ライフサイエンスコーパス: prohibitin

1 binding sites in the 1-kb promoter region of prohibitin.

2 repression of E2F-mediated transcription by prohibitin.

3 ndent on the concerted activity of BASP1 and prohibitin.

4 ns and a potential tumor suppressor protein, prohibitin.

5 y transfects mature adipocytes by binding to prohibitin.

6 by knockdown of the mitochondrial chaperone, prohibitin.

7 ction between Syk and the chaperone protein, prohibitin.

8 ination with BAF155, BAF170, HDAC1, p300 and prohibitin.

9 Expression of prohibitin 1 (PHB), a multifunctional protein in the cel

10 Prohibitin 1 (PHB), a protein implicated in the regulati

11 ified an interaction with two host proteins, prohibitin 1 (PHB1) and PHB2.

12 Prohibitin 1 (PHB1) is a highly conserved protein that i

13 Prohibitin 1 (PHB1) is a highly conserved, ubiquitously

14 Prohibitin-1 (PHB1) is an evolutionarily conserved pleio

15 ) database, show high similarity to those of prohibitin-1 and prohibitin-2 proteins, respectively, re

16 ers of small gene families with at least two prohibitin-1 homologs and four prohibitin-2 homologs.

17 When we downregulated expression of prohibitin-1 using a Tobacco rattle virus-based (TRV), v

18 e mutant, phb-2(ad2154), a point mutation in prohibitin 2 (E130K) protects worms from drug-induced in

19 binds with high affinity and specificity to prohibitin 2 (PHB2), a highly conserved protein that reg

20 fy the inner mitochondrial membrane protein, prohibitin 2 (PHB2), as a crucial mitophagy receptor inv

21 sing cells exhibited increased expression of prohibitin 2 (Phb2), involved in the regulation of mitoc

22 Thus, prohibitin 2 is implicated in a previously uncharacteriz

23 icate that direct binding of hemiasterlin to prohibitin 2 is unlikely.

24 otic mitophagy and demonstrate a function of prohibitin 2 that may underlie its roles in physiology,

25 b-2, which encodes the mitochondrial protein prohibitin 2.

26 requires the prohibitin ring complex subunit prohibitin-2 (PHB2) at the mitochondrial inner membrane.

27 Here, we report that prohibitin-2 (PHB2), a single-span membrane protein, is

28 at least two prohibitin-1 homologs and four prohibitin-2 homologs.

29 Glial-specific deletion of Prohibitin-2 in mice impairs axo-glial interactions and

30 high similarity to those of prohibitin-1 and prohibitin-2 proteins, respectively, reported from yeast

31 Two allelic forms (C versus T) of the prohibitin 3'UTR exist, and carriers of the less common

32 xamined the tumor suppressor activity of the prohibitin 3'UTR in human breast cancer cells.

33 Thus, the C allele of prohibitin 3'UTR produces a functional RNA, whereas a si

34 t senescence is PHB1, the yeast homologue of prohibitin [3], a rodent gene initially identified as a

35 The identification of prohibitin, a "scaffold protein", as a propigmentation e

36 w that the CKGGRAKDC peptide associates with prohibitin, a multifunctional membrane protein, and esta

37 We recently observed that prohibitin, a potential tumor suppressor protein, binds

38 Prohibitin, a potential tumor suppressor protein, has be

39 Prohibitin, a potential tumor suppressor, is known to in

40 Prohibitin, a protein with cell-cycle regulatory activit

41 , we show that the nuclear-encoded mammalian prohibitin and BAP37 proteins are present in mitochondri

42 We demonstrate that prohibitin and BASP1 cooperate to recruit the chromatin

43 ough interruption of the association between prohibitin and Brg-1/Brm without affecting the prohibiti

44 of several genes, including up-regulation of prohibitin and elevated sensitivity to a relatively nonc

45 chromatography revealed unexpected roles for prohibitin and mitochondrial F1F0-adenotriphosphatase in

46 tress response within retinal cells, such as prohibitin and MMP2, may serve as novel biomarkers and t

47 oisomerase 1 inhibitor, led to the export of prohibitin and p53 from the nucleus to the mitochondria.

48 the identification of pyruvate carboxylase, prohibitin, and a subunit of ATP synthase in the prepara

49 ectrometry, we identified 3 proteins (VDAC1, prohibitin, and mitofilin) relevant to AD that interact

50 We show that an E2F repressor, prohibitin, and the chromatin modifiers Brg1/Brm are req

51 ribosome biogenesis genes, (2) mitochondrial prohibitins, and (3) chromatin regulators.

52 and specific distribution in normal tissue (prohibitin/annexin A2 in white adipose tissue) or cancer

53 Prohibitin appears to induce p53-mediated transcription

54 ATAD3 and prohibitin are tightly associated with the mitochondrial

55 Prohibitins are highly conserved proteins mainly implica

56 PID (proliferation, ion, and death) because prohibitins are involved in proliferation and cell cycle

57 tifunctional membrane protein, and establish prohibitin as a vascular marker of adipose tissue.

58 analysis in breast cancer cells, identifying prohibitin as a vitamin D target gene.

59 These observations, collectively, establish prohibitin as an endogenous neuroprotective protein invo

60 Although prohibitin associates with, and recruits, Brg-1 and Brm

61 Knockout of two Arabidopsis type-II prohibitins (AtPHB2 and AtPHB6) results in a decreased a

62 recruits, Brg-1 and Brm independently of Rb, prohibitin/Brg-1/Brm-mediated transcriptional repression

63 ogen antagonists, and thereby also implicate prohibitin/Brg1/Brm as potentially important targets for

64 ollectively, these findings suggest that the prohibitin/Brg1/Brm node is a major cellular target for

65 ling pathway in Ramos cells could inactivate prohibitin, but this had no effect on Rb function.

66 The depletion of prohibitin by small interfering RNA or antisense techniq

67 As seen with BASP1, prohibitin can associate with phospholipids.

68 d box region of E2F for repression; further, prohibitin can effectively inhibit colony formation indu

69 The potential tumor suppressor protein prohibitin can prevent cell proliferation and this requi

70 Southern blot analysis confirmed that the prohibitin cDNA clone was of P. carinii origin.

71 ased by S. Typhi interacts with the membrane prohibitin complex and inhibits IL-2 secretion from T ce

72 anscriptional regulation and uncover a BASP1-prohibitin complex that plays an essential role in the P

73 activity and cotransfection of an antisense prohibitin construct reduces p53-mediated transcriptiona

74 Repression by prohibitin correlates with histone deacetylation on prom

75 Prohibitin could bind to heterochromatin protein 1 (HP1)

76 Prohibitin could inhibit the activity of E2Fs 1, 2, 3, 4

77 Prohibitin could repress the transcriptional activity of

78 the recruitment of different corepressors by prohibitin, depending on the type of growth arrest.

79 r respiratory chain supercomplex assembly in prohibitin-depleted neurons.

80 n/flotillin/HflK/C domain (also known as the prohibitin domain or band 7 domain).

81 ohibitin and Brg-1/Brm without affecting the prohibitin-E2F interaction.

82 Prohibitin exerts beneficial effects on neurons by reduc

83 Prohibitin expression was detected cutaneously, with mor

84 miR-128 can downregulate prohibitin expression, and subsequently promote apoptosi

85 Two members of the prohibitin family of proteins, Phb1 and Phb2, were deter

86 and novel proteins, including members of the Prohibitin family.

87 AtHIR proteins contain the stomatin/prohibitin/flotillin/HflK/C domain (also known as the pr

88 e basis of amino acid sequence homology with prohibitin from mammalian sources.

89 suggest that the regulated translocation of prohibitin from the nucleus to the mitochondria facilita

90 ar export signal at the C-terminal region of prohibitin; fusion of the nuclear export signal (NES) of

91 of E2F1 is sufficient for being targeted by prohibitin; fusion of this region to GAL4-VP16 construct

92 ly that microinjection of RNA encoded by the prohibitin gene 3'untranslated region (3'UTR) blocks the

93 e finding that TCM62 and the analogous human prohibitin gene also inhibit mammalian cell death follow

94 total P. carinii protein indicated that the prohibitin gene is transcribed and translated in vivo.

95 In mammals, the prohibitin gene product has been shown to negatively reg

96 slices was markedly neuroprotective, whereas prohibitin gene silencing increased neuronal vulnerabili

97 The P. carinii prohibitin gene was expressed in vivo in human fibroblas

98 A cDNA clone encoding the P. carinii prohibitin gene was isolated from a P. carinii cDNA libr

99 ve amino-terminal membrane-docking domain of prohibitin had no effect on its ability to suppress cell

100 ons in the nucleus, a mitochondrial role for prohibitin has also been proposed.

101 At the same time, prohibitin has been implicated in mediating the proper f

102 The sub-cellular localization of prohibitin has been variously attributed to the mitochon

103 Though prohibitin has potent transcriptional functions in the n

104 The protective effect of prohibitin has potential translational relevance in dise

105 Sequences with high similarity to prohibitins have been identified in a number of plant sp

106 Prohibitins, highly conserved mitochondrial proteins, ha

107 Highly conserved prohibitin homologues have been identified in mammals [9

108 The prohibitin homology domain of the slit diaphragm protein

109 iple for the assembly of proteins containing prohibitin homology domains.

110 tance proteins, and proteins of the stomatin/prohibitin/hypersensitive response family, suggesting th

111 To determine the importance of prohibitin in androgen-stimulated growth, we used transi

112 direct physical interaction between VDR and prohibitin in cell lysates was not detectable.

113 Sustained expression of prohibitin in intestinal epithelial cells in vitro and i

114 lts provide the first evidence of a role for prohibitin in mitochondrial inheritance and in the regul

115 Earlier studies had proposed a role for prohibitin in modulating cellular senescence, but the un

116 Upregulation of prohibitin in neuronal cultures or hippocampal slices wa

117 ation prompted us to investigate the role of prohibitin in neuronal death and survival.

118 we evaluated the functional significance of prohibitin in relation to the cellular response to vitam

119 Targeting a proapoptotic peptide to prohibitin in the adipose vasculature caused ablation of

120 Confocal microscopy showed localization of prohibitin in the nucleus as well as the mitochondria of

121 ined suggest a potential role for P. carinii prohibitin in the regulation of P. carinii proliferation

122 gs provide new insights into the function of prohibitin in transcriptional regulation and uncover a B

123 he current study documents the expression of prohibitins in human and rodent islets and their key rol

124 ibitin (Tet-On model), the overexpression of prohibitin inhibited cell proliferation and enhanced vit

125 Prohibitin interacts with BASP1, colocalizes with BASP1

126 Prohibitin is a candidate tumor suppressor gene located

127 Prohibitin is a growth regulatory gene that has pleiotro

128 Prohibitin is a growth-suppressive protein that has mult

129 We believe that prohibitin is a novel regulator of E2F activity that res

130 We believe that prohibitin is a novel regulator of E2F function which ch

131 It therefore seems that the regulation of prohibitin is a vital part of the cellular growth respon

132 Because prohibitin is also expressed in blood vessels of human w

133 Prohibitin is an essential mitochondrial protein that ha

134 These results suggest that prohibitin is capable of modulating Rb/E2F as well as p5

135 The data presented here also show that prohibitin is capable of physically interacting with p53

136 Upon apoptotic stimulation by camptothecin, prohibitin is exported to perinuclear regions where it l

137 pic immunolabeling studies demonstrated that prohibitin is localized to neuronal mitochondria.

138 matin immunoprecipitation assays showed that prohibitin is needed for the recruitment of HP1gamma to

139 we report that the transcriptional repressor prohibitin is part of the WT1-BASP1 transcriptional repr

140 Here we show that prohibitin is predominantly nuclear in two breast cancer

141 We found that prohibitin is upregulated also in the ischemic tolerance

142 cerebellar fastigial nucleus, we found that prohibitin is upregulated in mitochondria.

143 BAP37, a protein with sequence similarity to prohibitin, is thought to be involved in lymphocyte func

144 In addition, prohibitin level had no significant effect on the vitami

145 on in cell cycle, while cells with increased prohibitin levels showed a clear reduction in the percen

146 Prohibitin, like Rb, could repress transcription from SV

147 It thus appears that prohibitin may be inhibiting apoptosis by downregulating

148 sponse to androgen stimulation in LNCaPs and prohibitin may have a nuclear regulatory role in cell-cy

149 he data with complex I activity suggest that prohibitin may stabilize the function of complex I.

150 of a negative regulator of the cell cycle (a prohibitin) may at least partially explain the delayed d

151 Prohibitin mediated transcriptional repression required

152 itin-mediated repression of E2F and relieves prohibitin-mediated growth suppression.

153 Prohibitin-mediated recruitment of HP1gamma occurred in

154 c-Raf-1, and Raf-1 could effectively reverse prohibitin-mediated repression of E2F activity.

155 of a dominant-negative Brg-1 or Brm releases prohibitin-mediated repression of E2F and relieves prohi

156 Surprisingly, prohibitin-mediated repression of E2F could not be rever

157 kinase, and cyclins D and E had no effect on prohibitin-mediated repression of E2F1, but all of these

158 coprotein, SV40 large T antigen, can reverse prohibitin-mediated suppression of E2F-mediated gene tra

159 -VP16 construct could make it susceptible to prohibitin-mediated, but not Rb-mediated repression.

160 Using mice lacking prohibitin membrane scaffolds as a model of neurodegener

161 Here we show that a subset of prohibitin molecules are present in the nucleus where it

162 A prohibitin mutant that could not bind to Rb was impaired

163 show that the camptothecin-induced export of prohibitin occurs preferentially in transformed cell lin

164 rane integrity, such as heat shock proteins, prohibitin, or nucleophosmin, as well as to the up-regul

165 in treatment, but this increase is absent in prohibitin overexpressing cells.

166 C and possible roles of AR cofactors such as prohibitin (PHB) are poorly understood.

167 ome-wide siRNA screening, we have identified prohibitin (PHB) as an essential factor in self-renewal

168 Prohibitin (PHB) has been reported to play a crucial rol

169 nsgenic mouse model, Mito-Ob, overexpressing prohibitin (PHB) in adipocytes.

170 Prohibitin (PHB) is a cell cycle regulatory protein, kno

171 Prohibitin (PHB) is a highly conserved protein that has

172 Prohibitin (PHB) is an evolutionarily conserved and ubiq

173 Our previous studies showed that prohibitin (PHB) levels are decreased during colitis and

174 ng the tumour suppressor and AR corepressor, Prohibitin (PHB).

175 ne-containing transmembrane adaptor proteins prohibitin (Phb)1 and Phb2 bind to CD86.

176 tic and proteomic interactions of Mdm33 with prohibitins, Phb1 and Phb2, which are key components of

177 Phb2p and its homolog, prohibitin (Phb1p), were localized to the mitochondrial

178 In yeast and mammals, prohibitins (PHBs) are considered as structural proteins

179 Prohibitins (PHBs) are highly conserved proteins that ar

180 Prohibitin physically interacts with all three Rb family

181 Our data indicate that prohibitins play a key role in plant development and sen

182 These studies show that prohibitin plays a vital role in inducing cellular senes

183 ery of a peptide corresponding to the NES of prohibitin prevented the export of prohibitin to cytopla

184 The ablation of prohibitin prevented the recruitment of HPIgamma, but no

185 In addition, prohibitin protected complex I activity from the inhibit

186 We now find that prohibitin protects cells from apoptosis mediated by cam

187 of a P. carinii gene encoding the P. carinii prohibitin protein.

188 ely disrupts the Rb/Raf-1 but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding.

189 We show here that prohibitin recruits Brg-1/Brm to E2F-responsive promoter

190 Our earlier studies had shown that prohibitin represses the activity of E2F transcription f

191 These growth regulatory functions of prohibitin require a physical interaction with the Rb pr

192 Here we demonstrate that prohibitin requires the marked box region of E2F for rep

193 e of mitochondrial function and requires the prohibitin ring complex subunit prohibitin-2 (PHB2) at t

194 This is the first report to suggest that prohibitin serves as a novel vitamin D target gene, whic

195 D2, LDH-A, MNT, PTMa, ODC, NM23B, nucleolin, prohibitin, SHMT1, and SHMT2] demonstrate significant se

196 sis showed that cells with reduced levels of prohibitin showed a slight but reproducible increase in

197 omycin B could inhibit the nuclear export of prohibitin showing that it was a CRM-1-dependent event d

198 Prohibitins, stomatins, and a group of plant defense res

199 CF-7 cells expressing tetracycline-inducible prohibitin (Tet-On model), the overexpression of prohibi

200 E2F-mediated gene transcription, and targets prohibitin through interruption of the association betwe

201 Prohibitin thus appears to repress E2F-mediated transcri

202 he NES of prohibitin prevented the export of prohibitin to cytoplasm and protected cells from apoptos

203 fusion of the nuclear export signal (NES) of prohibitin to green fluorescence protein led to its expo

204 Further, HP1gamma could synergize with prohibitin to repress E2F1-mediated transcriptional acti

205 A-damaging agents causes the localization of prohibitin to specific heterochromatic foci.

206 tinal epithelial cells in vitro and in vivo (prohibitin transgenic mice, PHB TG) resulted in a marked

207 Prohibitin up-regulation by 1alpha(OH)D5 treatment at bo

208 Prohibitin upregulation was associated with reduced prod

209 Knockdown of prohibitin was accompanied by increased number of cells

210 Prohibitin was also found to interact with the signaling

211 n the nuclei of MCF-7 cells and a portion of prohibitin was colocalized with VDR, but direct physical

212 Prohibitin was found to enhance p53-mediated transcripti

213 Confirming this, prohibitin was found to physically interact with CRM-1,

214 Confocal microscopic analysis showed that prohibitin was localized in the nuclei of MCF-7 cells an

215 pendent kinase activity, the inactivation of prohibitin was not.

216 p, a homolog of the tumor suppressor protein prohibitin, was identified in a genetic screen for suppr

217 ls that did not display the translocation of prohibitin were refractive to the apoptotic effects of c

218 requently identified proteins were ATAD3 and prohibitin, which have been identified previously as nuc

219 reported that a potential tumor suppressor, prohibitin, which interacts with retinoblastoma protein

220 Similar defects are found in cells lacking prohibitins, which are required for proper OPA1 processi

221 of quiescent Ramos cells inactivated Rb and prohibitin with different kinetics; further, while the s

222 nes were introduced: four closely related to prohibitins (Zm-phb1, Zm-phb2, Zm-phb3, and Zm-phb4), on