ライフサイエンスコーパス: prolongation

1 Ca(2)(+)-handling and action potential (AP) prolongation.

2 and management of autoimmune-associated QTc prolongation.

3 bradycardia and PQ interval and QRS complex prolongation.

4 ole of anti-Ro Abs in the development of QTc prolongation.

5 a plausible explanation of action potential prolongation.

6 r block-induced ventricular action potential prolongation.

7 seline, 30% (n=1528) of participants had QRS prolongation.

8 ent, sedation, or clinically significant QTc prolongation.

9 were associated with the development of QRS prolongation.

10 e during AVB with the bradycardia-induced QT prolongation.

11 he two targets most likely to produce FRD AP prolongation.

12 with Ca(2+) overload leading to even greater prolongation.

13 fects of cardiac memory lead to excessive QT prolongation.

14 aused by localized action potential duration prolongation.

15 ing cardiac dysfunction and action potential prolongation.

16 T score was correlated with drug-induced QTc prolongation.

17 e MCS may offer an important chance for life prolongation.

18 ricular fibrillation, but did not prevent QT prolongation.

19 nd the dose-limiting toxicity was grade 3 QT prolongation.

20 ults in I(Ks) reduction and action potential prolongation.

21 r declared 3588 (42.1%) "Normal" despite QTc prolongation.

22 elease after SCR, and this contributes to AP prolongation.

23 ion of cell-free HSV-2, allowing for episode prolongation.

24 r reverse use dependency of action potential prolongation.

25 ssor responses, tachycardia, and QT interval prolongation.

26 rate pathogenic inhibitory Abs and cause QTc prolongation.

27 A/Ro Ab-positive sera from patients with QTc prolongation.

28 ng QT syndrome (LQTS) is characterized by QT prolongation.

29 ognized risk of dosage-dependent QT interval prolongation.

30 the surface electrocardiogram as QT interval prolongation.

31 hospital length of stay (7 vs 6 d; relative prolongation, 1.10; p = 0.02) compared with the no-delay

32 ere greater with versus without baseline QRS prolongation: 12.6% (95% confidence interval [CI], 11.0-

33 , increased proportion of mild or severe QTc prolongation (13.1% and 5.8% versus 3.4% and 0.0% [NESDA

34 24%), as well as dose-related, transient QTc prolongation (17%).

35 CI, -1.97 to -0.13; P = .03) and QT interval prolongation (18.1 ms; 95% CI, 6.1-30.1; P = .01) were s

36 herapy, MK-8776 was well tolerated, with QTc prolongation (19%), nausea (16%), fatigue (14%), and con

37 more prevalent in people with epilepsy (QTc prolongation: 5% vs 0%; p=0.002; ERP: 34% vs 13%, p<0.00

38 ; P=0.007) and activation recovery intervals prolongation (69+/-32 versus 39+/-29 versus 21+/-12 ms;

39 nt at moderate or high risk for QTc interval prolongation, a computer alert appeared on the screen to

40 Drug-induced QT interval prolongation, a risk factor for life-threatening ventric

41 dently associated with a reduced risk of QTc prolongation (adjusted odds ratio, 0.65; 95% confidence

42 Despite the absence of manifest QT prolongation, adolescent anorexic females have impaired

43 es of E-pore peptide Abs and significant QTc prolongation after immunization.

44 ficiency, hyponatremia, and prothrombin time prolongation (all P < 0.001).

45 with baseline QT interval to drug-induced QT prolongation and arrhythmias is not known.

46 t (IKr) blockade to predict long QT syndrome prolongation and arrhythmogenesis.

47 dium channel, is associated with PR-interval prolongation and atrial fibrillation (AF).

48 evidence demonstrates high prevalence of QTc prolongation and complex ventricular arrhythmias in pati

49 l and are associated with corrected QT (QTc) prolongation and complex ventricular arrhythmias.

50 ed these effects, and also the effects of CL prolongation and dysrhythmic spontaneous beating (produc

51 in mild heart failure (HF) patients with QRS prolongation and ejection fraction (EF) </=30%.

52 Severe QTc prolongation and ERP were more prevalent in people with

53 Ks channel), who presented with excessive QT prolongation and high serum levels of norfluoxetine, we

54 Electrocardiographically, PR interval prolongation and high-grade atrioventricular block were

55 show similar problems including QTc interval prolongation and hypothermia.

56 HV interval prolongation and increased number of ventricular tachyca

57 ortion of the variability in drug-induced QT prolongation and is a significant predictor of drug-indu

58 te ID are likely to provide insights into QT prolongation and its associated disorders.

59 mal resting QTc values and only developed QT prolongation and malignant arrhythmias after exposure to

60 ring AVB is independently associated with QT prolongation and may be arrhythmogenic during AVB.

61 ts patients at highest risk for QTc interval prolongation and may be useful in guiding monitoring and

62 edema exacerbated action potential duration prolongation and produced EADs, in particular, at slow p

63 changes are accompanied by action potential prolongation and reductions in transient outward current

64 h V4, with either persistent or transient QT prolongation and severe disease expression of exercise-i

65 luding pronounced action and field potential prolongation and severe reduction or absence of IKs.

66 ain may contribute to ischemia-associated QT prolongation and sudden cardiac death.

67 we report a correlation between QT interval prolongation and T-wave notching in LQTS2 patients and u

68 The degree of QT-interval prolongation and the number of breakthrough cardiac even

69 yndrome characterized by deafness, marked QT prolongation, and a high risk of sudden death.

70 h early childhood cardiac arrest, extreme QT prolongation, and a negative family history.

71 ts causing hypertension, thromboembolism, QT prolongation, and atrial fibrillation.

72 Among subjects with mild HF, QRS prolongation, and LVEF >30%, CRT produced reverse remode

73 ERP and severe QTc prolongation appear to be more prevalent in people with

74 Indeed, progressive corrected QT prolongation, arrhythmias, and ischemic changes were not

75 ated systemic and pulmonary hypertension, QT prolongation, arrhythmias, pericardial disease, and radi

76 We defined QRS prolongation as QRS>/=100 ms.

77 in HRV over 24h at 10 dpa, accompanied by QT prolongation as well as diurnal variations, followed by

78 The prominent AP prolongation at action potential duration at 30% repolar

79 erolemia is associated with action potential prolongation because of increased I(Ca) and reduces occu

80 yte migration and the retraction of neuronal prolongations, both processes in which internal forces a

81 of age, corresponding to the presence of PR prolongation, but not P1, suggesting, at least in part,

82 on occurs in the heart and contributes to QT prolongation by altering cardiac sodium current properti

83 resynaptic spikes without preventing further prolongation by brief depolarizing somatic prepulses.

84 21 points, respectively, best predicted QTc prolongation (C statistic=0.823).

85 ively predicts the action potential duration prolongation caused by exposure to four concentrations o

86 The prolongation caused by reverse rate dependent agents is

87 ver, it is unclear whether to what extent QT prolongation coexisting with ECG-LVH can explain the pro

88 Corrected QT (QTc) interval prolongation (defined as QTc>500 ms or an increase of >6

89 The adjusted odds ratio (OR) for QTc prolongation, defined as a QTc >/= 450 msec in men and >

90 Underlying abnormalities include QT prolongation, delayed repolarization from downregulation

91 h autoimmune diseases and corrected QT (QTc) prolongation directly target and inhibit the human ether

92 Consistent with QT prolongation, epileptic rats had longer ventricular acti

93 PR prolongation (first degree AV block) was present at 4 we

94 models and led to reduced relative survival prolongation following temozolomide treatment of orthoto

95 INaP in myocytes translated into QT interval prolongation for both types of diabetic mice.

96 was 403 (standard deviation, 30) ms, and no prolongation >450 ms occurred.

97 r, innate susceptibility to PM-associated QT prolongation has not been characterized.

98 nonfamilial pattern of disease, PR interval prolongation, high-grade atrioventricular block, signifi

99 We revealed Amiodarone-mediated QTc prolongation, HR reduction and HRV increase otherwise ma

100 management, and clinical consequences of QT prolongation in a large cohort of patients treated with

101 e genetic susceptibility to PM-associated QT prolongation in a multi-racial/ethnic, genome-wide assoc

102 QRS prolongation in African Americans was associated with in

103 blockade in vivo is associated with a 3-fold prolongation in allograft survival.

104 precluded by a low therapeutic window to QTc prolongation in cardiovascular models consistent with in

105 n = 21; p < 0.004) and abolished the 3-fold prolongation in collagen adenosine diphosphate-induced c

106 is underscored by evidence that QT interval prolongation in diabetes mellitus also may result from c

107 Exercise testing is useful in unmasking QT prolongation in disorders associated with abnormal repol

108 ricular repolarization delay (19.6% mean QTc prolongation in females; P<0.05) and aldosterone-depende

109 g drugs and reduces the risk of QTc interval prolongation in hospitalized patients with torsades de p

110 (CDSS) for reducing the risk of QT interval prolongation in hospitalized patients.

111 to develop and validate a risk score for QT prolongation in hospitalized patients.

112 ory Abs to the HERG E-pore region induce QTc prolongation in immunized guinea-pigs by targeting the H

113 Such marked action potential prolongation in individual cardiac cells, in turn, is ac

114 0.75; 95% CI, 0.59 to 0.96; P = .016) and a prolongation in median PFS from 15.6 months with letrozo

115 ipoprotein (LDL), L5, is correlated with QTc prolongation in patients with coronary artery disease (C

116 w that L5 was positively correlated with QTc prolongation in patients with ischemic heart disease.

117 ctors associated with the development of QRS prolongation in patients with normal baseline QRS.

118 therapy for recurrent disease, has led to a prolongation in PFS, particularly, in patients with a BR

119 y alter susceptibility to PM10-associated QT prolongation in populations protected by the U.S. Enviro

120 rosine kinase inhibitors have demonstrated a prolongation in progression-free survival (PFS) followin

121 trebananib provided a clinically meaningful prolongation in progression-free survival.

122 gree of conduction delay in the RVOT and not prolongation in repolarization time.

123 The magnitude of QT prolongation in response to bradycardia, rather than the

124 with reduced levels of Mer had a significant prolongation in survival compared with mice transplanted

125 The percentages of APD prolongation in the last 4 hearts at 2000 ms PCL after a

126 elevation and activation recovery intervals prolongation in the RVOT, RV, or left ventricle.

127 er arsenic or urinary arsenic with PR or QRS prolongation in women or men.

128 ) was associated with subsequent QT-interval prolongation in women.

129 Factors associated with developing QRS prolongation included age, male sex, prior myocardial in

130 Independent predictors of QTc prolongation included the following: female (odds ratio,

131 ventricular tachycardia in the absence of QT prolongation, indicating a novel proarrhythmic syndrome.

132 omputational model to test the degree of APD prolongation induced by small electrical perturbations i

133 incorporating a validated risk score for QTc prolongation influences the prescribing of QT-prolonging

134 QT interval prolongation is a heritable risk factor for ventricular

135 QT prolongation is a risk factor for ventricular arrhythmia

136 en death, and the increased prevalence of QT prolongation is an independent risk factor for cardiovas

137 QRS prolongation is associated with adverse outcomes in most

138 QT interval prolongation is common with ATO and can pose a barrier t

139 QT interval prolongation is common with ATO treatment, but clinicall

140 The percent APD prolongation is negatively correlated with baseline APD

141 he animal model of autoimmune-associated QTc prolongation is the first to provide strong evidence for

142 Gs for three markers of SCA risk: severe QTc prolongation (male >450 ms, female >470 ms), Brugada ECG

143 Severe activated partial thromboplastin time prolongation may be a marker of combined hyperfibrinolyt

144 This prolongation may result from periodic drug-binding to a

145 n=1 [1%]; imatinib group, n=1 [1%]), and QT prolongation (nilotinib group, n=1 [1%]; imatinib group,

146 mbryos resulted in action potential duration prolongation, occasionally a 2:1 atrioventricular block,

147 QT prolongation occurred in 49 (3%) patients given neratini

148 Na-L prolonged APD acutely but no additional prolongation occurred on chronic superfusion.

149 transport of Abeta, resulted in significant prolongation of Abeta40 half-life, but only in the latte

150 monolayers display a cycle length dependent prolongation of action potential duration (245 ms untrea

151 Patch clamp experiments showed prolongation of action potential duration (APD) in TAC a

152 stemizole or sertindole caused heterogeneous prolongation of action potential duration and a high inc

153 hat Kir2.1-52V is associated with a dramatic prolongation of action potential duration with evidence

154 with the Du51 peptide resulted in indefinite prolongation of allograft survival.

155 diators contributes to the amplification and prolongation of anaphylaxis.

156 ithout EADs (no-EAD response) showed gradual prolongation of AP duration (APD), and were annihilated

157 contributes to increased BVR by interspersed prolongation of AP duration, which is exacerbated during

158 The prolongation of auditory obligatory and novelty ERPs in

159 n ck2beta(-/-) mice, accompanied by a slight prolongation of bleeding time.

160 owing function often lead to the unnecessary prolongation of cannulation time.

161 A large number of drugs can induce prolongation of cardiac repolarization and life-threaten

162 However, adhiron A6 abolished C3-induced prolongation of clot lysis, reducing mean lysis time fro

163 rior analyses of human fIIa(MZ), significant prolongation of clotting times was observed for fII(MZ)

164 response rate (57.6% vs 31.6%, P = .06), and prolongation of EFS (hazard ratio [HR] = 0.59, P = .08)

165 l and show that this protocol results in the prolongation of electrically evoked spike train duration

166 ly enhanced with an increase of pressure and prolongation of encapsulation time.

167 Selective prolongation of engineered donor cell AP duration (31.9-

168 iii) enhanced F-actin formation; (iv) marked prolongation of eosinophil lifespan (via a NF-kappaB and

169 a by direct fXa inhibitors and corrected the prolongation of ex vivo clotting times by such inhibitor

170 ce homology with C3 and abolished C3-induced prolongation of fibrin clot lysis by interfering with C3

171 Cell-cycle analysis shows prolongation of G0/G1 with LRH-1 silencing, consistent w

172 rnal age in C57BL/6J mice is associated with prolongation of gestation and length of labour.

173 Pharmacological prolongation of glutamatergic synaptic transmission in j

174 r CTLA4Ig induced significant and equivalent prolongation of graft survival in both groups of chimeri

175 particular transitional B cells, can promote prolongation of graft survival, a function dependent on

176 D910A/D910A) , recipients exhibit indefinite prolongation of heart allograft survival.

177 In vivo, the atropine-dependent prolongation of heart rate increase was blunted in PDE4D

178 arsenic exposure from drinking water and the prolongation of heart rate-corrected QT (QTc), PR, and Q

179 zed ECG analysis system performs in labeling prolongation of heart rate-corrected QT interval (QTc),

180 When subjected to PH, Wls-LKO showed prolongation of hepatocyte proliferation for up to 4 day

181 equiring further surgery and/or resulting in prolongation of hospitalization of at least 24 h, and/or

182 KA), rather than PKCepsilon, dependence; (3) prolongation of hyperalgesia induced by an activator of

183 Loss of Arrb2 also results in prolongation of inflammatory pain and neuropathic pain a

184 The purpose of this study was to explore prolongation of islet allograft survival by cotransplant

185 ccumulation of PTCH1 at the plasma membrane, prolongation of its half-life, and increased cell death

186 protection of the cytokine's active site and prolongation of its half-life.

187 after kidney transplantation rather than the prolongation of life.

188 Intriguingly, Wnt5a-LKO did not display any prolongation of LR because of compensation by other cell

189 In vivo evaluation showed a relative prolongation of median survival in an intracranial model

190 Identical prolongation of memory follows localized digestion of PN

191 mice displayed a comparable but more subtle prolongation of ovarian lifespan compared with IL-1alpha

192 diograms demonstrated that MetS-VLDL induced prolongation of P wave (P = 0.041), PR intervals (P = 0.

193 of host and parasite genotypes as risks for prolongation of parasite clearance kinetics, measured ev

194 symptoms of myelofibrosis (MF), and possible prolongation of patients' survival, some have disease th

195 The greatest effect is on prolongation of PFS and, by adding to the effects of sta

196 tion potential (AP) transmission delay and a prolongation of pre- and postsynaptic APs.

197 tory chronic lymphocytic leukemia (CLL) with prolongation of progression-free and overall survival.

198 red with rituximab-chlorambucil, resulted in prolongation of progression-free survival (hazard ratio,

199 The trade-off between the prolongation of progression-free survival and the qualit

200 O induced mechanical hyperalgesia and marked prolongation of prostaglandin E2 (PGE2) hyperalgesia, a

201 els back to the terminal to mediate a marked prolongation of prostaglandin E2-induced hyperalgesia.

202 responses, or tachycardia but abolished the prolongation of QT interval.

203 Prolongation of QT, T(peak)-T(end) intervals, and left v

204 imetinib 60 mg once a day 21/7 had a grade 3 prolongation of QTc; and two patients on a schedule of v

205 formation, and affects the initiation and/or prolongation of remission stages of UC.

206 ay, E. coli may affect the initiation and/or prolongation of remission stages of UC.

207 tributions were the single best predictor of prolongation of sIPSCs.

208 However, prolongation of skin graft survival was lost when B cell

209 ation and thereby contributes to the massive prolongation of SR Ca(2+) release events.

210 ug of the antibody resulted in a significant prolongation of survival as compared to the same amount

211 place in perspective the significance of the prolongation of survival associated with ruxolitinib the

212 st responses (0% cures but two- to threefold prolongation of survival compared with negative controls

213 tumors showed no reduction in tumor size or prolongation of survival following immunotoxin treatment

214 ted infusions of IL-2S4B6 resulted in marked prolongation of survival, which directly correlated with

215 renal function and further contribute to the prolongation of survival.

216 improved management of systemic disease and prolongation of survival.

217 enhanced systolic function without excessive prolongation of systolic ejection time, which may compro

218 p < 0.005) and was negatively related to the prolongation of tactile latencies (p < 0.01); tactile gn

219 associated mutation G1349D all abolished the prolongation of taucf at pHi 6.3.

220 tudies revealed epicardial (EPI)-predominant prolongation of the action potential duration (APD) at 5

221 the peak and late sodium currents leading to prolongation of the action potential duration and an inc

222 s with a frequency of 2.5 Hz, and a variable prolongation of the action potential duration of up to s

223 the decrease in resting membrane potential, prolongation of the action potential, and occurrence of

224 ltered intracellular Ca(2+) cycling causes a prolongation of the action potential, as determined by w

225 sing (100 mg.kg(-1)), with a significant 43% prolongation of the activated partial thromboplastin tim

226 ish orthologs of NEURL and CAND2 resulted in prolongation of the atrial action potential duration (17

227 diovascular drugs frequently cause excessive prolongation of the cardiac action potential (AP) and le

228 e data indicate a strong correlation between prolongation of the decay time course of sIPSCs and pote

229 We observed prolongation of the early stages of action potential (AP

230 of rise of the action potential upstroke, a prolongation of the effective refractory period secondar

231 ween Galphaq and GRK2 were associated with a prolongation of the interaction between GRK2 and the M3-

232 Most agree that prolongation of the length of stay following a cardiac s

233 Decrement was defined as rate-dependent prolongation of the local ventriculo-atrial time by >30

234 one administration resulted in a significant prolongation of the oestrous cycle and blockade of LH su

235 ng group can easily be removed, allowing the prolongation of the peptide chain at the C-terminus.

236 adrenergic agonist isoproterenol resulted in prolongation of the plateau of action potentials accompa

237 T2* measured in the soleus muscle, and (3) a prolongation of the posterior tibial vein SvO2 washout t

238 del of temporal lobe epilepsy, and it led to prolongation of the PR interval in ECG recordings in rod

239 The mechanism causing a prolongation of the QT interval during epilepsy remains

240 Several reports have demonstrated that prolongation of the QT interval is associated with sudde

241 Prolongation of the QT interval on the electrocardiogram

242 ditions can occasionally produce exaggerated prolongation of the QT interval on the electrocardiogram

243 There was no evidence of increased risks of prolongation of the QT interval or dysglycemia with the

244 Although prolongation of the QT interval was associated with a 49

245 y responsible for delayed repolarization and prolongation of the QT interval.

246 Risk factors for prolongation of the QTc interval are chronic hepatitis C

247 e leads to HuR detachment and the subsequent prolongation of the SOX2 mRNA half-life.

248 isk of SCD with the QT interval is driven by prolongation of the T-wave onset to T-peak component.

249 s (LA) is largely determined by drug-induced prolongation of the time course of repriming (recovery f

250 elated gene (hERG) K(+) channel leads to the prolongation of the ventricular action potential that ca

251 unctions of most beta-band activity, so that prolongation of these beta episodes, as observed in Park

252 Prolongation of transient porcine chimerism via transgen

253 esolution of these findings does not require prolongation of treatment beyond that recommended by gui

254 F group at 28 days postinjection, there were prolongations of PR interval (after versus before: 130 +

255 Ro antigen-immunized guinea pigs showed QTc prolongation on ECG after developing high titers of anti

256 thrombocytopenia [cohort 2], one grade 3 QT prolongation on electrocardiogram [cohort 3], and one gr

257 Arrhythmias associated with QT prolongation on the ECG often lead to sudden unexpected

258 tients with autoimmune diseases and with QTc prolongation on the ECG target the human ether-a-go-go-r

259 g delayed repolarization seen as QT interval prolongation on the ECG.

260 ake on positron emission tomography, and QTc prolongation on the ECG.

261 lengthen the action potential and cause QTc prolongation on the surface ECG.

262 n clears dead cells and matrix debris, while prolongation or expansion of the inflammatory response r

263 ate markers of TdP-risk, such as QT-interval prolongation or inhibition of the rapid delayed-rectifie

264 opped for 105 patients (7.5%) because of QTc prolongation or TdP.

265 -most common primary suspect in cases of QTc prolongation or torsade de pointes after dofetilide (a k

266 Monthly reports of QTc prolongation or torsade de pointes increased from a mean

267 thmia or cardiac arrest and 379 cases of QTc prolongation or torsade de pointes were associated with

268 dical-legal decision-making (relating to the prolongation, or otherwise, of life after severe brain i

269 ORadj 2.4, 95% CI 1.1 to 5.5) and severe QTc prolongation (ORadj 9.9, 95% CI 1.1 to 1317.7).

270 as associated with more episodes (p = 0.02), prolongation (p = 0.01), and greater cumulative duration

271 patients who developed corrected QT-interval prolongation (p = 0.16), extrapyramidal symptoms (p = 0.

272 l group vs six in the placebo group) and QTc prolongation (seven patients in the haloperidol group vs

273 outine ECG screening and that those with QTc prolongation should receive counseling about drugs that

274 renergic stimulation caused action potential prolongation specifically in JLNS-CMs.

275 Hence, they are prone to participate in the prolongation step of the radical chain reactions occurri

276 Na- and K-channel mutations in Mendelian QT prolongation syndromes.

277 Such prolongation tends to be seen among patients who require

278 o not know why some patients develop more QT prolongation than others, despite similar bradycardia.

279 e report a mechanism for diabetes-induced QT prolongation that involves an increase in INaP caused by

280 Kr demonstrated significant action potential prolongation, to which IKs block contributed importantly

281 he association of citalopram with cardiac QT prolongation, use of this agent to treat agitation may b

282 s also a prerequisite for aging-dependent QT prolongation, ventricular fibrillation and SCD immediate

283 )-induced Ca(2+) release by SCR underlies AP prolongation via increased I(CaL.) These data provide no

284 After risk adjustment, QRS prolongation was associated with increased mortality (ha

285 QTc interval prolongation was defined as QTc interval >500 ms or incr

286 patients who presented with QTc >500 ms, QTc prolongation was defined solely as increase in QTc >/=60

287 incorporating a validated risk score for QTc prolongation was developed and implemented using informa

288 abbits, and cynomolgus monkeys; however, the prolongation was less pronounced in rats.

289 The APD prolongation was mediated by an increase of L-type calci

290 QTc prolongation was observed in all patients (by 60 +/- 6 m

291 Further drug release prolongation was reached with formation of the tube-end

292 Activation-recovery interval prolongation was spatially heterogeneous, with repolariz

293 ents occurred in 26 (8%) of 329 patients; QT prolongation was the most common serious adverse event (

294 the full analysis population, the 7.2 months prolongation we noted with the addition of everolimus in

295 the validation group, the incidences of QTc prolongation were 15% (low risk); 37% (moderate risk); a

296 om patients with autoimmune diseases and QTc prolongation were tested on IKr using HEK293 cells expre

297 limits, with no significant increase in QTc prolongation with increasing courses of DP.

298 ominently featuring cardiac action potential prolongation with paroxysms of life-threatening arrhythm

299 g autologous BMT led to significant survival prolongation, with 30% to 40% of the treated mice displa

300 sion to normal rhythm was associated with QT prolongation yet absent proarrhythmia markers for Torsad