ライフサイエンスコーパス: prolactin receptor

1 ming growth factor beta receptor type II, or prolactin receptor).

2 er retrovirus encoding the non-hematopoietic prolactin receptor.

3 , indicating transport is independent of the prolactin receptor.

4 binding domain in a fashion analogous to the prolactin receptor.

5 ot only the ER but also the progesterone and prolactin receptors.

6 lymphocytes, and both B and T cells express prolactin receptors.

7 several candidate genes (cyclin D1, Stat5A, prolactin receptor) abrogates normal mammary gland devel

8 location of STAT5 can be used as a marker of prolactin receptor activation in hypothalamic dopaminerg

9 that Stat5a and Stat5b respond similarly to prolactin receptor activation, but also suggested that t

10 zed acini, allowing both the exposure of the prolactin receptor and sustained activation of STAT5.

11 f matrices also increased co-localization of prolactin receptors and integrin-activated FAK, implicat

12 termini of the long (LF) or short (SF) human prolactin receptors and luciferase/GFP such that biolumi

13 kinases reportedly also are associated with prolactin receptors and may phosphorylate Stat5.

14 However, the enzymatic coupling between prolactin receptors and Stat5 in this process has not be

15 in mice have established a critical role for prolactin receptors and transcription factor Stat5 in ma

16 o the molecular mechanisms involved in human prolactin receptor antagonist (hPRL-G129R)-induced apopt

17 Many genes that are activated by the prolactin receptor are associated with tumorigenesis and

18 dues necessary for functional binding to the prolactin receptor are clustered on the prolactin surfac

19 We have scrutinized the prolactin receptor as an archetype model of homodimeric

20 d surface plasmon resonance to measure human prolactin receptor binding kinetics and stoichiometries

21 hese data support an "induced-fit" model for prolactin receptor binding where binding of the first re

22 xpress the short 1b form (SF1b) of the human prolactin receptor, but DU145 and PC3 cells express only

23 olecular architecture of the monomeric human prolactin receptor by combining experimental and computa

24 erated against hPRL and the ECD of the human prolactin receptor, co-immunoprecipitation analyses of h

25 e brain in PRLR(-/-) mice lacking functional prolactin receptors compared to control mice, indicating

26 acts to promote Stat5 activation by the JAK2.prolactin receptor complex, while negatively modulating

27 sis was that prolactin induced activation of prolactin receptor coupled signaling leads to increased

28 sion of angiotensin-vasopressin receptor and prolactin receptor, decreased 5 alpha-reductase, and mix

29 Moreover, retinas from prolactin receptor-deficient mice exhibited photorespons

30 IGF-2 expression restores alveologenesis in prolactin receptor(-/-) epithelium.

31 tion factor results in increased steroid and prolactin receptor expression concomitant with a 10-fold

32 concomitant appearance of a cell-associated prolactin receptor fragment containing the extracellular

33 The prolactin receptor fragment was labeled by surface bioti

34 Three promoters are operative in the rat prolactin receptor gene as follows: promoter I (PI) and

35 The inactivation of the prolactin receptor gene by homologous recombination has

36 hat promoter III is of central importance in prolactin receptor gene transcription across species.

37 t were due to a heterozygous mutation in the prolactin receptor gene, PRLR, resulting in an amino aci

38 nscriptional activation of promoter I of the prolactin receptor gene, which may explain the tissue-sp

39 ed binding mechanism for the human prolactin/prolactin receptor heterotrimeric complex.

40 binds the extracellular domain of the human prolactin receptor (hPRLbp) using surface plasmon resona

41 Estradiol (E(2)) induces human prolactin receptor (hPRLR) gene expression through stimu

42 have identified a novel exon 11 of the human prolactin receptor (hPRLR) gene that is distinct from it

43 a-estradiol (E2)-induced activation of human prolactin receptor (hPRLR) gene transcription.

44 To determine why, we explored the human PRL-prolactin receptor (hPRLR)-Janus kinase 2 (JAK2)-signal

45 f a similar mechanism was at play with human prolactin receptor (hPRLr).

46 growth hormone receptor (hGHR) and the human prolactin receptor (hPRLR).

47 gand on the endogenous "long" isoform of the prolactin receptor in breast cancer cells.

48 the expression of the long form of the human prolactin receptor in fetal, prepubertal, and adult pros

49 On the basis of high expression of the prolactin receptor in the choroid plexus, it has been hy

50 at signal transduction mechanisms coupled to prolactin receptors in hypothalamic dopaminergic neurons

51 Indeed, ovine prolactin activated the prolactin receptors in most subpopulations of hypothalam

52 is the first indication of a role for short prolactin receptors in the regulation of cell proliferat

53 In this model, the expression levels of prolactin receptors in the retina were upregulated.

54 is study, we have analyzed the expression of prolactin receptors, including the long receptor form (L

55 uclear translocation of STAT5 as a marker of prolactin receptor induced signaling and expression of F

56 The prolactin receptor is an archetype member of the class I

57 We show that in 2D cultures, the prolactin receptor is basolaterally localized and physic

58 to assess the extent to which the absence of prolactin receptor is limiting, under systemic condition

59 Overexpression of the prolactin receptor is seen in more than 95% of human bre

60 The expression of the prolactin receptor is under the control of two putative

61 Prolactin receptor knockout females are infertile due to

62 esult from systemic endocrine alterations in prolactin receptor knockout mice, mammary epithelium fro

63 During pregnancy, the prolactin receptor knockout transplants showed normal si

64 eptor knockout mice, mammary epithelium from prolactin receptor knockouts was transplanted into mamma

65 tion was associated with reductions in islet prolactin receptor levels, STAT5 nuclear localization an

66 oming peptides as a mimic peptide of natural prolactin receptor ligands.

67 In knockout mice lacking the prolactin receptor, mammary development is normal up to

68 The aim of this study was to correlate prolactin receptor mediated signaling and prolactin indu

69 Human prolactin (hPRL) binds two human prolactin receptor molecules, creating active heterotrim

70 IGF-2 and prolactin receptor mRNAs colocalize in the mammary epith

71 investigate whether increased expression of prolactin receptor (PRL-R) during lactation is caused by

72 l mutation that uncouples signaling from the prolactin receptor (PRL-R) to its downstream mediator St

73 male mice in the presence and absence of the prolactin receptor (PRLR(-/-)).

74 in and placental lactogen signal through the prolactin receptor (PRLR) and contribute to adaptive bet

75 ), is significantly reduced due to decreased prolactin receptor (Prlr) and ErbB4 expression in Xbp1-d

76 comes by activating their cognate receptors, prolactin receptor (PrlR) and erythropoietin receptor (E

77 show that CN/Nfatc1 regulates expression of prolactin receptor (Prlr) and that canonical activation

78 e examined the specific contributions of the prolactin receptor (PrlR) and the signal transducers and

79 cently showed that a retrovirally transduced prolactin receptor (PrlR) efficiently supports the diffe

80 The short form (S1b) of the prolactin receptor (PRLR) silences prolactin-induced act

81 induce the oncogenic activation of the human prolactin receptor (PRLR) was examined by deleting 178 a

82 led that >98% of ovarian cancers express the prolactin receptor (PRLR), forming the basis of a new mo

83 The prolactin receptor (PRLR), its associated Janus kinase 2

84 e prolactin and downstream activation of the prolactin receptor (Prlr)-Jak-Stat5 pathway.

85 other cytokine receptors: IL-4R, IL-9R, and prolactin receptor (PRLR).

86 result of ligand-induced dimerization of the prolactin receptor (PRLr).

87 n neuroblastoma SH-SY5Y cells, we employed a prolactin receptor (PrlR)/erythropoietin receptor (EpoR)

88 Prolactin receptors (PRLr) expressed in a majority of br

89 We found that MPOA neurons expressing prolactin receptors (Prlr) form the nexus of a complex p

90 As these neurons express prolactin receptors (Prlr), prolactin may regulate GABA

91 ng through hepatocyte-predominant short-form prolactin receptors (PRLR-S), constrained TNF receptor-a

92 Prolactin receptors (PRLRs) are widely expressed, and mu

93 istribution and ontogenesis of expression of prolactin receptors (PRLRs) in human fetal tissues at 7.

94 igh-affinity ligand-binding interface of the prolactin receptor, resulting in a loss of downstream si

95 rolactin, a lactogenic hormone, binds to two prolactin receptors sequentially, the first receptor bin

96 d OAS expression may result in modulation of prolactin receptor signaling and thus contribute to supp

97 correlated with the luteal induction of the prolactin receptor signaling inhibitors suppressor of cy

98 Functional prolactin receptor signaling was further demonstrated in

99 st cancer progression and therapy as loss of prolactin receptor-Stat5 signaling occurs frequently and

100 Members of the cytokine/growth hormone (GH)/prolactin receptor superfamily transduce signals by asso

101 ellular or intracellular domains enabled the prolactin receptor to copatch with EpoR.

102 h impaired intercellular junction formation, prolactin receptor trafficking, and alveolar lumen devel

103 Quantification of differential expression of prolactin receptor variants by real-time PCR in 15 pairs

104 Both the long and short form of the prolactin receptor was expressed, yet only the long isof

105 Since the presence of prolactin receptors was earlier demonstrated in hypothal

106 Using a novel conditional deletion of the prolactin receptor, we have identified functional subpop

107 tinal polypeptide, purinergic, androgen, and prolactin receptors were also expressed in gland of Wolf

108 Kisspeptin neurons, which express prolactin receptors, were recently identified as major r

109 in barrier, was examined for the presence of prolactin receptors, which would render it a potential s