ライフサイエンスコーパス: proline oxidase

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1 Proline oxidase, a mitochondrial enzyme involved in the

2 suppressed the ability of p53 to up-regulate proline oxidase, activate calcineurin, and induce apopto

3 ic agent etoposide up-regulated both p53 and proline oxidase, activated calcineurin, and induced apop

4 Proline oxidase, also known as proline dehydrogenase (PO

5 The results directly implicate proline oxidase and the proline/P5C pathway in p53-induc

6 Both proline oxidase- and p53-induced activation of NFAT were

7 A proline oxidase antisense vector repressed p53-induced u

8 A proline oxidase antisense vector suppressed the ability

9 together, these findings support a role for proline oxidase as a downstream effector in p53-mediated

10 These effects of proline oxidase, as well as its decreased levels in tumo

11 The metabolic signaling by proline oxidase between oxidized low-density lipoprotein

12 , which displayed little or no expression of proline oxidase, expressed p53s that were less capable o

13 tant p53 proteins were deficient in inducing proline oxidase expression and in activating calcineurin

14 3 phenotype can be modulated by temperature, proline oxidase expression and ROS production could only

15 in the presence and absence of a functional proline oxidase, followed by selection and screening for

16 We observed absent or reduced expression of proline oxidase in 8 of 12 primary renal cell carcinomas

17 The presence of proline oxidase in mitochondria, a primary organelle tha

18 , we provide evidence implicating a role for proline oxidase in renal carcinoma.

19 Forced up-regulation of proline oxidase induced the formation of reactive oxygen

20 ), a proline-derived metabolite generated by proline oxidase, inhibited the proliferation and surviva

21 We report that proline oxidase is a downstream effector in p53-mediated

22 Proline oxidase is a p53-induced gene that can mediate a

23 Proline oxidase is a p53-induced redox gene that can gen

24 lcineurin and calcium mobilization abolished proline oxidase-mediated apoptosis and reduced p53-induc

25 We propose that proline oxidase mediates apoptosis through the generatio

26 n-regulated transcription factor pathways by proline oxidase might affect gene expression events impo

27 proline and hydroxyproline are catalyzed by proline oxidase (POX) and hydroxyproline oxidase (OH-POX

28 Proline oxidase (POX) catalytically converts proline to

29 Proline oxidase (POX) is a novel mitochondrial tumor sup

30 Proline oxidase (POX) is a redox enzyme localized in the

31 stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen

32 Proline oxidase (POX), a flavoenzyme localized at the in

33 apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing

34 ome/DiGeorge syndrome (VCFS/DGS) and encodes proline oxidase (POX), a mitochondrial inner-membrane en

35 Proline oxidase (POX), catalyzing the first step in prol

36 Proline oxidase (POX), often considered a 'housekeeping

37 Finally, we show that proline oxidase (PRODH1) is required for PDAC cell proli

38 A recombinant proline oxidase protein tagged with a green fluorescent

39 ector repressed p53-induced up-regulation of proline oxidase, release of cytochrome c from mitochondr

40 ssed p53s that were less capable of inducing proline oxidase than p53 isolated from normal renal tiss

41 of either hut induction or the expression of proline oxidase, the first enzyme in proline degradation

42 during stress to make proline available, and proline oxidase, the first enzyme in proline degradation

43 The activation of calcineurin by p53 and proline oxidase was detected by activation of the nuclea

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