ライフサイエンスコーパス: proline-rich domain

1 ing is mutually exclusive and dependent on a proline-rich domain.

2 hatase domain, a 5-phosphatase domain, and a proline-rich domain.

3 mily kinases (Src or Hck) via its C-terminal proline-rich domain.

4 al LIM domains, but one lacks the N-terminal proline-rich domain.

5 erminal acidic and conserved PR motif or the proline-rich domain.

6 of the Cdc42 binding domain but required the proline-rich domain.

7 eviously unrecognized extended region of the proline-rich domain.

8 binding to an amino-terminal region near the proline-rich domain.

9 apoptosis in p53 have been mapped, e.g., the proline-rich domain.

10 es mainly on 69 amino acids within Blimp-1's proline-rich domain.

11 calmodulin, as well as, the presence of its proline-rich domain.

12 the role of its unique, conserved histidine-proline-rich domain.

13 pleckstrin homology domain, and a C-terminal proline-rich domain.

14 l protein paxillin through its COOH-terminal proline-rich domain.

15 hown to bind directly through the C-terminal proline-rich domain.

16 he amino-terminal segment of hDlg containing proline-rich domain.

17 hSOS1 in vitro within the carboxyl-terminal proline-rich domain.

18 transmembrane segment, and an intracellular proline-rich domain.

19 rminal domains of CR, but not by the central proline-rich domain.

20 nsus SH2 binding sites, an SH3 domain, and a proline-rich domain.

21 nd basic domains of Tat, but not against the proline-rich domain.

22 KD2 interacts with CIB1a via its alanine and proline-rich domain.

23 ssion of Bmf expression independent of p53's proline-rich domain.

24 phosphorylation within the C-terminal serine/proline-rich domain.

25 s) of, or protein interactions with, the p63 proline-rich domain.

26 wo phosphoinositol phosphatase domains and a proline-rich domain.

27 nal domain, and a previously uncharacterized proline-rich domain.

28 he N-terminal Bro1 domain and the C-terminal proline-rich domain.

29 e L104PPPPP site located within the migfilin proline-rich domain.

30 physically associates with Sjl2 through its proline-rich domain.

31 recruitment through its own coiled coil and proline-rich domains.

32 ne-rich, interleukin-1 receptor-related, and proline-rich domains.

33 shown to bind known proteins that contained proline-rich domains.

34 with a C2H2-type zinc finger motif, a serine/proline-rich domain, a basic domain, and a leucine-zippe

35 ar structure consisting of an NH(2)-terminal proline-rich domain, a central region of homology specif

36 s four distinct domains: a signal peptide, a proline-rich domain, a histidine-rich basic domain and a

37 cysteine-rich domains interspersed by eight proline-rich domains; a glycine- and serine-rich domain

38 Previous studies suggest that the proline-rich domain (aa 43-70) in FasLCyt (FasLPRD) inhi

39 n activation domains 1-2 and deletion of the proline-rich domain abolish mutant p53 to regulate Gro1

40 The C-terminal serine/proline-rich domain (amino acids 202-446) cannot dimeriz

41 omain are inessential, as are the C-terminal proline-rich domain (amino acids 382-476) and two zinc-b

42 An N-terminal proline-rich domain (amino acids 85-106) of SH2-Bbeta is

43 The protein lacks the extensive proline rich domain and leucine zipper seen in c-cbl and

44 d C-terminal sequence including an extensive proline-rich domain and a C-terminal amphipathic helix.

45 ved leader peptide followed by an N-terminal proline-rich domain and a C-terminal cysteine-rich domai

46 acid nuclear protein with an amino-terminal proline-rich domain and a carboxyl-terminal DNA binding

47 All alleles have a proline-rich domain and a choline-binding repeat domain

48 p process, with recruitment dependent on the proline-rich domain and activation dependent on binding

49 We found that the membrane proximal proline-rich domain and adjacent 16 residues are essenti

50 esence of a C-terminal extension featuring a proline-rich domain and an actin-binding WASP-Homology 2

51 present a C-terminal extension containing a proline-rich domain and an actin-binding Wiskott-Aldrich

52 synthesized peptide based on the functional proline-rich domain and examined its biological function

53 To further delineate the function of the proline-rich domain and its potential role in transactiv

54 on of profilin-actin complexes with the VASP-proline-rich domain and the binding of the VASP-F-actin

55 p53-(DeltaPRDDeltaBD), which lacks both the proline-rich domain and the C-terminal basic domain, are

56 ional analysis demonstrates that the central proline-rich domain and the C-terminal domain of ADAP ar

57 EBNA 3C contains glutamine-rich and proline-rich domains and a region in the N terminus cons

58 STEP(61) binds to Fyn through one of its proline-rich domains and the kinase-interacting motif do

59 ases, possesses an N-terminal BRCT domain, a proline-rich domain, and a C-terminal polymerase beta-li

60 c domain with three key tyrosines, a central proline-rich domain, and a C-terminal Src homology 2 dom

61 near the N terminus followed by a repetitive proline-rich domain, and a cysteine-rich C-terminal PAC

62 erved regions include a saposin-like domain, proline-rich domain, and a putative signal peptide.

63 those of Rho-specific GEFs, a PDZ domain, a proline-rich domain, and an area of homology to Lsc, p11

64 ncluding the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosi

65 p53, the SH3 domain of which binds the WAVE2 proline-rich domain, and PIR121/Sra-1, which forms a pen

66 n domains of MTF1, namely the acidic domain, proline-rich domain, and serine-threonine rich domain, a

67 s, such as the second activation domain, the proline-rich domain, and the C-terminal basic domain, ar

68 ons, contains two transmembrane domains, two proline-rich domains, and a kinase-interacting motif.

69 so found that activation domains 1-2 and the proline-rich domain are required for mutant p53 gain of

70 conformational changes in the head, tail and proline-rich domains are linked structurally and thermod

71 ation domain 1, activation domain 2, and the proline-rich domain), are required for inducing cell cyc

72 usceptibility gene 1 C-terminal domain and a proline-rich domain at its N-terminus, we used a mass sp

73 h RING finger B-box-1 (PML-prb-), the serine-proline-rich domain at the C-terminal (PMLsp-), and the

74 ne kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end.

75 ls-), the dimerization domain (PMLdim-), the proline-rich domain at the N-terminal (PMLpro-), the pro

76 was absent, as expected, due to removal of a proline-rich domain between amino acids 151-160 that is

77 These results suggest that the proline-rich domain between amino acids 301 and 315 in P

78 n has a unique 120-amino acid glutamine- and proline-rich domain between the SH2 and C-terminal SH3 d

79 e C-terminal fragment, although having three proline-rich domains, bound to Grb2 and Crk less efficie

80 lization to the cell membrane, requiring the proline-rich domain, but not on the Src homology 2 domai

81 sphatidylinositol 3-kinase/AKT, required the proline-rich domains, but not the ZNF domains, of ZNF198

82 ing mutations in the IQ, TH-1-like, SH3, and proline-rich domains by frameshift or in-frame deletions

83 ons are often mediated by the recognition of proline-rich domains by SH3 or WW modules.

84 protein with a pleckstrin homology (PH) and proline-rich domain, by interaction with the MBC SH3 dom

85 activation domain as well as deletion of the proline-rich domain, completely loses its activity.

86 e further demonstrate that the non-enzymatic proline-rich domain confers the increase in fidelity of

87 e cytoplasmic C terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate

88 In addition, retention of proline-rich domain-containing FasL in the cytoplasm was

89 eucine-rich repeat, tropomodulin domain, and proline-rich domain-containing protein (RLTPR); moesin;

90 Its long C-terminal proline-rich domain contains 13 PXXP motifs, which orche

91 tant (delta pro AE), which lacks this entire proline-rich domain (deleted for amino acids 62-91), was

92 The inhibitory effect of a dynamin proline-rich domain deletion mutant on the recruitment o

93 he p53 point mutation L22Q/W23S, but not the proline-rich domain deletion mutants 83-393 and DeltaPro

94 ation of Abp1 with GST fusion of the dyanmin proline-rich domain demonstrate the interaction of Abp1

95 Bax to promote MDA-mediated cell death in a proline-rich domain-dependent manner through both transc

96 Using a proline-rich domain derived from formin (a product of th

97 yloid fibril formation, while the C-terminal Proline Rich Domain destabilizes fibrils and enhances ol

98 Although deletion of the proline-rich domain did not affect general membrane asso

99 Gravin displays nine proline-rich domains distributed throughout the molecule

100 MDM2 binding site, ATM phosphorylation site, proline rich domain, DNA binding domains (DBDs) II-V, nu

101 o DNA damage, indicating that removal of the proline-rich domain does not disrupt p53's upstream regu

102 3 (SH3) domain of c-SRC, but deletion of the proline-rich domain does not totally ablate the interact

103 h the p85 subunit of PI 3-kinase through its proline-rich domain during virus internalization and exp

104 s through a selective influence of the dyn-2 proline-rich domain (dyn-2 PRD) on the eNOS reductase do

105 phospho- or phospho-mimetic mutations in the proline-rich domain eliminate the acceleration phase by

106 The proline-rich domain-Ena/VASP homology 2 structure is req

107 s of FcmuR deletion mutants, we identified a proline-rich domain essential for cell surface expressio

108 namin localization to the tails required its proline-rich domain, expression of a dynamin mutant lack

109 lts suggest that activation domain 2 and the proline-rich domain form an activation domain for induci

110 horylates primarily serine 857 (S857) in the proline-rich domain, found only in 1xa, one of the alter

111 ASP homology 2 domain and a profilin-binding proline-rich domain from espin did not decrease lengthen

112 adhesion targeting (FAT) sequence and second proline-rich domain from the tyrosine kinase domain and

113 e C terminus of DOC-2/DAB2, containing three proline-rich domains, has not been explored.

114 On the other hand, this deletion of the p53 proline-rich domain impairs p53's ability to suppress tu

115 clude that a functional peptide derived from proline-rich domain in DOC-2/DAB2 has growth-inhibitory

116 Furthermore, depletion of the proline-rich domain in GPVI (Pro(-)-GPVI) prevented bind

117 transcription factor which contains a large proline-rich domain in its C terminus.

118 PEPD binds to the proline-rich domain in p53, which inhibits phosphorylati

119 W domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein,

120 For example, a glycine/proline-rich domain in the central variable region funct

121 ot required for Duox function, mutation of a proline-rich domain in the Duox C terminus, a potential

122 oning of GPVI has revealed the presence of a proline-rich domain in the sequence of GPVI cytoplasmic

123 etal protein paxillin through its C-terminal proline-rich domain in TrHBMEC.

124 Our results demonstrate use of the WW and proline-rich domains in protein-engineered materials and

125 malian endocytic DRP, dynamin 1, lacking the proline-rich domain, in its nucleotide-free state.

126 A unique glutamine/proline-rich domain (insert domain) of unknown function

127 In addition, a 65-residue, proline-rich domain is characterized by a strong amino a

128 The proline-rich domain is located within residues 60-90, wh

129 In CstF-77, a proline-rich domain is necessary not only for binding bo

130 Additionally, the ADAP proline-rich domain is required for optimal Ag-induced a

131 In addition, we show that the proline-rich domain is required for optimal Ca2+ release

132 nd the cysteine-rich domain or intracellular proline-rich domain is required for Wnt5a-induced recrui

133 The ADAP proline-rich domain is sufficient to bind and stabilize

134 ent of alternating cysteine-rich domains and proline-rich domains is strikingly similar to that found

135 Two proline-rich domains located amino-terminal to the homeo

136 a novel 374 amino acid protein containing a proline-rich domain near its N terminus and two LIM doma

137 or the Src family of tyrosine kinases, and a proline-rich domain near the C terminus that contains mu

138 human cell extracts which phosphorylate the proline rich domain of human p53 in vitro.

139 The proline rich domain of murine p53 is a substrate for pho

140 at of variable length and culminating with a proline-rich domain of 50 amino acids.

141 The interaction occurs between a proline-rich domain of ACK2 and the Src homology 3 domai

142 with simulations suggest that the N-terminal proline-rich domain of apoA-I influences the stability o

143 yeast two-hybrid screen that identified the proline-rich domain of ASPP2 as a host cellular target.

144 arboxyl-terminal, approximately 200 residue, proline-rich domain of CARMIL.

145 iation of Lyn's SH3 and SH2 domains with the proline-rich domain of Cbl.

146 er, the SH3 domain of p85 interacts with the proline-rich domain of Cbl.

147 involves the recruitment of Src through the proline-rich domain of Cbl.

148 tivated AKT by forming a complex between the proline-rich domain of CKAP4 and the Src homology 3 doma

149 s between the C terminus of K(V)10.1 and the proline-rich domain of cortactin, regions targeted by ma

150 The expressed proline-rich domain of Dab2 (#600-730) bound Grb2, but o

151 The carboxy-terminal proline-rich domain of DAZAP1 interacts with and neutral

152 In this study, we further showed that the proline-rich domain of DOC-2/DAB2 could also interact wi

153 -specific peptides, we found that the second proline-rich domain of DOC-2/DAB2 is the key binding sit

154 The proline-rich domain of Drosophila dynamin was used to id

155 clathrin-coated pits and interacted with the proline-rich domain of dynamin.

156 of two mutations, either of which alters the proline-rich domain of Gag and is sufficient to confer d

157 in ER-accumulating domain) is the N-terminal proline-rich domain of gamma-zein that is sufficient to

158 ly, and the presence of the novel C-terminal proline-rich domain of GluR3salpha imparts lateral membr

159 These findings demonstrate that the proline-rich domain of GPVI mediates the association wit

160 SH3 domains of both Src kinases to bind the proline-rich domain of GPVI.

161 Here, we show that the C-terminal proline-rich domain of Hip1R binds to the SH3 domain of

162 Ubc9-depleted cell lines indicated that the proline-rich domain of HMGA1b positively influences tran

163 nd C-terminal domains, but not the histidine-proline-rich domain of HPRG, also bound plasminogen and

164 Htt, and Happ1, an intrabody recognizing the proline-rich domain of Htt, both reduce mHtt-induced tox

165 This activity requires a Src-kinase-binding proline-rich domain of Nef and a conserved tyrosine-base

166 The unique glutamine- and proline-rich domain of OsDr1 had no repression activity.

167 The proline-rich domain of p53 has potential for SH3 protein

168 This polymorphism occurs in the proline-rich domain of p53, which is necessary for the p

169 lustrated by the dispensable function of the proline-rich domain of p53.

170 53 through its Src homology 3 domain and the proline-rich domain of p53.

171 ition was conferred by the carboxyl-terminal proline-rich domain of PI31, which appears to have an ex

172 The proline-rich domain of Prrp interacts with profilin, a p

173 of a peptide derived from the COOH-terminal proline-rich domain of PTP HSCF revealed that a subset o

174 placing two critical proline residues in the proline-rich domain of PTP1B between amino acids 301 and

175 talytically deficient mutant of SHIP2 or the proline-rich domain of SHIP2 enhanced Akt activation.

176 cond gene-trapped line, in which most of the proline-rich domain of Ssdp1 is retained, did not show a

177 interactions occur via two NPF motifs in the proline-rich domain of stonin 2 and Eps15 homology domai

178 y virus type 1 virions via contacts with the proline-rich domain of the Gag polyprotein.

179 was dependent on a threonine amino acid in a proline-rich domain of the protein.

180 29 and 53 of Zta, containing homology to the proline-rich domain of the tumor suppressor protein p53.

181 ng was not due to an interaction between the proline-rich domain of WASP and the SH3 domain of these

182 -hybrid assay showed that the NH(2)-terminal proline-rich domain of Zimp7 and the region spanning ami

183 The C-terminal, proline-rich domains of TANGO1 molecules in the ring are

184 icted 42-amino acid deletion between the two proline-rich domains of the enzyme.

185 residues 250 to 392, which contain the three proline-rich domains, of hnRNP K.

186 ains a 211- (rat) or 205- (human) amino acid proline-rich domain on the carboxyl terminus.

187 icted Wasp homology 2 (WH2) domains, and two proline-rich domains, one with similarity to eukaryotic

188 e transcriptional activation domain, the p53 proline-rich domain plays a critical role in the transmi

189 pTalpha cytoplasmic tail, in particular the proline-rich domain, plays a crucial role in pre-TCR sig

190 ic scaffold Pan1 contains an uncharacterized proline-rich domain (PRD) at its carboxy (C)-terminus.

191 l modification site or of the downstream MTS proline-rich domain (PRD) increased mitochondrial import

192 expression of p130(CAS) containing a deleted proline-rich domain (PRD) inhibited adenovirus cell entr

193 the mutant Dyn2 protein, indicating that the proline-rich domain (PRD) is required for Dyn2 recruitme

194 e intramolecular interaction site within the proline-rich domain (PRD) of ALIX transforms cytosolic A

195 the cortactin-SH3 domain associates with the proline-rich domain (PRD) of dynamin.

196 This interaction is dependent on the proline-rich domain (PRD) of Rin1 as Rin1DeltaPRD, a mut

197 PVI receptor utilizes a unique intracellular proline-rich domain (PRD) to accelerate platelet activat

198 A C-terminal proline-rich domain (PRD) was identified as the mediator

199 mediated in part through association of its proline-rich domain (PRD) with the Src homology 3 (SH3)

200 containing 17 amino acids (N17), polyQ, and proline-rich domain (PRD)) become ordered at very differ

201 e tandem activation domains (AD1 and AD2), a proline-rich domain (PRD), and a C-terminal basic domain

202 a PTAP mutant also depends on its C-terminal proline-rich domain (PRD), but not on the binding sites

203 , a homolog of hPLSCR1 that lacks N-terminal proline-rich domain (PRD), did not show scramblase activ

204 Through interactions via its proline-rich domain (PRD), dynamin binds several protein

205 by a second mutation in the carboxy-terminal proline-rich domain (PRD), one that prevents dynamin fro

206 tution of proline by arginine within the p53 proline-rich domain (PRD).

207 ly regulated and partially depend on the p53 proline-rich domain (PRD).

208 he affinity for Sec23 is concentrated in the proline-rich domains (PRDs) of TANGO1 and cTAGE5, but Se

209 phosphorylation sites within their specific proline-rich domains (PRDs) that are differentially regu

210 oss-reactive antibodies were directed to the proline-rich domain present in both molecules.

211 homeodomain, there is an acidic domain and a proline-rich domain present in the protein.

212 A human Kv3.3 mutation within a conserved proline-rich domain produces channels that bind Hax-1 bu

213 Tat protein that contained a deletion of the proline-rich domain promoted neuronal aggregation.

214 the C-terminal domain of FAK containing the proline-rich domains PRR2 and PRR3.

215 A series of peptides derived from the proline-rich domain (residues 174-251) of tau was synthe

216 he activation domain (residues 1-59) and the proline-rich domain (residues 67-127) are required for T

217 of either the COOH-terminal actin binding or proline-rich domains resulted in enhanced adhesion and c

218 d serine-rich domain and at least one of the proline-rich domains show sequence similarity to protein

219 H2-type zinc fingers, and glutamine-rich and proline-rich domains, suggesting that it functions as a

220 terminus of the HIV-1 Gag protein contains a proline-rich domain termed p6(Gag).

221 entral and the C-terminal end of the dynamin proline-rich domain that account for a significant incre

222 ddition, the hDlg contains an amino-terminal proline-rich domain that is absent in other MAGUKs.

223 utants define discrete subregions of a novel proline-rich domain that is required for subcellular loc

224 However, neither the SLP-76 proline-rich domain that links to GADS and LAT, nor LAT,

225 talytic RING finger domain, and a C-terminal proline-rich domain that mediates interactions with Src

226 DHR1 and DHR2 (or "Docker"), and C-terminal proline-rich domains that associate with the adapter pro

227 Both proteins contain COOH-terminal proline-rich domains that can interact with a variety of

228 the N-terminal SH2 domain and the C-terminal proline-rich domain to mediate its inhibitory effect.

229 ed the disulfide bond bridging the histidine-proline-rich domain to the N/C fragment.

230 region of the PRCC protein, which includes a proline-rich domain, to the entire TFE3 protein.

231 However, the proline-rich domain towards the N-terminus of p53 (resid

232 s only the amino-terminal Q and glycine- and proline-rich domains typical of the Groucho/AES subfamil

233 two proteins requires both a TRPV4-specific proline-rich domain upstream of the ankyrin repeats of t

234 The TEF-1 proline-rich domain was essential for TBP binding, but p

235 In addition, a proline-rich domain was found to promote TARP oligomeriz

236 e loss of function seen with deletion of the proline-rich domain was not due to a DNA-binding defect,

237 The proline-rich domain was shown to bind to two proteins, i

238 hin a TPXK cdk5 phosphorylation motif in the proline-rich domain) was not affected by cdk5 phosphoryl

239 Based on the sequences of the proline-rich domains, we sought to determine whether Sir

240 ro-786-Pro-793) at the N-terminal end of the proline-rich domain, whereas the amphiphysin SH3 binds S

241 N-terminal p53 fragment (transactivation and proline-rich domains), which induces apoptosis in non-ne

242 ngly, the pleckstrin homology domain and the proline-rich domain, which are known to bind to coated-p

243 g conditions releases the central, histidine-proline-rich domain, which contains 15 tandem repeats of

244 The histidine-proline-rich domain, which contains 34 of the 53 histidi

245 In contrast, deletion of an MIM proline-rich domain, which is required for an optimal bi

246 ipeptide sequence, adjacent to the conserved proline-rich domain, which was potentially a key differe

247 LNK recruitment was dependent upon the Grap2 proline-rich domain, while modulation of phosphorylation

248 -binding functions: an N-terminal serine and proline-rich domain with a predicted immunoglobulin-like

249 Dab2 contains a C-terminal proline-rich domain with sequences similar to those foun

250 domains, two highly charged regions, and two proline-rich domains with multiple PPXY and PXXP motifs.

251 HPK1 interacts, through its proline-rich domains, with growth factor receptor-bound

252 Deletion of a proline-rich domain within RARgamma abrogated this inter

253 basic domain within residues 364-393 and the proline-rich domain within residues 64-91 are required f

254 ITA, and this interaction was dependent on a proline-rich domain within RFX5.