1 s P, E, V and K within the NH(2) terminus of
projectin.
2 r to the kinase domains of the twitchins and
projectin.
3 e projectin sequence analysis, which defines
projectin as a 1 MDa protein, composed of 39 immunoglobu
4 is consistent with the proposed function of
projectin as a scaffold and ruler.
5 t the nearly complete sequence of Drosophila
projectin,
as well as the possible splicing patterns use
6 These isoforms are discussed in view of
projectin differential size and localization.
7 Twitchin and
projectin evolved later by truncation.
8 Sequence similarity between twitchin and
projectin further suggests how some domains may possibly
9 Projectin has been suggested as the elastic component of
10 cludes the giant kinases titin, twitchin and
projectin,
has sequences composed predominantly of seria
11 known as titin in vertebrates or kettin and
projectin in insects.
12 The
projectin insect protein functions jointly as a "scaffol
13 Drosophila
projectin is an extremely large protein found within the
14 The overall domain organization in
projectin is composed of repeated motifs I and II in a f
15 Projectin is encoded by a single gene and the isoforms w
16 The general domain organization of
projectin is highly conserved, as are the protein sequen
17 In Drosophila melanogaster,
projectin is so far the only member of this family for w
18 fferent set of protein interactions for each
projectin isoform.
19 The synchronous
projectin isoforms contain a PEVK-like region, and the p
20 The PEVK-like domain of the
projectin isoforms in indirect flight muscles may contri
21 An evolutionary analysis of the
projectin molecule could potentially provide insight int
22 The length of the
projectin PEVK-like region varies from 100 to 624 amino
23 This may suggest distinct functions for the
projectin protein in various muscles, as well as a diffe
24 s at the COOH terminus, leading to a shorter
projectin protein lacking some of the terminal motifs II
25 alyses include assessing the localization of
Projectin protein, a titin homolog, in sarcomeres as wel
26 Phylogenetic analysis of the
projectin proteins also supports a reclassification of t
27 Here, we describe the completion of the
projectin sequence analysis, which defines projectin as
28 Drosophila
projectin,
the giant protein component of the third fila
29 Twitchin and
projectin,
which are presumed to be orthologs, have unde