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1 ren who received IPT than those who received proguanil.
2 f patients took <75% of their daily doses of proguanil.
3 nct from the activity of its parent compound proguanil.
4 eventing malaria than daily prophylaxis with proguanil.
5 , six participants received daily atovaquone-proguanil 1 day before CHMI (cohort 1B), and six partici
6 amodiaquine (2.9%) and artesunate-atovaquone-proguanil (1.0%) groups.
7 lligrams of atovaquone and 400 milligrams of proguanil (1000/400 milligrams) on day -7.
8 n additional group received daily atovaquone-proguanil (250-100 mg) for 9 days, starting 1 day before
9 lligrams of atovaquone and 100 milligrams of proguanil (250/100 milligrams) 1 day prior to infectious
10 lligrams of atovaquone and 200 milligrams of proguanil (500/200 milligrams) on day -7 or, (5) 1000 mi
11 s, as indicated by their hypersensitivity to proguanil, a drug that collapsed the membrane potential
12  To investigate suggestions that WR99210 and proguanil act against a target other than the reductase
13 re prodrugs analogous to the relationship of proguanil and its active metabolite cycloguanil.
14 n only (95 AL, 162 mefloquine, 36 atovaquone-proguanil [AP], and 17 others), and 87 were administered
15 w alternative non-ACTs, including atovaquone-proguanil, are currently available.
16 a-blocker propranolol, the antimalarial drug proguanil, certain antidepressants and barbiturates, and
17 before CHMI and six of six in the atovaquone-proguanil cohort were protected, whereas placebo recipie
18 nt to the synergistic effects of atovaquone/ proguanil combination.
19 were also found for atovaquone, chloroquine, proguanil, cycloguanil and methylene blue.
20  anti-malarial drug used in combination with proguanil (e.g. Malarone(TM)) for the curative and proph
21 iaquine (SPAQ) was more effective than daily proguanil for malaria prevention in subjects with SCD.
22 r Papua New Guinea, in which case atovaquone-proguanil is best, with mefloquine or quinine plus tetra
23                                The target of proguanil itself is separate from DHFR.
24 e randomized to receive daily treatment with proguanil or IPT with either MQAS or SPAQ once every 2 m
25  resistance, a combination of atovaquone and proguanil or quinine plus tetracycline or doxycycline or
26 signed to artesunate-amodiaquine, atovaquone-proguanil, or artesunate-atovaquone-proguanil treatment
27             Allocation to DSM265, atovaquone-proguanil, or placebo was randomised by an interactive w
28                       Single-dose atovaquone-proguanil provides effective malaria chemoprophylaxis ag
29 terest in the antimalarial drugs WR99210 and proguanil, the cycloguanil precursor.
30  after artesunate-amodiaquine and atovaquone-proguanil therapies, respectively.
31 f susceptibility of transformed parasites to proguanil, thus providing evidence of intrinsic activity
32 rial to establish the efficacy of atovaquone-proguanil to prevent malaria with the goal of simulating
33        However, the proportion of atovaquone-proguanil-treated patients with positive smears on day 3
34 ovaquone-proguanil, or artesunate-atovaquone-proguanil treatment groups and followed for 28 days, acc
35                        Artesunate-atovaquone-proguanil was a highly effective alternative treatment.
36                                   Atovaquone-proguanil was characterized by a slow blood schizontocid
37                        Artesunate-atovaquone-proguanil was not associated with any failure.
38                                   Atovaquone/proguanil was the most commonly prescribed antimalarial
39 fficacy against malaria, compared with daily proguanil, was 61% (95% confidence interval, 3%-84%) for

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