 or cardiovascular disease (CVD), is becoming progressively more prevalent in our societies.

217 mal tubule recovery but persisted and became progressively more severe in tubule cells that failed to

218 haracterize therapeutic response have become progressively more varied and complex.

219 itively correlated with the concentration of progressively motile sperm.

220 The patient became progressively obtunded and underwent emergency surgical

221 Ant colonies progressively optimize pathway to food discovered by one

222 N2-fixing symbionts progressively outcompete isogenic non-fixers within root

223 Growing season length increased progressively over the observation period, and this shif

224 an CRT-associated hospital charges increased progressively over the years.

225 ye involvement requiring treatment increases progressively over time, a same-day bilateral injection

226 m visit to visit, all areas and BCVA changed progressively (P < .001).

227 stnatal mice, we discover that Gli1(+) cells progressively produce osteoblasts in all skeletal sites.

228 ation (scES) and activity-based training can progressively promote the recovery of volitional leg mov

229 ence of increasing greenhouse gas emissions, progressively raises the modal temperature threshold of

230 covery of more common ncRNA classes, whereas progressively rarer classes are correspondingly more dif

231 ly strongly reduced at high irradiances, but progressively recovers to allow responses to moderate co

232 Motor neurons were progressively recruited for the full range of submaximal

233 KRT16 mRNA expression were significantly and progressively reduced after days 1 and 3 of tofacitinib

234 ng technology, the potential yields could be progressively reduced due to warmer and drier climates.

235 LSM for the diagnosis of F3-F4 fibrosis was progressively reduced from lower to middle and further t

236 the context of chronic infection results in progressively reduced responsiveness of T cells to patho

237 This progressively reduced the flux of intermediates through

238 hat varied with the pathway investigated and progressively reduced the maximal pilocarpine response.

239 increased, the strong luminescent signal is progressively reduced.

240 to analyse nanopore sequencing reads, which progressively refines candidate alignments to robustly h

241 This also results in progressively reinforced autoinhibition and decreased DN

242 nal feedback: The phenotype of the parent is progressively reinforced in the distribution of phenotyp

243 us early in the maturation process, which is progressively removed as maturation proceeds.

244 ry segment (AIS), located within the CBD, is progressively removed by Ca(2+) and Ca(2+)/CaM, whereas

245 -thermally activated domain wall dynamics is progressively replaced by an intense thermally activated

246 s) drive elongation by generating a scaffold progressively replaced by bone.

247 functions lost due to W69 mutations could be progressively restored with amino acids of increasing al

248 lf-renewing features established early while progressively restricting lineages as they experience dy

249 in both axial and transversal directions is progressively retarded, suggesting a scale-dependent, hi

250 es collected from a Flint residence revealed progressively rising water lead levels (104, 397, and 70

251 erogroup A conjugate vaccine (MACV) has been progressively rolled out since 2010.

252 Progressively separated pObs pools then continue regener

253 s, on the day of birth, to nuclei of neurons progressively settling in layers V to II.

254 n 3 and 15 years of age (median = 9.5), with progressively severe myoclonus and rare tonic-clonic sei

255 Substrate-walking progressively shifted the target acceptor substrate from

256 proliferation of T cells and that telomeres progressively shorten in a heterogeneous population of T

257 d with increased cell divisions as telomeres progressively shorten.

258 lavage, the APRV group was ventilated with a progressively shorter time at low pressure, which increa

259 bers conduct successive action potentials at progressively slower speeds, but the impact of this acti

260 The rainbow trapping is related to the progressively slowing group velocity, and the extremely

261 ver approximately 10 d, the responses became progressively smaller in size, consistent with gating-ou

262 ir overall number decreased, they occupied a progressively smaller percentage of the ice sheet perime

263 archical addition of ribosomal proteins that progressively stabilize the folded 16S rRNA.

264 beta cell mass increased progressively starting at 4 weeks, principally through n

265 rneuron circuits are thus neither static nor progressively strengthened but follow a layer-specific c

266 nctional and medial myosin II that result in progressively stronger cortical contractions during ingr

267 of southern coastal British Columbia become progressively suitable with short-term and long-term pro

268 e separated from platelets within the PRP by progressively syphoning clarified PRP away from the conc

269 .05 compared with at baseline) and increased progressively thereafter to reach 57 +/- 3 g/d at 36 mo

270 urons are decreased and that cerebral cortex progressively thins in Aspa(Nur7/Nur7) mice.

271 emission limits in leading markets have been progressively tightened, but current diesel vehicles emi

272 of HIV in kidney epithelial cells will lead progressively to end-stage renal disease.

273 Mean anti-HBs declined progressively to month 6, plateauing at a protective tit

274 ly store memories in fast variables and then progressively transfer them to slower variables.

275 ions in the ATP-binding site of PI3Kalpha to progressively transform the pocket to mimic that of ATR.

276 ally by 1 surgeon with 3 additional surgeons progressively transitioning from open to robotic during

277 We found thatFaah(-/-)decidual cells progressively underwent premature senescence as marked b

278 a suggest that potential future outcomes are progressively unraveled during multistep decision making

279 oelii plasmei2(-) liver stage size increased progressively until late in development, similar to wild

280 uniform shape equilibria, in which filaments progressively unwind from their native twist with increa

281 OTCH3 is differentially overexpressed; it is progressively up-regulated with disease development and

282 voked responses from the auditory nerve grew progressively weaker following denervation, sound-evoked

283 This observation implies a progressively weaker functionality of LRCs as their leng

284 microscopy confirms that GO nanosheets align progressively well with increasing magnetic field streng

285 Cardiac iron levels increased progressively with age, which was exacerbated in Hfe-def

286 n addition, circulating BMP-9 levels reduced progressively with an increasing number of MetS componen

287 LTS bursts, somatic AP half-width increases progressively with increasing spike number, allowing lat

288 In addition, the elastic modulus increased progressively with indentation.

289 duration of these stable interactions ceased progressively with lowering peptide major histocompatibi

290 The value of n decreases progressively with shortening and, during V0 shortening

291 males per plant and their fecundity declined progressively with temperatures above 17.5 degrees C for

292 the maximum isometric force T0 , n decreases progressively with the increase of shortening (range 30-

293 most atoms at the guest end groups increases progressively with the molecular size, the beta-nitrogen

294 significantly across diagnosis and age, with progressively worse performance across degrees of impair

295 (N = 132) without psychiatric morbidity had progressively worse performance on the Stroop color-word

296 hylation losses and abnormal phenotypes that progressively worsen over generations.

297 female was referred because of diplopia and progressively worsening headaches.

298 lly modified mice, we discovered a series of progressively worsening phenotypes that could not be eas

299 matter volume was evident in schizophrenia, progressively worsening with age to a maximal loss of 8%

300 emergence of a deficit in white matter that progressively worsens with age at a constant rate.