ライフサイエンスコーパス: prolonged

1 ng, and resolution of joint inflammation was prolonged.

2 l microvascular responses to acute (2 h) and prolonged (10 h) poikilocapnic normobaric hypoxia.

3 r silenced excitatory synapses, whereas more prolonged (24 hr) firing depressed both AMPAR and NMDAR

4 n (UW) solution + H2 S (150 muM NaSH) during prolonged (24-h) cold (4 degrees C) storage exhibited si

5 o persist over millennial time scales in the prolonged absence of fire.

6 , and persistent nicotine seeking even after prolonged abstinence.

7 aticity, reduced phase 0 upstroke slope, and prolonged action potential duration.

8 Prolonged activation of somatic MORs in POMC neurons rob

9 Prolonged activation of these synapses leads to initial

10 s decreases chromatin accessibility, whereas prolonged activation prevents the gradual chromatin comp

11 f O2 and that high temperature together with prolonged activation time increases the population of su

12 lity of cells to recover this response after prolonged activation, which is in accord with the establ

13 iquitin-linked receptor downregulation after prolonged activation.

14 ylaxis of Plasmodium falciparum malaria with prolonged activity would substantially advance malaria c

15 This rapid adaptation contrasted with the prolonged adaptation in step length symmetry ( approxima

16 f the proportion of patients presenting with prolonged air leakage (7.8% in the FOREseal group vs 11.

17 rway smooth muscle (ASM) axis that underlies prolonged airway hyperreactivity (AHR) in mice.

18 have been reported as side effects following prolonged Aldara use.

19 omoting intragraft accumulation of Tregs and prolonged allograft survival.

20 letal muscle loss and lay the foundation for prolonged ammonia-lowering therapy to reverse sarcopenia

21 hat do not cause these side-effects and have prolonged anabolic effects on bone.

22 tudies are needed to validate the effects of prolonged anakinra on peak Vo2 and rehospitalization for

23 We suggest that prolonged and aberrant hormone-evoked Ca(2+) increases m

24 Voluntary prolonged and excessive alcohol consumption in a 2-bottl

25 Results indicated that prolonged and large-scale droughts had a strong negative

26 roughout the majority of 2015-16, indicating prolonged and nearly continuous spawning of adults throu

27 d shows a further significant increase after prolonged and severe sleep loss, suggesting that it may

28 A previous classification into simple, prolonged, and difficult weaning ignored weaning failure

29 ction vs vehicle controls (P < .0001) and in prolonged animal survival.

30 y innocuous to cells, the d-peptide exerts a prolonged anti-proliferative activity.

31 ic therapy in the reduction of SSI, and that prolonged antibiotic courses have no established benefit

32 , T cells that become fully exhausted during prolonged antigen exposure remain refractory to ICB-medi

33 lease of peptide resulted in both higher and prolonged antigen presentation when compared to disulfid

34 Continuation of prolonged antivirals beyond initial clearance was not as

35 Prolonged application of AMPA caused loss of afferent te

36 Moreover, in prolonged arrest caused by nocodazole treatment, the ove

37 -M checkpoint, inducing a hypersensitive and prolonged arrest.

38 hyperacute infection may be associated with prolonged ART-free remission.

39 their contribution to the SIV reservoir with prolonged ART-mediated viral suppression.

40 n graft survival on high CD47 recipients was prolonged as well, in 1 case showing no signs of rejecti

41 Both vernakalant and AP14145 significantly prolonged atrial refractoriness and reduced AF duration

42 analyses vary regarding the effectiveness of prolonged beta-lactam infusion.

43 Complement factor 3 (C3) deficiency causes prolonged bleeding, reduced thrombus incidence, thrombus

44 nland in late December, it was followed by a prolonged blocking period in early 2016 that sustained t

45 e pharmacological manipulations suggest that prolonged burst durations are caused by dendritically lo

46 relaxation time (RT50) at 60 per minute was prolonged by 13% in HHD and by 18% in HHD+HFpEF (both P<

47 ition from oscillatory to more sustained and prolonged Ca(2+) increases.

48 l brain metabolism are altered in those with prolonged cannabis exposure.

49 (N=101) to determine the association between prolonged cannabis use and the following neurophysiologi

50 g several exciting avenues for selective and prolonged cardiac therapeutics.

51 ant difference in the composite end point of prolonged catecholamine infusion, use of left ventricula

52 for this group were poor and often involved prolonged chemotherapy; on NWTS-5, 4-year EFS for all ch

53 udy revealed that DC nanozymes significantly prolonged circulation of active SOD1 in the blood stream

54 e of the drug from the linker, combined with prolonged circulation of the dendrimer, enabled administ

55 f liposomal formulation was characterized by prolonged circulation time (5.5h) along with increase in

56 exaggerated ventilatory responses to CO2 and prolonged circulation time, implicates the ventilatory c

57 Genetically modified PAEC significantly prolonged clotting time of human blood (115.0 +/- 16.1 m

58 s, shorter lag phase, decreased D-Drate, and prolonged CLT were independent predictors of recurrences

59 inimize the detrimental clinical outcomes of prolonged cold IRI during RTx.

60 ved syngraft function and survival following prolonged cold storage compared to UW solution.

61 comparing mortality or clinical efficacy of prolonged (continuous or >/=3 h) versus short-term (</=6

62 Prolonged cooling, for 60 min, was associated with a fur

63 rainage of corneal edema and a trend towards prolonged corneal opacification.

64 ivation of glutamatergic PPT neurons induced prolonged cortical activation and behavioral wakefulness

65 y infection (OR = 1.01, 95% CI: 0.99, 1.02), prolonged cough (OR = 1.00, 95% CI: 0.99, 1.02), or diar

66 dren who were susceptible to frequent and/or prolonged Ct infection had a less focussed antibody resp

67 ntagonist, RU486, into the AVPV reversed the prolonged cycle length and rescued the progesterone bloc

68 Prolonged DAPT resulted in harm in patients with low DAP

69 imary efficacy outcome varied by stent type; prolonged DAPT with high scores was effective only in pa

70 ntense white flash induced a small amplitude prolonged dark current composed of discrete unitary curr

71 imed to determine the therapeutic effects of prolonged dark therapy or melatonin administration on he

72 After cardiac ischaemia, a prolonged decrease of coronary microvascular perfusion o

73 childhood, partial hearing loss can produce prolonged deficits in speech perception and temporal pro

74 was observed in rejuvenated leaves following prolonged defoliation.

75 Prolonged delay in treatment is associated with less imp

76 ingly, another EspP mutant likewise formed a prolonged, deleterious interaction with the Bam complex

77 Infection with low-dose A/X31 H3N2 led to prolonged deterioration of lung function, aggravated muc

78 Previously, we found prolonged development of some GABAergic proteins in huma

79 ed 3D object representations emerges after a prolonged developmental trajectory and is contingent on

80 feration, but could be beneficial during the prolonged differentiation stage.SIGNIFICANCE STATEMENT I

81 Given that prolonged disruptions of normal rhythms are highly detri

82 origin of PIM resistance engineered through prolonged drug treatment of MOLM16 cell lines and succes

83 ter bamboo lemur populations will experience prolonged dry seasons similar to those of the localities

84 ding and reduced myocardial infarctions with prolonged dual antiplatelet therapy, findings that suppo

85 the retention of sodium ions in the mouth is prolonged due to the mucoadhesive nature of the polysacc

86 unknown, respiratory virus infections have a prolonged duration in CF.

87 ponse was of surprisingly high magnitude and prolonged duration, implying prolonged presentation of v

88 ofibrils with D137L/G126R or D137L Tm showed prolonged durations of the slow phase of relaxation and

89 ASB with high rates of treatment of ASB and prolonged durations of therapy for ASB and symptomatic U

90 Prolonged dwell time and catheter insertion under emerge

91 ergic signaling in enteric glia mediates the prolonged effect of morphine on constipation.

92 changes, including membrane depolarization, prolonged elevation of intracellular Ca(2+) and diminuti

93 tococcus neoformans (52D), which resulted in prolonged elevations in fungal burden and histopathologi

94 zed controlled trial (RCT) hypothesized that prolonged enteral nutrition (EN) with supplemental eicos

95 ession in hippocampal neuronal injury during prolonged epileptic seizures.

96 en subject to dosage balance constraints for prolonged evolutionary times, which may have repercussio

97 n complication of shingles that manifests as prolonged excruciating pain, which has proven difficult

98 In response to prolonged exercise, IL-6 is synthesized by contracting s

99 y a combination of a 3-d controlled diet and prolonged exercise.

100 Prolonged exit from quiescence by hematopoietic stem cel

101 iple gene fusions are limited by tedious and prolonged experimental protocols, thus limiting their us

102 ANOG, SOX2) remained unaffected, until after prolonged exposure (96 hrs).

103 exposure, dermal absorption of BPA leads to prolonged exposure and may lead to higher proportions of

104 s neutralization, supports the proposal that prolonged exposure of the bNAb epitope enabled the matur

105 Prolonged exposure of trypanosomes to AEE788 inhibited t

106 ors assessed changes in brain function after prolonged exposure therapy across three emotional reacti

107 Prolonged exposure to an AWC sensed odor in the absence

108 -nephrin(+) EVs ratio and may be mediated by prolonged exposure to cellfree HbF.

109 ral feature of addictions or are a result of prolonged exposure to drugs of abuse.

110 these defects could be overcome by early or prolonged exposure to IL-2, or by addition of IL-12 to c

111 Initial EMT was induced by prolonged exposure to IL6, a cytokine also generated by

112 ing and phenotypic changes we observed after prolonged exposure to lumican.

113 Likewise, colonic inflammation related to prolonged exposure to morphine was significantly attenua

114 However, prolonged exposure to the SASP causes a subsequent cell-

115 After prolonged exposure to the selective and potent CDK4/6 in

116 logical and neurobiological complications of prolonged exposure to vehicle emissions remain unknown.

117 ion along the intracellular route and, under prolonged exposure, desensitization.

118 injured Ccr2(-/-) sciatic nerves demonstrate prolonged expression of neutrophil chemokines, a concomi

119 The prolonged, extrovert assembly of Rodinia from thickened

120 cose production, especially during states of prolonged fasting.

121 dence of epilepsy was lower in patients with prolonged febrile seizures (14.3%, 6.3-29.4) and survivo

122 One participant (2.9%, 0.5-14.5) in the prolonged febrile seizures group developed temporal lobe

123 tial of satellite cells in the prevention of prolonged frailty in burn survivors.

124 attributes, aiming to quantify the impact of prolonged frying on potatoes nutrients, and the potentia

125 tension (OHT) is a serious adverse effect of prolonged GC therapy that can lead to iatrogenic glaucom

126 NA insertion lines for visible defects under prolonged growth at 5 degrees C.

127 n, halted the adaptive transition and led to prolonged growth inhibition in multiple patient-derived

128 The prolonged growth of dopamine axons represents an extraor

129 g 11-cis to an 11,13-dicis configuration for prolonged Gt activation.

130 s on 30-day mortality, 30-day morbidity, and prolonged (>/=7 days) postoperative LOS, controlling for

131 growth, with the exception of sensitivity to prolonged heat but not other proteotoxic stress.

132 It allows prolonged hemodialysis sessions in critically ill patien

133 Collectively, these changes enhanced edema, prolonged hemorrhage, and impaired forelimb functional r

134 tically improved insulin sensitivity despite prolonged high-fat diet feeding.

135 of operative mortality, major adverse event, prolonged hospital length of stay, and wound infection/d

136 Liver failure (LF) is associated with prolonged hospital stay, increased cost and substantial

137 Important obstacles for achieving TO were a prolonged hospital stay, postoperative complications, an

138 iven leukemogenesis reduced tumor burden and prolonged host survival.

139 nt increases in angiogenic factor levels and prolonged hyperemia characterize the soft tissue respons

140 n increase in arrhythmias during spontaneous prolonged hypoglycemia in patients with T2DM.

141 ck is often problematic, with development of prolonged hypotension and edema.

142 including re-intubations, ICU readmissions, prolonged ICU and hospital stay, persistent cognitive pr

143 ransfer of malaria-specific antibodies and a prolonged IgG3 half-life in infants and that its presenc

144 ival time (35 +/- 31 days) was significantly prolonged in both 5C8H1-treated (142 +/- 26, P < 0.002)

145 Tail bleeding time was prolonged in DREAM KO control mice, but not in WT or DRE

146 Contraction and relaxation are prolonged in isolated myocardium from patients with HHD

147 Ventricular activation was prolonged in old Scn5a+/DeltaKPQ mice (p = 0.03).

148 wed a stimulation protocol was significantly prolonged in PMCA1(cko) atrial myocytes under basal cond

149 Reaction times were prolonged in SCI participants compared with control subj

150 severe neutropenia and thrombocytopenia were prolonged in the intensive arm, but there were no differ

151 (MCV) causes an aggressive skin cancer after prolonged infection and requires an active large T (LT)

152 lack adaptive immune responses, leading to a prolonged infection prior to clinical disease.

153 In diabetes, macrophages display a prolonged inflammatory phenotype in late wound healing.

154 gase to an E2-conjugating enzyme, leading to prolonged inflammatory signaling.

155 INTERPRETATION: Prolonged infusion of antipseudomonal beta-lactams for t

156 the majority of mouse tumor models lack the prolonged initial phases of multistage tumor evolution p

157 d MDSCs had increased nosocomial infections, prolonged intensive care unit stays, and poor functional

158 The prolonged intermediate state allowed us to identify prot

159 on sites (C terminus phosphonull) leads to a prolonged intrinsic light response.

160 endent, these native ecosystems subjected to prolonged invasion by exotic plants may be instrumental

161 h, when blocked, led to HSC mobilization and prolonged islet allograft survival.

162 bination of XVX with R1 and R2 significantly prolonged its cytotoxicity.

163 were significantly less likely to experience prolonged length of stay (odds ratio [OR], 0.50; 95% CI,

164 urce use following both surgeries, including prolonged length of stay (OR, 1.37; 95% CI, 1.11-1.70) f

165 ns (USMG: 14.5%, IMG: 14.3%; P = 0.032), and prolonged length of stay (pLOS) (USMG: 22.7%, IMG: 22.8%

166 e observed that dC+dT delayed disease onset, prolonged life span of Tk2-deficient mice and restored m

167 lopment, da1-1 and bb/eod1-2 leaves showed a prolonged longevity, which was enhanced in the double mu

168 Prolonged LPS-induced activation of p38 and JNK, phospho

169 kely than those without reactivation to have prolonged lymphopenia (median, 95 versus 22 days; P = 0.

170 ation (median, 52 versus 42 ms; P=0.007) and prolonged mean epicardial activation-recovery intervals

171 Maternal smoking was associated with prolonged mechanical ventilation and respiratory support

172 factors that predict long-term mortality in prolonged mechanical ventilation patients.

173 increased feelings of regret about choosing prolonged mechanical ventilation.

174 he sustained decrease in binding may reflect prolonged mGluR5 internalization in response to the glut

175 ng, such that cells are unable to maintain a prolonged mitotic arrest in the presence of unaligned ch

176 To ascertain a more direct effect on prolonged MMP13 production we examined the potential mol

177 We term this effect Prolonged Morning Wakefulness (PMW).

178 Prolonged morphine treatment results in a "leaky" gut, p

179 n significant inhibition of tumor growth and prolonged mouse median survival.

180 ery mediated significant tumor reduction and prolonged mouse survival.

181 ing study demonstrates that CCL2 enables the prolonged MSC-T cell interactions needed for sufficient

182 sumption of large meals during situations of prolonged negative energy balance.

183 Pase (SERCA) pump activity with thapsigargin prolonged NMDAR-DeltaCa(2+) responses in MNCs of sham ra

184 BoNT serotype A (BoNT/A) has the most prolonged or persistent effects, which can last several

185 corporates genetic effect, natural aging and prolonged oral environmental toxicity administered to mu

186 birth defects-treatment following surgery is prolonged over a lifetime and often involves multidiscip

187 postexpression enhancement in cocaine SA and prolonged (over 5 weeks) increases in reinstatement of c

188 ycobacterial burden in lung and spleen and a prolonged overall survival in animals that received a tr

189 -derived xenografts reduced tumor burden and prolonged overall survival without affecting murine hema

190 owth and distal metastasis and substantially prolonged overall survival.

191 e powder further explain previously observed prolonged oxidation capability of TiO2 powder without li

192 After prolonged P. aeruginosa exposure, ASER-specific SOD-1 ex

193 ar whether ischemic risk and the benefits of prolonged P2Y12 inhibition in this population remain con

194 anscriptional changes and the development of prolonged pain.

195 ential in the development and maintenance of prolonged pain.

196 productive and seasonal environments, where prolonged parent-offspring associations are likely to be

197 A diffused prolonged pattern of FAdE expression and delayed regress

198 h to withstand strong cross-flow shear for a prolonged period (120 h) while maintaining NaCl rejectio

199 dicating that plasma cells may persist for a prolonged period of time in the absence of cell division

200 Prolonged periods of extreme heat or drought in the firs

201 risingly, the amount of LDs increases during prolonged periods of nutrient deprivation.

202 Prolonged periods of simulated microgravity did not caus

203 They have stable firing rates during prolonged periods of stimulation and respond to a wide r

204 Systems capable of residing for prolonged periods of time in the gastric cavity have tra

205 rowing along the natural gravity vector over prolonged periods of time, as well as the ability to ind

206 to sustain this anti-depressive function for prolonged periods remains unclear.

207 udying endothelial dysfunction in vitro over prolonged periods.

208 ination of higher stability and potency with prolonged pharmacokinetics could be compatible with very

209 ion with reduced aquaporin-2 endocytosis and prolonged plasma membrane aquaporin-2 retention.

210 of lytic granules revealed their dynamic and prolonged polarization toward neighboring NK cells witho

211 Patients with prolonged postictal symptoms lasting up to 8 wk displaye

212 , strokes and other diseases occurred during prolonged power outages.

213 h magnitude and prolonged duration, implying prolonged presentation of viral antigens.

214 ce of MRD negativity was not associated with prolonged progression-free survival (PFS) and overall su

215 Indeed, deep responses and prolonged progression-free survival can be achieved in r

216 Despite somewhat prolonged progression-free survival, treatment with lomu

217 Rotating treatment did not result in prolonged progression-free-survival, fewer toxic effects

218 find that low concentrations of 20E support prolonged proliferation in explanted wing discs in the a

219 uality, expertly annotated seizure data from prolonged recordings.

220 The biological consequences of prolonged reduction in expression of this essential chap

221 An in vivo pilot study showed a prolonged release of insulin from swellable MN patches,

222 ous reservoir layers are intended to promote prolonged release of nanoparticles into the submucosal t

223 nsplantation diabetes mellitus (PTDM) with 2 prolonged-release tacrolimus corticosteroid minimization

224 A prolonged-release tacrolimus, basiliximab, and mycopheno

225 All patients received prolonged-release tacrolimus, basiliximab, mycophenolate

226 aily seizures are uncommon in Rett syndrome, prolonged remission is less common than in other causes

227 ly to shaping cytosolic Ca(2+) except during prolonged repetitive firing.

228 within anatomic segments, it correlated with prolonged repolarization, electric markers of scar, and

229 Early flowering time, a prolonged reproductive growth phase, and, thereby, incre

230 that temporal sensing mechanisms controlled prolonged responses to these ligands.

231 the septum (38+/-15 ms post-QRS onset); (2) prolonged right-to-left transseptal activation with abse

232 oneal dose of compounds I and II exhibited a prolonged serum residence time of 48 hours and concentra

233 d showed superior efficacy and significantly prolonged serum t1/2 The combination of higher stability

234 Here we study whether prolonged shedders within the immunocompromised populati

235 loablative conditioning were associated with prolonged shedding.

236 Progression-free survival was prolonged significantly in patients allocated ramuciruma

237 ng acute zero gravity (parabolic flight) and prolonged simulated microgravity (6 deg head-down tilt b

238 panicle and dark green and thick leaves with prolonged source activity are among the desirable traits

239 t, decreased sRBC adhesion, but overswelling prolonged sRBC transit times in capillary-sized microcha

240 in sensor development, superior sensitivity, prolonged stability, and lack of non-specific sensor fou

241 nt, we found that women living in towns with prolonged state ownership had significantly lower odds o

242 INTERPRETATION: Prolonged state ownership was associated with protection

243 rwise leptosperin was chemically stable over prolonged storage at 37 degrees C.

244 phenyllactic acid are chemically stable over prolonged storage, but not 2-methoxybenzoic acid and 2'-

245 0.98, 95% CI: 0.92, 1.05), skin reaction to prolonged sun exposure (for painful burn with blisters v

246 We report a case of a 17-year-old boy with a prolonged super-refractory status epilepticus that event

247 ps to maintain an ICM-like epigenetic state, prolonged suppression results in irreversible changes th

248 2 h after the last administered dose, and a prolonged surveillance after discharge of 48 h.

249 Improved therapeutic options and prolonged survival have further increased the need for s

250 cell maturation, induced growth arrest, and prolonged survival in an AML mouse model.

251 owth and colony formation, and significantly prolonged survival in murine AML xenografts.

252 t, is associated with reduced metastasis and prolonged survival in pancreatic ductal adenocarcinoma (

253 Furthermore, HPssCD-HET0016 significantly prolonged survival in PDX GBM811 model.

254 mmune modulating effect, leading to markedly prolonged survival of donor swine skin xenografts that m

255 These findings as well as the prolonged survival of f10(-/-) mutants will enable us to

256 erapy with compound 7 and gammadelta T cells prolonged survival of mice inoculated with either human

257 The studies demonstrated prolonged survival of rats subjected to hemorrhagic inju

258 nt cell transplant or zileuton treatment had prolonged survival, reduced GVHD clinical scores, reduce

259 revented neurodegeneration and significantly prolonged survival.

260 l treatment modality that offers a chance of prolonged survival.

261 tastases now have the potential to achieve a prolonged survival.

262 vels dramatically decreased tumor burden and prolonged survival.

263 IR prolonged survival; the mean number of life-years per pa

264 ynchronous release indeed does not produce a prolonged synaptic signal after a stimulus train and doe

265 wever, it enhanced ET-1 vasoconstriction and prolonged the increase in blood pressure in anaesthetise

266 Moreover, inhibition or deletion of SphK1 prolonged the lifetime of sphingosine-induced vesicles.

267 Enriching the olfactory environment of mice prolonged the period over which abGCs were strongly and

268 hich explains why higher amylolytic activity prolonged the productive fermentation time only.

269 time, with the deeper the delivery, the more prolonged the residence time.

270 y and browning index of fresh cut apples and prolonged the shelf life.

271 Intranasal infection with attenuated RABV prolonged the survival of mice bearing established GL261

272 ivery of cGAMP inhibited melanoma growth and prolonged the survival of the tumor-bearing mice.

273 cyte infiltration via genetic Ccl2 reduction prolonged the survival of tumor-bearing mice.

274 ninvasive ventilation to home oxygen therapy prolonged the time to readmission or death within 12 mon

275 her SK current than wildtype (WT) and apamin prolonged their APs.

276 In addition, HS showed a significantly prolonged therapeutic efficacy as compared to N-acetylcy

277 signature that selectively persisted during prolonged therapy.

278 increases in Mean-Squared-Displacement over prolonged time periods according to t(alpha) with 0 < al

279 ding of multiple chemosensory stimuli over a prolonged time scale.

280 ndothelial cells and neonatal porcine islets prolonged time to clot formation.

281 at patients with higher DACH1 expression had prolonged time to death, recurrence and metastasis, whil

282 Here, we investigated the effect of prolonged TNFalpha exposure on the fate of endothelial c

283 venting bioadhesion when the contact time is prolonged to 2-5 s, or when the membranes are exposed to

284 Prolonged tomato consumption can mitigate ultraviolet (U

285 Wild-type mice initially learnt, but with prolonged training came to withhold responding during th

286 almost until weaning, potentially indicating prolonged trans-intestinal transfer of IgG.

287 The aim was to investigate the prolonged treatment effect of A1PI on the progression of

288 However, high concentrations or prolonged treatment with low doses of HU can cause cell

289 ting this secondary inflammatory response to prolonged treatment with morphine.

290 Besides, excellent tumor accumulation and prolonged tumor retention of GC-PEG-PpIX were realized a

291 Prolonged UPR activation, and in particular the PERK bra

292 Severe or chronic/prolonged UPR can breach the threshold for survival and

293 s not receiving corticosteroids supports the prolonged use of corticosteroids after DMEK.

294 g extended stays in the intensive care unit, prolonged ventilator management, and possible dialysis a

295 We aimed to identify the effectiveness of prolonged versus short-term infusion of antipseudomonal

296 esponse against MCMV infection, resulting in prolonged viral persistence.

297 HIV/CMV co-infected persons despite prolonged viral suppression often experience persistent

298 nce of the long-lived PCs, it also generated prolonged virus-neutralizing antibodies (VNAs), resultin

299 formance during acute sleep deprivation (one prolonged wake episode), chronic sleep restriction (mult

300 has been linked with traumatic brain injury, prolonged wakefulness, and aging.