ライフサイエンスコーパス: proline-rich

1 onstrating that the PTP catalytic domain and Proline-rich 1 (P1) domain are respectively binding to t

2 The two isoforms differ only by a proline-rich 15-amino-acid sequence near the amino-termi

3 ormula-fed infants at three CpGs in the gene proline rich 5 like (PRR5L) (p < 10(4)).

4 Here, we show that the synaptic component Proline rich 7 (PRR7) accumulates in the nucleus of hipp

5 We previously reported that synaptopodin, a proline-rich actin-binding protein, induces stress fibre

6 ion factor 4E-binding protein 1 (4EBP1), and proline rich Akt substrate 40 kDa (PRAS40).

7 RC1 regulatory binding partners, the role of Proline Rich AKT Substrate of 40 kDa (PRAS40) in control

8 The proline-rich Akt (v-akt murine thymoma viral oncogene ho

9 nduced mTOR hyperactivity is mediated by the proline-rich Akt substrate 40 (PRAS40) as we show that t

10 d priming induced phosphorylation of AKT and proline-rich AKT substrate 40 kDa (PRAS 40), which in tu

11 am targets (glycogen synthase kinase 3 beta, proline-rich Akt substrate 40 kDa and tuberous sclerosis

12 in the same cells allowed us to identify the proline-rich Akt substrate of 40 kDa (PRAS40) as the uni

13 The proline-rich Akt substrate of 40 kDa (PRAS40) has recent

14 In contrast, expression of proline-rich Akt substrate of 40 kDa (PRAS40) inhibited

15 blocked the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, 40 kD(a) and neutralized the

16 ecreases in mRNA levels were observed of the proline-rich anchor of AChE, PRiMA, no changes were seen

17 a bilayered mechanism of phosphotyrosine and proline-rich anchoring motifs.

18 s been well documented, the influence of the proline-rich and presumably disordered carboxy terminus

19 Bac7 is a proline-rich antimicrobial peptide, selective for Gram-n

20 Proline-rich antimicrobial peptides (PrAMPs) are instead

21 pidaecins, which refer to a series of small, proline-rich antimicrobial peptides, are predominantly a

22 f the predicted J-domain, central acidic and proline-rich (APR) domain, and C-terminal domain of TopJ

23 ved the coverage of missing and particularly proline-rich areas of the proteome.

24 hat expression of a 17-amino acid N-terminal proline-rich attachment domain of collagen Q is sufficie

25 catalytic subunits, incubated with synthetic proline-rich attachment domain peptides containing the e

26 by PI31 are conferred by the HbYX-containing proline-rich C-terminal domain but do not require HbYX r

27 hat serves as its proteasome docking site; a proline-rich C-terminal hRpn2 extension stretches across

28 structurally divergent catalytic site and a proline-rich C-terminal subdomain suggest that this prot

29 e that the OCRE domain directly binds to the proline-rich C-terminal tail of the essential snRNP core

30 We identify the proline-rich C-terminus as a new domain of CE that is re

31 Neither the proline-rich, C-terminal domain of aSyn nor the hydrolyt

32 entify four genes, ATP11C, IQCB1, TUBD1, and proline-rich coiled-coil 2C (PRRC2C), with a significant

33 SH3 domains usually interact with a proline-rich consensus sequence, but the region of param

34 s and cavity size on catalytic efficiency of proline-rich cyclopeptoids under phase-transfer conditio

35 Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multipl

36 A long, proline-rich, disulfide-bonded pigtail loop in TSR1 over

37 yloid fibril formation, while the C-terminal Proline Rich Domain destabilizes fibrils and enhances ol

38 omain are inessential, as are the C-terminal proline-rich domain (amino acids 382-476) and two zinc-b

39 l modification site or of the downstream MTS proline-rich domain (PRD) increased mitochondrial import

40 e intramolecular interaction site within the proline-rich domain (PRD) of ALIX transforms cytosolic A

41 containing 17 amino acids (N17), polyQ, and proline-rich domain (PRD)) become ordered at very differ

42 , a homolog of hPLSCR1 that lacks N-terminal proline-rich domain (PRD), did not show scramblase activ

43 tution of proline by arginine within the p53 proline-rich domain (PRD).

44 A series of peptides derived from the proline-rich domain (residues 174-251) of tau was synthe

45 n activation domains 1-2 and deletion of the proline-rich domain abolish mutant p53 to regulate Gro1

46 esence of a C-terminal extension featuring a proline-rich domain and an actin-binding WASP-Homology 2

47 present a C-terminal extension containing a proline-rich domain and an actin-binding Wiskott-Aldrich

48 on of profilin-actin complexes with the VASP-proline-rich domain and the binding of the VASP-F-actin

49 so found that activation domains 1-2 and the proline-rich domain are required for mutant p53 gain of

50 e cytoplasmic C terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate

51 Its long C-terminal proline-rich domain contains 13 PXXP motifs, which orche

52 phospho- or phospho-mimetic mutations in the proline-rich domain eliminate the acceleration phase by

53 s of FcmuR deletion mutants, we identified a proline-rich domain essential for cell surface expressio

54 PEPD binds to the proline-rich domain in p53, which inhibits phosphorylati

55 nd the cysteine-rich domain or intracellular proline-rich domain is required for Wnt5a-induced recrui

56 yeast two-hybrid screen that identified the proline-rich domain of ASPP2 as a host cellular target.

57 tivated AKT by forming a complex between the proline-rich domain of CKAP4 and the Src homology 3 doma

58 s between the C terminus of K(V)10.1 and the proline-rich domain of cortactin, regions targeted by ma

59 The carboxy-terminal proline-rich domain of DAZAP1 interacts with and neutral

60 clathrin-coated pits and interacted with the proline-rich domain of dynamin.

61 -hybrid assay showed that the NH(2)-terminal proline-rich domain of Zimp7 and the region spanning ami

62 A human Kv3.3 mutation within a conserved proline-rich domain produces channels that bind Hax-1 bu

63 entral and the C-terminal end of the dynamin proline-rich domain that account for a significant incre

64 talytic RING finger domain, and a C-terminal proline-rich domain that mediates interactions with Src

65 horylates primarily serine 857 (S857) in the proline-rich domain, found only in 1xa, one of the alter

66 malian endocytic DRP, dynamin 1, lacking the proline-rich domain, in its nucleotide-free state.

67 ro-786-Pro-793) at the N-terminal end of the proline-rich domain, whereas the amphiphysin SH3 binds S

68 eucine-rich repeat, tropomodulin domain, and proline-rich domain-containing protein (RLTPR); moesin;

69 ing is mutually exclusive and dependent on a proline-rich domain.

70 KD2 interacts with CIB1a via its alanine and proline-rich domain.

71 ssion of Bmf expression independent of p53's proline-rich domain.

72 phosphorylation within the C-terminal serine/proline-rich domain.

73 eviously unrecognized extended region of the proline-rich domain.

74 he affinity for Sec23 is concentrated in the proline-rich domains (PRDs) of TANGO1 and cTAGE5, but Se

75 phosphorylation sites within their specific proline-rich domains (PRDs) that are differentially regu

76 The C-terminal, proline-rich domains of TANGO1 molecules in the ring are

77 the C-terminal domain of FAK containing the proline-rich domains PRR2 and PRR3.

78 icted Wasp homology 2 (WH2) domains, and two proline-rich domains, one with similarity to eukaryotic

79 recruitment through its own coiled coil and proline-rich domains.

80 tains a proline-rich (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligo

81 Together, our findings indicate that the proline-rich exons are modular cassettes that convert WN

82 EXT, "short" EXTs, leucine-rich repeat-EXTs, proline-rich extensin-like receptor kinases, and other c

83 The 18 amino acid proline-rich extracellular domain that is responsible fo

84 on and fibrillation of SAA, we truncated the proline-rich final 13 residues of SAA2.2.

85 B(59-80), indicating a critical role for the proline rich first seven amino acids in this protein.

86 and semi-rigid polyproline II helices in the proline-rich flanking domain (PRD).

87 e genes encoding a family of proteins termed proline-rich gamma-carboxyglutamic acid (PRRG) proteins

88 the transmembrane and cytoplasmic regions of proline-rich Gla protein 2.

89 nd a peptide comprised of PEMV CP fused to a proline-rich hinge (-P-) and green fluorescent protein (

90 poietically expressed homeodomain protein or proline-rich homeodomain protein (HHEX/PRH), which there

91 We have shown previously that the Proline-Rich Homeodomain protein (PRH/Hex) self-assemble

92 shown previously that phosphorylation of the Proline-Rich Homeodomain protein (PRH/Hhex) by CK2 inhib

93 PRH/HHex (proline-rich homeodomain protein) is a transcription fac

94 is pattern of amino acid usage is typical of proline-rich IDRs.

95 ants were located in a region that encodes a proline-rich, intrinsically disordered domain of the pro

96 essed, but least studied, kinases in PMNs is proline rich kinase 2 (Pyk2).

97 ly induces STIM1 phosphorylation at Y361 via proline-rich kinase 2 (Pyk2) in ECs.

98 Unlike other EVH1 domains that interact with proline-rich ligands, the crystal structure of the Flfl

99 RDs contain repeated PPP motifs separated by proline-rich linkers, so a single TANGO1/cTAGE5 receptor

100 sidue N-terminal alpha-domain connected by a proline-rich loop to a compact alpha/beta-domain.

101 rway to target the FKBP52 FK1 domain and the proline-rich loop with small molecule inhibitors.

102 onstrated that the FKBP52 FK1 domain and the proline-rich loop within this domain are functionally im

103 ric form that is anchored to membranes via a proline-rich membrane anchor (PRiMA).

104 found that BChE is anchored at the TSC by a proline-rich membrane anchor, the small transmembrane pr

105 that the stalk cysteines were adjacent to a proline-rich microdomain unique to the Henipavirus genus

106 of the Ena/VASP EVH1 domain with an extended proline rich motif in Abi.

107 The unique C-terminal 96 aa bearing the proline-rich motif (PPPCPP) of VIL-4 appeared to confer

108 ther bare or functionalized by mimicking the proline-rich motif (PRM) ligand (PPPVPPRR) and compare i

109 MP contains an N-terminal SH3 domain-binding proline-rich motif and forms a complex with the tyrosine

110 Individual prolines in the 6-residue proline-rich motif are highly tolerant of alanine substi

111 Although the prolines in the proline-rich motif do not directly interact with membran

112 Here we identify an atypical proline-rich motif in chimaerins that binds to the adapt

113 hen induces the Wnt-PCP pathway by binding a proline-rich motif in disheveled (Dvl) and consequently

114 We identified a conserved proline-rich motif in V3 required for association with C

115 linker molecule that couples the C-terminal proline-rich motif of CD28 to the recruitment and activa

116 ats of TRPA1 directly bind to the C-terminal proline-rich motif of FGFR2 inducing the constitutive ac

117 able decoy peptide corresponding to the same proline-rich motif reduced SFK binding to WT GST-TRAF6 c

118 strate that SH3 (Src homology 3) domain-PRM (proline-rich motif) interactions involving multivalent l

119 terminal 96 aa including a signaling-related proline-rich motif.

120 ein interactions mediated via its C-terminal proline-rich motif.

121 that phase-separates when mixed with a poly-proline-rich-motif (polyPRM) ligand.

122 0 regulator of kinase II (CrkII), recognizes proline-rich motifs (PRMs) of binding partners, such as

123 ybrid and pull-down experiments identify two proline-rich motifs in PakB-1-180 that directly interact

124 Src homology 3 (nSH3) domain of CrkII to the proline-rich motifs of cAbl (PRMs(cAbl)).

125 A and nRNP C initially targeted restricted, proline-rich motifs.

126 , in the hinge region between the disordered proline-rich N-terminal domain and the DBD, folds back o

127 Most importantly, the large proline-rich N-terminal domain is not exposed to the ext

128 Trib2 has 3 distinct regions, a proline-rich N-terminus, a serine/threonine kinase homol

129 microvilli via a mechanism that requires its proline-rich N-terminus.

130 ly promoted initiation at AUG872, yielding a proline-rich oligopeptide.

131 ins, being particularly reactive towards the proline-rich ones.

132 (2+)-sensing riboswitch, harbors an 18 codon proline-rich open reading frame-termed mgtL-that permits

133 ing to the kinase domain effects dynamics of proline-rich or phosphorylated peptide ligand binding si

134 leader of the mgtA mRNA contains a 17-codon, proline-rich ORF, mgtL, whose translation regulates the

135 primary structure, with alanine-rich (A) and proline-rich (P) repeats flanking a V region that is pro

136 n-binding site or its vicinity, the arm-like proline-rich (P-) domain of calreticulin contributes to

137 The proline rich peptide H-AP10CP10CP10-NH2 was site-directe

138 h amelogenin peptide (TRAP), and a synthetic proline-rich peptide (P2) on acute wound healing after a

139 Second, a proline-rich peptide in HD-PTP binds the SH3 domain of S

140 domain with metallopeptides based on a known proline-rich peptide ligand.

141 njugated with either one or two repeats of a proline-rich peptide to each arm (P1 or P2, respectively

142 s encoding human butyrylcholinesterase and a proline-rich peptide under elongation factor promoter co

143 for the interaction between the human saliva proline-rich peptides (IB714 and IB937) and procyanidins

144 xt was significant cis-trans isomerism, with proline-rich peptides containing aromatic residues exhib

145 alpha-amylase inhibitors are cysteine-rich, proline-rich peptides found in the Amaranthaceae and Apo

146 Proline-rich peptides have been shown to promote periodo

147 Similar proline-rich peptides on UBPY also bind STAM2 SH3 to fac

148 f the Src homology 3 (SH3) domain with short proline-rich peptides.

149 ctures of the plant profilin in complex with proline-rich peptides.

150 p-interacting protein (WIP) is a 503-residue proline-rich polypeptide expressed in human T cells.

151 lass, nucleation is actively suppressed by a proline-rich polyQ segment covalently attached to htt(NT

152 nalyses of DAB2IP protein indicate that both proline-rich (PR) and PERIOD-like (PER) domains, in addi

153 Importantly, Bag6 contains a proline-rich (PR) domain termed PDP (Proline rich-DUF358

154 ein reveal a distinct role of the C-terminal proline-rich (PR) domain to obstruct the engagement of a

155 similarity and contain highly cross-reactive proline-rich (PR) regions.

156 n of the yeast protein Sho1 with its cognate proline-rich (PR) sequence of Pbs2.

157 STAT3-driven expression of small proline rich protein 2a (SPRR2a), which acts as an src h

158 transcription of neuropeptide y (npy), small proline-rich protein 1a (sprr1a), and vasoactive intesti

159 The cornified envelope protein small proline-rich protein 1B (SPRR1B) is a biomarker for squa

160 a using a biomarker of keratinization, small proline-rich protein 1B.

161 onfirm this prediction and show that a small proline-rich protein 3 (SPRR3) variant confers susceptib

162 R14 and the mutants, our work uncovered this proline-rich protein as a novel activator of the PI3K pa

163 ine, one or more bitter receptor or salivary proline-rich protein genes on chromosome 12 have alleles

164 ZmHyPRP is a proline-rich protein with a C-terminal domain having eig

165 Other major secretory proteins (amylase, proline-rich protein) are not bound to isolated granule

166 ochemical analysis revealed that PRR14, as a proline-rich protein, binds to the Src homology 3 (SH3)

167 Specifically, acidic proline-rich protein, cystatin, statherin and protein S1

168 kout cell envelope, in addition to the small proline rich proteins.

169 the interaction between a family of salivary proline-rich proteins (aPRPs) and representative pyranoa

170 tions between basic, glycosylated and acidic proline-rich proteins (bPRPS, gPRPs, aPRPs) and P-B pept

171 nteraction of Actinomyces oris with salivary proline-rich proteins (PRPs), which serve as fimbrial re

172 d extensins (EXTs), and lightly glycosylated proline-rich proteins (PRPs).

173 ing the upregulation of genes encoding small proline-rich proteins and S100 calcium-binding proteins,

174 ipts, including those encoding various small proline-rich proteins and S100 calcium-binding proteins,

175 ily old salivary proteins such as mucins and proline-rich proteins contain large regions of tandem re

176 Prolamins are proline-rich proteins occurring in cereal grains.

177 the arabinogalactan proteins, extensins, and proline-rich proteins, in reality, a continuum of struct

178 nteracts with phosphoinositides and multiple proline-rich proteins, including the WAS protein (WASp)/

179 s and the expression of involucrin and small proline-rich proteins, which covalently bind ceramides.

180 omponents and processes such as histones and proline-rich proteins.

181 etail that RBP C-terminal SH3 domains bind a proline-rich (PxxP) motif of Aplip1/JIP1 with submicromo

182 identified the immunoglobulin-containing and proline-rich receptor-1 (IGPR-1, also called TMIGD2) gen

183 Although Ig-containing and proline-rich receptor-1(IGPR-1) was recently identified

184 d identify serine 986 (S986) within a serine-proline rich region of MED14 as the major ERK phosphoryl

185 While removal of the proline-rich region (P domain) of PAB1 substantially red

186 Here, we report that the C-terminal proline-rich region (PRR) of ALIX folds back against the

187 dition to these WW domains, Itch possesses a proline-rich region (PRR) that has been shown to interac

188 d in sensing the cell cycle and a C-terminal proline-rich region (PRR) that may have a role in protei

189 ERK signaling by the concerted action of its proline-rich region (PRR), RhoGAP domain, and the BNIP-2

190 nding of a conserved PxRPxK motif within the proline-rich region 1 of THEMIS to the C-terminal SH3-do

191 orylation were mapped to a YY-motif close to proline-rich region 1.

192 we find that FAK activity and FAK C-terminal proline-rich region 2 (PRR2) and PRR3 are required for F

193 Deletion of this proline-rich region also induced a gene expression signa

194 The N-terminal of MyRF, which contains a proline-rich region and a DNA binding domain (DBD), is a

195 zes via two intermolecular interactions (SH3:proline-rich region and BH:BH) to selectively bind unpho

196 nts consisting of six and seven sites in the proline-rich region and carboxy terminus of tau by amino

197 nt receptor potential subtype V1 (TRPV1) via Proline-rich region and regulates TRPV1 surface expressi

198 AVS and a truncated MAVS lacking part of the proline-rich region and the C-terminal transmembrane dom

199 The proline-rich region contains two highly conserved aspara

200 and STAM-1 physically interact and that the proline-rich region in AIP4 and the SH3 domain in STAM-1

201 o the P3 block ((396)PAIPPKKPRP(405)) of the proline-rich region in CIN85.

202 The first antibody, ADx201, binds the Tau proline-rich region independently of the phosphorylation

203 Unexpectedly, deletion of the proline-rich region induced mesenchymal-like conversion

204 domain-containing proteins, and the central proline-rich region of SLP-76 have been well studied and

205 lternatively spliced exons embedded within a proline-rich region of WNK1 that contain PY motifs, whic

206 rious sizes, sequences, and locations in the proline-rich region ofenv Outside theenvregion, all E-ML

207 omology 3) domain of PSD-95 interacts with a proline-rich region within the microtubule end-binding p

208 ains two conserved cysteine-based domains, a proline-rich region, and a nuclear localization signal.

209 on at CME sites are the third EH domain, the proline-rich region, and the coiled-coil region.

210 urs between the actin-binding domain and the proline-rich region, generating a C-terminal mAbp1 fragm

211 are found within coiled-coil domains and the proline-rich region, motifs essential in other fusion sy

212 quences of ankyrin repeat-, SH3 domain-, and proline-rich region-containing protein 2 (ASPP2), a hapl

213 tein-protein interactions via the N-terminal proline-rich region.

214 the microtubule-binding domain and upstream proline-rich region.

215 optosis-linked gene-2 (ALG-2) and the Sec31A proline-rich region: 1) targeted disruption of ALG-2/Sec

216 (VRA and VRB, respectively), to include the proline rich-region (PRR) of SU.

217 posed of 2 N-terminal domains (N1 and N2), 2 proline-rich regions (PRR1 and PRR2) that flank a histid

218 ain cleavage site between the two C-terminal proline-rich regions after Ser-745, resulting in a C-ter

219 rase may be required to effectively fold the proline-rich regions of the C-terminal propeptide to all

220 of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2.

221 ecifically to glutamine repeat sequences and proline-rich regions, and interacts with RNA polymerase

222 BCR-ABL1 SH3 domain interacts with RAD51 proline-rich regions, resulting in direct phosphorylatio

223 adhesin domains flanked by alpha-helical and proline-rich regions.

224 Interestingly, a deletion in a proline-rich repeat region (amino acids 274 to 289) of E

225 r structures with the number of alanine- and proline-rich repeats determining their length.

226 n mutation mlt-10(mg364), which disrupts the proline-rich repeats, causes the most severe phenotype.

227 ohydrate binding module revealed a short and proline-rich rigid linker that anchored together the cat

228 tein-tyrosine kinase Fyn, which binds to the proline-rich RTPPKSP motif conserved in both MAP2 and ta

229 crotubule (MT)-binding domain and the serine-proline-rich (S/P-rich) region of DCXs in-cis in the sam

230 MTC28 is a 28-kDa proline-rich secretary antigen of Mycobacterium tubercul

231 bronectin-related motif (Fn3), a repetitive, proline-rich segment (PEVK), and, at the N-terminus, a u

232 sis and growth, through the serine threonine proline-rich segment in its N-terminus and a signaling p

233 Mechanistically, a proline-rich segment in the carboxyl terminus of GILZ ph

234 egment of consecutive glutamines (QN), and a proline-rich segment.

235 -homology 3 (SH3) domains that bind multiple proline-rich segments in the actin regulatory protein ne

236 s include domains specialized in recognizing proline-rich segments, including Src-homology 3 (SH3), W

237 well as the impact of the polyglutamine and proline-rich segments, remains, however, mostly uncharac

238 ibly recruited through its SH3.1 domain to a proline-rich sequence (PRS) in CD3epsilon after TCR enga

239 ted through its src homology 3.1 domain to a proline-rich sequence (PRS) in CD3epsilon.

240 psilon cytoplasmic tail contains a conserved proline-rich sequence (PRS) that influences TCR-CD3 expr

241 ubunits to expose the CD3epsilon cytoplasmic proline-rich sequence (PRS).

242 TAM, the CD3 epsilon subunit also contains a proline-rich sequence and a basic-rich stretch (BRS).

243 g repeats, and a weaker interaction with the proline-rich sequence and the termini of tau.

244 Because this interaction masks the proline-rich sequence binding site of the SH3.2 domain,

245 with quantitative differences in CD3epsilon proline-rich sequence exposure and Nck recruitment.

246 n open reading frame 3 (ORF3) protein, and a proline-rich sequence in ORF3 was important for egress f

247 A proline-rich sequence in PDK1 bound to an Src homology 3

248 at this characteristic of HOXB4 depends on a proline-rich sequence near the N terminus, which is uniq

249 The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intra

250 is N-terminal subdomain of CagA with a 7-kDa proline-rich sequence of ASPP2 reveals that this domain

251 2 (WH2) domain that binds actin, and (ii) a proline-rich sequence that binds profilin-actin complexe

252 A proline-rich sequence within VP1/2 is required for the e

253 quitylation is mediated by the CD3varepsilon proline-rich sequence, Lck, c-Cbl, and SLAP, which colle

254 tory domains, and its FH1 domain has minimal proline-rich sequence.

255 h a selectivity filter formed by an uncommon proline-rich sequence.

256 elongation, but in the presence of profilin, proline-rich sequences are required to support polymeras

257 ine phosphorylation, kinase activity, and/or proline-rich sequences in the C-terminal FAT domain.

258 In between NRD and CRD, proline-rich sequences mediate the incorporation of prof

259 d that different SH3 domains target distinct proline-rich sequences overlapping significantly.

260 Collaboration between WH2 and proline-rich sequences thus strikes a balance between fi

261 s by its SH3 domain, which bound directly to proline-rich sequences within EspF(U).

262 able specificity of Nck toward proteins with proline-rich sequences.

263 ctions and acting through the recognition of proline-rich sequences.

264 tion relies on the integrity of a C-terminal proline-rich SH3 binding region of M2 and its interactio

265 CE) precursor proteins (involucrin and small proline-rich [Sprr] -1a, -1b, -2a, -2b, -2f, and -2g pro

266 audin-1, a tight junction protein, and small proline-rich (Sprr2) protein, a major component of corni

267 Together, these data indicate that the proline-rich Src homology 3 domain-binding motif in TRAF

268 repeat (TSR) domains in TRAP connect through proline-rich stalk, transmembrane, and cytoplasmic domai

269 ic stretch (N17) and a C-terminal 38-residue proline-rich stretch (C38).

270 These results indicate that proline-rich stretches attenuate the potential of stem c

271 (PR) domain termed PDP (Proline rich-DUF3587-Proline rich) that forms homo-oligomer, allowing the UBL

272 Because the region is proline rich, the hypothesis that it targets Src homolog

273 elated protein SynDIG4 [also known as Prrt1 (proline-rich transmembrane protein 1)] has recently been

274 Proline-rich transmembrane protein 2 (PRRT2) has been id

275 Proline-Rich Transmembrane Protein 2 (PRRT2) has been sh

276 PRRT2 (proline-rich transmembrane protein 2 gene) has been iden

277 ncing has identified mutations in the PRRT2 (proline-rich transmembrane protein 2) gene as the leadin

278 transducer) was mediated by FA formation and proline-rich tyrosine kinase 2 (PYK2) activity.

279 In cultured cells, phosphorylation of a FAK/proline-rich tyrosine kinase 2 (PYK2) consensus site in

280 Despite the involvement of proline-rich tyrosine kinase 2 (Pyk2) in endothelial cel

281 Proline-rich tyrosine kinase 2 (Pyk2) is a member of the

282 Proline-rich tyrosine kinase 2 (Pyk2) is a member of the

283 Proline-rich tyrosine kinase 2 (Pyk2) is activated by va

284 FAK and its homolog Proline-rich tyrosine kinase 2 (Pyk2) modulate paxillin

285 results reveal that tyrosine kinases Src and proline-rich tyrosine kinase 2 (Pyk2) regulate SHP-1-dep

286 Proline-rich tyrosine kinase 2 (PYK2), a redox-sensitive

287 Proline-rich tyrosine kinase 2 (PYK2), also known as cel

288 to-oncogene tyrosine-protein kinase) and the proline-rich tyrosine kinase 2 (Pyk2), and they can also

289 actin as a novel substrate and interactor of proline-rich tyrosine kinase 2 (Pyk2).

290 erentiation primary response gene-88 (MYD88)/proline-rich tyrosine kinase 2 (PYK2)/LYN complexes, whi

291 Inhibition of proline-rich tyrosine kinase 2 improved insulin-induced

292 Inhibition of proline-rich tyrosine kinase 2 restores insulin-induced

293 itory residue Y657 of eNOS and expression of proline-rich tyrosine kinase 2 that phosphorylates this

294 DPH oxidase, Syk, focal adhesion kinase, and proline-rich tyrosine kinase 2, and in the absence of De

295 Proline-rich tyrosine kinase 2, in turn, caused activati

296 and Syk that activated the downstream kinase proline-rich tyrosine kinase 2.

297 lying this process: a phospholipase C/Ca(2+)/proline-rich tyrosine kinase 2/cJun N-terminal kinase pa

298 the calcium-regulated focal adhesion protein proline-rich tyrosine kinase-2 (Pyk2) and the effector p

299 Here we demonstrate that proline-rich tyrosine kinase-2 (PYK2) deficiency impairs

300 Aldosterone infusion increased proline-rich WNK1 isoform abundance in WT mice but did n