ライフサイエンスコーパス: prohibitive

1 dual change had so far been methodologically prohibitive.

2 e, GCTA becomes increasingly computationally prohibitive.

3 es of large data sets may be computationally prohibitive.

4 mber of subjects remains both cost- and time-prohibitive.

5 ecause its analysis is often computationally prohibitive.

6 ding or accurate but time consuming and cost prohibitive.

7 om the risk of re-do aortic valve surgery is prohibitive.

8 rgery is not feasible or if surgical risk is prohibitive.

9 larger, such pair-based calculation becomes prohibitive.

10 location to the water phase is energetically prohibitive.

11 patients in whom surgical risk is considered prohibitive.

12 inate and the cost disadvantages become less prohibitive.

13 here assay costs or platform limitations are prohibitive.

14 mentation and running costs are perceived as prohibitive.

15 ficulty of the full quantum problem had been prohibitive.

16 to the length of the sequence, which can be prohibitive.

17 experimental protein interaction networks is prohibitive.

18 d search, which is otherwise computationally prohibitive.

19 where the monetary cost of continuous ART is prohibitive.

20 groups, a process that can be energetically prohibitive.

21 nalogues of 1 were found to be energetically prohibitive.

22 progressively more expensive and eventually prohibitive.

23 development of a specific resource would be prohibitive.

24 of stress ulcer gastrointestinal bleeding is prohibitive.

25 elated hemorrhage is substantial, and may be prohibitive.

26 cently, have been either unavailable or cost prohibitive.

27 candidate compounds, exhaustive screening is prohibitive.

28 es required for in-person recruitment can be prohibitive.

29 re biased, lack sequencing depth or are cost prohibitive.

30 ough the significant cost of the drug may be prohibitive.

31 complicates such toxicities and may even be prohibitive.

32 multiple miRNAs, fast, robust, and not cost-prohibitive.

33 sensitivity and specificity, and/or are cost-prohibitive.

34 xperiments are often time-consuming and cost prohibitive.

35 but recording uniformly sampled data is time-prohibitive.

36 hods are cumbersome, time consuming and cost-prohibitive.

37 mbrane systems where isotope labeling may be prohibitive.

38 wever, their analysis can be computationally prohibitive.

39 n this population are substantial and likely prohibitive.

40 ations one-by-one can become computationally prohibitive.

41 quired to detect occupancy declines would be prohibitive.

42 The costs can be prohibitive.

43 l-to-all local association studies otherwise prohibitive.

44 ize, and comorbidities gradually become less prohibitive.

45 tional cost of the Monte Carlo method can be prohibitive.

46 used by Na(+)-coupled transporters to avoid prohibitive activation barriers for charge translocation

47 exactly two datasets, and/or they require a prohibitive amount of computational resources.

48 al pulmonary valve replacement in previously prohibitive anatomies.

49 No donor was excluded because of prohibitive anatomy.

50 bly is still a necessity, which becomes cost-prohibitive and a logistical challenge with increasing s

51 s normal mode motions can be computationally prohibitive and is often unnecessary.

52 ith some reports finding increased morbidity prohibitive and others finding increased morbidity accep

53 The cost of this gold standard can be prohibitive, and alternative approaches are needed.

54 runtime and main memory usage, which become prohibitive as dataset size grows past twenty-five taxa.

55 symbolic calculations, which quickly becomes prohibitive as the problem size increases.

56 the cost/benefit ratio of an intervention is prohibitive, as supported by pharmacoeconomic data, comm

57 that monomeric NO dissociation is subject to prohibitive barriers on Ag metal and is thus unlikely to

58 Typically, this is prohibitive, but in weak-field spectroscopy we can move

59 The lack of prohibitive cardiovascular effects and the generally acc

60 7SK.P-TEFb interaction was not caused by any prohibitive changes in 7SK but by the dephosphorylation

61 r size or function, absence of symptoms, and prohibitive comorbidities.

62 th a large number of observations involves a prohibitive computational burden.

63 the lack of global optimum guarantee and the prohibitive computational complexity have been the bottl

64 istency and poor reliability, or suffer from prohibitive computational complexity.

65 on energy stability parameters, which are of prohibitive computational cost in large scale applicatio

66 over multiple possible future states incurs prohibitive computational costs.

67 for large numbers of genomes at once, due to prohibitive computational demands.

68 t to apply to rare variants because of their prohibitive computational time and poor ability.

69 in performing functional mapping arise from prohibitive computational times required as well as from

70 y, off-target effects present a real but not prohibitive concern that should be considered for RNAi e

71 d giving up on disease treatment (27.6%) and prohibitive cost (21%).

72 The prohibitive cost and limited availability of tracers cou

73 The prohibitive cost and scarcity of the noble-metal catalys

74 set of the population to survive without the prohibitive cost of constantly expressing resistance mac

75 The prohibitive cost of platinum for catalyzing the cathodic

76 characterized comprehensively because of the prohibitive cost of standard technologies and the techni

77 rovide an escape, except at a high, possibly prohibitive cost.

78 t half-life (T(1/2) = 45.6 min) on site, and prohibitive cost.

79 Because of prohibitive costs and the required length of follow-up,

80 Prohibitive costs for clinical assessment of periodontal

81 means for detecting infectious disease, but prohibitive costs have impeded their use in resource-lim

82 are systems for diagnosis is hindered by the prohibitive costs of existing chloride sensors.

83 ficantly higher resolution without incurring prohibitive costs or increasing the amount of sample req

84 Giving up on treatment and prohibitive costs remain primary reasons for not seeking

85 omen included poor knowledge of drug safety, prohibitive costs, and self-treatment practices, used by

86 hetic difficulties, process complexities and prohibitive costs.

87 atterns with tremendous depth, it comes with prohibitive costs.

88 oncurrent whole-breast irradiation result in prohibitive cutaneous toxicity.

89 conferring the ability to inhabit otherwise prohibitive ecological niches.

90 to launch their seeds despite its seemingly prohibitive energy cost.

91 in (35 patients), nonendocardial origin with prohibitive epicardial access because of pericardial adh

92 h, as an NP-hard problem, is computationally prohibitive even for modest-size networks.

93 ing contigs will require significant (if not prohibitive) finishing efforts.

94 ere sickle cell disease, but toxicity may be prohibitive for adults.

95 owed for 3TC escape under culture conditions prohibitive for any WT viral growth.

96 ng the routine analysis of toxic metals cost-prohibitive for applications such as occupational exposu

97 iency leads to multipolar divisions that are prohibitive for cell proliferation.

98 that the size of the animals does not become prohibitive for end-stage evaluation or therapeutic inte

99 ich could increase the sensitivity, has been prohibitive for genome-wide screens due to its extreme c

100 under these conditions and thereby has been prohibitive for HXMS analyses of larger proteins and man

101 ut sample reagent and sequencing cost can be prohibitive for hypothesis-driven studies where the aim

102 most accurate method, but is computationally prohibitive for large data sets with many individuals an

103 current limits to multiplexing capacity are prohibitive for large sample sizes and impose limitation

104 s linearly with the aggregate length becomes prohibitive for lower concentrations and is relieved via

105 l constraints that typically make osmotrophy prohibitive for macroscopic life forms.

106 mples, the low throughput has made them cost prohibitive for many applications.

107 sequence data on a population scale is still prohibitive for many laboratories.

108 easing running time to O(N(2)), rendering BP prohibitive for modern-day big-data.

109 toxicities of myeloablative conditioning are prohibitive for most adults with this disease.

110 ce the short-lived 15O tracer, which is cost-prohibitive for most clinical PET centers.

111 This task is far from trivial, and can be prohibitive for non-bioinformaticians.

112 and placing of individual crystals-a process prohibitive for producing devices at high density and wi

113 -up but remain logistically and economically prohibitive for routine screening in resource-limited se

114 t programs; however, these vaccines are cost-prohibitive for routine use in LMICs.

115 regimens required for BMT to succeed are too prohibitive for routine use.

116 ies, whole-genome shotgun sequencing is cost-prohibitive for species with complex genomes.

117 he full permutation approach computationally prohibitive for the newer arrays that contain tens of th

118 eyed 10 Gbit s(-1) systems and is absolutely prohibitive for today's (>)100 Gbit s(-1) coherent syste

119 pment may prove both time-consuming and cost-prohibitive for treatment of all forms of RP.

120 all genetic variants, but it is financially prohibitive for well-powered GWAS studies.

121 rations, it is not known why therapeutically prohibitive high doses are needed for suppression of tum

122 tive structures in otherwise computationally prohibitive, high-dimensionality landscapes.

123 randomized trial appears to be logistically prohibitive; however, an international registry should b

124 y HIV-infected patients, it can be toxic and prohibitive in cost.

125 Objectively assessed operative risk was not prohibitive in many unoperated patients.

126 d require Omega(n(2)) memory, which could be prohibitive in practice when n is greater than a hundred

127 ive RABV PEP is currently resource- and cost-prohibitive in regions of the world where RABV is most p

128 at severe intestinal rejection occurs, it is prohibitive in these cases to remove the intestinal port

129 the variables and leading to computationally prohibitive inference algorithms.

130 SD showed initial therapeutic promise before prohibitive legislature in the mid-1960s effectively end

131 icacy, but previous such drug strategies had prohibitive limitations.

132 These can be cost-prohibitive, motivating investigations into their role i

133 characteristics of caspase-8 mutants bearing prohibitive mutations at the interdomain cleavage sites

134 tem-cell transplantation has been limited by prohibitive non-relapse-related mortality rates and by a

135 uch CRMs is a challenging problem due to the prohibitive number of sequence sets that need to be anal

136 sm of inhibition is due to a steric blockade prohibitive of substrate binding, and is distinct from t

137 hence allowing analyses that would have been prohibitive on a single computer.

138 f up to 92%, but the conditions required are prohibitive on an industrial scale.

139 e not uniformly translated into increased or prohibitive operative morbidity and mortality in this po

140 Also, these techniques can be cost or time prohibitive or not amenable to the biological system of

141 ntact tracing either uncertain, logistically prohibitive, or both.

142 r constructing haplotypes is computationally prohibitive, our approach uses a greedy algorithm based

143 to direct chemical reactivity down otherwise prohibitive pathways.

144 ng cardiac surgery are often thought to have prohibitive perioperative risk despite the lack of suffi

145 I) complexes has been shown to be a slow and prohibitive process that generally requires elevated tem

146 vely identified as meeting the definition of prohibitive risk and had 1-year follow-up (median: 1.47

147 A proportion of these patients is at high or prohibitive risk for surgical aortic valve replacement,

148 s with symptomatic severe aortic stenosis at prohibitive risk for surgical valve replacement.

149 le for femoral artery access and had high or prohibitive risk of complications from transthoracic acc

150 angina deemed to be at "high risk" or even "prohibitive risk" for CABG, PTCA is an alternative revas

151 al valve replacement surgery poses a high or prohibitive risk.

152 A prohibitive-risk DMR cohort was identified by a multidis

153 transcatheter mitral valve repair (TMVR) in prohibitive-risk DMR patients have not been previously r

154 review of procedural and 30-day outcomes of prohibitive-risk patients who underwent TAVR via caval-a

155 ceived approval in 2013 for the treatment of prohibitive-risk patients with primary mitral regurgitat

156 ears to be reasonably well tolerated without prohibitive risks for adverse events among selected NOAC

157 with symptomatic severe aortic stenosis with prohibitive risks for surgery.

158 r a prospective superiority trial are likely prohibitive, studies such as these provide clinically re

159 York Heart Association class III/IV), and at prohibitive surgical risk (STS score: 13.2 +/- 7.3%).

160 ue challenge as many patients are at high or prohibitive surgical risk and, therefore, an open surgic

161 TMVR in prohibitive surgical risk patients is associated with sa

162 icate that TAVR is underutilized in high and prohibitive surgical risk patients with severe aortic st

163 ents who underwent TAVI because of a high or prohibitive surgical risk profile had died at a mean fol

164 gitation (MR) in patients with severe DMR at prohibitive surgical risk undergoing TMVR.

165 nning, and management of patients at high or prohibitive surgical risk, thus improving outcomes.

166 ral regurgitation (MR) considered at high or prohibitive surgical risk.

167 egurgitation are also deemed at very high or prohibitive surgical risk.

168 with severe TR and right heart failure with prohibitive surgical risk.

169 xpanding TAVR in patients with severe AS and prohibitive surgical risk.

170 ed as an alternative for patients at high or prohibitive surgical risk.

171 with symptomatic aortic stenosis at high or prohibitive surgical risk.

172 h aortic stenosis at intermediate to high or prohibitive surgical risk.

173 Current research is limited by the prohibitive time necessary to perform tree search on a r

174 Clearly, it is computationally prohibitive to analyze all network properties, but the l

175 d confounding gamma emissions of (52g)Mn are prohibitive to clinical translation, but the short-lived

176 the stage where it is becoming commercially prohibitive to conduct new studies.

177 ortunately, it has been challenging and cost prohibitive to generate antidotes for most therapeutic a

178 g this process, its expense and scarcity are prohibitive to large-scale commercialization.

179 ods are either impossible or computationally prohibitive to obtain.

180 ge number of legacy wells would make it cost-prohibitive to sample all wells for all measurements as

181 ion of a near-complete, scaffolded genome is prohibitive to small research communities due to the exp

182 cing of target regions, although it is still prohibitive to test more than a few individuals.

183 e and targeted sequencing tests is no longer prohibitive to their application.

184 k illustrates that large energetic barriers, prohibitive toward chemical reaction, may be overcome th

185 ry 2 weeks until a maximum dose of 800 mg or prohibitive toxicity was reached.

186 In the absence of disease progression or prohibitive toxicity, patients received a maximum of 16

187 ts were treated until disease progression or prohibitive toxicity.

188 y every 3 weeks until disease progression or prohibitive toxicity.

189 y every 21 days until disease progression or prohibitive toxicity.

190 y every 21 days until disease progression or prohibitive toxicity.

191 gefitinib 500 mg daily until progression or prohibitive toxicity.

192 ar models, however, would be computationally prohibitive unless some independence assumptions are mad

193 large-scale sequence-similarity searches is prohibitive using even the fastest of the extant algorit

194 many areas throughout the world that renders prohibitive vegetables and crop production in general.

195 stom synthesis is expensive and costs can be prohibitive when a wide range of markers is to be analyz

196 However, the MRFs can be computationally prohibitive when beta strands are interleaved in complex

197 demands synapse analysis on a scale that is prohibitive with current methods.

198 ny of the technical complexities that may be prohibitive with standard laparoscopic surgery such as i