ライフサイエンスコーパス: prohibitively

1 ck at the more exposed diradical center, was prohibitively (35.9 kcal/mol) higher in energy.

2 pristine crystals absent of defects has been prohibitively challenging.

3 inhibitors has historically been considered prohibitively challenging.

4 ect measurements of oxygen consumption prove prohibitively challenging.

5 the signal used for detection or the use of prohibitively complex instrumentation, and prospects for

6 However, mass spectra are often prohibitively complex when fragment ions are analyzed fo

7 owering the dose of 6OHDA below toxic levels prohibitively compromises its antitumor effect.

8 , existing maximum-likelihood methods can be prohibitively computationally expensive, especially sinc

9 atory specimens, though this practice can be prohibitively costly and can be associated with an incre

10 tional cloning and sequencing approaches are prohibitively costly and labor-intensive.

11 individual being studied, but this is often prohibitively costly.

12 gy, due in large part to the requirement for prohibitively cumbersome experimental procedures and dau

13 But this is prohibitively difficult at experimental level.

14 le experiments in central axon terminals are prohibitively difficult but the biophysical requirements

15 s interaction mapping in humans has remained prohibitively difficult due to computational and statist

16 -way functions are inexpensive to fabricate, prohibitively difficult to duplicate, admit no compact m

17 omprehensive species-level identification is prohibitively difficult with traditional methods.

18 ing each candidate gene from every region is prohibitively expensive and computational methods that s

19 xtraction of 18O/16O from water is generally prohibitively expensive and often is designed to interfa

20 r fabrication over large areas, which can be prohibitively expensive and time consuming using convent

21 mmercially available pure compounds is often prohibitively expensive and time-consuming, and many lab

22 is compound is commercially available but is prohibitively expensive because of the circuitous routes

23 reover, large-scale datasets typically incur prohibitively expensive computation overhead and thus re

24 By exploiting precomputed data, the often prohibitively expensive computations associated with hig

25 its potential toxicity, natural hepcidin is prohibitively expensive for human application and has un

26 ovide high-quality intake data but have been prohibitively expensive for large epidemiologic studies.

27 synthesis for their preparation, and/or are prohibitively expensive for large-scale application.

28 ever, classical HLA typing methods are often prohibitively expensive for large-scale studies.

29 h next-generation sequence (NGS) data remain prohibitively expensive for many investigators.

30 ing ancient genomes to high coverage remains prohibitively expensive for most laboratories.

31 igital PCR (ddPCR), however, the hardware is prohibitively expensive for widespread utility.

32 TIPS should be regarded as experimental and prohibitively expensive in Child's class A cirrhosis.

33 kidney injury can be life-saving, but can be prohibitively expensive in low-income settings.

34 es individual testing of at-risk individuals prohibitively expensive in many settings.

35 od organisms, and developing a new model was prohibitively expensive or time-consuming.

36 to DNA oligonucleotides, they are typically prohibitively expensive to chemically synthesize, and un

37 ouses with residual insecticide, is becoming prohibitively expensive to implement and new approaches

38 enome-wide association studies (GWAS), it is prohibitively expensive to sequence all cohort members.

39 However, it is prohibitively expensive to sequence all the samples from

40 tality, are a threat to health-care workers, prohibitively expensive to treat, and are therefore a se

41 iations, next-generation sequencing is still prohibitively expensive when applied to large samples.

42 sampling of conformational space, and become prohibitively expensive when exploring the collective dy

43 However, manual analysis can be prohibitively expensive, creating a bottleneck between c

44 teins and de novo immunoassay development is prohibitively expensive, few candidate biomarkers are te

45 le rates of progression of BE to EAC, and be prohibitively expensive, from a policy perspective.

46 cases and their direct simulation can become prohibitively expensive, precluding thorough analysis.

47 radiolabeled derivatives is laborious and/or prohibitively expensive.

48 for AIDS has become more effective but also prohibitively expensive.

49 ber of possible secondary targets makes this prohibitively expensive.

50 A strategy of culturing all children may be prohibitively expensive.

51 s and oral valganciclovir are unavailable or prohibitively expensive.

52 e when employing FSM, whereas SB systems are prohibitively expensive.

53 statistically significant genomic result is prohibitively expensive.

54 at the sites, with low-incidence sites being prohibitively expensive.

55 can shift the ICER into a cost range that is prohibitively expensive.

56 screening more often than every 10 years was prohibitively expensive; annual rehydrated FOBT plus sig

57 ling of solvent and solute dynamics is often prohibitively expensive; however, the master equation of

58 and distal oxygen atoms of this species have prohibitively high barriers to carry out the aromatic hy

59 o differences in licensure status as well as prohibitively high costs.

60 ure calculations attribute this finding to a prohibitively high interconversion barrier of approximat

61 fter high-dose conditioning regimens imposes prohibitively high risks of morbidity and mortality for

62 limited to 6 hours on the OCS system due to prohibitively high vascular resistance, edema, and worse

63 ked anions and Na(+) complexes are, however, prohibitively high.

64 n the hydrophobic part of the bilayer is not prohibitively high.

65 an RCT with HIV incidence as its outcome are prohibitively high.

66 ier for the organic base DBU was found to be prohibitively high.

67 mography have been applied to muscle but are prohibitively invasive, sensitive to motion artifact, an

68 the intake-balance method, this technique is prohibitively labor-intensive and expensive, requiring r

69 The frozen bank of allogeneic CTLs is less prohibitively labour intensive and expensive for wide sc

70 uorescence in situ hybridization (FISH), are prohibitively labour-intensive on a genomic scale.

71 mpler 2-methoxyethylidene system that show a prohibitively large barrier for the methoxy shift and a

72 n physics and physical chemistry, due to the prohibitively large computational resources that would b

73 mia due to high beta cell densities creating prohibitively large diffusional distances for nutrients.

74 or even hundreds of gigabytes of disk space, prohibitively large for many users.

75 It is generally believed that prohibitively large pressures would be required to suppr

76 The prohibitively large solution space of all possible netwo

77 Inadequate heat dissipation can lead to prohibitively large temperature rises that degrade perfo

78 ed to control a dynamical complex network is prohibitively large when there are only a few control in

79 pace of feasible RNA secondary structures is prohibitively large, and accurate prediction of function

80 o detect such interactions may be considered prohibitively large, making a meta-analysis of published

81 of families required to do this reliably is prohibitively large.

82 rder (HCs with evidence of AD pathology) are prohibitively large.

83 The computations can become, however, prohibitively long for the change in the free energy upo

84 at the mobile phase to column temperature is prohibitively long.

85 0-100 mum equilibration times already become prohibitively long.

86 nomenon and the timescale for melting can be prohibitively long.

87 extinction in the absence of control may be prohibitively long.

88 We find detection accuracy to be prohibitively low in all assessments, both in terms of s

89 est that the cells themselves must then have prohibitively low internal error rates.

90 mplified shotgun libraries (LASLs), which is prohibitively low throughput, and whole-genome amplifica

91 sible only for favorable amino acids or with prohibitively low yields.

92 However, catalytic activity onsets at prohibitively negative potentials and is highly dependen

93 to use H2 as a clean source of electricity, prohibitively rare and expensive precious metal electroc

94 Some argue that arboreal bipedalism was prohibitively risky for hominins whose increasingly mode

95 r between the two ligands was designed to be prohibitively short, so that unfavorable protein-protein

96 However, complete circuit reconstruction is prohibitively slow and may not be necessary for many pur

97 This approach is often considered to be prohibitively slow and/or computationally expensive but

98 d general graph search algorithms, which are prohibitively slow as putative metabolic networks may ex

99 under conditions when spontaneous folding is prohibitively slow as to compete with other non-producti

100 stic simulations of such multiscale BRNs are prohibitively slow due to high computational cost for th

101 historically been considered fast, but it is prohibitively slow for building trees from increasingly

102 flexibility, standard implementations can be prohibitively slow for large datasets and complex transc

103 on alloy was shown to catalyze the otherwise prohibitively slow formation of abiogenic CH(4) from dis

104 te that the search for a cognate site may be prohibitively slow if a TF has a low copy number and is

105 First, the computational method may be prohibitively slow or difficult to implement for large d

106 gand environment that resembles NHase is not prohibitively slow so as to disallow catalytic action in

107 ransfer of gaseous NO2 into bulk solution is prohibitively slow.

108 ity due largely to xylose fermentation being prohibitively slower than that of glucose.

109 y is commonly unknown or they are present in prohibitively small numbers.

110 ing) except in the cases where inhibition is prohibitively strong.

111 This level of sensitivity could be prohibitively time consuming, but CloudBurst uses the op

112 "capture and detection" probes, which can be prohibitively time-consuming and expensive in a drug dis

113 As a result, instances which were once prohibitively time-consuming to solve are brought into t

114 micrometers, making ultrastructural analysis prohibitively time-consuming.

115 es, and reconstruction procedures can become prohibitively time-consuming.

116 of computations in the O(n(2)) algorithm is prohibitively time-intensive.

117 like B cell depletion, pan-T cell aplasia is prohibitively toxic.

118 st 5 kcal/mol higher activation barriers and prohibitively unfavorable product energies.

119 ., substrate one-electron oxidation) becomes prohibitively uphill, the ETPT pathway occurs.

120 Furthermore, these limitations scale prohibitively with increasing model size.

121 However, the effect of age was not prohibitively worse, and is comparable to the effects of