ライフサイエンスコーパス: prolong(|s|ed) the (lifetime|survival) of

1 In vivo, as a single agent, pevonedistat prolonged the survival of 2 MCL-bearing mouse models whe

2 ium animalis) in the gastrointestinal tracts prolonged the survival of adult and neonatal bg/bg-nu/nu

3 B/FeJ (C3H; H2k) neonates up to 6-7 days old prolonged the survival of adult C3H skin grafts.

4 transplantation of skin from neonatal donors prolongs the survival of adult skin allografts on rabbit

5 been shown to suppress immune responses and prolong the survival of allografts; however, the underly

6 ty of FTY720, a novel immunosuppressant that prolongs the survival of allografts in experimental anim

7 en-positive passenger leukocytes effectively prolongs the survival of allografts, it has been hypothe

8 CsA treatment prolonged the survival of ALS transgenic mice as compare

9 This papA RNA segment can prolong the lifetime of an otherwise short-lived mRNA to

10 r 1 day before transplantation, was found to prolong the survival of an allogeneic (C57BL/10 H2(b); N

11 with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden

12 reas OTX2 knockdown in medulloblastoma cells prolonged the survival of animals bearing xenograft tumo

13 In vivo MDA-7/IL-24 prolonged the survival of animals carrying orthotopic tu

14 Inhibition of Pla expression prolonged the survival of animals with the disease, offe

15 Moreover, an extra Chk1 allele prolongs the survival of ATR-Seckel mice, which suffer f

16 lated by activated T cells, and because IL-4 prolongs the survival of B cells cultured with anti-Ig,

17 t can improve function and proliferation and prolong the survival of beta-cells.

18 /kg/day) delivered intravenously for 14 days prolonged the survival of BN SB grafts in LEW recipients

19 In vivo, MAb D11 prolonged the survival of both normal and C4-deficient m

20 tment with a depleting anti-CD4 mAb markedly prolonged the survival of both skin and islet xenografts

21 (anti-CD40-ligand) monoclonal antibody (mAb) prolongs the survival of both allografts and rat xenogra

22 s metastatic tumor lesions and significantly prolongs the survival of brain tumor-bearing mice.

23 clinical use of trastuzumab (Herceptin) has prolonged the survival of breast cancer patients with er

24 y second day (q.o.d.) per gavage for 28 days prolonged the survival of Brown Norway (BN; RT1n) SB all

25 ess prostate cancer cell growth in vitro and prolong the survival of C3(1)/SV40 transgenic mice in vi

26 experiments, WI-1 immunization significantly prolonged the survival of C57BL/6 and BALB/c mice compar

27 Administration of IgG1 prior to infection prolonged the survival of C57BL/6J mice but had no effec

28 Anti-CD154 antibody markedly prolongs the survival of cardiac allografts in primates

29 Our studies demonstrate that Bcl-X(L) prolongs the survival of CD28(-/)- T cells but does not

30 ignaling induced resistance to apoptosis and prolonged the survival of CD4(+) T(reg).

31 The knockdown of Sig-1Rs dramatically prolonged the lifetime of CGalT without affecting the tr

32 with MLs led to initial higher chimerism and prolonged the survival of circulating pig cells in baboo

33 hepatocytes restored metabolic function and prolonged the survival of cirrhotic rats, as well as rat

34 omegaly and spontaneous colony formation and prolongs the survival of CMML-bearing mice, suggesting t

35 d antigen (GAA)-derived CTL epitope peptides prolonged the survival of CNS GL261 glioma-bearing mice,

36 sgene in mice carrying the rd1 mutation also prolongs the survival of cone photoreceptors, and partia

37 This has important implications as it can prolong the survival of CRPC patients by restoring the t

38 UDP both induced phosphorylation of ERK and prolonged the survival of cytokine-starved hMCs and mBMM

39 ivates immature DCs and, more interestingly, prolongs the survival of DNA-activated DCs by inhibiting

40 We reason that a strategy that prolongs the survival of DNA-transduced DCs will enhance

41 These cells can transfer protection and prolong the survival of donor-specific BALB/c, but not t

42 uction alone, but also increased numbers and prolonged the survival of donor cells in the spleen, as

43 that were infiltrated with CD4+Foxp3+ cells, prolonged the survival of donor-strain hearts in naive r

44 M(-/-) DCs eliminates established tumors and prolongs the survival of EG7 or B16.f10 tumor-bearing mi

45 In contrast, anti-CD8 mAb did not prolong the survival of either islet or skin xenografts

46 ent with a Rho kinase inhibitor considerably prolonged the survival of fully allogeneic heart transpl

47 sponses to allogeneic antigen and profoundly prolonged the survival of fully allogeneic islet grafts

48 otective effect of HK which predominates and prolongs the lifetime of FXIa after platelet activation.

49 naling, we compared the capacity of Tregs to prolong the survival of grafts in the presence or absenc

50 t depletion of recipient CD8+ cells markedly prolonged the survival of grafts transfected with either

51 and 5 after transplantation) treatment alone prolonged the survival of hamster liver xenografts in Le

52 nti-CD80 or CD86 antisense ODN significantly prolonged the survival of heart allografts.

53 at VEGF potentiates angiogenesis in vivo and prolongs the survival of human dermal microvascular endo

54 damage-inducible protein 45beta (GADD45beta) prolonged the survival of hypertrophic chondrocytes in t

55 this treatment regimen did not significantly prolong the survival of IFN-gamma-deficient (B6.129S7-If

56 ion, fibrosis, and alveolar destruction, and prolonged the survival of IL-13-transgenic animals.

57 nventional or plasmacytoid DCs significantly prolongs the survival of IL-2-KO mice, demonstrating tha

58 in FLT3-ITD knock-in mice, and significantly prolonged the survival of immunodeficient mice implanted

59 homolog delayed the process of apoptosis and prolonged the survival of infected 293 cells.

60 poptosis after La Crosse virus infection and prolonged the survival of infected cells.

61 Because in vivo depletion of IL-2 prolongs the survival of infected IL-27R-/- mice, these

62 Inhibitors of SPSB2-iNOS interaction may prolong the lifetime of iNOS and thereby enhance the kil

63 The ability of E2A-HLF to prolong the survival of interleukin-3 (IL-3)-dependent m

64 Cetuximab in particular prolonged the survival of intracranially xenografted mic

65 ptors for IL-2, IL-4, IL-7, IL-9, and IL-15, prolonged the survival of islet allografts in DKO mice.

66 EUK-8 treatment also prolonged the survival of islet allografts in newly diab

67 amine treatment inhibited Th1 cells in vivo, prolonged the survival of islet grafts in diabetic recip

68 IP-9125, suspended in Euro-Collins solution, prolonged the survival of kidney allografts in rats.

69 nous administration of 2.5 mg/kg/day IP-9125 prolonged the survival of kidney allografts to 39.2+/-16

70 h treatment of LEW rats with Rapamycin (RPM) prolongs the survival of LBNF1 cardiac allografts to ca.

71 switch variants of the anti-capsular 3E5 MAb prolong the survival of lethally infected mice, whereas

72 However, celecoxib treatment prolonged the survival of lethally infected animals.

73 odels, treatment with IMC-EB10 significantly prolongs the survival of leukemia-bearing mice.

74 oncogenic KIT-expressing cells in vitro and prolonged the survival of leukemic mice in vivo.

75 , a decrease in TFPI levels dose-dependently prolonged the survival of low-TF mice and rescued the he

76 on of either pathway reduced tumour size and prolonged the survival of lymphoma-bearing mice.

77 only 3 x 10 mg/kg oral dosing, seven dimers prolong the lifetime of malaria-infected mice to days 14

78 imide significantly, and often indefinitely, prolongs the survival of male skin graft transplants in

79 Rather, Hsp70 prolongs the lifetime of mature protein kinase C; disrup

80 pressing T cells restricted tumor growth and prolonged the survival of melanoma-bearing mice.

81 Enzalutamide significantly prolonged the survival of men with metastatic castration

82 Intranasal infection with attenuated RABV prolonged the survival of mice bearing established GL261

83 of tumor cells at the inoculation site, and prolonged the survival of mice bearing intracerebral tum

84 N566/DeltaN599-mutant-mediated signaling and prolonged the survival of mice bearing intracranial xeno

85 ntly suppressed metastatic tumour growth and prolonged the survival of mice bearing metastatic breast

86 junction with chemotherapy, vaccination also prolonged the survival of mice bearing pre-existing tumo

87 DC-flk1 immunization also significantly prolonged the survival of mice challenged with Lewis lun

88 d tumor expansion in vivo, and significantly prolonged the survival of mice following intracranial tr

89 IgG1 and IgG2a MAbs significantly prolonged the survival of mice infected with H. capsulat

90 tion of inhibitor 9i (AP24226) significantly prolonged the survival of mice injected intravenously wi

91 their ability to form metastatic tumors and prolonged the survival of mice injected with the corresp

92 mycin treatment alone, or with cyclosporine, prolonged the survival of mice inoculated with renal can

93 antitumor immune responses and significantly prolonged the survival of mice with established metastat

94 umor challenge, and therapeutic immunization prolonged the survival of mice with established tumors.

95 PD166326 also prolonged the survival of mice with imatinib mesylate-re

96 th in flank and brain allografts in vivo and prolonged the survival of mice with intracranial transpl

97 ibiotic-resistant gram-positive bacteria and prolonged the survival of mice with lethal S. aureus cha

98 nistration of the Her2/neu-specific T-bodies prolonged the survival of mice with tumors in which most

99 ic tumors in 2 different strains of mice and prolonged the survival of mice.

100 A498 and human prostate carcinoma DU145 and prolongs the survival of mice bearing i.p. implanted hum

101 Furthermore, Celastrol prolongs the survival of mice in a model of an aggressiv

102 Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus

103 ibits tumor growth, prevents metastasis, and prolongs the survival of mice inoculated with human pros

104 mono- or dimeric immunotoxins significantly prolongs the survival of mice with implanted human B-cel

105 lus a brief course of anti-CD154 mAb greatly prolongs the survival of murine islet, skin, and cardiac

106 activate the cell cycle, it is sufficient to prolong the survival of naive resting B cells in vitro.

107 alis infection in the nematode intestine and prolonged the survival of nematodes exposed to pathogeni

108 r-1,25-dihydroxyvitamin D2, to mice markedly prolonged the survival of neonatal mouse heart allograft

109 gainst the autophagic machinery Atg7 or Atg5 prolonged the survival of neurons co-treated with BDNF a

110 rophages enhanced the migratory capacity and prolonged the survival of neutrophils in vitro.

111 ventional therapy in vitro and significantly prolongs the survival of NOD/SCID mice engrafted with pr

112 Protective NCD layers may prolong the lifetime of nuclear cladding and consequentl

113 n addition, combined treatment significantly prolonged the survival of nude mice bearing day 14 advan

114 Knocking down ATF6alpha also prolonged the survival of nude mice bearing dormant tumo

115 tant human lung tumor xenografts by >70% and prolonged the survival of nude mice bearing these tumors

116 ns of adult mice with recombinant murine TNF prolong the survival of NZB/W F1 mice, and suppress type

117 bility to stimulate canonical Wnt signaling, prolong the survival of osteoblasts and uncommitted oste

118 evelopment of intraperitoneal xenografts and prolongs the survival of ovarian cancer-bearing mice.

119 multiple components of the MAPK pathway can prolong the survival of patients with BRAFV600E melanoma

120 yte colony-stimulating factor (rh G-CSF) has prolonged the survival of patients with SCN increasingly

121 kinase inhibitor imatinib mesylate markedly prolongs the survival of patients with gastrointestinal

122 otherapy regimens, bevacizumab significantly prolongs the survival of patients with metastatic cancer

123 In addition, this strategy significantly prolonged the survival of pig skin on recipient mice.

124 rcine CD86 but not murine CD86 in vitro, and prolonged the survival of porcine islet grafts in vivo.

125 s induced by dexamethasone or bortezomib and prolongs the survival of primary MM cells cultured alone

126 ion of key enzyme inhibitors can effectively prolong the survival of radiolabeled peptides in the cir

127 ansplantation can improve liver function and prolong the survival of rats with irreversible, decompen

128 with XJB-5-131 (2 micromol/kg) significantly prolonged the survival of rats subjected to profound blo

129 rs of NO synthesis, L-arginine or adenosine, prolonged the survival of rats that received 16-hr-prese

130 yocardial infarction are proposed as ways to prolong the survival of renal transplant patients with i

131 munosuppression of the eye with cyclosporine prolongs the survival of RPE xenografts in the subretina

132 peripheral blood of a patient with PTLD, and prolonged the survival of SCID-beige mice with establish

133 Finally, bortezomib significantly prolonged the survival of severe combined immunodeficien

134 ant reductions in plasma viral load and also prolonged the survival of SIV-infected macaques.

135 Intriguingly, sorafenib prolonged the survival of skin allograft without major t

136 ne (CsA), and sirolimus (rapamycin; RAPA) to prolong the survival of small bowel (SB) allografts.

137 Moreover, inhibition or deletion of SphK1 prolonged the lifetime of sphingosine-induced vesicles.

138 To prolong the lifetime of such a subsurface ocean to the p

139 Weekly serum administration prolonged the survival of susceptible mice.

140 determine whether a genetic intervention can prolong the survival of T cells in HIV-infected individu

141 d found that the Id1 inhibitor significantly prolonged the survival of t(8;21)(+) leukemic mice, wher

142 form of an essential viral protein, Rev M10, prolongs the survival of T cells transduced with a nonvi

143 rrying the oncolytic adenovirus Delta-24-RGD prolonged the survival of TGF-beta-secreting GSC xenogra

144 analogous to the ability of ACK1 and PAK1 to prolong the lifetime of the active GTP-bound state of Cd

145 how extensive trade of finished steel could prolong the lifetime of the Chinese steelmaking assets.

146 nges, a stepwise mechanism is anticipated to prolong the lifetime of the Fe-protein-MoFe-protein comp

147 His30 and Tyr166 in wild-type Mn-SOD act to prolong the lifetime of the inhibited complex.

148 C2 domain and the slow conformational change prolong the lifetime of the PKC betaII-membrane ternary

149 Both bulbar and mucosal cell preparations prolong the survival of the explants.

150 ibition improved the cardiac performance and prolonged the survival of the animals.

151 Weekly treatments (4) with HAT significantly prolonged the survival of the ATL-bearing mice when comp

152 eatment with unmodified HeFi-1 significantly prolonged the survival of the karpas299-bearing mice com

153 delayed the progression of the leukemia and prolonged the survival of the tumor-bearing mice.

154 ivery of cGAMP inhibited melanoma growth and prolonged the survival of the tumor-bearing mice.

155 Furthermore, the CdS shell prolongs the lifetime of the 5-CT triplet and thus enhan

156 Although the D96A mutation dramatically prolongs the lifetime of the M intermediate, it does not

157 The cognate initiating ATP prolongs the lifetime of the open state, plausibly expla

158 esistance to emerge; thus, new strategies to prolong the lifetime of these drugs are needed.

159 Inhibiting caspase-1 can prolong the survival of these HD mice.

160 sical theory to analyze why mechanical force prolongs the lifetime of these bonds rather than shorten

161 attenuates lung adenocarcinoma formation and prolongs the survival of these mice.

162 The same tolerogenic protocol did not prolong the survival of third-party Brown Norway (RT1.An

163 These interactions significantly prolong the lifetime of Tnp, in vitro.

164 caspase-8) with DNA encoding model antigens prolongs the survival of transduced DCs.

165 However, MnSOD overexpression failed to prolong the survival of transgenic mice on exposure to g

166 against the islet-reactive CD4 T cells, and prolonged the survival of transplanted islets.

167 om fully transformed AML cells substantially prolonged the survival of transplanted mice.

168 ) responses were transient but significantly prolonged the survival of treated mice after i.n. F. tul

169 We found that although imatinib prolonged the survival of treated mice, histone deacetyl

170 ith the anti-DNA Ig-based peptide pConsensus prolongs the survival of treated animals and effectively

171 ultiple immunizations with CPs significantly prolonged the survival of tumor-bearing A2xneu mice.

172 -2Ralpha (sIL-2Ralpha) levels (P < .001) and prolonged the survival of tumor-bearing mice (P < .0001)

173 nto established B16 melanomas, significantly prolonged the survival of tumor-bearing mice and could i

174 rtant, the double recombinant vaccinia virus prolonged the survival of tumor-bearing mice.

175 cyte infiltration via genetic Ccl2 reduction prolonged the survival of tumor-bearing mice.

176 ll lines suppressed metastatic potential and prolonged the survival of tumor-bearing mice.

177 We found that PTA treatment significantly prolonged the survival of tumor-bearing mice.

178 burdens in both spleens and lymph nodes, and prolonged the survival of tumor-bearing mice.

179 ificantly inhibited tumor growth in vivo and prolonged the survival of tumor-bearing mice.

180 o, and in vivo, delays tumor growth and thus prolongs the survival of tumor-bearing mice.

181 y monocytes, inhibits metastasis in vivo and prolongs the survival of tumour-bearing mice.

182 liver DEC205+B220+CD19- cells significantly prolonged the survival of vascularized cardiac allograft

183 ne increases movement, promotes feeding, and prolongs the survival of VMAT2-/- animals, indicating th

184 b significantly slowed virus progression and prolonged the survival of VSV-infected Stat1 knockout mi

185 ineering strategies for products that either prolong the survival of VWF or limit VWF-mediated cleara

186 ast, 10 microg of alpha1h u62-69-RT1.Aa only prolonged the survival of WF heart allografts in ACI hos

187 jected subcutaneously into ACI rats modestly prolonged the survival of WF hearts to 14.0+/-10.3 days

188 in donor cells and organs has significantly prolonged the survival of xenografts.