ライフサイエンスコーパス: proline

1 of Delta(1)-pyrroline-5-carboxylate (P5C) to proline.

2 erentially the hardest to digest amino acid, proline.

3 use of either commercially available d- or l-proline.

4 reparing novel OCF2H-analogues of GABA and l-proline.

5 closer to primary alpha-amino acids than to proline.

6 ritically important for poor substrates like proline.

7 sual and key catalytic role of an N-terminal proline.

8 iring assistance with the formation of oligo-prolines.

9 gate other aggregating proteins that contain prolines.

10 ns with multiple instances of H-bond-forming prolines.

11 In addition, proline-138 and gluntamine-140 at the (137)P-X-P-X(140)

12 PIN1 also catalyses the isomerization of proline 205 of BRD4 and induces its conformational chang

13 -function variant, in which leucine replaces proline 376 (P376L), in SCARB1, the gene encoding SR-BI.

14 at the (137)P-X-P-X(140) motif, leucine-66, proline-67, and asparagine-176 may account for the broad

15 Notably, leaf free proline abundance showed a strong effect of genotype x t

16 tein kinase 4 (WNK4) and STE20/SPS1-related, proline alanine-rich kinase (SPAK) in human urinary exos

17 osphorylates the kinases SPAK (Ste20-related proline alanine-rich kinase) and OSR1 (oxidative stress

18 AS2R38 polymorphisms encode functional (PAV: proline, alanine, and valine at positions 49, 262, and 2

19 in the WNK signaling pathway, Ste20-related proline-alanine-rich kinase (SPAK).

20 Depletion of the SPS/STE20-related proline-alanine-rich kinase, a WNK1-activated enzyme, al

21 STE20 (Sterile 20)/SPS-1 related proline/alanine-rich kinase (SPAK) and oxidative stress-

22 WNK) kinase phosphorylation of Ste20-related proline/alanine-rich kinase (SPAK), a kinase that direct

23 the (L)P stereocenter promotes a cis-alanine-proline amide bond.

24 g that CfPutA dimerizes in the presence of a proline analog and NAD(+) These results are consistent w

25 a ternary complex containing NADPH and a P5C/proline analog provides a model of the Michaelis complex

26 Though most proline analogs require eIF5A for efficient peptide synt

27 These proline analogues were prepared by [2 + 2] photocycloadd

28 with 2000mg/kg of DHA and either alanine or proline and alanine added.

29 ine-2-carboxylic acid (Aze), a dual mimic of proline and alanine, is activated by both human prolyl-

30 reactions enabled other amino acids, such as proline and aspartate, to directly acquire this nitrogen

31 also visible in the DART spectra, including proline and free sugars.

32 d first, then multiple perturbants (alanine, proline and iron, and combinations of these) were fitted

33 the key gene involved in the biosynthesis of proline and is significantly induced by drought stress.

34 ity to functionalize biologically relevant l-proline and l-trans-hydroxyproline, delivering unique 2,

35 idence suggests that PrP's centrally located proline and lysine residues act as conformational switch

36 Multiple collagen proline and lysine-modifying enzymes were identified in

37 and Phe-tRNAPro, we show that the imino acid proline and not tRNAPro imposes the primary eIF5A requir

38 and 1-pyrroline derived from the amino acids proline and ornithine.

39 ic residues but did show enhancement next to proline and phenylalanine.

40 trans isomerization of peptide bonds between proline and phosphorylated serine/threonine residues.

41 ivatives, and notably the stress metabolites proline and raffinose.

42 ll degradation and increased accumulation of proline and secondary metabolites ingrained higher therm

43 The proline and soluble sugar content increased contrarily.

44 ectively cleave the peptide bond between the proline and the phenylalanine at the carboxyl terminus o

45 caffolds, such as alpha-quaternary beta-homo prolines and beta-lactams, are also prepared in two- to

46 simple secondary amine catalyst, 2-methyl-l-proline, and its tetrabutylammonium salt function as an

47 ced by higher total soluble solids (TSS) and proline, and lower malic acid, 3-isobutyl-2-methoxypyraz

48 s, including glucose and taurine, but prefer proline, and they actively synthesize and export metabol

49 A total of 67 peptides showing methionine, proline, and tryptophan oxidations were identified in co

50 oselective beta-arylations of phenylalanine, proline- and pipecolinic acid-containing peptides are a

51 en acceptor while alanine, aspartic acid and proline are nitrogen donors in cancerous cells.

52 eport that an extracellular matrix component proline/arginine-rich end leucine-rich repeat protein (P

53 The toxic proline:arginine (PRn) poly-dipeptide encoded by the (GG

54 e, prokaryotes have been known to use free l-proline as a precursor to form Hyp.

55 sulted in modulation of key metabolites like proline, asparagine, valine and several flavonoids.

56 led amino acid metabolism, such as arginine, proline, aspartate and glutamate metabolism, were predom

57 120 min, and leucine, isoleucine, valine and proline at 90 and 120 min, whereas infants fed CSS-based

58 aled that P3h1 preferentially 3-hydroxylates proline at a single site in collagen type I chains, wher

59 istant viruses revealed that substitution of proline at amino acid 219 (P219) of the nonstructural pr

60 Unexpectedly, the WoA variant with a proline at position 121 (WoA-P121) was found to have L-g

61 the substitution of a conserved threonine by proline at position 387 (T387P) in hEAAT1.

62 As in wild-type Klf4 (E446), the proline at position 446 does not interact directly with

63 ion state of the amino-acids l-alanine and l-proline at the air/water surface and in the bulk.

64 inopeptidases, which hydrolyze peptides with proline at the second position (P1').

65 xidase (CO) histochemistry analysis or [(3)H]proline autoradiography.

66 n of myo-inositol 1,3,5-orthoformate using a proline-based chiral anhydride as an acylation precursor

67 nd subsequent optimization of the center (S)-proline-based lead 7 has led to the discovery of noncova

68 hocholine, glycine betaine, N-methylproline, proline betaine (stachydrine), beta-alanine betaine, 4-g

69 s showed that glycine betaine, trigonelline, proline betaine, N(epsilon)-trimethyllysine were metabol

70 of glutamic acid, alanine, aspartic acid and proline between cancer and healthy cells.

71 by mutations in the canonical actin- or poly-proline-binding sites of profilin.

72 late reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent r

73 anonical amino acids (4R)-hydroxyproline and proline by cysteine or homocysteine, which reduces the p

74 ed that, while branched-chain amino acid and proline catabolism are very old mitochondrial functions

75 thermore, the spatial environment around the proline catalyst can override its innate stereochemical

76 n of the aldol products is controlled by the proline chirality, and consequently, the R/S configurati

77 Furthermore, proline clusters or residues in their vicinity were iden

78 se-pair change that introduced an additional proline codon into mgtL, generating three consecutive pr

79 rthermore, substitution of three of the four proline codons in mgtL rendered mgtA uninducible.

80 We hypothesize that the proline codons present an impediment to the translation

81 odon into mgtL, generating three consecutive proline codons; (ii) lesions in rpmA and rpmE, which enc

82 factor EF-P that assists the translation of proline codons; and (iv) a heat-sensitive mutation in tr

83 tablished their structures as new stilbene-l-proline conjugates, prolbenes A (compound 3) and B (comp

84 y PSD-95 occurs at specific serine-threonine/proline consensus motifs localized in the linker region

85 Bioinformatics analyses reveal enrichment of proline-containing motifs, in which both methylation sit

86 Analysis of other TNFR sequences suggests proline-containing sequences as common motifs for recept

87 content, and higher chlorophyll content and proline content than the control wheat plants under drou

88 remarkably improved soluble protein content, proline content, antioxidant enzymes activities, and ant

89 The data showed that the phenolic and proline contents significantly increased with the increa

90 imited conditions, and that collagen-derived proline contributes to PDAC cell metabolism.

91 d a significant effect on several compounds (proline, cysteine, tryptophan, phenylalanine, alpha-terp

92 Incorporation of the unnatural d-proline ((D)P) stereoisomer into a polypeptide sequence

93 ation of proline to glutamate using separate proline dehydrogenase (PRODH) and l-glutamate-gamma-semi

94 enzyme that contains the DUF in addition to proline dehydrogenase and l-glutamate-gamma-semialdehyde

95 orter, LutABC lactate dehydrogenase and PutA proline dehydrogenase became more abundant with increasi

96 Crabtree and colleagues report that proline dehydrogenase deficits produce excessive cytosol

97 nsistently, expression of both of the poplar Proline Dehydrogenase orthologs and two of the Flavonol

98 Proline-dependent and basophilic kinases phosphorylate h

99 mma-glutamyl dipeptides, acylcarnitines, and proline derivatives.

100 ,5-disubstituted pyrrolidines, 5-substituted proline derivatives.

101 armeniaspirol analogues was achieved using L-proline derived bifunctional squaramide which outperform

102 arise from a conserved mechanism in which a proline-derived pyrrolyl group bound to a carrier protei

103 s of binary complexes of PYCR1 with NADPH or proline determined at 1.9 A resolution provide insight i

104 confirmed serine 14 as a target of MAPKs and proline-directed kinases like cyclin-dependent kinase 5

105 quired for CDK4 activation, we proposed that proline-directed kinases might specifically initiate the

106 /T)P sites, i.e., at sites phosphorylated by proline-directed kinases, which represent 40% of all sit

107 transporter ligands on DAT residue Thr-53, a proline-directed phosphorylation site previously implica

108 tral common signaling mechanism in cancer is proline-directed phosphorylation, which is further regul

109 eral post-translational mechanisms including proline-directed phosphorylation.

110 fied ZNF503/ZEPPO2 zinc-finger elbow-related proline domain protein 2 (ZPO2) as a transcriptional rep

111 ent allowing us to discuss about the role of proline during the alcoholic fermentation and the genera

112 In contrast, substituting Glu446 with proline (E446P) increased affinity for 5mC by two orders

113 lamino-1-naphthalenesulfonamide and dansyl-l-proline from the two major drug-binding sites on HSA (pr

114 al substitution of these glycine residues to proline, functional and structural asymmetry was observe

115 horylation of the PEVK (titin domain rich in proline, glutamate, valine, and lysine) region of titin.

116 es of the neuroprotective tripeptide glycine-proline-glutamate (GPE) is reported.

117 induced by interactions of the IkappaBalpha proline-glutamate-serine-threonine-rich sequence with po

118 Cytoplasmic localization of proline, glutamic acid, leucine-rich protein 1 (PELP1) i

119 of the IkappaBalpha C-terminal PEST (rich in proline, glutamic acid, serine, and threonine residues)

120 th NOTCH2 mutations causing deletions of the proline-, glutamic acid-, serine-, and threonine-rich (P

121 ere depleted more slowly than predicted, and proline, glycine, glutamate, lysine and arginine, which

122 minal portion of Aap contains a 135-aa-long, proline/glycine-rich region (PGR) that has not yet been

123 Derivatives of 4-hydantoin-proline have been synthesized via a direct two-step alky

124 Short poly-proline helices have a period of three, so large changes

125 tingly, AKG also inhibited the expression of proline hydroxylase 3 (PHD3), one of the important oxido

126 tability is increased in hypoxia via reduced proline hydroxylation and, hence, inefficient degradatio

127 Proline hydroxylation is the most prevalent post-transla

128 ts of gelatin increased circulating glycine, proline, hydroxyproline, and hydroxylysine, peaking 1 h

129 to the hydrophobic face or of helix-breaking prolines impaired palmitoylation of both YFP-NCX1 and FL

130 ality and hydration number of l-serine and l-proline in the presence of the studied preservatives.

131 nt mutation in Btr1, changing a leucine to a proline in the protein product.

132 ction of vaccine strains that do not contain prolines in antigenic loops, so as to elicit antibodies

133 nt the structural and thermodynamic basis of proline-induced integrin alphaIIbbeta3 TM complex stabil

134 ynthesis by most amino acids, the imino acid proline is a poor substrate for protein synthesis.

135 The rigidity of poly-l-proline is an important contributor to the stability of

136 Surprisingly, more proline is consumed than any other nutrient, including g

137 ides being oxidized through the Krebs cycle, proline is used to make citrate via reductive carboxylat

138 (NPL) domain and a C-terminal FKBP peptidyl-proline isomerase domain.

139 tment and inhibition of the 12-kDa cis-trans proline isomerase FK506-binding protein (FKBP12).

140 on, which is further regulated by the unique proline isomerase Pin1.

141 a complex mechanism involving a cis-to-trans proline isomerization, reorganization of a beta-sheet, a

142 forms the local structure of this region via proline isomerization.

143 glycosylation, disulfide-bond formation and proline isomerization.

144 omposed of two turns of helix separated by a proline kink.

145 bilization to understand the introduction of proline kinks in membrane proteins.

146 amine, l-threonine, l-arginine, l-glycine, l-proline, l-serine, l-alanine, and l-glutamic acid.

147 For the first time, significantly elevated proline levels in response to drought were demonstrated

148 result from changing the length of the poly-proline linker by a single residue.

149 Here, we used proline linkers to constrain and alter the relative orie

150 lix, a 310 helix, and a recently evolved tri-proline loop.

151 including decreased amino acids (alanine and proline; median change [25th-75th], -38.26 [-100.3 to 28

152 pid metabolism (P=6.6x10(-5) ), arginine and proline metabolism (P=1.12x10(-7) ), glycerophospholipid

153 Furthermore, within the arginine and proline metabolism pathway, a positive correlation betwe

154 ysis, compounds associated with arginine and proline metabolism were found to be the most changed.

155 , indicating that the structural rigidity of proline might contribute to the requirement for eIF5A.

156 regulatory pathway in which an N-terminal di-proline motif in the Drosophila Delta9-desaturase mediat

157 Surprisingly, these domains use proline motifs to create optimal packing in homotrimer a

158 We estimate that introduction of the proline mutation decreases the energy required to open t

159 p within the PL-2 epitope due to a serine-to-proline mutation, locking the loop in a conformation tha

160 s due to cis/trans isomerization of a single proline near the C-terminus.

161 arly establishes the H-bonding capability of proline nitrogen and its prevalence in protein structure

162 ptides from N-termini of substrates having a proline or alanine in second position.

163 Citrate, made either from (13)C proline or from (13)C glucose, is preferentially exporte

164 Finally, we show that proline oxidase (PRODH1) is required for PDAC cell proli

165 lation of CDK4 is conditioned by an adjacent proline (P173), which is not present in CDK6 and CDK1/2.

166 residues, so the cis/trans isomerization of proline peptide bonds is the rate-limiting step during t

167 carboxypeptidase activities that cleave the proline-phenylalanine dipeptide bond in Ang II.

168 eneous levels of IgG hydrolyzing the generic proline-phenylalanine-arginine-methylcoumarinamide (PFR-

169 A wide proline pocket as well as molecular complementarity and

170 ine, valine, leucine, isoleucine, lysine and proline pre-determines the reliance on external sources

171 The full extent of proline (Pro) hydroxylation has yet to be established, a

172 Gid4 recognized the N-terminal proline (Pro) residue and the 5-residue-long adjacent s

173 though animal and plant P4Hs target peptidyl proline, prokaryotes have been known to use free l-proli

174 in a translation factor needed for efficient proline-proline bond formation, EF-P, suppress Deltarep

175 In this work, we demonstrate that proline-proline-glutamic acid (PPE)17 protein of Mycobac

176 Thus, RBM5 OCRE represents a poly-proline recognition domain that mediates critical intera

177 ere we demonstrate that collagen serves as a proline reservoir for PDAC cells to use as a nutrient so

178 no acid mutagenesis, that replacement of the proline residue at position 28 of the insulin B-chain (P

179 OD1-dependent hydroxylation of a neighboring proline residue resulting in 40S ribosomal subunits that

180 oints of stabilization throughout gp140, 149 proline residue substitutions at every residue of the gp

181 in GluK2/GluK5 heteromers results from a key proline residue that produces architectural changes in t

182 n and an unusual preference for a C-terminal proline residue.

183 Proline residues are uniformly distributed along the pol

184 t regio- and stereospecifically hydroxylates proline residues in a peptide chain into R-4-hydroxyprol

185 ), due to posttranslational modifications of proline residues in the substrate.

186 The orientation of proline residues is regulated by cis/trans peptidyl-prol

187 rdered proteins, like tau, are enriched with proline residues that regulate both secondary structure

188 carbonyl carbon atom linked to the N atom of proline residues within di- and tripeptides.

189 amma-amino acid being flanked by two d- or l-proline residues, have been synthesized and tested as or

190 Collagen contains a large number of proline residues, so the cis/trans isomerization of prol

191 w for connecting triple-helical collagen via proline residues.

192 at CyP40 interacts with tau at sites rich in proline residues.

193 taining acidic side-chains and N-terminal to proline residues; UVPD did not exhibit preferential clea

194 ormula-fed infants at three CpGs in the gene proline rich 5 like (PRR5L) (p < 10(4)).

195 Here, we show that the synaptic component Proline rich 7 (PRR7) accumulates in the nucleus of hipp

196 kout cell envelope, in addition to the small proline rich proteins.

197 Because the region is proline rich, the hypothesis that it targets Src homolog

198 ein reveal a distinct role of the C-terminal proline-rich (PR) domain to obstruct the engagement of a

199 audin-1, a tight junction protein, and small proline-rich (Sprr2) protein, a major component of corni

200 d priming induced phosphorylation of AKT and proline-rich AKT substrate 40 kDa (PRAS 40), which in tu

201 in the same cells allowed us to identify the proline-rich Akt substrate of 40 kDa (PRAS40) as the uni

202 pidaecins, which refer to a series of small, proline-rich antimicrobial peptides, are predominantly a

203 ved the coverage of missing and particularly proline-rich areas of the proteome.

204 hat serves as its proteasome docking site; a proline-rich C-terminal hRpn2 extension stretches across

205 e that the OCRE domain directly binds to the proline-rich C-terminal tail of the essential snRNP core

206 containing 17 amino acids (N17), polyQ, and proline-rich domain (PRD)) become ordered at very differ

207 esence of a C-terminal extension featuring a proline-rich domain and an actin-binding WASP-Homology 2

208 present a C-terminal extension containing a proline-rich domain and an actin-binding Wiskott-Aldrich

209 e cytoplasmic C terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate

210 Its long C-terminal proline-rich domain contains 13 PXXP motifs, which orche

211 PEPD binds to the proline-rich domain in p53, which inhibits phosphorylati

212 tivated AKT by forming a complex between the proline-rich domain of CKAP4 and the Src homology 3 doma

213 ro-786-Pro-793) at the N-terminal end of the proline-rich domain, whereas the amphiphysin SH3 binds S

214 eucine-rich repeat, tropomodulin domain, and proline-rich domain-containing protein (RLTPR); moesin;

215 ing is mutually exclusive and dependent on a proline-rich domain.

216 The C-terminal, proline-rich domains of TANGO1 molecules in the ring are

217 and semi-rigid polyproline II helices in the proline-rich flanking domain (PRD).

218 ly induces STIM1 phosphorylation at Y361 via proline-rich kinase 2 (Pyk2) in ECs.

219 RDs contain repeated PPP motifs separated by proline-rich linkers, so a single TANGO1/cTAGE5 receptor

220 ats of TRPA1 directly bind to the C-terminal proline-rich motif of FGFR2 inducing the constitutive ac

221 strate that SH3 (Src homology 3) domain-PRM (proline-rich motif) interactions involving multivalent l

222 ein interactions mediated via its C-terminal proline-rich motif.

223 Most importantly, the large proline-rich N-terminal domain is not exposed to the ext

224 ins, being particularly reactive towards the proline-rich ones.

225 for the interaction between the human saliva proline-rich peptides (IB714 and IB937) and procyanidins

226 transcription of neuropeptide y (npy), small proline-rich protein 1a (sprr1a), and vasoactive intesti

227 Specifically, acidic proline-rich protein, cystatin, statherin and protein S1

228 the interaction between a family of salivary proline-rich proteins (aPRPs) and representative pyranoa

229 tions between basic, glycosylated and acidic proline-rich proteins (bPRPS, gPRPs, aPRPs) and P-B pept

230 the arabinogalactan proteins, extensins, and proline-rich proteins, in reality, a continuum of struct

231 Although Ig-containing and proline-rich receptor-1(IGPR-1) was recently identified

232 dition to these WW domains, Itch possesses a proline-rich region (PRR) that has been shown to interac

233 The N-terminal of MyRF, which contains a proline-rich region and a DNA binding domain (DBD), is a

234 nt receptor potential subtype V1 (TRPV1) via Proline-rich region and regulates TRPV1 surface expressi

235 rious sizes, sequences, and locations in the proline-rich region ofenv Outside theenvregion, all E-ML

236 on at CME sites are the third EH domain, the proline-rich region, and the coiled-coil region.

237 are found within coiled-coil domains and the proline-rich region, motifs essential in other fusion sy

238 egment of consecutive glutamines (QN), and a proline-rich segment.

239 ubunits to expose the CD3epsilon cytoplasmic proline-rich sequence (PRS).

240 at this characteristic of HOXB4 depends on a proline-rich sequence near the N terminus, which is uniq

241 2 (WH2) domain that binds actin, and (ii) a proline-rich sequence that binds profilin-actin complexe

242 tory domains, and its FH1 domain has minimal proline-rich sequence.

243 h a selectivity filter formed by an uncommon proline-rich sequence.

244 elongation, but in the presence of profilin, proline-rich sequences are required to support polymeras

245 d that different SH3 domains target distinct proline-rich sequences overlapping significantly.

246 Collaboration between WH2 and proline-rich sequences thus strikes a balance between fi

247 ctions and acting through the recognition of proline-rich sequences.

248 These results indicate that proline-rich stretches attenuate the potential of stem c

249 PRRT2 (proline-rich transmembrane protein 2 gene) has been iden

250 transducer) was mediated by FA formation and proline-rich tyrosine kinase 2 (PYK2) activity.

251 Despite the involvement of proline-rich tyrosine kinase 2 (Pyk2) in endothelial cel

252 Proline-rich tyrosine kinase 2 (PYK2), a redox-sensitive

253 actin as a novel substrate and interactor of proline-rich tyrosine kinase 2 (Pyk2).

254 Inhibition of proline-rich tyrosine kinase 2 improved insulin-induced

255 Inhibition of proline-rich tyrosine kinase 2 restores insulin-induced

256 itory residue Y657 of eNOS and expression of proline-rich tyrosine kinase 2 that phosphorylates this

257 DPH oxidase, Syk, focal adhesion kinase, and proline-rich tyrosine kinase 2, and in the absence of De

258 lying this process: a phospholipase C/Ca(2+)/proline-rich tyrosine kinase 2/cJun N-terminal kinase pa

259 that phase-separates when mixed with a poly-proline-rich-motif (polyPRM) ligand.

260 slowed peptide bond formation at successive proline sequence positions and electrostatic interaction

261 phosphorylation at specific serine/threonine-proline sequences by their cognate kinases.

262 o promote translation elongation of iterated proline sequences.

263 cids namely (alanine, asparagine, glutamine, proline, serine and valine) for Sudanese food.

264 acterized protein family consisting of three proline/serine-rich proteins (PRPs) that are substrates

265 re flexible four-membered ring derivative of proline, shows relaxed eIF5A dependency, indicating that

266 ve site motif and a conserved C-terminal cis-proline, signature features of a thiol-disulfide oxidore

267 leucine, phenylalanine, tyrosine, valine and proline significantly associated with obesity (OR = 1.57

268 is responsible for 3-hydroxylating multiple proline sites in collagen types I, II, IV, and V.

269 w that BaP4H can hydroxylate unique peptidyl proline sites in collagen-derived peptides with asymmetr

270 -mediated phosphorylation on multiple serine-proline sites.

271 arameters, SOD, POD, PPO, CAT activity, free proline, soluble protein and MDA contents fluctuated in

272 chanism for the selective recruitment of cis-proline-specific regulatory factors and region-specific

273 ults suggest that this response occurs under proline starvation as well.

274 s stalling at many sequences, not limited to proline stretches.

275 y, a SCA5 mutation resulting in a leucine-to-proline substitution (L253P) in the actin-binding domain

276 T46P, with a disulphide bond at 53-142 and a proline substitution at 46, showed a 22-fold increase of

277 interactions, questioning the acceptance of proline substitutions and evolutionary origin of kinks.

278 Proline substitutions on the PC1-proximal side completel

279 tructure, a series of disulphide bridges and proline substitutions were created in the xylanase by PC

280 egion of TM10' are explored using the sodium/proline symporter PutP as a model.

281 Here, the function of TM6' in the sodium/proline symporter PutP, a member of the solute/sodium sy

282 man pathogens to dehydrate trans-4-hydroxy-l-proline, the product of the most abundant human posttran

283 bones are rich in the disordering amino acid proline, they contain repeated sequence motifs and exten

284 A (PutA) catalyzes the two-step oxidation of proline to glutamate using separate proline dehydrogenas

285 Mutation of the invariant proline to leucine (P838L) caused dominant restrictive c

286 tamine, or the nonpreferred nitrogen source, proline, to cells growing in nitrogen-limited chemostats

287 changing the amino acid at position 431 from Proline-to-Lysine.

288 We demonstrate here for the first time that proline tRNA 3' end maturation in Escherichia coli emplo

289 suggest that the mature 5' nucleotide of the proline tRNAs may be responsible for the cleavage specif

290 n the inner core without disturbing the poly-proline type II helical conformation of each chain.

291 d acts on peptidyl substrates but not free l-proline, using elements characteristic of an Fe(II)/alph

292 The bifunctional flavoenzyme proline utilization A (PutA) catalyzes the two-step oxid

293 Proline utilization A from Sinorhizobium meliloti (SmPut

294 A proline variant of an evolved sortase A (SrtA 7M) was N-

295 y involving cleavage of peptides lacking P1' proline was also detected in the purified enzymes.

296 ssive cytosolic levels of the GABA-mimetic l-proline which impairs GABA synthesis and gamma oscillati

297 four amino acid motif, (serine-X-isoleucine-proline) which exists within an intrinsically disordered

298 e of a nonpreferred nitrogen source, such as proline, which supports a slower growth rate.

299 ro-Xaa sequence, where Pro is either l- or d-proline, which was chosen to favor nucleation of canonic

300 However, it inserts into proteins as proline, with toxic consequences in vivo.