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1 en obtained via lateral gene transfer from a prokaryote.
2 e modules that are ubiquitous in free-living prokaryotes.
3 ve and inducible promoters in eukaryotes and prokaryotes.
4 the first documentation of this activity in prokaryotes.
5 nd fungi, but remain largely unidentified in prokaryotes.
6 mins as it is biosynthesized only by certain prokaryotes.
7 modes of gradient sensing in eukaryotes and prokaryotes.
8 rs that are widely distributed in plants and prokaryotes.
9 prototype of patterning and morphogenesis in prokaryotes.
10 systems mediate adaptive immunity in diverse prokaryotes.
11 in plants, animals, and humans and later in prokaryotes.
12 e system against foreign genetic elements in prokaryotes.
13 the importance of stygofauna as vectors for prokaryotes.
14 nt protein remodeling in both eukaryotes and prokaryotes.
15 remediating, water purifying and pathogenic prokaryotes.
16 icant rise of sequencing projects, mainly in prokaryotes.
17 over a few days to account for about 40% of prokaryotes.
18 he dominant mode of extracellular sensing in prokaryotes.
19 4 plants and green algae but is not found in prokaryotes.
20 sodium channels that are widely expressed in prokaryotes.
21 eading to a disperse distribution pattern in prokaryotes.
22 -Cas systems silence plasmids and viruses in prokaryotes.
23 e order, yet they are not typically found in prokaryotes.
24 es independently amongst both eukaryotes and prokaryotes.
25 te fungi associated with wood decay and from prokaryotes.
26 es for t(6)A synthesis are essential in most prokaryotes.
27 adaptive immunity against viral infection in prokaryotes.
28 looping is important for gene repression in prokaryotes.
29 e preserved from archaea to human pathogenic prokaryotes.
30 y-dependent, membrane-associated function in prokaryotes.
31 mostly eukaryotes to mostly nitrogen-fixing prokaryotes.
32 es in the post-transcriptional regulation in prokaryotes.
33 in stability in the cytosolic compartment of prokaryotes.
34 sphatase signaling networks that function in prokaryotes.
35 eukaryotic cells evolved from endosymbiotic prokaryotes.
36 controlling Mg(2+) uptake and homeostasis in prokaryotes.
37 he crucial focal point of gene expression in prokaryotes.
38 omic patterns of cis-regulatory evolution in prokaryotes.
39 independently in cyanobacteria versus other prokaryotes.
40 and the local-concurrent chromosome cycle of prokaryotes.
41 m and could therefore be a common feature in prokaryotes.
42 xin-antitoxin (TA) systems are widespread in prokaryotes.
43 urprisingly different between eukaryotes and prokaryotes.
44 covery of homologues of tubulin and actin in prokaryotes.
45 tured representative deep-sea methanotrophic prokaryotes.
46 e present in diverse cells of eukaryotes and prokaryotes.
47 ected glycerophospholipids in eukaryotes and prokaryotes.
48 nder polygenic lineage-specific selection in prokaryotes.
49 are no more bioenergetically efficient than prokaryotes.
50 widely used for orthology identification in prokaryotes.
51 ish an RNA-based adaptive immunity system in prokaryotes.
52 kable dynamic filaments nearly ubiquitous in prokaryotes.
53 thesis of adenosylcobalamin (AdoCbl) in many prokaryotes.
54 re thought to have originated as free-living prokaryotes.
55 ever, such a mechanism remains unexplored in prokaryotes.
56 des a barrier to horizontal gene transfer in prokaryotes.
57 n into bioavailable ammonium in diazotrophic prokaryotes.
58 y microalgae acquire vitamin B12 from marine prokaryotes.
59 ing our knowledge across the whole domain of prokaryotes.
60 al system of self/non-self discrimination in prokaryotes [1], which protects hosts from exogenous DNA
63 d an analogous elemental milieu and harbored prokaryotes affiliated with fifty-nine phyla, among whic
65 an adaptive immune system that protects the prokaryotes against exogenous genetic elements such as p
67 codes an adaptive immune system that defends prokaryotes against infectious viruses and plasmids.
73 NA-directed immune systems are found in most prokaryotes, an opportunity exists to harness the endoge
76 han 55,000 organisms (>4800 viruses, >40,000 prokaryotes and >10,000 eukaryotes; RefSeq release 71),
77 that bifurcates to favor direct tunneling in prokaryotes and a two-step hopping mechanism in eukaryot
79 ilaments are frequent in both eukaryotes and prokaryotes and are involved in vital cellular processes
80 esponding to group II RNAs are found in many prokaryotes and are particularly prevalent within plants
81 ed short palindromic repeat (CRISPR) loci in prokaryotes and by V(D)J recombination of immunoglobulin
82 are the most abundant signalling pathways in prokaryotes and control a wide range of biological proce
84 there is a long-standing effort to search in prokaryotes and eukarya for proteins promoting HJ migrat
85 osed as part of defense systems that protect prokaryotes and eukaryotes against the proliferation of
87 rence Sequence (RefSeq) genomes for viruses, prokaryotes and eukaryotes are the primary foundation fo
88 from 9282 complete genome chromosomes of all prokaryotes and eukaryotes available at NCBI, we observe
89 th quorum sensing and 'community effects' in prokaryotes and eukaryotes can be drawn, arguing that a
90 tant implications for signal transduction in prokaryotes and eukaryotes due to conservation of aromat
91 me-copper oxidases (HCOs) are key enzymes in prokaryotes and eukaryotes for energy production during
92 e the intrinsic growth rates of phototrophic prokaryotes and eukaryotes from the equatorial to temper
93 mming from the earliest interactions between prokaryotes and eukaryotes have evolved to mediate micro
95 is a widespread lipophilic molecule in both prokaryotes and eukaryotes in which it primarily acts as
96 nsmembrane receptors (7TMRs) have evolved in prokaryotes and eukaryotes over hundreds of millions of
99 d our ability to study the transcriptomes of prokaryotes and eukaryotes separately, limitations in ex
100 droplets (LDs) are ubiquitous organelles in prokaryotes and eukaryotes that play a key role in cellu
102 g examples of HGT among prokaryotes, between prokaryotes and eukaryotes, and even between multicellul
103 GyrI-like proteins are widely distributed in prokaryotes and eukaryotes, and recognized as small-mole
104 id intermediate for several pathways in both prokaryotes and eukaryotes, being produced by CDP-DAG sy
106 olution mechanisms that are employed in both prokaryotes and eukaryotes, including how deregulating S
110 AH) domain-containing proteins occur in both prokaryotes and eukaryotes, where they carry out diverse
111 proteins that store copper in the cytosol of prokaryotes and eukaryotes, where this reactivity is als
123 its metabolic capabilities uncharacterized, prokaryotes and fungi have the potential to act as mutua
124 he Fluc family of F(-) ion channels protects prokaryotes and lower eukaryotes from the toxicity of en
125 ring winter, showed that vertical patches of prokaryotes and microplankton developed and persisted fo
128 SPR-Cas systems provide adaptive immunity in prokaryotes and promising gene-editing tools from bacter
129 other HPP superfamilies known previously in prokaryotes and resembles myo-inositol monophosphatases
130 hrough independent horizontal transfers from prokaryotes and that expansion by gene duplication led t
131 that is exclusive to oxygenic photosynthetic prokaryotes and that is based on the primary sequence th
132 d our understanding of the interplay between prokaryotes and their environment, and CRISPR-based mole
133 sic principles of DNA damage repair (DDR) in prokaryotes and unicellular and multicellular eukaryotes
134 e lipoylated has been extensively studied in prokaryotes and yeast (Saccharomyces cerevisiae), but li
135 was further identified from both Plantae and prokaryotes and, together with site-directed mutagenesis
136 ms (TCS) are the main signalling pathways of prokaryotes, and control a wide range of biological phen
137 served in the genomic DNA of bacteriophages, prokaryotes, and eukaryotes that play a role in restrict
138 esses routinely interfere with each other in prokaryotes, and mounting evidence now suggests that RNA
140 of stochastic mRNA:ncRNA interactions across prokaryotes, and that these have a greater impact on pro
141 re found ubiquitously in both eukaryotes and prokaryotes, and they comprise the largest of all of the
142 f eukaryotes alongside more rapidly evolving prokaryotes, archaea, and viruses posed immunological ch
144 cyanobacteria occupy a unique position among prokaryotes as a hub between anaerobes and obligate aero
148 roduce antibacterials, which have evolved in prokaryotes as the result of eons of interbacterial comp
152 ryotes for regulation of kinases, however in prokaryotes auto-phosphorylation of number of kinases ha
153 Here, we show that fumarase of the model prokaryote Bacillus subtilis (Fum-bc) is induced upon DN
155 fter a month of operation, the most-abundant prokaryote belonged to an uncharacterized clade of Chlor
156 the web of life using examples of HGT among prokaryotes, between prokaryotes and eukaryotes, and eve
160 oteome consists of proteins with homologs in prokaryotes, but without a robust phylogenetic signal af
162 espiratory electron transport system of some prokaryotes by shuttling electrons between membrane-boun
164 fic metabolic and pathological phenotypes in prokaryotes can be predictable from current genomes.
166 rginine translocation (Tat) system, found in prokaryotes, chloroplasts, and some mitochondria, allows
167 transporters for vitamins and metal ions in prokaryotes consist of two ATP-binding cassette-type ATP
169 cally, progressive chromosome segregation in prokaryotes demands a single duplicon per chromosome, wh
170 howed P. persalinus has acquired many unique prokaryote-derived genes that potentially contribute to
171 advance our understanding of the strategies prokaryotes employ to regulate cellular processes relate
176 by discoveries that fill in the gaps of the prokaryote:eukaryote "discontinuity." Second, eukaryogen
181 This reshaping removes the role of C-Ala in prokaryotes for docking tRNA and instead repurposes it t
182 for 58 of the 121 large protein families in prokaryotes for which three-dimensional structures are n
183 oss of defense genes during the evolution of prokaryotes; formation of genomic defense islands; evolu
187 f fundamental importance to the evolution of prokaryote genomes and has important practical consequen
189 ation that extremely large viruses infecting prokaryotes (giant phages) can be found in many environm
191 th and quorum sensing are direct examples of prokaryote group behaviors, wherein cells coordinate the
194 imal and plant P4Hs target peptidyl proline, prokaryotes have been known to use free l-proline as a p
197 eukaryotes and the cytoskeletal polymers of prokaryotes have yielded new insights due to recent adva
198 ds, which are well-studied drivers of HGT in prokaryotes, have been reported previously in red algae
199 Almost all organisms, from eukaryotes to prokaryotes, have evolved enzymes to make and break thes
200 acterization of five previously unidentified prokaryote homologs with high sequence similarity (24-32
201 f acetylcholine receptors, ion channels from prokaryote homologs-Erwinia chrysanthemi ligand-gated io
203 ish the distinctive roles played by abundant prokaryotes in cobalamin-based microbial interdependenci
204 likely more susceptible to genotoxicity than prokaryotes in the ecosystem when exposed to these ENMs.
206 which is synthesized de novo only by certain prokaryotes, including the majority of cyanobacteria.
207 ight be expected, taxonomic biases for donor prokaryotes indicate that shared habitat is a major fact
209 most common membrane constriction system in prokaryotes is based on the tubulin homologue FtsZ, whos
210 tabolic processes, although only a subset of prokaryotes is capable of synthesizing B12 and other cob
211 d sequentially, suggesting that evolution in prokaryotes is governed by functional assembly patterns.
214 als, we find that the information content of prokaryotes is similar to plants and animals at the pres
217 CorA, the major Mg(2+) uptake system in prokaryotes, is gated by intracellular Mg(2+) (KD approx
219 OP via an ATP-dependent 5-oxoprolinase; most prokaryotes lack homologs of this enzyme (and the gamma-
221 m, Local Distribution of Short Sequences for Prokaryotes (LDSS-P), to identify conserved short motifs
222 ions between NusG/Spt5 and RNA polymerase in prokaryotes, little is known about how the binding of eu
229 ty against invasive mobile genetic elements, prokaryotes must first integrate fragments of foreign DN
230 s in the two conserved Higher Eukaryotes and Prokaryotes Nucleotide-binding (HEPN) domains, mutations
232 m Thaumarchaeota are among the most abundant prokaryotes on Earth and are widely distributed in marin
236 analyze a dynamical model of CRISPR-mediated prokaryote-phage coevolution that incorporates classical
241 ion factor, eEFSec in eukaryotes and SelB in prokaryotes, promotes selenocysteine incorporation into
245 nstruction of the pan genome of thousands of prokaryote samples possible on a standard desktop withou
248 ibution of the lactate racemase system among prokaryotes, showing the high significance of both lacta
251 Rubisco is a strategy used by photosynthetic prokaryotes such as cyanobacteria for more efficient inc
252 plays a key role in the iron homeostasis of prokaryotes, such as bacterial pathogens, but the molecu
253 higher eukaryotes but absent from yeast and prokaryotes suggesting its role as a thermal and kinetic
256 plants develop opportunistic mutualisms with prokaryotes that solve context-dependent ecological prob
258 In contrast to the DNA-based viruses in prokaryotes, the emergence of eukaryotes provided the ne
260 are critical sensors of external stimuli in prokaryotes, the mechanisms by which their sensor domain
262 ements, e.g., the Shine-Dalgarno sequence in prokaryotes, the rRNA-binding site in the HCV IRES funct
263 mechanism affecting genome rearrangements in prokaryotes, the symmetrical inversions around the origi
264 e and spread of an important group of marine prokaryotes, the vibrios, which are responsible for seve
266 modifications differ between eukaryotes and prokaryotes; thus, they can serve to define the innate p
268 etter understand the functional responses in prokaryotes to dissolved organic matter (DOM), we compar
269 extensively, the evolutionary rise of these prokaryotes to ecological dominance in many habitats rem
270 y implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a sou
271 a direct, causal role in the transition from prokaryotes to eukaryotes and the subsequent explosive d
274 rminal domain (C-Ala) that is conserved from prokaryotes to humans but with a wide sequence divergenc
275 nases (ROXs) occur in organisms ranging from prokaryotes to humans raises questions as to their struc
276 erived from a diverse range of species, from prokaryotes to humans, with a mechanism of action that o
277 ome size distributions in multiple groups of prokaryotes to predictions of mathematical models of pop
278 ental change in J-protein biology during the prokaryote-to-eukaryote transition allows for increased
281 ogether, all these findings indicate that in prokaryotes, translation start signals are subject to we
283 fate of RNA in eukaryotes; however, whether prokaryotes use RNA spatial organization as a mechanism
285 e evolutionary impact of such constraints in prokaryotes, using probabilistic ancestral reconstructio
287 ein structures from two eukaryotes and three prokaryotes, we explore the connections between the prot
288 sed on the knowledge about the role of PG in prokaryotes, we hypothesize that the synthesis of Chl an
289 nts has bombarded nuclei since the ancestral prokaryotes were engulfed by a precursor of the nucleate
291 en a powerful tool for uncovering biology in prokaryotes, where whole-genome saturating screens have
292 nique glycosidic linkages, particularly from prokaryotes, which are resistant to enzymatic or chemica
293 t little is known of its influence on marine prokaryotes, which represent the largest living biomass
294 ong-standing importance of the Psp system in prokaryotes, while inter- and intra-phyla variations wit
295 ke up RNA-guided, adaptive immune systems in prokaryotes whose effector proteins have become powerful
296 s between an ancient, obligate endosymbiotic prokaryote with its obligate plant-symbiotic fungal host
298 allic nodules provide a suitable habitat for prokaryotes with an abundant and diverse prokaryotic com
299 l code exist, particularly in organelles and prokaryotes with small genomes, they are limited in scop
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