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1 tase, which appeared to be essential for the proliferative effect.
2 polyphosphate levels and abrogates the anti-proliferative effect.
3 hibits MMP activity, has no significant anti-proliferative effect.
4 ro IGF-I induced both an antiapoptotic and a proliferative effect.
5 in they undergo apoptosis, counteracting the proliferative effect.
6 t-dependent, manifesting both inhibitory and proliferative effects.
7 nt but does not significantly alter the anti-proliferative effects.
8 reonine kinase which has anti-viral and anti-proliferative effects.
9 rr virus (EBV) oncogenes exert potent B cell proliferative effects.
10 ects of insulin, whereas IR-A rather signals proliferative effects.
11 eta-cells versus possible adverse pancreatic proliferative effects.
12 that this property is essential to its anti-proliferative effects.
13 ogenous PR abrogated progestin-mediated anti-proliferative effects.
14 atherosclerotic, anti-inflammatory, and anti-proliferative effects.
15 ptide mimetic that exhibits significant anti-proliferative effects against erbB-2-dependent breast ca
16 ts and vegetables, has shown remarkable anti-proliferative effects against various malignant cell lin
18 in either order resulted in synergistic anti-proliferative effects, although the mechanism of synergy
20 r transcription factor, which possesses anti-proliferative effects and is frequently silenced in ovar
21 cytes is a pathway by which Shh produces its proliferative effects and offers a potential therapeutic
24 s, such as rheumatoid arthritis, without the proliferative effect associated with traditional estroge
27 ective inhibitor of CARM1 that exhibits anti-proliferative effects both in vitro and in vivo and, to
28 the permissive temperature does not exert a proliferative effect but causes p53-mediated apoptosis,
29 in the liver can have both antiapoptotic and proliferative effects, but it is unclear which liver cel
31 ve glucose homeostasis, TZDs also exert anti-proliferative effects by a mechanism that is unclear.
32 e results suggest that adiponectin can exert proliferative effects by activating Ras signaling pathwa
33 at quinoxaline antibiotics could exert anti- proliferative effects by inhibition of chromosomal DNA r
34 t anti-inflammatory, anti-apoptotic and anti-proliferative effects by modulating intracellular signal
36 y and G(2)-M phase to contribute to its anti-proliferative effect, degradation of activated Akt and B
37 uses p53-mediated apoptosis, i.e., the tal-1 proliferative effect depends on the integrity of the cel
39 pathways correlates with a significant anti-proliferative effect, due to cell-cycle regulation leadi
41 s mediate prominent differentiative and weak proliferative effects; (iii) the antiproliferative and a
42 IGF-I receptor alone but had an even greater proliferative effect in cells overexpressing both the IG
52 d PL and TRAIL demonstrated significant anti-proliferative effects in a triple-negative breast cancer
54 fore and during the treatment suggested that proliferative effects in BM may have preceded effects on
55 ve metabolite of vitamin D(3), mediates anti-proliferative effects in cells by regulating the express
56 synthetic processing intermediates also have proliferative effects in colonic mucosa and in some oeso
57 l program causes potent, NOTCH-specific anti-proliferative effects in cultured cells and in a mouse m
58 This is associated with anti-apoptotic and proliferative effects in epithelial progenitors, whereas
59 hese data indicate that Nef induces multiple proliferative effects in podocytes in culture and that n
60 ate that a key event in the artemisinin anti-proliferative effects in prostate cancer cells is the tr
62 ing human amphiregulin was examined for anti-proliferative effects in the human skin-severe combined
63 receptor (ER)-beta is thought to exert anti-proliferative effects in the normal prostate but support
64 verexpression of the H30N enzyme causes anti-proliferative effects in vitro and anti-tumor effects in
65 ignaling pathways mediating CAMKII-dependent proliferative effects in vivo are poorly understood.
66 These early-age neurotrophic and neurogenic (proliferative) effects in the Arg-61 mouse may be an ina
68 ZD4547 (1-5 microM) demonstrated potent anti-proliferative effects, inhibition of stemness, and suppr
69 ement of neuronal nitric-oxide synthase, the proliferative effect is mediated via an NO/cyclic guanos
71 y through which estrogen, independent of its proliferative effect, may induce heparanase overexpressi
72 rapamycin pathway and/or by facilitating the proliferative effect mediated by growth factors such as
73 Ras (N17) failed to significantly reduce the proliferative effect mediated by the sst(4) receptor but
78 vestigated whether TGFbeta mediates the anti-proliferative effect of atRA and BMS453 in normal breast
81 teins (cdk6R31C) was found to inactivate the proliferative effect of cdk6 and increase cytoplasmic lo
83 gainst IGF-II to cell cultures inhibited the proliferative effect of CRD-BP knockdown, suggesting tha
87 id (EPA, C20:5) shifted the pro-survival and proliferative effect of estrogen to a pro-apoptotic effe
91 tes is unclear, we hypothesize that the anti-proliferative effect of FOXO3 was dependent on lowering
96 ed the antiapoptotic effect of IGF-I and the proliferative effect of IL-6 in the myeloma cell lines.
99 tivity is necessary for the IRS-1/2-mediated proliferative effect of IL-9 and IL-4, Akt activation is
102 Bilateral nephrectomy did not diminish the proliferative effect of KGF on urothelium, suggesting th
104 H]thymidine incorporation, thus ruling out a proliferative effect of malignant cells on the surroundi
105 not dorsal growth, and that it mediates the proliferative effect of midline N signaling in a ventral
108 ts is one possible mechanism to modulate the proliferative effect of Notch in the committed osteoblas
109 l rat hippocampal cultures, we show that the proliferative effect of NPY on nestin(+) precursor cells
111 flammatory cytokines in vivo can inhibit the proliferative effect of PDGF on human RPE and, at the sa
112 Formation of heterodimers enhances the anti-proliferative effect of PF4 on endothelial cells in cult
116 small molecule inhibitor, augmented the anti-proliferative effect of RAPA on EBV+ B cell lymphomas.
118 the SCF-treated tissue, suggesting a direct proliferative effect of SCF; conversely, treatment with
120 lized p27-null cells to demonstrate that the proliferative effect of Spy1 depends on the presence of
121 Furthermore, forskolin abolished the anti-proliferative effect of tannic acid on cholangiocyte pro
124 strin decreased during hypergastrinemia, the proliferative effect of TGF-alpha on ECL cells was speci
127 We find that the combination of the anti-proliferative effect of the cytokine TGF- beta and the i
132 (HER2) to determine if it modifies the anti-proliferative effect of transforming growth factor (TGF)
133 o-L-arginine methyl ester prevented both the proliferative effect of VEGF and Raf-1 activation by VEG
135 orporation were reduced, suggesting that the proliferative effect of VEGF was restricted developmenta
139 lines revealed that sensitivity to the anti-proliferative effects of 1alpha, 25(OH)2D3 was strongly
140 r, our data support a model whereby the anti-proliferative effects of 1alpha,25(OH)2D3 are mediated,
141 the use of uridine, which reverses the anti-proliferative effects of A77 1726 caused by inhibition o
142 In this study, we investigated the anti-proliferative effects of adaphostin in the human prostat
144 783, and leucine 784) largely abolished the proliferative effects of alphavbeta6, but none of the mu
148 Abl-deficient mice are hyporesponsive to the proliferative effects of B cell Ag receptor (BCR) stimul
154 posure, are reassuring and contrast with the proliferative effects of conventional combined hormone t
157 D cells and reduced their sensitivity to the proliferative effects of E2, while having no effect on t
161 and investigated their role in mediating the proliferative effects of endothelin-1 (ET-1) on distal h
163 wth suppression in MCF-7 cells, but the anti-proliferative effects of ERbeta1 could be overridden by
164 tionally hyperactive AR, suggesting that the proliferative effects of ERG and PRMT5 are mediated thro
166 r prevention and treatment by inhibiting the proliferative effects of estrogen that are mediated thro
168 rapeutic target because ERalpha mediates the proliferative effects of estrogens on the mammary gland
171 se results demonstrate that rac mediates the proliferative effects of G-protein coupled receptors thr
176 olorectal cancers, its role in mediating the proliferative effects of gastrin1-17 (G-17) on these can
177 as a primer to sensitize hepatocytes to the proliferative effects of growth factors and offers a mec
178 tomas are known to produce GRP; however, the proliferative effects of GRP on neuroblastomas have not
179 naling pathway, we hypothesize that the cell proliferative effects of hamartin and tuberin are partly
181 biologically active, and it neutralized the proliferative effects of human CSF-1 in a dose-dependent
182 l line as a relevant model to study the anti-proliferative effects of ICI182,780 and identified the n
186 of events that functionally connect the anti-proliferative effects of interferons with the IRF1-depen
192 -gamma-positive spots on ELISPOT, and 7) the proliferative effects of MIG/CXCL9 were mediated via an
193 ICD in the c57MG cell line recapitulated the proliferative effects of MMP7 in vitro and in vivo.
195 ings that RU-486 could partially prevent the proliferative effects of N-CAM, inhibition of MAP kinase
204 by TRAF6-binding peptide abrogated the anti-proliferative effects of RANKL, suggesting the critical
205 Our results indicate that the pro- and anti-proliferative effects of ROS can be independently modula
207 ors, but how cells become insensitive to the proliferative effects of Shh is not well understood.
209 yeloid cell lines respond to the synergistic proliferative effects of SLF plus other cytokines in a m
211 eptor was first suggested by the strong anti-proliferative effects of soluble heparin-like molecules
212 ether with classic ER signaling, mediate the proliferative effects of synthetic estrogens such as tam
215 ted against IL-1alpha could abate the growth proliferative effects of TGF-beta without compromising i
217 t1-expressing neural crest and that the anti-proliferative effects of Tgfbeta depend on Arf in vivo.
219 the role of this receptor in the peroxisome proliferative effects of the endogenous steroid dehydroe
220 nsgenic mice were also hypersensitive to the proliferative effects of the skin tumor promoter, 12-0-t
221 increase in active TGFbeta mediates the anti-proliferative effects of these retinoids, a TGFbeta-bloc
223 human and murine cells, suggestive that the proliferative effects of TNF-alpha may be limited to ery
224 ingle TP53 target gene required for the anti-proliferative effects of TP53 during pharmacological act
225 sensitizes prostate cancer cells to the anti-proliferative effects of vitamin E and that this activit
226 nd forced expression of MBP-1 exerts an anti-proliferative effect on a number of human cancer cells.
227 is factor (TNF) ligand superfamily and has a proliferative effect on both normal and tumor cells.
228 kt phosphorylation and showed a greater anti-proliferative effect on EBV+ B lymphoma lines compared t
231 confirmed initially that EVO exerted an anti-proliferative effect on human epithelial ovarian cancer
232 pression of p202 was associated with an anti-proliferative effect on human prostate cancer cells.
238 ctor (KGF or FGF7) has a differentiative and proliferative effect on the epithelium of the developing
240 nd that has recently been shown to have anti-proliferative effects on a number of human cancer cell t
241 b (SCH727965, MK-7965), exhibits potent anti-proliferative effects on a panel of NB cell lines by blo
242 oliferative effects on Namalwa cells and pro-proliferative effects on CD34+ cells, whereas p21WAF-1 e
246 e indicates that extracellular factors exert proliferative effects on neurogenetic precursors in vivo
247 let-derived growth factor were found to have proliferative effects on Schwann cells, but they had no
248 st cell-derived bFGF might exert fibrogenic, proliferative effects on smooth muscle cell/myofibroblas
249 eviously shown that RSpo proteins can induce proliferative effects on the gastrointestinal epithelium
251 2 and E2F3 mutant backgrounds alleviated Myc proliferative effects on the pregnant mammary gland, red
252 ve hematopoietic cells and its ligand exerts proliferative effects on these cells in vitro in synergy
253 mAbs C225 and 4D5 resulted in additive anti-proliferative effects on these cells, which was accompan
256 active form of vitamin D, has selective anti-proliferative effects on tumor-derived endothelial cells
257 ependent protein kinase II inhibitors showed proliferative effects only on cardiomyocytes in early de
259 ese data indicate that the ouabain-activated proliferative effect previously observed in canine VSMCs
260 bservations indicate that progastrin induces proliferative effects, primarily in colonic progenitor c
262 nM, with a concentration of 100 nM achieving proliferative effects similar to those of 1 nM estradiol
263 of exogenous interleukin (IL)-2 also had no proliferative effect, suggesting that the mPEG-modified
264 to PL with hPL did not have significant anti-proliferative effects, suggesting that hPL is not membra
265 BRAF and MEK inhibition may reduce cutaneous proliferative effects that arise on BRAF inhibitor monot
266 constriction but also exerts profibrotic and proliferative effects that change vessel architecture, w
268 stem/progenitor cells TKIs exert potent anti-proliferative effects through a poorly understood mechan
269 mediates its potent anti-thrombotic and anti-proliferative effects through its G protein-coupled rece
270 line) ectopic tal-1 expression induces (i) a proliferative effect under suboptimal culture conditions
274 SN5 knockdown signature showed that the anti-proliferative effect was driven by a common subset of mo
282 east tumour explants, and had increased anti-proliferative effects when coupled with an ERalpha antag
283 human cancers and pro-apoptotic and/or anti-proliferative effects when re-expressed in tumor cell li
284 ression of securin resulted in a significant proliferative effect, whereas high levels of securin exp
285 tant being that FGF19 has both metabolic and proliferative effects, whereas FGF21 has only metabolic
286 ctivation was found to be essential for this proliferative effect, which was further confirmed by in
287 lar activation of p-ERK, p-AKT, and cellular proliferative effects, which were abrogated following Kl
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