ライフサイエンスコーパス: proliferative response

1 hogen challenge despite their poor secondary proliferative response.

2 naive B cells, which resulted in an abortive proliferative response.

3 beta cells without triggering a generalized proliferative response.

4 ate luminal epithelial cells provokes a mild proliferative response.

5 naling events that mediate the FGF-2-induced proliferative response.

6 , and elicits a robust TLR9-dependent B cell proliferative response.

7 at IGF1 replacement does not rescue the KIKO proliferative response.

8 nd plasminogen activator inhibitor-1-induced proliferative response.

9 rction consistent with resurgence of cardiac proliferative response.

10 of these factors in WT T cells inhibited the proliferative response.

11 g in Src-dependent activation of STAT3 and a proliferative response.

12 TNF-alpha, and IL-6 in the augmented T cell-proliferative response.

13 tion of CD8 T cells resulting from inhibited proliferative response.

14 the migratory response without affecting the proliferative response.

15 everolimus could inhibit the CD4CD28 T-cell proliferative response.

16 tibody binding and induction of human T-cell proliferative responses.

17 enes and vaccinia virus, despite weak recall proliferative responses.

18 and programmed death-1 inhibition increased proliferative responses.

19 n, and immunoglobulin secretion, and had low proliferative responses.

20 e sensitive to THPO, activating survival and proliferative responses.

21 sing cholesterol efflux suppressed stem cell proliferative responses.

22 disrupt NF-kappaB-induced cell survival and proliferative responses.

23 uding CD62L and IL-2 expression and enhanced proliferative responses.

24 anied by diminished antigen-specific, T-cell proliferative responses.

25 or ISGs and generation of IFN-inducible anti-proliferative responses.

26 mooth muscle cells thus controlling cellular proliferative responses.

27 arly normal lymphocyte numbers and mitogenic proliferative responses.

28 less reliant on GSK3 inactivation for their proliferative responses.

29 s had nearly equivalent in vivo alloreactive proliferative responses.

30 yme-linked immunospot responses and moderate proliferative responses.

31 faster graft rejection kinetics and greater proliferative responses.

32 s can also induce anti-inflammatory and anti-proliferative responses.

33 ediators, and failed to induce robust T cell proliferative responses.

34 ignificant adaptive CD4(+) and CD8(+) T cell proliferative responses.

35 ency of APCs and boost mitogen-driven T-cell proliferative responses.

36 line with these findings, the cardiomyocyte proliferative response after cardiac injury was lost in

37 paralleled reduced IL-2 secretion and T cell proliferative responses after TCR-CD28 stimulation indic

38 ls from CXCL14-Tg mice exhibited an enhanced proliferative response against collagen II and produced

39 innate immune responses and adaptive T cell proliferative responses, along with only transient antiv

40 sponse represented 16% of the total anti-HIV proliferative response and >70% of the anti-HIV multifun

41 anti-CTLA-4-Ab DC) showed significantly less proliferative response and enhanced IL-10 and TGF-beta1

42 nuation of alloantigen-specific T-lymphocyte proliferative response and IFN-gamma production, and (c)

43 t on T-cell activation, both in terms of the proliferative response and in the context of activation

44 Recipient splenocytes were analyzed for proliferative response and interferon (IFN)-gamma produc

45 remodeling, we demonstrate a myocardium-wide proliferative response and radial migration of progenito

46 colony survival after irradiation, impaired proliferative response and reduced counts of naive T cel

47 Although we found both a high CD4(+) T cell-proliferative response and TH2 cytokines production afte

48 regeneration is associated with a localized proliferative response and the transient expression of e

49 e BE dose greatly affect gene expression and proliferative response and will be crucial determinants

50 lysing CD25(bright) and FoxP3(+) expression, proliferative responses and cytokine production.

51 Drug-specific proliferative responses and cytokine secretion were meas

52 B-cell proliferative responses and differentiation to immunoglo

53 7-CD127(-)CD28(-)CD57(+) phenotype with poor proliferative responses and enhanced staurosporine-induc

54 Both subjects developed antigen-specific proliferative responses and have discontinued immunoglob

55 They display low proliferative responses and impaired antitumor activity

56 n of T-regulatory cells that suppress T-cell proliferative responses and induce tolerance.

57 ificant levels of OVA-specific CD4(+) T cell proliferative responses and OVA-induced IFN-gamma and IL

58 rowth factor-beta(1) (TGF-beta(1))-dependent proliferative responses and Smad signaling.

59 Ex vivo grass antigen-driven T-cell proliferative responses and the frequency of IL-4(+) CD4

60 cardial beta1-integrin was required for this proliferative response, and ventricular cardiomyocyte-sp

61 gene 3 (LAG3)(+) TR1 cells, antigen-specific proliferative responses, and cytokine production.

62 in SF dampened Borrelia burgdorferi-specific proliferative responses, and in 2 patients with antibiot

63 r, the molecular mechanisms that mediate the proliferative response are poorly understood.

64 en-driven IL-4(+) CD4(+) T cells, and T-cell proliferative responses are detectable in the periphery

65 -15/IL-15R homeostatic pathway, although the proliferative responses are enhanced by the stress agent

66 nt on the surface of donor DCs, donor T cell proliferative responses are generated only in response t

67 her hand, showed a prolonged and a sustained proliferative response as evident by an increased number

68 et recognition and stimulation, and enhanced proliferative responses as a result of both IL-2-depende

69 X-specific antibodies and ex vivo splenocyte proliferative responses, as well as haptenation of skin

70 s in p38delta-null mice involves a defect in proliferative response associated with aberrant signalin

71 tially impaired CD8(+)pp65-specific in vitro proliferative responses at 6 d, with concomitantly lower

72 gatively associated with HBV-specific T-cell proliferative responses at both time points.

73 BM4-pulsed mdDC induced enhanced proliferative responses at earlier time-points in Bet v

74 ation process, which revealed differences in proliferative responses between non-genotoxic and genoto

75 regulation of activated CD4(+) T-helper cell proliferative responses; blocking this interaction rever

76 e role for uterine epithelial ERalpha in the proliferative response, but ERalpha is required subseque

77 ital for host-protective anti-viral and anti-proliferative responses, but signaling via this interact

78 d may also contribute to the CSF-1-regulated proliferative response by activating Src family kinase.

79 we show that ELF4 controls the ERK-mediated proliferative response by maintaining normal levels of d

80 mation prior to the induction of full T cell proliferative responses by concurrent indirect Ag presen

81 cells that more efficiently suppress T cell proliferative responses by mixed leukocyte reaction.

82 The proliferative response coincided with detection of the g

83 B cells, or natural killer cells, or T-cell proliferative response compared with interferon beta alo

84 allogeneic DC, they exhibited much inferior proliferative responses compared with bulk CD4 or CD4CD1

85 thy individuals showed lower gluten-specific proliferative responses compared with those of CD patien

86 /EBPalpha as the molecular regulators of the proliferative response, correlating with the chronic hum

87 However, CMV-specific in vitro proliferative responses could be significantly rescued,

88 ned increase in p53 protein, which prevented proliferative responses despite strong signaling through

89 ption of SDF-1/CXCR4 signaling inhibited the proliferative response during vascular remodeling in bot

90 ivation of beta-catenin, and epithelial cell proliferative responses during C. rodentium infection.

91 mination of p53 by TCR signaling that allows proliferative responses, enforcing antigen specificity.

92 turnover but can nevertheless mount a rapid proliferative response following injury.

93 the intestinal epithelium fails to produce a proliferative response following radiation-induced damag

94 Whereas MZ B cells exhibit a robust proliferative response following stimulation with the TL

95 ts suppress telomerase activation during the proliferative response following vascular injury, indica

96 have shown that Gadd45b-/- mice have intact proliferative responses following administration of a si

97 reas beta-catenin-dependent signals elicit a proliferative response from intestinal cells, thymocytes

98 Furthermore, impaired CMV-specific proliferative responses from relapsers, along with T-bet

99 from PKCgamma(-/-) mice did not result in a proliferative response, further indicating the requireme

100 a toxin, triggers a significant compensatory proliferative response in 1-2-year-old animals.

101 aled that they induced a significantly lower proliferative response in allogenic MLR than the B cells

102 (+) cells) showed an enhanced and more rapid proliferative response in an autologous, APC-dependent c

103 udy identifies PKD as a major regulator of a proliferative response in differentiated KCs, probably t

104 s into the mechanism of reinitiation of this proliferative response in differentiated KCs, we examine

105 eeI, SeeL, and SeeM induced a dose-dependent proliferative response in equine CD4 T lymphocytes and s

106 -myc expression fully restored the defective proliferative response in FM B cells.

107 levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MC

108 lthioadenosine (MTA) inhibit mitogen-induced proliferative response in liver and colon cancer cells.

109 from N. lactamica mediate a B cell-dependent proliferative response in mucosal mononuclear cells that

110 FAP filament assembly and inhibition of cell proliferative response in Muller glia.

111 liferation in dermal fibroblasts but an anti-proliferative response in oral fibroblasts.

112 vitro, CTL-expressed Ag induced an abortive proliferative response in specific B lymphocytes, whereb

113 ulting in the lack of a robust cardiomyocyte proliferative response in the adult heart after injury.

114 There was a significant suppression of proliferative response in the GPC3 TG mice, as assessed

115 The prolonged proliferative response in the ILK/liver-/- mice seems to

116 lopmental abnormality in the epithelial cell proliferative response in those mice.

117 Vacc-4x was immunogenic, inducing proliferative responses in both CD4 and CD8 T-cell popul

118 e becomes apparent during analyses of T cell proliferative responses in mice, particularly when Fc-MB

119 e context of oncogene activation can promote proliferative responses in normal human hematopoietic pr

120 to disrupt AR-dependent transcriptional and proliferative responses in PCa, and can enhance efficacy

121 BAFF neutralization rescues aberrant B cell proliferative responses in such mice.

122 and elicited robust activation and vigorous proliferative responses in the absence of T cells.

123 both CD4(+) T-cell counts and their in vitro proliferative responses in these women.

124 stitute Rag1(-/-) mice and were defective in proliferative responses in vitro and in vivo.

125 olzeta in tolerating DNA damage and enabling proliferative responses in vivo.

126 functions for E2F proteins during a cellular proliferative response including a role for E2F1-3 in th

127 man HSCs did not stimulate allogeneic T-cell proliferative response, indicating that they are not pro

128 The proliferative response is impaired by a reduced fibrobla

129 r, CL injection, which largely abrogated the proliferative response of adoptively transferred OVA pep

130 liver, results in a 3-fold reduction in the proliferative response of Ag-specific CD8(+) T cells.

131 D27(-) atypical B cells showed the strongest proliferative response of all memory B cell subsets.

132 ukocyte reactions-while dampening the global proliferative response of allostimulated Balb/c T cells-

133 that increased c-Jun expression enhances the proliferative response of astrocytes to ET-1, whereas c-

134 glial cultures resulted in a dose-dependent proliferative response of astrocytes.

135 ed human MDSCs also similarly attenuated the proliferative response of autologous T cells to SEB.

136 elpers in that they not only induce a strong proliferative response of B cells in vitro but also trig

137 We show that the proliferative response of B cells to the latter stimuli

138 7(kip1) by adenoviral delivery decreases the proliferative response of beta-cells from non-diabetic d

139 pDC GrB levels inversely correlate with the proliferative response of coincubated T cells and that G

140 Thus, targeting Src prevents the proliferative response of dormant cells to external stim

141 t also that these T cells could suppress the proliferative response of effector T cells.

142 y, CPC transplantation triggered a prolonged proliferative response of endogenous cells, resulting in

143 that this increase is primarily because of a proliferative response of endogenous TM cells.

144 ed intrinsic mechanisms for the differential proliferative response of gray and white matter cells.

145 The deletion of FGFR4 has no effect on the proliferative response of hepatocytes after liver injury

146 Here, we demonstrate that the proliferative response of human beta-cells from T2D dono

147 Skp2 overexpression increased similarly the proliferative response of human beta-cells, only Skp2 wa

148 The proliferative response of human peripheral blood mononuc

149 In vitro, FR104 controlled the proliferative response of human preexisting Tfh cells mo

150 monstrate that the 5-HT(2B) receptor-induced proliferative response of ICC is through phospholipase C

151 Here, we measure the signalling and proliferative response of individual primary T-lymphocyt

152 TAZ are necessary for the stimulation of the proliferative response of intestinal epithelial cells to

153 e-specific response which contrasts with the proliferative response of most cell types and underlies

154 hown that RANKL is responsible for the major proliferative response of mouse mammary epithelium to pr

155 y antisense morpholino oligonucleotides, the proliferative response of Muller glia following injury w

156 toma also rely on its ability to disable the proliferative response of Myc, yet in this tumor context

157 Mst1 removes a barrier to the activation and proliferative response of naive T cells.

158 However, the proliferative response of neoblasts to amputation or gro

159 The proliferative response of neonatal ventricular cardiomyo

160 lination failure correlated with a truncated proliferative response of oligodendrocyte progenitor cel

161 of the induced subpopulations of MDSC on the proliferative response of OVA-specific CD4(+) T cells.

162 Skp2 was also able to double the proliferative response of T2D beta-cells.

163 ling to tracheal formation by regulating the proliferative response of the anterior ventral foregut.

164 mplication in liver diseases that triggers a proliferative response of the biliary tree.

165 Indeed, the proliferative response of the epithelium involves expres

166 In vitro, the proliferative response of TNFR2 deficient naive CD4 cell

167 Proliferative responses of allergen-specific T cells fro

168 er approach to demonstrate that two distinct proliferative responses of autologous T cells occur in v

169 bacterial lipoprotein Pam3CSK4, enhanced the proliferative responses of both conventional T cells and

170 We report here that antigen-specific proliferative responses of CD4(+) T cells required downm

171 regulating the oxidative, inflammatory, and proliferative responses of ECs to disturbed flow with OS

172 ependency on the inactivation of GSK3 in the proliferative responses of human naive and memory CD4(+)

173 cell carcinomas and amplifies migratory and proliferative responses of primary epithelial cells to t

174 his response in vivo correlated with reduced proliferative responses of RAGE-/- T cells in MLRs and i

175 cells, which may contribute to the enhanced proliferative responses of the former.

176 imulation of the T cell receptor whereas the proliferative responses of the Mst1-null effector/memory

177 cells were also capable of mounting a recall proliferative response on HSV reactivation and could do

178 rrelate with the strength of the Ag-specific proliferative response or the secretion of cytokines/cyt

179 guinal lymph nodes, without affecting T cell proliferative responses or levels of anticollagen antibo

180 c signaling perturb hepatocellular metabolic/proliferative responses, paradoxically resulting in mali

181 pment in which LOX-PP may act to inhibit the proliferative response possibly to allow cells to exit f

182 surface phenotype, secretory mediators, and proliferative responses (referred to as an "activated st

183 as protective and actually increased hepatic proliferative responses relative to control mice.

184 y cellular functions within 4 weeks, but the proliferative response remain impaired.

185 reversed in part within 4 weeks, whereas the proliferative response remains impaired.

186 sense systemic insulin demand and initiate a proliferative response remains unknown.

187 valve interstitial cells in vitro induces a proliferative response reminiscent of the fibrosis that

188 Inhibition of proliferative responses required T cell-MDSC contact and

189 To promote a proliferative response, samples were treated with EDTA a

190 nd reconstituted T cells exhibited defective proliferative responses suggesting incomplete recovery o

191 tching or wounding, epithelia display a fast proliferative response that allows for re-establishment

192 elped CD8(+) T cells impairs their secondary proliferative response that is reversible by TRAIL block

193 tion of any cell type in the heart induces a proliferative response that lasts at least 1 year.

194 o engraftment potential and triggers a hyper-proliferative response that leads to their exhaustion.

195 deranged processes culminate in an exuberant proliferative response that occludes the pulmonary arter

196 Depletion of Dkk1 induces a strong proliferative response that promotes wound repair after

197 es in limiting chemically induced injury and proliferative responses that lead to tumor development.

198 on, when wild-type hepatocytes mount a rapid proliferative response, those without dyskerin do not di

199 itic cell responses (flow cytometry), T-cell proliferative responses (thymidine incorporation), and c

200 dicating the requirement for PKCgamma in the proliferative response to 5-HT(2B) receptor activation.

201 specific Rb deletion resulted in an aberrant proliferative response to AFB1.

202 These cells suppressed the proliferative response to allogeneic stimulation of CD4(

203 th an antibody against CTLA4 increased their proliferative response to antigen and to CD3 stimulation

204 T cells from patients with ALF had a reduced proliferative response to antigen or CD3 stimulation com

205 agonists was greatly reduced, except for the proliferative response to ATF.

206 Here we show in mice that the proliferative response to bacterial infection or chemica

207 entricular cardiac myocytes display a robust proliferative response to beta-catenin-mediated signalin

208 Here, we show that the in vivo proliferative response to chronic PI3K activation profou

209 xpressing cells (MCF-7 x beclin) had a lower proliferative response to E(2) compared with cells trans

210 A proliferative response to EDTA was not found.

211 only partially reduced the naive CD8 T cell proliferative response to IL-15/IL-15Ralpha complex.

212 regulation is critical for the smooth muscle proliferative response to increased mechanical tension.

213 sion in the aged kidney acts to suppress the proliferative response to injury and introduce Zag as a

214 Mutation order influenced the proliferative response to JAK2 V617F and the capacity of

215 ex, which correlated with a poor homeostatic proliferative response to lymphopenia.

216 which express CCR2, demonstrate an enhanced proliferative response to MCP-1 when compared with WT SM

217 We hypothesized that the proliferative response to mitogens of human beta-cells f

218 Ealpha52-68 competitively reduced the proliferative response to mTg, mTg1677, and mTg2342 of l

219 FDG-PET is not predictive of proliferative response to mTOR inhibitor therapy in both

220 sociated with a significantly reduced T cell proliferative response to mycobacterial Hsp65, which was

221 reatment with BCR-specific Abs abrogated the proliferative response to N. lactamica outer membrane ve

222 NG2 cells in white matter exhibited greater proliferative response to PDGF AA than those in gray mat

223 white matter NG2 cells showed a more robust proliferative response to PDGF.

224 r NG2 cells in the developing brain in their proliferative response to PDGF.

225 ng cancer model because it lacks an in vitro proliferative response to PDGFRalpha activation.

226 vents and elicitation of a robust hepatocyte proliferative response to PH.

227 d growth factor (PDGF)-beta receptor and the proliferative response to platelet-derived growth factor

228 to therapeutic resistance via an unexpected proliferative response to repopulate residual tumours be

229 po pathway, is required in ISCs to drive the proliferative response to stress.

230 e were then generated and displayed a growth proliferative response to tamoxifen, whereas p21 wild-ty

231 blast populations demonstrate a differential proliferative response to TGF-beta(1), which is associat

232 M6P/IGF-2-R knockout cells have a reduced proliferative response to TGF-beta, and don't proliferat

233 sults from EGFR/CD44 coupling and leads to a proliferative response to TGF-beta1.

234 igenic, we demonstrate a maternal splenocyte proliferative response to the CD4(+) T cell restricted e

235 A proliferative response to the citrullinated aggrecan pep

236 into uninfected ApoE(-/-) HC mice had a weak proliferative response to their antigen, indicating impa

237 IL-7gly at intervals of 4-6 wk maximized the proliferative response to therapy but resulted in only t

238 Loss of RB yielded a unique proliferative response to this agent, which was distinct

239 on immature than on mature MKs, explaining a proliferative response to THPO of immature cells and a d

240 ckout T cells therefore lack the appropriate proliferative response to TL1A.

241 ated with a CB(1)R antagonist have a delayed proliferative response to two-thirds partial hepatectomy

242 l biopsies of adults and children and tested proliferative response to various gluten peptides.

243 on of FLAP-replete myeloid cells rescued the proliferative response to vascular injury.

244 , decreasing cell adhesion and promoting pro-proliferative responses to activin-A and Nodal.

245 The apoptotic and proliferative responses to acute UV radiation exposure a

246 D8(+) T cells from LTx patients showed lower proliferative responses to alloantigen, as well as to po

247 ocompromised, with reduced polyclonal T cell proliferative responses to alloantigen, defined peptide

248 These include BCR down-regulation, impaired proliferative responses to anti-CD40, and diminished cal

249 tion of the PDGF pathway leads to neointimal proliferative responses to artery injury; it promotes a

250 m cGVHD patients had significantly increased proliferative responses to BCR stimulation along with el

251 Proliferative responses to BM4 and Bet v 1 of peripheral

252 l interfering RNA silencing of Smad1 invoked proliferative responses to BMP4 in male hPASMCs.

253 s mellitus, anti-B cell mAb causes increased proliferative responses to diabetes Ags and attenuated b

254 T cell proliferative responses to diabetes-associated Ags were

255 nt C-peptide preservation at 6 mo (58%), the proliferative responses to diabetes-associated total (p

256 ompare changes in lymphocyte subsets, T cell proliferative responses to disease-associated target Ags

257 t the chimeric T cells had enhanced specific proliferative responses to donor airway alloantigens.

258 tion into grafts but not with altered T-cell proliferative responses to donor stimulators.

259 ent hyaluronan, coordinates the motility and proliferative responses to ECM stiffening.

260 Furthermore, proliferative responses to endogenous autoantigen and di

261 In summary, unliganded PR-B enhanced proliferative responses to estradiol and IGF1 via scaffo

262 ZV specificity were generated and probed for proliferative responses to every VZV protein and selecte

263 sufficient help to allow optimal CD8 T cell proliferative responses to exosomal protein.

264 talized stomach mesenchymal cells, to assess proliferative responses to gastrin.

265 mory T-cell gamma interferon (IFN-gamma) and proliferative responses to HCV peptide and control viral

266 seful strategy for studying and modifying MC proliferative responses to injury.

267 aliva IgA binding to insulin, or CD4+ T-cell proliferative responses to insulin were observed in 2 of

268 liva IgA binding to insulin, and CD4+ T-cell proliferative responses to insulin.

269 ermine whether KLF5 is involved in mediating proliferative responses to intestinal stressors in vivo,

270 kappaBNS knockout (KO) mice were impaired in proliferative responses to LPS and anti-CD40.

271 ity, improved lymphocyte numbers, and normal proliferative responses to mitogens.

272 developed polyclonal T-cell repertoires and proliferative responses to mitogens.

273 from unimmunized controls, were screened for proliferative responses to peptide panels spanning the K

274 oliferation graphs, which deconvolve dynamic proliferative responses to perturbations into the relati

275 The metabolic and hepatocellular proliferative responses to PH are modestly augmented in

276 1 cells that displayed greater longevity and proliferative responses to secondary infection.

277 II-DR15/DQ6 alleles significantly attenuated proliferative responses to Strep-SAgs, whereas their pre

278 lability facilitated the induction of T cell proliferative responses to suboptimal stimuli.

279 s cholesterol efflux to HDL and controls the proliferative responses to thrombopoietin.

280 o had a reduced capacity to stimulate T cell proliferative responses to tubercle bacillus Ag 85.

281 o, the role of this nuclear receptor for the proliferative response underlying neointima formation an

282 vivo Skp2 expression is increased during the proliferative response underlying neointima formation, a

283 cted by inhibition of the Ag-specific T cell proliferative response upon Ag presentation by IFN-beta-

284 ta2(-/-) mice exhibited significantly higher proliferative responses upon TCR stimulation.

285 The IL-33-dependent proliferative response was mediated by an increase in th

286 despite the central role of HIF2alpha, this proliferative response was not initiated by in vivo Vhl

287 The enhanced proliferative response was observed in the CD62L(-) memo

288 ude and duration of tubular and interstitial proliferative responses was consistently greater in inju

289 bsets of lymphocytes and quantitative T-cell proliferative response were assessed in an exploratory p

290 bjects, HCV-specific IFN-gamma-producing and proliferative responses were commonly observed in the ly

291 amma2Vdelta2 cell phenotype, repertoire, and proliferative responses were compared between newborns e

292 M- and anti-CD40 plus anti-Ig-induced B cell proliferative responses were decreased in BXD2-Aicda-DN-

293 HC)-mismatched pairs, that T cell restricted proliferative responses were dictated by donor rather th

294 ing the entire IRBP molecule, and lymphocyte proliferative responses were measured.

295 Indeed, HSC and multipotent progenitor proliferative responses were most suppressed in IL-1RI(-

296 rthermore, specific CD4(+) and CD8(+) T cell proliferative responses were significantly increased and

297 CSCs exhibit marked chemotactic and proliferative responses when cocultured with MSCs but no

298 nized animals exhibited significantly higher proliferative responses, when stimulated ex vivo with he

299 Abeta1-15:DT conjugate resulted in a strong proliferative response, whereas proliferation was absent

300 ion without affecting the estrogen-dependent proliferative response, which suggests that p23 differen