ライフサイエンスコーパス: proliferative potential

1 nd was accompanied by a profound decrease in proliferative potential.

2 f-renew and produce progenitors with limited proliferative potential.

3 trated that up to 3.6% of Foxl1(+) cells had proliferative potential.

4 (PSCs) express telomerase and have unlimited proliferative potential.

5 te cell differentiation by restricting their proliferative potential.

6 creased progenitor and stem cell numbers and proliferative potential.

7 nctions was associated with a decline of the proliferative potential.

8 gth of telomeres within a cell regulates its proliferative potential.

9 ade apoptosis rather than to simply increase proliferative potential.

10 iation, thereby indefinitely extending their proliferative potential.

11 ansit amplifying cells, which have a limited proliferative potential.

12 bsequent recovery of their original size and proliferative potential.

13 und that meristems retain their identity and proliferative potential.

14 sformed counterparts, which possess enhanced proliferative potential.

15 ls and discriminated by their clonogenic and proliferative potential.

16 otective immunity because of their increased proliferative potential.

17 hat cells must eliminate to attain unlimited proliferative potential.

18 an CD34- cells (p<0.05), indicating a higher proliferative potential.

19 sorders and laboratory work suggesting their proliferative potential.

20 e important for cancer cells to extend their proliferative potential.

21 s have been thought to have limited, if any, proliferative potential.

22 al myogenic commitment connected to impaired proliferative potential.

23 reduced as cells approached the end of their proliferative potential.

24 a view to possible manipulation of cellular proliferative potential.

25 tently gives rise to progenitors with robust proliferative potential.

26 iverse subpopulations of cells with distinct proliferative potential.

27 s in terms of both their phenotype and their proliferative potential.

28 onfirmed the correlation of this marker with proliferative potential.

29 including neoplastic cells, with and without proliferative potential.

30 ors in the culture medium and maintain their proliferative potential.

31 n, it's deletion led to a reduction in their proliferative potential.

32 subnetwork signatures as a function of tumor proliferative potential.

33 erentiated cancer cells that possess limited proliferative potential.

34 e progression, and establish their extensive proliferative potential.

35 heir broad Notch-dependent developmental and proliferative potential.

36 T(SCM)) that include increased longevity and proliferative potential.

37 reast cancer define tumors with CIN and high proliferative potential.

38 a2T cell phenotype, cytokine production, and proliferative potential.

39 50% of effector T cells, and preservation of proliferative potential.

40 ect upon the OPC population, modifying their proliferative potential.

41 er telomerase activity indicative of greater proliferative potential.

42 aximizing protective efficacy and preserving proliferative potential.

43 mors accumulate polyploid cells with limited proliferative potential.

44 tory mediators as critical inhibitors of NPC proliferative potential.

45 entiation in the number of dNSCs and altered proliferative potential.

46 d Vbeta repertoire and intact functional and proliferative potential.

47 omeric DNA damage in order to maintain their proliferative potential.

48 , these cells showed comparable survival and proliferative potential.

49 hematopoietic stem cells demonstrate normal proliferative potentials.

50 ibit distinct phenotypic characteristics and proliferative potentials.

51 -domain of SIX1 and SIX2 in tumors with high proliferative potential (18.1% of blastemal cases); muta

52 56% of Lin- Rho(low)/Ho(low) cells are high-proliferative potential (7 factor-responsive) colony-for

53 cyte population, which affects cardiomyocyte proliferative potential after injury.

54 tic growth, chromosomal aneuploidy, and high proliferative potential after transplantation into adult

55 erentiation marker expression, and increased proliferative potential, all effects that occur with ars

56 k between increased senescence and decreased proliferative potential among cancers.

57 Here we assess lineage capacity and proliferative potential among five distinct components o

58 re is a continuous generation of variants in proliferative potential among growing cells that provide

59 olony-forming efficiency, a longer long-term proliferative potential, an enriched quiescent cell popu

60 Because CPCeA exhibit remarkable proliferative potential, an inducible system mediating n

61 rarchy of EPCs based on their clonogenic and proliferative potential, analogous to the hematopoietic

62 n N-terminal fragment (GrB-EH(ITSN)) with EC proliferative potential and a C-terminal product with do

63 PCs were the sole population that maintained proliferative potential and an undifferentiated state in

64 Knockdown of CD46 decreased proliferative potential and beta1 integrin-mediated adhe

65 +)KDR(+) cell subset, endowed with long-term proliferative potential and bilineage differentiation ca

66 are postnatal hepatic progenitors with high proliferative potential and bipotent differentiation abi

67 Because of its higher proliferative potential and capacity to produce IL-2, we

68 Differences in oRG behaviors, including proliferative potential and daughter cell fates, may con

69 plays an important role in determining their proliferative potential and demonstrate that O-2A cell K

70 ered by a lack of functional assays to gauge proliferative potential and differentiation capacity.

71 ted by many existing strategies have limited proliferative potential and display vascular instability

72 led to reveal any significant trends between proliferative potential and donor age.

73 ograms that restrict cancer cells' long-term proliferative potential and drive their differentiation.

74 As basal cells become suprabasal, they lose proliferative potential and embark on a terminal differe

75 ut T cells demonstrate significantly reduced proliferative potential and fail to effectively induce e

76 We conclude that proliferative potential and gain of effector function ar

77 They maintain their proliferative potential and globally repressing undesira

78 r of a distinct NKT subset endowed with high proliferative potential and have developed artificial an

79 om the involuted thymus exhibit a diminished proliferative potential and increased rate of apoptosis

80 f IFN-gamma, but not IL-2, decreased ex vivo proliferative potential and increased susceptibility to

81 tes epidermal differentiation by restricting proliferative potential and inducing cell-cycle exit.

82 is principally restricted to cells with high proliferative potential and is absent from the cells tha

83 E2F3 is an oncogene with strong proliferative potential and is regularly dysregulated or

84 T within normal epithelial cells that retain proliferative potential and its presence at the earliest

85 Reduced T cell homeostatic proliferative potential and life span in vivo were found

86 pected link between chromatin accessibility, proliferative potential and patterns of human variation.

87 ize of pNSC clones, which exhibited enhanced proliferative potential and precocious neuronal differen

88 y CD8+ T cell quantity but reportedly erodes proliferative potential and protective efficacy.

89 of cellular senescence (irreversible loss of proliferative potential and senescent morphology).

90 effectors yielded memory cells with enhanced proliferative potential and stronger protective capacity

91 omeres, characteristics that suggest greater proliferative potential and that have been linked to gre

92 table endothelial phenotype with high clonal proliferative potential and the capacity to form human v

93 ains can exhibit marked differences in their proliferative potential and timing of differentiation.

94 ein (MEZ) results in an irreversible loss of proliferative potential and tumorigenic properties with

95 from these immortalized cell lines had high proliferative potential and were able to differentiate i

96 alpha expression on ECFCs selects for higher proliferative potential and when removed from the cell s

97 ymus and make T cells, but possess different proliferative potentials and lineage capacities.

98 te-erythrocyte-macrophage-monocyte, CFU-high proliferative potential) and primitive hemopoietic stem

99 altered patterns of gene expression, reduced proliferative potential, and a loss of tumorigenicity.

100 d with a higher clonogenicity, a longer-term proliferative potential, and a slower cycling cell popul

101 ey are slow cycling, possess a high in vitro proliferative potential, and can reconstitute highly bra

102 However, the origin, proliferative potential, and differentiation capacity of

103 nsplanted EMPs home to the PBI, show limited proliferative potential, and do not seed subsequent hema

104 cells compromised their differentiative and proliferative potential, and enhanced growth factor with

105 onally distinct from CFU-ECs, display robust proliferative potential, and form perfused vessels in vi

106 peripheral blood, primitive cells with high proliferative potential, and mature lineage-restricted m

107 e no significant effect on cell viability or proliferative potential, and recovered cells were demons

108 enhanced cell-substratum adhesion, increased proliferative potential, and reduced cell motility, feat

109 sform has been linked to their longevity and proliferative potential, and stimulation of the B cell r

110 haracteristics, including multipotency, high proliferative potential, and their cardinal feature of q

111 to define a hierarchy of EPCs based on their proliferative potential, and they identify a unique popu

112 estly retards telomere shortening, increases proliferative potential, and, importantly, enhances cyto

113 fected rejection of primitive (CFU-HPP [high-proliferative potential]) and lineage-committed (CFU-IL3

114 bestow therapeutic resistance and limitless proliferative potential are incompletely understood.

115 cular mechanisms controlling glial precursor proliferative potential are unknown.

116 n melanocytes exhibit a physiologic decay in proliferative potential as it transitions to a growth-ar

117 proliferate or, minimally, to secure future proliferative potential as latent reservoirs.

118 A novel paradigm using proliferative potential as one defining aspect of EPC bi

119 arts, but are remarkably endowed with a high proliferative potential as revealed in cell culture assa

120 rythrocyte-megakaryocyte-monocyte , CFU-high proliferative potential), as well as 2- and 3-fold incre

121 urthermore, c-Kit was a functional marker of proliferative potential, as c-Kit inhibition by short ha

122 n were spleen CD4 T cells, but had a similar proliferative potential based on their response to CD3 l

123 n has been used to detect cells of increased proliferative potential but further stem cell markers ar

124 ssion (Id1(low)) identifies tumor cells with proliferative potential but limited self-renewal capacit

125 ntiation within stem cell lineages can check proliferative potential, but nodal pathways that can lim

126 n that differentiation can regulate cellular proliferative potential by modulating the balance of pos

127 l PRC2 activity is required to maintain DIPG proliferative potential, by repressing neuronal differen

128 This exhaustion of proliferative potential, called senescence, can be trigg

129 ted with a disease characterized by unabated proliferative potential, cancer.

130 Based on their longevity and proliferative potential, CD4(+) T memory stem cells (TSC

131 High proliferative-potential CFCs that generated multilineage

132 The total number of high proliferative-potential CFCs with erythroid, myeloid, an

133 ssessed phenotypic properties as well as the proliferative potential characteristic of primitive HSCs

134 ive loss of both their effector function and proliferative potential, clonal deletion, and significan

135 idually cultured low Ho/Rh cells formed high proliferative potential clones.

136 and delayed terminal differentiation of low proliferative potential cluster-forming cells.

137 A maximal increase in frequency of high proliferative potential colonies (HPPC) (11-fold) and CF

138 precursor cell population, measured in high-proliferative potential colony assay and day 12 colony-f

139 suppressed the colony formation by the high proliferative potential colony-forming cell (HPP-CFC), w

140 plenic erythroid burst-forming unit and high-proliferative potential colony-forming cell levels in bo

141 rogenitors assayed in vitro as high- and low-proliferative potential colony-forming cells (HPP- and L

142 was efficiently transduced into single high proliferative potential colony-forming cells (HPP-CFC) a

143 Increased high proliferative potential colony-forming cells (HPP-CFC) w

144 hage, burst-forming unit-erythroid, and high proliferative potential colony-forming cells (HPP-CFC) w

145 ursors, we investigated the kinetics of high proliferative potential colony-forming cells (HPP-CFC),

146 also a potent suppressor of bone marrow low proliferative potential colony-forming cells, a committe

147 ematopoietic progenitors, including the high-proliferative potential colony-forming cells.

148 iple drug resistance 1 (MDR1) mRNA from high proliferative potential-colony forming cell (HPP-CFC) co

149 uency of colony-forming units (CFU) and high proliferative potential-colony forming cells (HPP-CFC) d

150 ferative potential-colony forming cells, low proliferative potential-colony forming cells, and cells

151 ent potential contained the majority of high proliferative potential-colony forming cells, low prolif

152 TGF-beta 1 resulted in a maintenance of high proliferative potential-colony-forming cell (HPP-CFC) du

153 SOC showed a significantly greater in vitro proliferative potential compared with EOCs of similar pa

154 cells from the Hex(-/-) EBs showed enhanced proliferative potential compared with those from wild-ty

155 ursors that undergo differentiation as their proliferative potential decreases.

156 bitor of the TNF-alpha receptor-1, increases proliferative potential, delays loss of CD28 expression,

157 C competitiveness, lineage bias, or enhanced proliferative potential, demonstrating that pulse exposu

158 tress, leading to loss of reconstitution and proliferative potential, diminished self-renewal, increa

159 ss through a coherent program in which their proliferative potential diminishes in a predictable mann

160 1p substrates that may affect maintenance of proliferative potential during stationary phase, we sear

161 an ITSN fragment with endothelial cell (EC) proliferative potential (EHITSN), present in the lungs o

162 nd they identify a unique population of high proliferative potential-endothelial colony-forming cells

163 erived KO pNSCs and dNSCs displayed impaired proliferative potential, enhanced cell death and altered

164 layed: impaired lineage restriction, reduced proliferative potential, enhanced late-stage self-renewa

165 Proliferative potential for regeneration and adaptive re

166 ced migration of keratinocytes with retained proliferative potential, forming a confluent layer for r

167 ons of a single PI3K isoform can enhance the proliferative potential, function, and survival of CD8(+

168 ming an endothelial colony forming cell with proliferative potential has been given.

169 tic beta cells during aging and limits their proliferative potential; however, its effects on beta ce

170 lomere length, colony size distribution, and proliferative potential in 2 BEAC cell lines, BIC-1 and

171 Normal cells have limited proliferative potential in culture, a fact that has been

172 postnatal keratinocytes in their much lower proliferative potential in culture; isolated single kera

173 loid and lymphoid cells, and (4) have a high proliferative potential in long-term stromal cell-free l

174 gnaling identifies CD8 T cells with enhanced proliferative potential in part independent of commonly

175 n-induced apoptosis but showed a decrease in proliferative potential in the absence of interleukin-3

176 , survive androgen deprivation, and maintain proliferative potential in the hypoxic, androgen-deprive

177 ic progenitor cells (HPCs) have an increased proliferative potential in vitro and in vivo.

178 Low Ho/low Rh cells clone with high proliferative potential in vitro in the presence of stem

179 les were sufficient to induce changes in AT1 proliferative potential in vitro.

180 oncomitant loss of their differentiative and proliferative potential in vivo have largely been unsucc

181 cells cultured from skin exhibit prodigious proliferative potential; in fact, for >20 years now, cul

182 Obstacles to the expansion of cells with proliferative potential include the induction of cell de

183 Although adaptive immune cells have high proliferative potential, innate immune cells are mostly

184 hematopoietic cells and measurement of their proliferative potential is critical in many research and

185 Since ECFC proliferative potential is increased in cord versus peri

186 rd transplantation conditions, the stem cell proliferative potential is not compromised during hemato

187 gth; it is possible that, as a result, their proliferative potential is reduced.

188 ells as a means of enforcing their unlimited proliferative potential is widely accepted, yet identifi

189 ECs were characterized by greatly stimulated proliferative potential, loss of contact inhibition, and

190 y reactivate telomerase to achieve unlimited proliferative potential, making telomerase a unique ther

191 gene-corrected cells had normal morphology, proliferative potential, matrix attachment and motility.

192 Loss of HIPK2 leads to increased proliferative potential, more rapid G1-S transition in c

193 of divisions to apoptosis, which limits the proliferative potential of a stem cell to the precise ti

194 We demonstrate that Celastrol suppresses the proliferative potential of acute myeloid leukemia (AML)

195 subsequent DNA methylation affect the finite proliferative potential of Ag-specific CD8+ T cells with

196 r cell proliferation in vivo and altered the proliferative potential of airway progenitors in vitro.

197 ess is due at least in part to the decreased proliferative potential of aneuploid hematopoietic cells

198 ls in culture have generally shown a limited proliferative potential of approximately 10 to 40 popula

199 ll subsets differently and uncovers the high proliferative potential of B and non-Treg T cells in thi

200 ification during development and maintaining proliferative potential of basal keratinocytes in mature

201 We show that Ezh2 controls proliferative potential of basal progenitors by repressi

202 nt pathway(s) might contribute to the higher proliferative potential of BCR/ABL-expressing and, perha

203 tal phenotype of stem cells and the aberrant proliferative potential of cancer cells.

204 r 3 weeks (Delta assay), the cytokine-driven proliferative potential of CD34(+) cells was not impaire

205 Here we investigated the proliferative potential of CD8(+) memory T cells induced

206 t1 resulted in a significant decrease in the proliferative potential of cells that was associated wit

207 MnSOD), an antioxidant enzyme, regulates the proliferative potential of confluent human fibroblasts.

208 rations in the diploid MEP strain--while the proliferative potential of daughter cells is eliminated.

209 rate significant, age-related defects in the proliferative potential of early B cell precursors and s

210 mechanics, leading to enhanced migratory and proliferative potential of ECs during the initiation of

211 d that expression with cell cycle status and proliferative potential of engrafting fractions.

212 The lack of a detailed understanding of the proliferative potential of EPCs and CECs has contributed

213 C-terminus links cell cycle control and the proliferative potential of epidermal progenitor cells vi

214 sively declines with age and correlates with proliferative potential of epidermal progenitors.

215 ectoderm to stratified epithelia and for the proliferative potential of epithelial stem cells.

216 way, which is crucial for the maintenance of proliferative potential of germ and stem cell population

217 Also, the proliferative potential of GP33-specific CD8 T cells fro

218 The proliferative potential of GrB-EH(ITSN) is mediated via

219 (i) epiphyseal fusion is triggered when the proliferative potential of growth plate chondrocytes is

220 Here we report that NPM enhances the proliferative potential of hematopoietic stem cells (HSC

221 leading to very short telomeres and limited proliferative potential of hematopoietic stem cells.

222 Moreover, the limited proliferative potential of HRS cells belies the clinical

223 rexpression of SIRT3 promoted an increase in proliferative potential of Hs294T melanoma cells and nor

224 changes in medium composition can expand the proliferative potential of human mammary epithelial cell

225 As a result, the mitogenic and proliferative potential of IGF-I and IGF-II were signifi

226 ional methods, to systematically analyze the proliferative potential of individual HSCs.

227 CDC25A inhibition reduces the clonogenic and proliferative potential of JAK2(V617F)-expressing cell l

228 lecular basis responsible for regulating the proliferative potential of keratinocytes has important i

229 erative index is dependent on the underlying proliferative potential of kidney tubule cells.

230 he limbal basal layer, the superior in vitro proliferative potential of limbal epithelial cells, and

231 ced tumour growth and markedly decreased the proliferative potential of lung cancer cells, leading to

232 uced in vivo effects on angiogenesis and the proliferative potential of MCF10AT xenografts.

233 Thus, the poor proliferative potential of memory T cells and altered me

234 Pf1 inactivation impairs the proliferative potential of mouse embryonic fibroblasts (

235 trate the enhancing effect of MLL-ELL on the proliferative potential of myeloid progenitors as well a

236 Although our studies clearly demonstrate the proliferative potential of myeloma plasma cells, they ar

237 t has been suggested that an increase in the proliferative potential of neural progenitors (NPs) unde

238 cytokines, we examined whether the increased proliferative potential of NFS-60 cells in response to S

239 The finite proliferative potential of normal human fibroblasts can

240 Exposure to PPA had no effect on proliferative potential of normal intestinal cells.

241 ose and glutamine metabolism compromises the proliferative potential of NPCs and that this is exacerb

242 suggesting a role for these subunits in the proliferative potential of OPs in situ.

243 egatively regulatory effects that reduce the proliferative potential of OSE cells leading to the low-

244 d expression may be associated with enhanced proliferative potential of pancreatic cancer cells and o

245 or Ikaros function, which is to suppress the proliferative potential of persistent TCR signals and to

246 To determine the proliferative potential of polzeta-deficient skin epithe

247 ing epidermis fails to properly restrict the proliferative potential of progenitor cells, and culture

248 pansion has been attributed to the increased proliferative potential of radial glia (RG; neural stem

249 load at the time of vaccination and the low proliferative potential of responding T cells are likely

250 l cycle progression required to maintain the proliferative potential of stem cells of many different

251 , but no significant correlation between the proliferative potential of the cell lines and donor age

252 Vaccines aim to harness the proliferative potential of the immune system by expandin

253 The proliferative potential of the liver has been well docum

254 in expression and suggest that the increased proliferative potential of the mutant cells may be suppr

255 uitment, and that is to enhance the survival/proliferative potential of the responding B cells.

256 a dose-dependent manner and can modulate the proliferative potential of the retinal pigment epithelia

257 trial, suggest that telomere length and the proliferative potential of the transferred T cells may p

258 mechanisms of IGF-I-mediated enhancement of proliferative potential of these cells.

259 hile chromosomes 10 or 14 did not affect the proliferative potential of these cells.

260 its essential role for maintaining the high proliferative potential of those corneal epithelial prog

261 These findings, which suggested that the proliferative potential of transferred T cells may play

262 Here we have evaluated the proliferative potential of transplanted primary hepatocy

263 showed that knockdown of Id2 can restore the proliferative potential of tumor cells inhibited by with

264 e and is required for the maintenance of the proliferative potential of tumor cells.

265 s mammary tumour progression by reducing the proliferative potential of tumour cells.

266 pressing differentiation and maintaining the proliferative potential of vascular SMCs.

267 atients with inflammatory disease can confer proliferative potential on cells from patients with noni

268 trols, by 30%, indicating either a decreased proliferative potential or increased cell death of the L

269 Calculation of proliferative potential per Tg+ cell demonstrates that n

270 obblestone areas contain both primitive high-proliferative potential progenitors and in vivo repopula

271 e senescence, causing a reduction in overall proliferative potential, reduced telomerase activity, an

272 e NTERA-2 clone D1 (NT2/D1) displays limited proliferative potential, reduced tumorigenicity, and mor

273 y of 95-98% in vivo, suggesting that maximal proliferative potential requires either a naive phenotyp

274 Proliferative potential, response to multiple cytokines,

275 neonatal rat lungs contain ECFCs with robust proliferative potential, secondary colony formation on r

276 However, these cells exhibited robust proliferative potential showing that expression of CD45R

277 This ultimately led to loss of proliferative potential, stem cell exhaustion, alopecia,

278 m-line BRCA founder mutations have a greater proliferative potential than cancers in women without su

279 ver progenitors were found to have a greater proliferative potential than CD4- CD34++ Lin- progenitor

280 of the cutaneous epithelium and had a higher proliferative potential than Krt1-15-EGFP-negative cells

281 tured faster and had a higher efficiency and proliferative potential than non-CMS cells.

282 interleukin-2 (IL-2) secretion and decreased proliferative potential that are collectively termed 'ex

283 stabilization and blocked the diminution in proliferative potential that normally accompanied REST l

284 counterbalanced by intrinsic differences in proliferative potential that ultimately determine the ra

285 GFR is linked to increased DNA synthesis and proliferative potential, the pathological significance o

286 onstrating that TN cells have a considerable proliferative potential, the results provide insights in

287 istics, most prominently in maintaining high proliferative potential through an unconventional cell-c

288 ed with long-lived memory and have identical proliferative potential to long-boosted T cells Both pop

289 place in vivo, these events could alter the proliferative potential, viability, and even the functio

290 A subset of c-Kit(+) cells with high proliferative potential was found in the luminal ER(+) p

291 enotype lacking direct ex vivo cytotoxic and proliferative potential was identified that was further

292 This IGF-I-induced increase in proliferative potential was mediated via activation of t

293 Adhesiveness and proliferative potential were restored by overexpressing

294 ro conditions show a significantly increased proliferative potential, which is also observed but to a

295 of the lateral ventricle contains cells with proliferative potential, which share morphological and f

296 Loss of PKD2 enhanced KC proliferative potential while loss of PKD3 resulted in a

297 of the committed cardiomyoblast that retains proliferative potential will inform cardiac regenerative

298 d to compare their gene expression and their proliferative potential with those of in vitro counterpa

299 demonstrate that EMPs possess only transient proliferative potential, with differentiated progeny rem

300 Last, PD-1+ CD4 T cells predict impaired proliferative potential yet preferentially secrete the T